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Volumn 5, Issue JUN, 2014, Pages

Using the zebrafish model for Alzheimer's disease research

Author keywords

Alzheimer disease; Amyloid beta protein precursor; Gamma secretase; MAPT; Presenilins; Zebrafish

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN [1-42]; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; BETA SECRETASE 1; BETA SECRETASE 2; CHAPERONE; ENDONUCLEASE; GAMMA SECRETASE; PRESENILIN; PRESENILIN 1; PRESENILIN 2; PROTEIN P53; TRANSCRIPTION ACTIVATOR LIKE EFFECTOR NUCLEASE; UBIQUITIN; UNCLASSIFIED DRUG; ZINC FINGER NUCLEASE;

EID: 84906282905     PISSN: None     EISSN: 16648021     Source Type: Journal    
DOI: 10.3389/fgene.2014.00189     Document Type: Review
Times cited : (115)

References (108)
  • 1
    • 84882872060 scopus 로고    scopus 로고
    • The zebrafish amyloid precursor protein-b is required for motor neuron guidance and synapse formation
    • doi: 10.1016/j.ydbio.2013.06.026
    • Abramsson, A., Kettunen, P., Banote, R. K., Lott, E., Li, M., Arner, A., et al. (2013). The zebrafish amyloid precursor protein-b is required for motor neuron guidance and synapse formation. Dev. Biol. 381, 377-388. doi: 10.1016/j.ydbio.2013.06.026
    • (2013) Dev. Biol. , vol.381 , pp. 377-388
    • Abramsson, A.1    Kettunen, P.2    Banote, R.K.3    Lott, E.4    Li, M.5    Arner, A.6
  • 2
    • 77950901539 scopus 로고    scopus 로고
    • Phenotypic analysis of images of zebrafish treated with Alzheimer's gamma-secretase inhibitors
    • doi: 10.1186/1472-6750-10-24
    • Arslanova, D., Yang, T., Xu, X. Y., Wong, S. T., Augelli-Szafran, C. E., and Xia, W. M. (2010). Phenotypic analysis of images of zebrafish treated with Alzheimer's gamma-secretase inhibitors. BMC Biotechnol. 10:24. doi: 10.1186/1472-6750-10-24
    • (2010) BMC Biotechnol , vol.10 , pp. 24
    • Arslanova, D.1    Yang, T.2    Xu, X.Y.3    Wong, S.T.4    Augelli-Szafran, C.E.5    Xia, W.M.6
  • 3
    • 0030795794 scopus 로고    scopus 로고
    • Both apolipoprotein E and A-I genes are present in a nonmammalian vertebrate and are highly expressed during embryonic development
    • doi: 10.1073/pnas.94.16.8622
    • Babin, P. J., Thisse, C., Durliat, M., Andre, M., Akimenko, M. A., and Thisse, B. (1997). Both apolipoprotein E and A-I genes are present in a nonmammalian vertebrate and are highly expressed during embryonic development. Proc. Natl. Acad. Sci. U.S.A. 94, 8622-8627. doi: 10.1073/pnas.94.16.8622
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , pp. 8622-8627
    • Babin, P.J.1    Thisse, C.2    Durliat, M.3    Andre, M.4    Akimenko, M.A.5    Thisse, B.6
  • 4
    • 78751704164 scopus 로고    scopus 로고
    • Zebrafish models of tauopathy
    • doi: 10.1016/j.bbadis.2010.09.004
    • Bai, Q., and Burton, E. A. (2011). Zebrafish models of tauopathy. Biochim. Biophys. Acta 1812, 353-363. doi: 10.1016/j.bbadis.2010.09.004
    • (2011) Biochim. Biophys. Acta , vol.1812 , pp. 353-363
    • Bai, Q.1    Burton, E.A.2
  • 5
    • 36148960495 scopus 로고    scopus 로고
    • Generation of a transgenic zebrafish model of Tauopathy using a novel promoter element derived from the zebrafish eno2 gene
    • doi: 10.1093/nar/gkm608
    • Bai, Q., Garver, J. A., Hukriede, N. A., and Burton, E. A. (2007). Generation of a transgenic zebrafish model of Tauopathy using a novel promoter element derived from the zebrafish eno2 gene. Nucleic Acids Res. 35, 6501-6516. doi: 10.1093/nar/gkm608
    • (2007) Nucleic Acids Res. , vol.35 , pp. 6501-6516
    • Bai, Q.1    Garver, J.A.2    Hukriede, N.A.3    Burton, E.A.4
  • 6
    • 34250745912 scopus 로고    scopus 로고
    • The Q(o) site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production
    • doi: 10.1083/jcb.200609074
    • Bell, E. L., Klimova, T. A., Eisenbart, J., Moraes, C. T., Murphy, M. P., Budinger, G. R. S., et al. (2007). The Q(o) site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production. J. Cell Biol. 177, 1029-1036. doi: 10.1083/jcb.200609074
    • (2007) J. Cell Biol. , vol.177 , pp. 1029-1036
    • Bell, E.L.1    Klimova, T.A.2    Eisenbart, J.3    Moraes, C.T.4    Murphy, M.P.5    Budinger, G.R.S.6
  • 7
    • 84861418194 scopus 로고    scopus 로고
    • Apolipoprotein E controls cerebrovascular integrity via cyclophilin A
    • doi: 10.1038/nature11087
    • Bell, R. D., Winkler, E. A., Singh, I., Sagare, A. P., Deane, R., Wu, Z., et al. (2012). Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. Nature 485, 512-516. doi: 10.1038/nature11087
    • (2012) Nature , vol.485 , pp. 512-516
    • Bell, R.D.1    Winkler, E.A.2    Singh, I.3    Sagare, A.P.4    Deane, R.5    Wu, Z.6
  • 8
    • 82455184945 scopus 로고    scopus 로고
    • Evaluation of exon-skipping strategies for Duchenne muscular dystrophy utilizing dystrophin-deficient zebrafish
    • doi: 10.1111/j.1582-4934.2011.01260.x
    • Berger, J., Berger, S., Jacoby, A. S., Wilton, S. D., and Currie, P. D. (2011). Evaluation of exon-skipping strategies for Duchenne muscular dystrophy utilizing dystrophin-deficient zebrafish. J. Cell Mol. Med. 15, 2643-2651. doi: 10.1111/j.1582-4934.2011.01260.x
    • (2011) J. Cell Mol. Med. , vol.15 , pp. 2643-2651
    • Berger, J.1    Berger, S.2    Jacoby, A.S.3    Wilton, S.D.4    Currie, P.D.5
  • 9
    • 12944299273 scopus 로고    scopus 로고
    • Notch-Delta signaling is required for spatial patterning and Muller glia differentiation in the zebrafish retina
    • doi: 10.1016/j.ydbio.2004.11.018
    • Bernardos, R. L., Lentz, S. I., Wolfe, M. S., and Raymond, P. A. (2005). Notch-Delta signaling is required for spatial patterning and Muller glia differentiation in the zebrafish retina. Dev. Biol. 278, 381-395. doi: 10.1016/j.ydbio.2004.11.018
    • (2005) Dev. Biol. , vol.278 , pp. 381-395
    • Bernardos, R.L.1    Lentz, S.I.2    Wolfe, M.S.3    Raymond, P.A.4
  • 10
    • 33746310315 scopus 로고    scopus 로고
    • Alzheimer's disease
    • doi: 10.1016/S0140-6736(06)69113-7
    • Blennow, K., De Leon, M. J., and Zetterberg, H. (2006). Alzheimer's disease. Lancet 368, 387-403. doi: 10.1016/S0140-6736(06)69113-7
    • (2006) Lancet , vol.368 , pp. 387-403
    • Blennow, K.1    De Leon, M.J.2    Zetterberg, H.3
  • 11
    • 84863622571 scopus 로고    scopus 로고
    • Alzheimer's-related peptide amyloid-beta plays a conserved role in angiogenesis
    • doi: 10.1371/journal.pone.0039598
    • Cameron, D. J., Galvin, C., Alkam, T., Sidhu, H., Ellison, J., Luna, S., et al. (2012). Alzheimer's-related peptide amyloid-beta plays a conserved role in angiogenesis. PLoS ONE 7:e39598. doi: 10.1371/journal.pone.0039598
    • (2012) PLoS ONE , vol.7
    • Cameron, D.J.1    Galvin, C.2    Alkam, T.3    Sidhu, H.4    Ellison, J.5    Luna, S.6
  • 12
    • 33645101015 scopus 로고    scopus 로고
    • Zebrafish lacking Alzheimer presenilin enhancer 2 (Pen-2) demonstrate excessive p53-dependent apoptosis and neuronal loss
    • doi: 10.1111/j.1471-4159.2006.03648.x
    • Campbell, W. A., Yang, H., Zetterberg, H., Baulac, S., Sears, J. A., Liu, T., et al. (2006). Zebrafish lacking Alzheimer presenilin enhancer 2 (Pen-2) demonstrate excessive p53-dependent apoptosis and neuronal loss. J. Neurochem. 96, 1423-1440. doi: 10.1111/j.1471-4159.2006.03648.x
    • (2006) J. Neurochem. , vol.96 , pp. 1423-1440
    • Campbell, W.A.1    Yang, H.2    Zetterberg, H.3    Baulac, S.4    Sears, J.A.5    Liu, T.6
  • 13
    • 80052803868 scopus 로고    scopus 로고
    • Conserved synteny and the zebrafish genome
    • doi: 10.1016/B978-0-12-374814-0.00015-X
    • Catchen, J. M., Braasch, I., and Postlethwait, J. H. (2011). Conserved synteny and the zebrafish genome. Methods Cell Biol. 104, 259-285. doi: 10.1016/B978-0-12-374814-0.00015-X
    • (2011) Methods Cell Biol. , vol.104 , pp. 259-285
    • Catchen, J.M.1    Braasch, I.2    Postlethwait, J.H.3
  • 14
    • 70350507090 scopus 로고    scopus 로고
    • Complex splicing and neural expression of duplicated tau genes in zebrafish embryos
    • doi: 10.3233/JAD-2009-1145
    • Chen, M., Martins, R. N., and Lardelli, M. (2009). Complex splicing and neural expression of duplicated tau genes in zebrafish embryos. J. Alzheimers Dis. 18, 305-317. doi: 10.3233/JAD-2009-1145
    • (2009) J. Alzheimers Dis. , vol.18 , pp. 305-317
    • Chen, M.1    Martins, R.N.2    Lardelli, M.3
  • 15
    • 84865086929 scopus 로고    scopus 로고
    • Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells
    • doi: 10.1083/jcb.201201076
    • Coen, K., Flannagan, R. S., Baron, S., Carraro-Lacroix, L. R., Wang, D., Vermeire, W., et al. (2012). Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells. J. Cell Biol. 198, 23-35. doi: 10.1083/jcb.201201076
    • (2012) J. Cell Biol. , vol.198 , pp. 23-35
    • Coen, K.1    Flannagan, R.S.2    Baron, S.3    Carraro-Lacroix, L.R.4    Wang, D.5    Vermeire, W.6
  • 16
    • 35248862496 scopus 로고    scopus 로고
    • Single molecule profiling of tau gene expression in Alzheimer's disease
    • doi: 10.1111/j.1471-4159.2007.04857.x
    • Conrad, C., Zhu, J., Conrad, C., Schoenfeld, D., Fang, Z., Ingelsson, M., et al. (2007). Single molecule profiling of tau gene expression in Alzheimer's disease. J. Neurochem. 103, 1228-1236. doi: 10.1111/j.1471-4159.2007.04857.x
    • (2007) J. Neurochem. , vol.103 , pp. 1228-1236
    • Conrad, C.1    Zhu, J.2    Conrad, C.3    Schoenfeld, D.4    Fang, Z.5    Ingelsson, M.6
  • 17
    • 77956884129 scopus 로고    scopus 로고
    • Presenilin-1 regulates induction of hypoxia inducible factor-1alpha: altered activation by a mutation associated with familial Alzheimer's disease
    • doi: 10.1186/1750-1326-5-38
    • De Gasperi, R., Sosa, M. A., Dracheva, S., and Elder, G. A. (2010). Presenilin-1 regulates induction of hypoxia inducible factor-1alpha: altered activation by a mutation associated with familial Alzheimer's disease. Mol. Neurodegener. 5:38. doi: 10.1186/1750-1326-5-38
    • (2010) Mol. Neurodegener , vol.5 , pp. 38
    • De Gasperi, R.1    Sosa, M.A.2    Dracheva, S.3    Elder, G.A.4
  • 18
    • 57449084208 scopus 로고    scopus 로고
    • apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain
    • doi: 10.1172/JCI36663 36663
    • Deane, R., Sagare, A., Hamm, K., Parisi, M., Lane, S., Finn, M. B., et al. (2008). apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain. J. Clin. Invest. 118, 4002-4013. doi: 10.1172/JCI36663 36663
    • (2008) J. Clin. Invest. , vol.118 , pp. 4002-4013
    • Deane, R.1    Sagare, A.2    Hamm, K.3    Parisi, M.4    Lane, S.5    Finn, M.B.6
  • 19
    • 24744449320 scopus 로고    scopus 로고
    • Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice
    • doi: 10.1074/jbc.M505249200
    • Dominguez, D., Tournoy, J., Hartmann, D., Huth, T., Cryns, K., Deforce, S., et al. (2005). Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice. J. Biol. Chem. 280, 30797-30806. doi: 10.1074/jbc.M505249200
    • (2005) J. Biol. Chem. , vol.280 , pp. 30797-30806
    • Dominguez, D.1    Tournoy, J.2    Hartmann, D.3    Huth, T.4    Cryns, K.5    Deforce, S.6
  • 20
    • 77954446968 scopus 로고    scopus 로고
    • A beta peptides accelerate the senescence of endothelial cells in vitro and in vivo, impairing angiogenesis
    • doi: 10.1096/Fj.09-146456
    • Donnini, S., Solito, R., Cetti, E., Corti, F., Giachetti, A., Carra, S., et al. (2010). A beta peptides accelerate the senescence of endothelial cells in vitro and in vivo, impairing angiogenesis. FASEB J. 24, 2385-2395. doi: 10.1096/Fj.09-146456
    • (2010) FASEB J. , vol.24 , pp. 2385-2395
    • Donnini, S.1    Solito, R.2    Cetti, E.3    Corti, F.4    Giachetti, A.5    Carra, S.6
  • 21
    • 0034904642 scopus 로고    scopus 로고
    • Inhibition of zebrafish fgf8 pre-mRNA splicing with morpholino oligos: a quantifiable method for gene knockdown
    • doi: 10.1002/gene.1053
    • Draper, B. W., Morcos, P. A., and Kimmel, C. B. (2001). Inhibition of zebrafish fgf8 pre-mRNA splicing with morpholino oligos: a quantifiable method for gene knockdown. Genesis 30, 154-156. doi: 10.1002/gene.1053
    • (2001) Genesis , vol.30 , pp. 154-156
    • Draper, B.W.1    Morcos, P.A.2    Kimmel, C.B.3
  • 22
    • 18444417998 scopus 로고    scopus 로고
    • aph-1 and pen-2 are required for notch pathway signaling, gamma-secretase cleavage of beta APP, and presenilin protein accumulation
    • doi: 10.1016/S1534-5807(02)00189-2
    • Francis, R., Mcgrath, G., Zhang, J. H., Ruddy, D. A., Sym, M., Apfeld, J., et al. (2002). aph-1 and pen-2 are required for notch pathway signaling, gamma-secretase cleavage of beta APP, and presenilin protein accumulation. Dev. Cell 3, 85-97. doi: 10.1016/S1534-5807(02)00189-2
    • (2002) Dev. Cell , vol.3 , pp. 85-97
    • Francis, R.1    Mcgrath, G.2    Zhang, J.H.3    Ruddy, D.A.4    Sym, M.5    Apfeld, J.6
  • 23
    • 84655162701 scopus 로고    scopus 로고
    • Twenty years of Alzheimer's disease-causing mutations
    • doi: 10.1111/j.1471-4159.2011.07575.x
    • Goate, A., and Hardy, J. (2012). Twenty years of Alzheimer's disease-causing mutations. J. Neurochem. 120(Suppl. 1), 3-8. doi: 10.1111/j.1471-4159.2011.07575.x
    • (2012) J. Neurochem. , vol.120 , Issue.SUPPL. 1 , pp. 3-8
    • Goate, A.1    Hardy, J.2
  • 24
    • 33750705653 scopus 로고    scopus 로고
    • A century of Alzheimer's disease
    • doi: 10.1126/science.1132814
    • Goedert, M., and Spillantini, M. G. (2006). A century of Alzheimer's disease. Science 314, 777-781. doi: 10.1126/science.1132814
    • (2006) Science , vol.314 , pp. 777-781
    • Goedert, M.1    Spillantini, M.G.2
  • 25
    • 0036935846 scopus 로고    scopus 로고
    • Identification of a second presenilin gene in zebrafish with similarity to the human Alzheimer's disease gene presenilin2
    • doi: 10.1007/s00427-002-0269-5
    • Groth, C., Nornes, S., Mccarty, R., Tamme, R., and Lardelli, M. (2002). Identification of a second presenilin gene in zebrafish with similarity to the human Alzheimer's disease gene presenilin2. Dev. Genes Evol. 212, 486-490. doi: 10.1007/s00427-002-0269-5
    • (2002) Dev. Genes Evol. , vol.212 , pp. 486-490
    • Groth, C.1    Nornes, S.2    Mccarty, R.3    Tamme, R.4    Lardelli, M.5
  • 26
    • 45549103009 scopus 로고    scopus 로고
    • Gal4/UAS transgenic tools and their application to zebrafish
    • doi: 10.1089/zeb.2008.0530
    • Halpern, M. E., Rhee, J., Goll, M. G., Akitake, C. M., Parsons, M., and Leach, S. D. (2008). Gal4/UAS transgenic tools and their application to zebrafish. Zebrafish 5, 97-110. doi: 10.1089/zeb.2008.0530
    • (2008) Zebrafish , vol.5 , pp. 97-110
    • Halpern, M.E.1    Rhee, J.2    Goll, M.G.3    Akitake, C.M.4    Parsons, M.5    Leach, S.D.6
  • 27
    • 84864284879 scopus 로고    scopus 로고
    • Temporally-controlled site-specific recombination in zebrafish
    • doi: 10.1371/journal.pone.0004640
    • Hans, S., Kaslin, J., Freudenreich, D., and Brand, M. (2009). Temporally-controlled site-specific recombination in zebrafish. PLoS ONE 4:e4640. doi: 10.1371/journal.pone.0004640
    • (2009) PLoS ONE , vol.4
    • Hans, S.1    Kaslin, J.2    Freudenreich, D.3    Brand, M.4
  • 28
    • 0026597063 scopus 로고
    • Alzheimer's disease: the amyloid cascade hypothesis
    • doi: 10.1126/science.1566067
    • Hardy, J. A., and Higgins, G. A. (1992). Alzheimer's disease: the amyloid cascade hypothesis. Science 256, 184-185 doi: 10.1126/science.1566067
    • (1992) Science , vol.256 , pp. 184-185
    • Hardy, J.A.1    Higgins, G.A.2
  • 29
    • 10744231282 scopus 로고    scopus 로고
    • BACE1 (beta-secretase) transgenic and knockout mice: identification of neurochemical deficits and behavioral changes
    • doi: 10.1016/S1044-7431(03)00227-6
    • Harrison, S. M., Harper, A. J., Hawkins, J., Duddy, G., Grau, E., Pugh, P. L., et al. (2003). BACE1 (beta-secretase) transgenic and knockout mice: identification of neurochemical deficits and behavioral changes. Mol. Cell. Neurosci. 24, 646-655. doi: 10.1016/S1044-7431(03)00227-6
    • (2003) Mol. Cell. Neurosci. , vol.24 , pp. 646-655
    • Harrison, S.M.1    Harper, A.J.2    Hawkins, J.3    Duddy, G.4    Grau, E.5    Pugh, P.L.6
  • 30
    • 66349105109 scopus 로고    scopus 로고
    • Assaying autophagic activity in transgenic GFP-Lc3 and GFP-Gabarap zebrafish embryos
    • doi: 10.4161/auto.5.4.7768
    • He, C., Bartholomew, C. R., Zhou, W., and Klionsky, D. J. (2009). Assaying autophagic activity in transgenic GFP-Lc3 and GFP-Gabarap zebrafish embryos. Autophagy 5, 520-526. doi: 10.4161/auto.5.4.7768
    • (2009) Autophagy , vol.5 , pp. 520-526
    • He, C.1    Bartholomew, C.R.2    Zhou, W.3    Klionsky, D.J.4
  • 31
    • 77955397599 scopus 로고    scopus 로고
    • Analyzing autophagy in zebrafish
    • doi: 10.4161/auto.6.5.12092
    • He, C., and Klionsky, D. J. (2010). Analyzing autophagy in zebrafish. Autophagy 6, 642-644. doi: 10.4161/auto.6.5.12092
    • (2010) Autophagy , vol.6 , pp. 642-644
    • He, C.1    Klionsky, D.J.2
  • 32
    • 84880442012 scopus 로고    scopus 로고
    • Trans-dominant negative effects of pathogenic PSEN1 mutations on gamma-secretase activity and Abeta production
    • doi: 10.1523/JNEUROSCI.0954-13.2013
    • Heilig, E. A., Gutti, U., Tai, T., Shen, J., and Kelleher, R. J. (2013). Trans-dominant negative effects of pathogenic PSEN1 mutations on gamma-secretase activity and Abeta production. J. Neurosci. 33, 11606-11617. doi: 10.1523/JNEUROSCI.0954-13.2013
    • (2013) J. Neurosci. , vol.33 , pp. 11606-11617
    • Heilig, E.A.1    Gutti, U.2    Tai, T.3    Shen, J.4    Kelleher, R.J.5
  • 33
    • 13044278313 scopus 로고    scopus 로고
    • Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency
    • doi: 10.1073/pnas.96.21.11872
    • Herreman, A., Hartmann, D., Annaert, W., Saftig, P., Craessaerts, K., Serneels, L., et al. (1999). Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency. Proc. Natl. Acad. Sci. U.S.A. 96, 11872-11877. doi: 10.1073/pnas.96.21.11872
    • (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 11872-11877
    • Herreman, A.1    Hartmann, D.2    Annaert, W.3    Saftig, P.4    Craessaerts, K.5    Serneels, L.6
  • 34
    • 84892670711 scopus 로고    scopus 로고
    • Genome editing using artificial site-specific nucleases in zebrafish
    • doi: 10.1111/dgd.12094
    • Hisano, Y., Ota, S., and Kawahara, A. (2014). Genome editing using artificial site-specific nucleases in zebrafish. Dev. Growth Differ. 56, 26-33. doi: 10.1111/dgd.12094
    • (2014) Dev. Growth Differ. , vol.56 , pp. 26-33
    • Hisano, Y.1    Ota, S.2    Kawahara, A.3
  • 35
    • 84863337843 scopus 로고    scopus 로고
    • Alzheimer mechanisms and therapeutic strategies
    • doi: 10.1016/j.cell.2012.02.040
    • Huang, Y., and Mucke, L. (2012). Alzheimer mechanisms and therapeutic strategies. Cell 148, 1204-1222. doi: 10.1016/j.cell.2012.02.040
    • (2012) Cell , vol.148 , pp. 1204-1222
    • Huang, Y.1    Mucke, L.2
  • 36
    • 84874617789 scopus 로고    scopus 로고
    • Efficient genome editing in zebrafish using a CRISPR-Cas system
    • doi: 10.1038/nbt.2501
    • Hwang, W. Y., Fu, Y., Reyon, D., Maeder, M. L., Tsai, S. Q., Sander, J. D., et al. (2013). Efficient genome editing in zebrafish using a CRISPR-Cas system. Nat. Biotechnol. 31, 227-229. doi: 10.1038/nbt.2501
    • (2013) Nat. Biotechnol. , vol.31 , pp. 227-229
    • Hwang, W.Y.1    Fu, Y.2    Reyon, D.3    Maeder, M.L.4    Tsai, S.Q.5    Sander, J.D.6
  • 37
    • 78650072640 scopus 로고    scopus 로고
    • Cypermethrin has the potential to induce hepatic oxidative stress, DNA damage and apoptosis in adult zebrafish (Danio rerio )
    • doi: 10.1016/j.chemosphere.2010.09.072
    • Jin, Y. X., Zheng, S. S., Pu, Y., Shu, L. J., Sun, L. W., Liu, W. P., et al. (2011). Cypermethrin has the potential to induce hepatic oxidative stress, DNA damage and apoptosis in adult zebrafish (Danio rerio ). Chemosphere 82, 398-404. doi: 10.1016/j.chemosphere.2010.09.072
    • (2011) Chemosphere , vol.82 , pp. 398-404
    • Jin, Y.X.1    Zheng, S.S.2    Pu, Y.3    Shu, L.J.4    Sun, L.W.5    Liu, W.P.6
  • 38
    • 70349786368 scopus 로고    scopus 로고
    • Amyloid precursor protein is required for convergent-extension movements during zebrafish development
    • doi: 10.1016/j.ydbio.2009.07.041
    • Joshi, P., Liang, J. O., Dimonte, K., Sullivan, J., and Pimplikar, S. W. (2009). Amyloid precursor protein is required for convergent-extension movements during zebrafish development. Dev. Biol. 335, 1-11. doi: 10.1016/j.ydbio.2009.07.041
    • (2009) Dev. Biol. , vol.335 , pp. 1-11
    • Joshi, P.1    Liang, J.O.2    Dimonte, K.3    Sullivan, J.4    Pimplikar, S.W.5
  • 39
    • 0034633628 scopus 로고    scopus 로고
    • Identification of a functional transposase of the Tol2 element, an Ac-like element from the Japanese medaka fish, and its transposition in the zebrafish germ lineage
    • doi: 10.1073/pnas.97.21.11403
    • Kawakami, K., Shima, A., and Kawakami, N. (2000). Identification of a functional transposase of the Tol2 element, an Ac-like element from the Japanese medaka fish, and its transposition in the zebrafish germ lineage. Proc. Natl. Acad. Sci. U.S.A. 97, 11403-11408. doi: 10.1073/pnas.97.21.11403
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 11403-11408
    • Kawakami, K.1    Shima, A.2    Kawakami, N.3
  • 40
    • 84856968896 scopus 로고    scopus 로고
    • Adult neurogenesis and brain regeneration in zebrafish
    • doi: 10.1002/dneu.20918
    • Kizil, C., Kaslin, J., Kroehne, V., and Brand, M. (2012). Adult neurogenesis and brain regeneration in zebrafish. Dev. Neurobiol. 72, 429-461. doi: 10.1002/dneu.20918
    • (2012) Dev. Neurobiol. , vol.72 , pp. 429-461
    • Kizil, C.1    Kaslin, J.2    Kroehne, V.3    Brand, M.4
  • 41
    • 84864759869 scopus 로고    scopus 로고
    • Pathology supported genetic testing and treatment of cardiovascular disease in middle age for prevention of Alzheimer's disease
    • doi: 10.1007/s11011-012-9296-9298
    • Kotze, M. J., and van Rensburg, S. J. (2012). Pathology supported genetic testing and treatment of cardiovascular disease in middle age for prevention of Alzheimer's disease. Metab. Brain Dis. 27, 255-266. doi: 10.1007/s11011-012-9296-9298
    • (2012) Metab. Brain Dis. , vol.27 , pp. 255-266
    • Kotze, M.J.1    van Rensburg, S.J.2
  • 42
    • 0032580152 scopus 로고    scopus 로고
    • A molecular timescale for vertebrate evolution
    • doi: 10.1038/31927
    • Kumar, S., and Hedges, S. B. (1998). A molecular timescale for vertebrate evolution. Nature 392, 917-920. doi: 10.1038/31927
    • (1998) Nature , vol.392 , pp. 917-920
    • Kumar, S.1    Hedges, S.B.2
  • 43
    • 39549108281 scopus 로고    scopus 로고
    • Generation of transgenic zebrafish expressing green fluorescent protein under control of zebrafish amyloid precursor protein gene regulatory elements
    • doi: 10.1089/zeb.2007.0516
    • Lee, J. A., and Cole, G. J. (2007). Generation of transgenic zebrafish expressing green fluorescent protein under control of zebrafish amyloid precursor protein gene regulatory elements. Zebrafish 4, 277-286. doi: 10.1089/zeb.2007.0516
    • (2007) Zebrafish , vol.4 , pp. 277-286
    • Lee, J.A.1    Cole, G.J.2
  • 44
    • 77953913051 scopus 로고    scopus 로고
    • Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations
    • doi: 10.1016/j.cell.2010.05.008
    • Lee, J. H., Yu, W. H., Kumar, A., Lee, S., Mohan, P. S., Peterhoff, C. M., et al. (2010). Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations. Cell 141, 1146-1158. doi: 10.1016/j.cell.2010.05.008
    • (2010) Cell , vol.141 , pp. 1146-1158
    • Lee, J.H.1    Yu, W.H.2    Kumar, A.3    Lee, S.4    Mohan, P.S.5    Peterhoff, C.M.6
  • 45
    • 0033550061 scopus 로고    scopus 로고
    • Zebrafish (Danio rerio ) presenilin promotes aberrant amyloid beta-peptide production and requires a critical aspartate residue for its function in amyloidogenesis
    • doi: 10.1021/bi991453n
    • Leimer, U., Lun, K., Romig, H., Walter, J., Grunberg, J., Brand, M., et al. (1999). Zebrafish (Danio rerio ) presenilin promotes aberrant amyloid beta-peptide production and requires a critical aspartate residue for its function in amyloidogenesis. Biochemistry 38, 13602-13609. doi: 10.1021/bi991453n
    • (1999) Biochemistry , vol.38 , pp. 13602-13609
    • Leimer, U.1    Lun, K.2    Romig, H.3    Walter, J.4    Grunberg, J.5    Brand, M.6
  • 46
    • 84858163218 scopus 로고    scopus 로고
    • Insight into molecular pathways of retinal metabolism, associated with vitellogenesis in zebrafish
    • doi: 10.1152/ajpendo.00310.2011
    • Levi, L., Ziv, T., Admon, A., Levavi-Sivan, B., and Lubzens, E. (2012). Insight into molecular pathways of retinal metabolism, associated with vitellogenesis in zebrafish. Am. J. Physiol. Endocrinol. Metab. 302, E626-E644. doi: 10.1152/ajpendo.00310.2011
    • (2012) Am. J. Physiol. Endocrinol. Metab. , vol.302
    • Levi, L.1    Ziv, T.2    Admon, A.3    Levavi-Sivan, B.4    Lubzens, E.5
  • 47
    • 84862913229 scopus 로고    scopus 로고
    • Tol2 gene trap integrations in the zebrafish amyloid precursor protein genes appa and aplp2 reveal accumulation of secreted APP at the embryonic veins
    • doi: 10.1002/Dvdy.23725
    • Liao, H. K., Wang, Y., Watt, K. E. N., Wen, Q., Breitbach, J., Kemmet, C. K., et al. (2012). Tol2 gene trap integrations in the zebrafish amyloid precursor protein genes appa and aplp2 reveal accumulation of secreted APP at the embryonic veins. Dev. Dyn. 241, 415-425. doi: 10.1002/Dvdy.23725
    • (2012) Dev. Dyn. , vol.241 , pp. 415-425
    • Liao, H.K.1    Wang, Y.2    Watt, K.E.N.3    Wen, Q.4    Breitbach, J.5    Kemmet, C.K.6
  • 48
    • 33747366304 scopus 로고    scopus 로고
    • Gene expression analysis of zebrafish heart regeneration
    • doi: 10.1371/journal.pbio.0040260
    • Lien, C. L., Schebesta, M., Makino, S., Weber, G. J., and Keating, M. T. (2006). Gene expression analysis of zebrafish heart regeneration. PLoS Biol. 4:e260. doi: 10.1371/journal.pbio.0040260
    • (2006) PLoS Biol , vol.4
    • Lien, C.L.1    Schebesta, M.2    Makino, S.3    Weber, G.J.4    Keating, M.T.5
  • 49
    • 34247186766 scopus 로고    scopus 로고
    • Animal models of human disease: zebrafish swim into view
    • doi: 10.1038/nrg2091
    • Lieschke, G. J., and Currie, P. D. (2007). Animal models of human disease: zebrafish swim into view. Nat. Rev. Genet. 8, 353-367. doi: 10.1038/nrg2091
    • (2007) Nat. Rev. Genet. , vol.8 , pp. 353-367
    • Lieschke, G.J.1    Currie, P.D.2
  • 50
    • 79959935576 scopus 로고    scopus 로고
    • Gamma-secretase substrates and their implications for drug development in Alzheimer's disease
    • doi: 10.2174/156802611795861004
    • Lleo, A., and Saura, C. A. (2011). Gamma-secretase substrates and their implications for drug development in Alzheimer's disease. Curr. Top. Med. Chem. 11, 1513-1527. doi: 10.2174/156802611795861004
    • (2011) Curr. Top. Med. Chem. , vol.11 , pp. 1513-1527
    • Lleo, A.1    Saura, C.A.2
  • 51
    • 0035931493 scopus 로고    scopus 로고
    • Presenilin-2 (PS2) expression up-regulation in a model of retinopathy of prematurity and pathoangiogenesis
    • doi: 10.1097/00001756-200101220-00019
    • Lukiw, W. J., Gordon, W. C., Rogaev, E. I., Thompson, H., and Bazan, N. G. (2001). Presenilin-2 (PS2) expression up-regulation in a model of retinopathy of prematurity and pathoangiogenesis. Neuroreport 12, 53-57 doi: 10.1097/00001756-200101220-00019
    • (2001) Neuroreport , vol.12 , pp. 53-57
    • Lukiw, W.J.1    Gordon, W.C.2    Rogaev, E.I.3    Thompson, H.4    Bazan, N.G.5
  • 52
    • 84883498629 scopus 로고    scopus 로고
    • Amyloid-beta and APP deficiencies cause severe cerebrovascular defects: important work for an old villain
    • doi: 10.1371/journal.pone.0075052
    • Luna, S., Cameron, D. J., and Ethell, D. W. (2013). Amyloid-beta and APP deficiencies cause severe cerebrovascular defects: important work for an old villain. PLoS ONE 8:e75052. doi: 10.1371/journal.pone.0075052
    • (2013) PLoS ONE , vol.8
    • Luna, S.1    Cameron, D.J.2    Ethell, D.W.3
  • 53
    • 0042334543 scopus 로고    scopus 로고
    • BACE1 (beta-secretase) knockout mice do not acquire compensatory gene expression changes or develop neural lesions over time
    • doi: 10.1016/S0969-9961(03)00104-9
    • Luo, Y., Bolon, B., Damore, M. A., Fitzpatrick, D., Liu, H., Zhang, J., et al. (2003). BACE1 (beta-secretase) knockout mice do not acquire compensatory gene expression changes or develop neural lesions over time. Neurobiol. Dis. 14, 81-88. doi: 10.1016/S0969-9961(03)00104-9
    • (2003) Neurobiol. Dis. , vol.14 , pp. 81-88
    • Luo, Y.1    Bolon, B.2    Damore, M.A.3    Fitzpatrick, D.4    Liu, H.5    Zhang, J.6
  • 54
    • 79251544549 scopus 로고    scopus 로고
    • Alzheimer's dementia begins as a disease of small blood vessels, damaged by oxidative-induced inflammation and dysregulated amyloid metabolism: implications for early detection and therapy
    • doi: 10.1096/fj.11-0102ufm
    • Marchesi, V. T. (2011). Alzheimer's dementia begins as a disease of small blood vessels, damaged by oxidative-induced inflammation and dysregulated amyloid metabolism: implications for early detection and therapy. FASEB J. 25, 5-13. doi: 10.1096/fj.11-0102ufm
    • (2011) FASEB J. , vol.25 , pp. 5-13
    • Marchesi, V.T.1
  • 55
    • 33746565284 scopus 로고    scopus 로고
    • Apolipoprotein E, cholesterol metabolism, diabetes, and the convergence of risk factors for Alzheimer's disease and cardiovascular disease
    • doi: 10.1038/sj.mp.4001854
    • Martins, I. J., Hone, E., Foster, J. K., Sunram-Lea, S. I., Gnjec, A., Fuller, S. J., et al. (2006). Apolipoprotein E, cholesterol metabolism, diabetes, and the convergence of risk factors for Alzheimer's disease and cardiovascular disease. Mol. Psychiatry 11, 721-736. doi: 10.1038/sj.mp.4001854
    • (2006) Mol. Psychiatry , vol.11 , pp. 721-736
    • Martins, I.J.1    Hone, E.2    Foster, J.K.3    Sunram-Lea, S.I.4    Gnjec, A.5    Fuller, S.J.6
  • 56
    • 67649534694 scopus 로고    scopus 로고
    • Presenilin-dependent regulated intramembrane proteolysis and gamma-secretase activity
    • doi: 10.1007/s00018-009-8435-9
    • McCarthy, J. V., Twomey, C., and Wujek, P. (2009). Presenilin-dependent regulated intramembrane proteolysis and gamma-secretase activity. Cell Mol. Life. Sci. 66, 1534-1555. doi: 10.1007/s00018-009-8435-9
    • (2009) Cell Mol. Life. Sci. , vol.66 , pp. 1534-1555
    • McCarthy, J.V.1    Twomey, C.2    Wujek, P.3
  • 57
    • 0033019465 scopus 로고    scopus 로고
    • Epidermal expression of apolipoprotein E gene during fin and scale development and fin regeneration in zebrafish
    • doi: 10.1002/(SICI)1097-0177(199903)214:3207::AID-AJA43.0.CO;2-5
    • Monnot, M. J., Babin, P. J., Poleo, G., Andre, M., Laforest, L., Ballagny, C., et al. (1999). Epidermal expression of apolipoprotein E gene during fin and scale development and fin regeneration in zebrafish. Dev. Dyn. 214, 207-215. doi: 10.1002/(SICI)1097-0177(199903)214:3<207::AID-AJA4>3.0.CO;2-5
    • (1999) Dev. Dyn. , vol.214 , pp. 207-215
    • Monnot, M.J.1    Babin, P.J.2    Poleo, G.3    Andre, M.4    Laforest, L.5    Ballagny, C.6
  • 58
    • 79956330460 scopus 로고    scopus 로고
    • The response of HMGA1 to changes in oxygen availability is evolutionarily conserved
    • doi: 10.1016/j.yexcr.2011.04.004
    • Moussavi Nik, S. H., Newman, M., and Lardelli, M. (2011). The response of HMGA1 to changes in oxygen availability is evolutionarily conserved. Exp. Cell Res . 317, 1503-1512. doi: 10.1016/j.yexcr.2011.04.004
    • (2011) Exp. Cell Res. , vol.317 , pp. 1503-1512
    • Moussavi Nik, S.H.1    Newman, M.2    Lardelli, M.3
  • 59
    • 84858010178 scopus 로고    scopus 로고
    • The BACE1-PSEN-AbetaPP regulatory axis has an ancient role in response to low oxygen/oxidative stress
    • doi: 10.3233/JAD-2011-110533
    • Moussavi Nik, S. H., Wilson, L., Newman, M., Croft, K., Mori, T. A., Musgrave, I., et al. (2012). The BACE1-PSEN-AbetaPP regulatory axis has an ancient role in response to low oxygen/oxidative stress. J. Alzheimers Dis. 28, 515-530. doi: 10.3233/JAD-2011-110533
    • (2012) J. Alzheimers Dis. , vol.28 , pp. 515-530
    • Moussavi Nik, S.H.1    Wilson, L.2    Newman, M.3    Croft, K.4    Mori, T.A.5    Musgrave, I.6
  • 60
    • 0035667028 scopus 로고    scopus 로고
    • Distinct expression patterns of two zebrafish homologues of the human APP gene during embryonic development
    • doi: 10.1007/s00427-001-0189-9
    • Musa, A., Lehrach, H., and Russo, V. A. (2001). Distinct expression patterns of two zebrafish homologues of the human APP gene during embryonic development. Dev. Genes Evol. 211, 563-567. doi: 10.1007/s00427-001-0189-9
    • (2001) Dev. Genes Evol. , vol.211 , pp. 563-567
    • Musa, A.1    Lehrach, H.2    Russo, V.A.3
  • 61
    • 84861821779 scopus 로고    scopus 로고
    • Robust homeostasis of Presenilin1 protein levels by transcript regulation
    • doi: 10.1016/j.neulet.2012.04.064
    • Newman, M., Nornes, S., Martins, R. N., and Lardelli, M. T. (2012). Robust homeostasis of Presenilin1 protein levels by transcript regulation. Neurosci. Lett. 519, 14-19. doi: 10.1016/j.neulet.2012.04.064
    • (2012) Neurosci. Lett. , vol.519 , pp. 14-19
    • Newman, M.1    Nornes, S.2    Martins, R.N.3    Lardelli, M.T.4
  • 62
    • 77953627393 scopus 로고    scopus 로고
    • A zebrafish melanophore model of amyloid beta toxicity
    • doi: 10.1089/zeb.2009.0628
    • Newman, M., Wilson, L., Camp, E., Verdile, G., Martins, R., and Lardelli, M. (2010). A zebrafish melanophore model of amyloid beta toxicity. Zebrafish 7, 155-159. doi: 10.1089/zeb.2009.0628
    • (2010) Zebrafish , vol.7 , pp. 155-159
    • Newman, M.1    Wilson, L.2    Camp, E.3    Verdile, G.4    Martins, R.5    Lardelli, M.6
  • 63
    • 84892449716 scopus 로고    scopus 로고
    • Differential, dominant activation and inhibition of Notch signalling and APP cleavage by truncations of PSEN1 in human disease
    • doi: 10.1093/hmg/ddt448
    • Newman, M., Wilson, L., Verdile, G., Lim, A., Khan, I., Moussavi Nik, S. H., et al. (2014). Differential, dominant activation and inhibition of Notch signalling and APP cleavage by truncations of PSEN1 in human disease. Hum. Mol. Genet. 23, 602-617. doi: 10.1093/hmg/ddt448
    • (2014) Hum. Mol. Genet. , vol.23 , pp. 602-617
    • Newman, M.1    Wilson, L.2    Verdile, G.3    Lim, A.4    Khan, I.5    Moussavi Nik, S.H.6
  • 64
    • 0242559054 scopus 로고    scopus 로고
    • Pathway studio-the analysis and navigation of molecular networks
    • doi: 10.1093/bioinformatics/btg290
    • Nikitin, A., Egorov, S., Daraselia, N., and Mazo, I. (2003a). Pathway studio-the analysis and navigation of molecular networks. Bioinformatics 19, 2155-2157. doi: 10.1093/bioinformatics/btg290
    • (2003) Bioinformatics , vol.19 , pp. 2155-2157
    • Nikitin, A.1    Egorov, S.2    Daraselia, N.3    Mazo, I.4
  • 65
    • 0242559054 scopus 로고    scopus 로고
    • Pathway studio-the analysis and navigation of molecular networks
    • doi: 10.1093/bioinformatics/btg290
    • Nikitin, A., Egorov, S., Daraselia, N., and Mazo, I. (2003b). Pathway studio-the analysis and navigation of molecular networks. Bioinformatics 19, 2155-2157. doi: 10.1093/bioinformatics/btg290
    • (2003) Bioinformatics , vol.19 , pp. 2155-2157
    • Nikitin, A.1    Egorov, S.2    Daraselia, N.3    Mazo, I.4
  • 66
    • 84885864424 scopus 로고    scopus 로고
    • Abeta secretion and plaque formation depend on autophagy
    • doi: 10.1016/j.celrep.2013.08.042
    • Nilsson, P., Loganathan, K., Sekiguchi, M., Matsuba, Y., Hui, K., Tsubuki, S., et al. (2013). Abeta secretion and plaque formation depend on autophagy. Cell Rep. 5, 61-69. doi: 10.1016/j.celrep.2013.08.042
    • (2013) Cell Rep. , vol.5 , pp. 61-69
    • Nilsson, P.1    Loganathan, K.2    Sekiguchi, M.3    Matsuba, Y.4    Hui, K.5    Tsubuki, S.6
  • 67
    • 0042162816 scopus 로고    scopus 로고
    • Developmental control of Presenilin1 expression, endoproteolysis, and interaction in zebrafish embryos
    • doi: 10.1016/S0014-4827(03)00257-X
    • Nornes, S., Groth, C., Camp, E., Ey, P., and Lardelli, M. (2003). Developmental control of Presenilin1 expression, endoproteolysis, and interaction in zebrafish embryos. Exp. Cell Res. 289, 124-132. doi: 10.1016/S0014-4827(03)00257-X
    • (2003) Exp. Cell Res. , vol.289 , pp. 124-132
    • Nornes, S.1    Groth, C.2    Camp, E.3    Ey, P.4    Lardelli, M.5
  • 68
    • 38349133632 scopus 로고    scopus 로고
    • Interference with splicing of Presenilin transcripts has potent dominant negative effects on Presenilin activity
    • doi: 10.1093/hmg/ddm317
    • Nornes, S., Newman, M., Verdile, G., Wells, S., Stoick-Cooper, C. L., Tucker, B., et al. (2008). Interference with splicing of Presenilin transcripts has potent dominant negative effects on Presenilin activity. Hum. Mol. Genet. 17, 402-412. doi: 10.1093/hmg/ddm317
    • (2008) Hum. Mol. Genet. , vol.17 , pp. 402-412
    • Nornes, S.1    Newman, M.2    Verdile, G.3    Wells, S.4    Stoick-Cooper, C.L.5    Tucker, B.6
  • 69
    • 68949150779 scopus 로고    scopus 로고
    • Independent and cooperative action of Psen2 with Psen1 in zebrafish embryos
    • doi: 10.1016/j.yexcr.2009.06.023
    • Nornes, S., Newman, M., Wells, S., Verdile, G., Martins, R. N., and Lardelli, M. (2009). Independent and cooperative action of Psen2 with Psen1 in zebrafish embryos. Exp. Cell Res. 315, 2791-2801. doi: 10.1016/j.yexcr.2009.06.023
    • (2009) Exp. Cell Res. , vol.315 , pp. 2791-2801
    • Nornes, S.1    Newman, M.2    Wells, S.3    Verdile, G.4    Martins, R.N.5    Lardelli, M.6
  • 70
    • 0141515736 scopus 로고    scopus 로고
    • MedScan, a natural language processing engine for MEDLINE abstracts
    • doi: 10.1093/bioinformatics/btg207
    • Novichkova, S., Egorov, S., and Daraselia, N. (2003a). MedScan, a natural language processing engine for MEDLINE abstracts. Bioinformatics 19, 1699-1706. doi: 10.1093/bioinformatics/btg207
    • (2003) Bioinformatics , vol.19 , pp. 1699-1706
    • Novichkova, S.1    Egorov, S.2    Daraselia, N.3
  • 71
    • 0141515736 scopus 로고    scopus 로고
    • MedScan, a natural language processing engine for MEDLINE abstracts
    • doi: 10.1093/bioinformatics/btg207
    • Novichkova, S., Egorov, S., and Daraselia, N. (2003b). MedScan, a natural language processing engine for MEDLINE abstracts. Bioinformatics 19, 1699-1706. doi: 10.1093/bioinformatics/btg207
    • (2003) Bioinformatics , vol.19 , pp. 1699-1706
    • Novichkova, S.1    Egorov, S.2    Daraselia, N.3
  • 73
    • 33748345432 scopus 로고    scopus 로고
    • Ubiquitin-proteasome system and Parkinson's disease
    • doi: 10.1002/mds.21013
    • Olanow, C. W., and McNaught, K. S. (2006). Ubiquitin-proteasome system and Parkinson's disease. Mov. Disord. 21, 1806-1823. doi: 10.1002/mds.21013
    • (2006) Mov. Disord. , vol.21 , pp. 1806-1823
    • Olanow, C.W.1    McNaught, K.S.2
  • 75
    • 66449115032 scopus 로고    scopus 로고
    • A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation
    • doi: 10.1172/JCI37537
    • Paquet, D., Bhat, R., Sydow, A., Mandelkow, E. M., Berg, S., Hellberg, S., et al. (2009). A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation. J. Clin. Invest. 119, 1382-1395. doi: 10.1172/JCI37537
    • (2009) J. Clin. Invest. , vol.119 , pp. 1382-1395
    • Paquet, D.1    Bhat, R.2    Sydow, A.3    Mandelkow, E.M.4    Berg, S.5    Hellberg, S.6
  • 76
    • 33748995351 scopus 로고    scopus 로고
    • Untangling the tau gene association with neurodegenerative disorders
    • doi: 10.1093/hmg/ddl190
    • Pittman, A. M., Fung, H. C., and De Silva, R. (2006). Untangling the tau gene association with neurodegenerative disorders. Hum. Mol. Genet. 15(Spec No. 2), R188-R195. doi: 10.1093/hmg/ddl190
    • (2006) Hum. Mol. Genet. , vol.15 , Issue.SPEC NO. 2
    • Pittman, A.M.1    Fung, H.C.2    De Silva, R.3
  • 77
    • 26044455494 scopus 로고    scopus 로고
    • Pathological opening of the blood-brain barrier to horseradish peroxidase and amyloid precursor protein following ischemia-reperfusion brain injury
    • doi: 10.1159/000086924
    • Pluta, R. (2005). Pathological opening of the blood-brain barrier to horseradish peroxidase and amyloid precursor protein following ischemia-reperfusion brain injury. Chemotherapy 51, 223-226. doi: 10.1159/000086924
    • (2005) Chemotherapy , vol.51 , pp. 223-226
    • Pluta, R.1
  • 78
    • 33646485521 scopus 로고    scopus 로고
    • Reverse genetic analysis of neurogenesis in the zebrafish retina
    • doi: 10.1016/j.ydbio.2005.12.056
    • Pujic, Z., Omori, Y., Tsujikawa, M., Thisse, B., Thisse, C., and Malicki, J. (2006). Reverse genetic analysis of neurogenesis in the zebrafish retina. Dev. Biol. 293, 330-347. doi: 10.1016/j.ydbio.2005.12.056
    • (2006) Dev. Biol. , vol.293 , pp. 330-347
    • Pujic, Z.1    Omori, Y.2    Tsujikawa, M.3    Thisse, B.4    Thisse, C.5    Malicki, J.6
  • 79
    • 68049123562 scopus 로고    scopus 로고
    • Recent insights into the molecular genetics of dementia
    • doi: 10.1016/j.tins.2009.05.005
    • Rademakers, R., and Rovelet-Lecrux, A. (2009). Recent insights into the molecular genetics of dementia. Trends Neurosci. 32, 451-461. doi: 10.1016/j.tins.2009.05.005
    • (2009) Trends Neurosci. , vol.32 , pp. 451-461
    • Rademakers, R.1    Rovelet-Lecrux, A.2
  • 80
    • 33748630498 scopus 로고    scopus 로고
    • Molecular characterization of retinal stem cells and their niches in adult zebrafish
    • doi: 10.1186/1471-213X-6-36
    • Raymond, P. A., Barthel, L. K., Bernardos, R. L., and Perkowski, J. J. (2006). Molecular characterization of retinal stem cells and their niches in adult zebrafish. BMC Dev. Biol. 6:36. doi: 10.1186/1471-213X-6-36
    • (2006) BMC Dev. Biol , vol.6 , pp. 36
    • Raymond, P.A.1    Barthel, L.K.2    Bernardos, R.L.3    Perkowski, J.J.4
  • 81
    • 0028337668 scopus 로고
    • No global neocortical nerve cell loss in brains from patients with senile dementia of Alzheimer's type
    • doi: 10.1016/0197-4580(94)90030-2
    • Regeur, L., Jensen, G. B., Pakkenberg, H., Evans, S. M., and Pakkenberg, B. (1994). No global neocortical nerve cell loss in brains from patients with senile dementia of Alzheimer's type. Neurobiol. Aging 15, 347-352. doi: 10.1016/0197-4580(94)90030-2
    • (1994) Neurobiol. Aging , vol.15 , pp. 347-352
    • Regeur, L.1    Jensen, G.B.2    Pakkenberg, H.3    Evans, S.M.4    Pakkenberg, B.5
  • 82
    • 17344388652 scopus 로고    scopus 로고
    • BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics
    • doi: 10.1093/hmg/10.12.1317
    • Roberds, S. L., Anderson, J., Basi, G., Bienkowski, M. J., Branstetter, D. G., Chen, K. S., et al. (2001). BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics. Hum. Mol. Genet. 10, 1317-1324. doi: 10.1093/hmg/10.12.1317
    • (2001) Hum. Mol. Genet. , vol.10 , pp. 1317-1324
    • Roberds, S.L.1    Anderson, J.2    Basi, G.3    Bienkowski, M.J.4    Branstetter, D.G.5    Chen, K.S.6
  • 83
    • 3142514201 scopus 로고    scopus 로고
    • Protein aggregation and neurodegenerative disease
    • doi: 10.1038/nm1066
    • Ross, C. A., and Poirier, M. A. (2004). Protein aggregation and neurodegenerative disease. Nat. Med. 10(Suppl.), S10-S17. doi: 10.1038/nm1066
    • (2004) Nat. Med. , vol.10 , Issue.SUPPL.
    • Ross, C.A.1    Poirier, M.A.2
  • 84
    • 84980053710 scopus 로고    scopus 로고
    • Can zebrafish be used as animal model to study Alzheimer's disease?
    • Santana, S., Rico, E. P., and Burgos, J. S. (2012). Can zebrafish be used as animal model to study Alzheimer's disease? Am. J. Neurodegener. Dis. 1, 32-48.
    • (2012) Am. J. Neurodegener. Dis. , vol.1 , pp. 32-48
    • Santana, S.1    Rico, E.P.2    Burgos, J.S.3
  • 85
    • 84887084914 scopus 로고    scopus 로고
    • Genomic editing opens new avenues for zebrafish as a model for neurodegeneration
    • doi: 10.1111/jnc.12460
    • Schmid, B., and Haass, C. (2013). Genomic editing opens new avenues for zebrafish as a model for neurodegeneration. J. Neurochem. 127, 461-470. doi: 10.1111/jnc.12460
    • (2013) J. Neurochem. , vol.127 , pp. 461-470
    • Schmid, B.1    Haass, C.2
  • 86
    • 84871417031 scopus 로고    scopus 로고
    • Role of mitochondrial homeostasis and dynamics in Alzheimer's disease
    • doi: 10.1016/j.nbd.2011.12.057
    • Selfridge, J. E., E, L., Lu, J., and Swerdlow, R. H. (2012). Role of mitochondrial homeostasis and dynamics in Alzheimer's disease. Neurobiol. Dis. 51, 3-12. doi: 10.1016/j.nbd.2011.12.057
    • (2012) Neurobiol. Dis. , vol.51 , pp. 3-12
    • Selfridge, J.E.1    Lu, J.2    Swerdlow, R.H.3
  • 87
    • 0030779784 scopus 로고    scopus 로고
    • Skeletal and CNS defects in Presenilin-1-deficient mice
    • doi: 10.1016/S0092-8674(00)80244-5
    • Shen, J., Bronson, R. T., Chen, D. F., Xia, W., Selkoe, D. J., and Tonegawa, S. (1997). Skeletal and CNS defects in Presenilin-1-deficient mice. Cell 89, 629-639. doi: 10.1016/S0092-8674(00)80244-5
    • (1997) Cell , vol.89 , pp. 629-639
    • Shen, J.1    Bronson, R.T.2    Chen, D.F.3    Xia, W.4    Selkoe, D.J.5    Tonegawa, S.6
  • 88
    • 84860184311 scopus 로고    scopus 로고
    • Knockdown of amyloid precursor protein in zebrafish causes defects in motor axon outgrowth
    • doi: 10.1371/journal.pone.0034209
    • Song, P., and Pimplikar, S. W. (2012). Knockdown of amyloid precursor protein in zebrafish causes defects in motor axon outgrowth. PLoS ONE 7:e34209. doi: 10.1371/journal.pone.0034209
    • (2012) PLoS ONE , vol.7
    • Song, P.1    Pimplikar, S.W.2
  • 89
    • 47549115789 scopus 로고    scopus 로고
    • What initiates the formation of senile plaques? The origin of Alzheimer-like dementias in capillary haemorrhages
    • doi: 10.1016/j.mehy.2008.04.007
    • Stone, J. (2008). What initiates the formation of senile plaques? The origin of Alzheimer-like dementias in capillary haemorrhages. Med. Hypotheses 71, 347-359. doi: 10.1016/j.mehy.2008.04.007
    • (2008) Med. Hypotheses , vol.71 , pp. 347-359
    • Stone, J.1
  • 90
    • 0037168586 scopus 로고    scopus 로고
    • Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences
    • doi: 10.1073/pnas.242603899
    • Strausberg, R. L., Feingold, E. A., Grouse, L. H., Derge, J. G., Klausner, R. D., Collins, F. S., et al. (2002). Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 99, 16899-16903. doi: 10.1073/pnas.242603899
    • (2002) Proc. Natl. Acad. Sci. U.S.A. , vol.99 , pp. 16899-16903
    • Strausberg, R.L.1    Feingold, E.A.2    Grouse, L.H.3    Derge, J.G.4    Klausner, R.D.5    Collins, F.S.6
  • 91
    • 84872727593 scopus 로고    scopus 로고
    • Presenilin1 regulates histamine neuron development and behavior in zebrafish, danio rerio
    • doi: 10.1523/JNEUROSCI.1802-12.2013
    • Sundvik, M., Chen, Y. C., and Panula, P. (2013). Presenilin1 regulates histamine neuron development and behavior in zebrafish, danio rerio. J. Neurosci. 33, 1589-1597. doi: 10.1523/JNEUROSCI.1802-12.2013
    • (2013) J. Neurosci. , vol.33 , pp. 1589-1597
    • Sundvik, M.1    Chen, Y.C.2    Panula, P.3
  • 92
    • 33751020850 scopus 로고    scopus 로고
    • Epidermal transient down-regulation of retinol-binding protein 4 and mirror expression of apolipoprotein Eb and estrogen receptor 2a during zebrafish fin and scale development
    • doi: 10.1002/dvdy.20921
    • Tingaud-Sequeira, A., Forgue, J., Andre, M., and Babin, P. J. (2006). Epidermal transient down-regulation of retinol-binding protein 4 and mirror expression of apolipoprotein Eb and estrogen receptor 2a during zebrafish fin and scale development. Dev. Dyn. 235, 3071-3079. doi: 10.1002/dvdy.20921
    • (2006) Dev. Dyn. , vol.235 , pp. 3071-3079
    • Tingaud-Sequeira, A.1    Forgue, J.2    Andre, M.3    Babin, P.J.4
  • 93
    • 84879489900 scopus 로고    scopus 로고
    • Genetic Variations of GAK in two Chinese Parkinson's disease populations: a case-control study
    • doi: 10.1371/journal.pone.0067506
    • Tseng, W. E., Chen, C. M., Chen, Y. C., Yi, Z., Tan, E. K., and Wu, Y. R. (2013). Genetic Variations of GAK in two Chinese Parkinson's disease populations: a case-control study. PLoS ONE 8:e67506. doi: 10.1371/journal.pone.0067506
    • (2013) PLoS ONE , vol.8
    • Tseng, W.E.1    Chen, C.M.2    Chen, Y.C.3    Yi, Z.4    Tan, E.K.5    Wu, Y.R.6
  • 94
    • 84887031752 scopus 로고    scopus 로고
    • Loss of Bace2 in zebrafish affects melanocyte migration and is distinct from Bace1 knock out phenotypes
    • doi: 10.1111/jnc.12198
    • van Bebber, F., Hruscha, A., Willem, M., Schmid, B., and Haass, C. (2013). Loss of Bace2 in zebrafish affects melanocyte migration and is distinct from Bace1 knock out phenotypes. J. Neurochem. 127, 471-481. doi: 10.1111/jnc.12198
    • (2013) J. Neurochem. , vol.127 , pp. 471-481
    • van Bebber, F.1    Hruscha, A.2    Willem, M.3    Schmid, B.4    Haass, C.5
  • 95
    • 78650591506 scopus 로고    scopus 로고
    • Presenilin mouse and zebrafish models for dementia: focus on neurogenesis
    • doi: 10.1016/j.pneurobio.2010.10.008
    • van Tijn, P., Kamphuis, W., Marlatt, M. W., Hol, E. M., and Lucassen, P. J. (2011). Presenilin mouse and zebrafish models for dementia: focus on neurogenesis. Prog. Neurobiol. 93, 149-164. doi: 10.1016/j.pneurobio.2010.10.008
    • (2011) Prog. Neurobiol. , vol.93 , pp. 149-164
    • van Tijn, P.1    Kamphuis, W.2    Marlatt, M.W.3    Hol, E.M.4    Lucassen, P.J.5
  • 96
    • 4043088415 scopus 로고    scopus 로고
    • The role of beta amyloid in Alzheimer's disease: still a cause of everything or the only one who got caught?
    • doi: 10.1016/j.phrs.2003.12.028
    • Verdile, G., Fuller, S., Atwood, C. S., Laws, S. M., Gandy, S. E., and Martins, R. N. (2004). The role of beta amyloid in Alzheimer's disease: still a cause of everything or the only one who got caught? Pharmacol. Res . 50, 397-409. doi: 10.1016/j.phrs.2003.12.028
    • (2004) Pharmacol. Res , vol.50 , pp. 397-409
    • Verdile, G.1    Fuller, S.2    Atwood, C.S.3    Laws, S.M.4    Gandy, S.E.5    Martins, R.N.6
  • 97
    • 79952256057 scopus 로고    scopus 로고
    • Mutations in zebrafish lrp2 result in adult-onset ocular pathogenesis that models myopia and other risk factors for glaucoma
    • doi: 10.1371/journal.pgen.1001310
    • Veth, K. N., Willer, J. R., Collery, R. F., Gray, M. P., Willer, G. B., Wagner, D. S., et al. (2011). Mutations in zebrafish lrp2 result in adult-onset ocular pathogenesis that models myopia and other risk factors for glaucoma. PLoS Genet. 7:e1001310. doi: 10.1371/journal.pgen.1001310
    • (2011) PLoS Genet , vol.7
    • Veth, K.N.1    Willer, J.R.2    Collery, R.F.3    Gray, M.P.4    Willer, G.B.5    Wagner, D.S.6
  • 98
    • 60249095437 scopus 로고    scopus 로고
    • Diagnosis and treatment of patients with severe Alzheimer's disease
    • doi: 10.2165/0002512-200926020-00005
    • Voisin, T., and Vellas, B. (2009). Diagnosis and treatment of patients with severe Alzheimer's disease. Drugs Aging 26, 135-144. doi: 10.2165/0002512-200926020-00005
    • (2009) Drugs Aging , vol.26 , pp. 135-144
    • Voisin, T.1    Vellas, B.2
  • 99
    • 0028122463 scopus 로고
    • Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease
    • doi: 10.1016/S0140-6736(94)92338-8
    • West, M. J., Coleman, P. D., Flood, D. G., and Troncoso, J. C. (1994). Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease. Lancet 344, 769-772. doi: 10.1016/S0140-6736(94)92338-8
    • (1994) Lancet , vol.344 , pp. 769-772
    • West, M.J.1    Coleman, P.D.2    Flood, D.G.3    Troncoso, J.C.4
  • 100
    • 33750455150 scopus 로고    scopus 로고
    • Control of peripheral nerve myelination by the beta-secretase BACE1
    • doi: 10.1126/science.1132341
    • Willem, M., Garratt, A. N., Novak, B., Citron, M., Kaufmann, S., Rittger, A., et al. (2006). Control of peripheral nerve myelination by the beta-secretase BACE1. Science 314, 664-666. doi: 10.1126/science.1132341
    • (2006) Science , vol.314 , pp. 664-666
    • Willem, M.1    Garratt, A.N.2    Novak, B.3    Citron, M.4    Kaufmann, S.5    Rittger, A.6
  • 101
    • 84881427117 scopus 로고    scopus 로고
    • The development of an in vivo gamma-secretase assay using zebrafish embryos
    • doi: 10.3233/JAD-130332
    • Wilson, L., and Lardelli, M. (2013). The development of an in vivo gamma-secretase assay using zebrafish embryos. J. Alzheimers Dis. 36, 521-534. doi: 10.3233/JAD-130332
    • (2013) J. Alzheimers Dis. , vol.36 , pp. 521-534
    • Wilson, L.1    Lardelli, M.2
  • 102
    • 17744401440 scopus 로고    scopus 로고
    • Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm
    • doi: 10.1038/387288a0
    • Wong, P. C., Zheng, H., Chen, H., Becher, M. W., Sirinathsinghji, D. J., Trumbauer, M. E., et al. (1997). Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm. Nature 387, 288-292. doi: 10.1038/387288a0
    • (1997) Nature , vol.387 , pp. 288-292
    • Wong, P.C.1    Zheng, H.2    Chen, H.3    Becher, M.W.4    Sirinathsinghji, D.J.5    Trumbauer, M.E.6
  • 103
    • 24344440632 scopus 로고    scopus 로고
    • The zebrafish gene map defines ancestral vertebrate chromosomes
    • doi: 10.1101/gr.4134305
    • Woods, I. G., Wilson, C., Friedlander, B., Chang, P., Reyes, D. K., Nix, R., et al. (2005). The zebrafish gene map defines ancestral vertebrate chromosomes. Genome Res. 15, 1307-1314. doi: 10.1101/gr.4134305
    • (2005) Genome Res. , vol.15 , pp. 1307-1314
    • Woods, I.G.1    Wilson, C.2    Friedlander, B.3    Chang, P.4    Reyes, D.K.5    Nix, R.6
  • 104
    • 77957036114 scopus 로고    scopus 로고
    • Alzheimer's Disease International 2010
    • World Alzheimer report. World Alzheimer Report 2010: The Global Impact of Dementia , eds A. Wimo and M. Prince (London: Alzheimer's Disease International).
    • World Alzheimer report. (2010). "Alzheimer's Disease International 2010," in World Alzheimer Report 2010: The Global Impact of Dementia , eds A. Wimo and M. Prince (London: Alzheimer's Disease International).
    • (2010)
  • 105
    • 77951905218 scopus 로고    scopus 로고
    • In vivo manifestation of notch related phenotypes in zebrafish treated with Alzheimer's amyloid reducing gamma-secretase inhibitors
    • doi: 10.1111/j.1471-4159.2010.06681.x
    • Yang, T., Arslanova, D., Xu, X., Li, Y. M., and Xia, W. (2010). In vivo manifestation of notch related phenotypes in zebrafish treated with Alzheimer's amyloid reducing gamma-secretase inhibitors. J. Neurochem. 113, 1200-1209. doi: 10.1111/j.1471-4159.2010.06681.x
    • (2010) J. Neurochem. , vol.113 , pp. 1200-1209
    • Yang, T.1    Arslanova, D.2    Xu, X.3    Li, Y.M.4    Xia, W.5
  • 106
    • 83355176479 scopus 로고    scopus 로고
    • Hypoxia due to cardiac arrest induces a time-dependent increase in serum amyloid beta levels in humans
    • doi: 10.1371/journal.pone.0028263
    • Zetterberg, H., Mortberg, E., Song, L., Chang, L., Provuncher, G. K., Patel, P. P., et al. (2011). Hypoxia due to cardiac arrest induces a time-dependent increase in serum amyloid beta levels in humans. PLoS ONE 6:e28263. doi: 10.1371/journal.pone.0028263
    • (2011) PLoS ONE , vol.6
    • Zetterberg, H.1    Mortberg, E.2    Song, L.3    Chang, L.4    Provuncher, G.K.5    Patel, P.P.6
  • 107
    • 84862883617 scopus 로고    scopus 로고
    • A role for presenilins in autophagy revisited: normal acidification of lysosomes in cells lacking PSEN1 and PSEN2
    • doi: 10.1523/JNEUROSCI.0556-12.2012
    • Zhang, X., Garbett, K., Veeraraghavalu, K., Wilburn, B., Gilmore, R., Mirnics, K., et al. (2012). A role for presenilins in autophagy revisited: normal acidification of lysosomes in cells lacking PSEN1 and PSEN2. J. Neurosci. 32, 8633-8648. doi: 10.1523/JNEUROSCI.0556-12.2012
    • (2012) J. Neurosci. , vol.32 , pp. 8633-8648
    • Zhang, X.1    Garbett, K.2    Veeraraghavalu, K.3    Wilburn, B.4    Gilmore, R.5    Mirnics, K.6
  • 108
    • 77952549255 scopus 로고    scopus 로고
    • Pathological role of hypoxia in Alzheimer's disease
    • doi: 10.1016/j.expneurol.2009.07.033
    • Zhang, X., and Le, W. (2010). Pathological role of hypoxia in Alzheimer's disease. Exp. Neurol. 223, 299-303. doi: 10.1016/j.expneurol.2009.07.033
    • (2010) Exp. Neurol. , vol.223 , pp. 299-303
    • Zhang, X.1    Le, W.2


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