Identification of a second presenilin gene in zebrafish with similarity to the human Alzheimer's disease presenilin2

Development Genes and Evolution

Volumn 212, Issue 10, 2002, Pages 486-490

  Groth, Casper ^a   Nornes, Svanhild ^a   McCarty, Rosa ^a   Tamme, Richard ^a   Lardelli, Michael ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

Alzheimer's disease; Melanocyte; Neural crest; Presenilin; Zebrafish

Indexed keywords

PRESENILIN 2;

ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; EMBRYO DEVELOPMENT; FERTILIZATION; GENE EXPRESSION; GENE ISOLATION; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC SIMILARITY; HUMAN; MELANOCYTE; MOUSE; NEURAL CREST CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; ORTHOLOGY; PATHOGENESIS; PRIORITY JOURNAL; RNA TRANSLATION; SEQUENCE HOMOLOGY; TRANSLATION REGULATION; ZEBRA FISH;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; ANIMALS; BLOTTING, WESTERN; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; MELANOCYTES; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; NEURAL CREST; PHYLOGENY; PRESENILIN-2; SEQUENCE HOMOLOGY, AMINO ACID; ZEBRAFISH;

DANIO RERIO; EUKARYOTA; VERTEBRATA;

EID: 0036935846     PISSN: 0949944X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00427-002-0269-5     Document Type: Article

References (27)

1. Berezovska O, Frosh M, McLean P, Knowles R, Koo E, Kang D, Shen J, Lu FM, Lux SE, Tonegawa S, Hyman BT (1999) The Alzheimer-related gene presenilin 1 facilitates notch 1 in primary mammalian neurons. Mol Brain Res 69:273-280
2. Chan YM, Jan YN (1999) Presenilins, processing of β-amyloid precursor protein, and Notch signaling. Neuron 23:201-204
3. De Strooper B, Beullens M, Contreras B, Levesque L, Craessaerts K, Cordell B, Moechars D, Bollen M, Fraser P, St George-Hyslop P, Van Leuven F (1997) Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins. J Biol Chem 272:3590-3598
4. Donoviel DB, Hadjantonakis AK, Ikeda M, Zeng H, St George-Hyslop P, Berstein A (1999) Mice lacking both presenilin genes exhibit embryonic patterning defects. Genes Dev 13:2801-2810
5. Felsenstein J (1989) PHYLIP - Phylogeny Inference Package (version 3.2). Cladistics 5:164-166
6. Fraser PE, Yang DS, Yu G, Levesque L, Nishimura M, Arawaka S, Serpell LC, Rogaeva E, St George-Hyslop P (2000) Presenilin structure, function and role in Alzheimer's disease. Biochem Biophys Acta 1502:1-15
7. Greenwald I (1998) LIN-12/Notch signaling: lessons from worms and flies. Genes Dev 12:1751-1762
8. Handler M, Yang X, Shen J (2000) Presenilin-1 regulates neuronal differentiation during neurogenesis. Development 127:2593-2606
9. Jacobsen H, Reinhardt D, Brockhaus M, Bur D, Kocyba C, Kurt H, Grim MG, Baumeister R, Loetscher H (1999). The influence of endoproteolytic processing of familial Alzheimer's disease presenilin2 and Aβ42 amyloid peptide formation. J Biol Chem 274:35233-35239
10. Jowett T (1997) Tissue in situ hybridization. Wiley, New York
11. Kimberly WT, Xia W, Rahmati T, Wolfe MS, Selkoe DJ (2000) The transmembrane aspartates in presenilin 1 and 2 are obligatory for γ-secretase activity and amyloid β-protein generation. J Biol Chem 275:3173-3178
12. Kovacs DM, Fausett HJ, Page KJ, Kim TW, Moir RD, Merriam DE, Hollister RD, Hallmark OG, Mancini R, Felsenstein KM, Hyman BT, Tanzi RE, Wasco W (1996) Alzheimer-associated presenilins 1 and 2: neuronal expression in the brain and localization to intracellular membranes in mammalian cells. Nat Med 2:224-229
13. Lee MK, Slut HH, Martin LJ, Thinakaran G, Kim G, Gandy SE, Seeger M, Koo E, Price DL, Sisodia SS (1996) Expression of presenilin 1 and 2 in human and murine tissues. J Neurosci 16:7513-7525
14. Leimer U, Lun K, Romig H, Walter J, Grünberg J, Brand M, Haas C (1999) Zebrafish (Danio rerio) presenilin promotes aberrant amyloid β-peptide production and requires a critical aspartate residue for its function in amyloidogenesis. Biochemistry 38:13602-13609
15. Li J, Min X, Ma J, Potter H (1997) Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation. Cell 90:917-927
16. Li X, Greenwald I (1998) Additional evidence for an eight-transmembrane-domain topology for Caenorhabditis elegans and human presenilins. Proc Natl Acad Sci USA 95:7109-7114
17. Petanceska S, Seeger M, Checler F, Gandy S (2000) Mutant Presenilin 1 increase the level of Alzheimer's arnyloid β-peptide aβ42 in late compartments of the constitutive secretory pathway. J Neurochem 74:1878-1884
18. Ratovitski T, Slunt HH, Thinakaran G, Price DL, Sisodia SS, Borchelt DR (1997) Endoproteolytic processing and stabilization of wild-type and mutant presenilin. J Biol Chem 272:24536-24541
19. Ray WJ, Yao M, Mumm J, Schroeter EH, Saftig P, Wolfe M, Selkoe DJ, Kopan R, Goate AM (1999) Cell surface Presenilin-1 participates in the γ-secretase-like proteolysis of Notch. J Biol Chem 274:36801-36807
20. Schwarzman AL, Singh N, Tsiper M, Gregori L, Dranovsky A, Vitek MP, Glabe CG, St George-Hyslop PH, Goldgaber D (1999) Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix. Proc Natl Acad Sci USA 96:7932-7937
21. Selkoe DJ (1996) Amyloid β-protein and the genetics of Alzheimer's disease. J Biol Chem 271:18295-18298
22. Selkoe DJ, Wolfe MS (2000) In search of γ-secretase: presenilin at the cutting edge. Proc Natl Acad Sci USA 97:5690-5692
23. Shen J, Bronson RT, Chen DF, Xia W, Selkoe DJ, Tonegawa S (1997) Skeletal and CNS defects in presenilin-1-deficient mice. Cell 89:629-639
24. Steiner H, Duff K, Capell A, Romig H, Grim MG, Lincoln S, Hardy J, Yu X, Picciano M, Fechteler K, Citron M, Kopan R, Pesold B, Keck S, Baader M, Tomita T, Iwatsubo T, Baumeister R, Haas C (1999) A loss of function mutation of presenilin-2 interferes with amyloid β-peptide production and Notch signaling. J Biol Chem 274:28669-28673
25. Thompson JD, Higgins DG, Gibson TJ (1994) CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res 22:4673-4680
26. Wolozin B, Iwasaki K, Vito P, Ganjei J, Lacana E, Sunderland T, Zhao B, Kusiak JW, Wasco W, D'Adamio L (1996) Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation. Science 274:1710-1713
27. Wong PC, Zheng H, Chen H, Becher MW, Sirnathsinghji DJS, Trumbauer ME, Chen HY, Price DL, Van der Ploeg LHT, Sisodia SS (1997) Presenilin 1 is required for Notch1 and Dll1 expression in the paraxial mesoderm. Nature 387:288-292