메뉴 건너뛰기




Volumn 5, Issue 1, 2010, Pages

Presenilin-1 regulates induction of hypoxia inducible factor-1α: Altered activation by a mutation associated with familial Alzheimer's disease

Author keywords

[No Author keywords available]

Indexed keywords

COBALT CHLORIDE; GAMMA SECRETASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INSULIN; INSULIN RECEPTOR; LENTIVIRUS VECTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PRESENILIN 1; PROTEASOME; PROTEIN KINASE B;

EID: 77956884129     PISSN: None     EISSN: 17501326     Source Type: Journal    
DOI: 10.1186/1750-1326-5-38     Document Type: Article
Times cited : (32)

References (89)
  • 1
    • 0035066332 scopus 로고    scopus 로고
    • Alzheimer's disease: Genes, proteins, and therapy
    • 11274343
    • Alzheimer's disease: genes, proteins, and therapy. DJ Selkoe, Physiol Rev 2001 81 2 741 766 11274343
    • (2001) Physiol Rev , vol.81 , Issue.2 , pp. 741-766
    • Selkoe, D.J.1
  • 2
    • 34447316702 scopus 로고    scopus 로고
    • Genetics of Alzheimer's disease: A centennial review
    • 10.1016/j.ncl.2007.03.009. 17659183
    • Genetics of Alzheimer's disease: a centennial review. N Ertekin-Taner, Neurol Clin 2007 25 3 611 667 10.1016/j.ncl.2007.03.009 17659183
    • (2007) Neurol Clin , vol.25 , Issue.3 , pp. 611-667
    • Ertekin-Taner, N.1
  • 4
    • 1342344129 scopus 로고    scopus 로고
    • Clinical, pathological, and biochemical spectrum of Alzheimer disease associated with PS-1 mutations
    • 15010344
    • Clinical, pathological, and biochemical spectrum of Alzheimer disease associated with PS-1 mutations. A Lleo O Berezovska JH Growdon BT Hyman, Am J Geriatr Psychiatry 2004 12 2 146 156 15010344
    • (2004) Am J Geriatr Psychiatry , vol.12 , Issue.2 , pp. 146-156
    • Lleo, A.1    Berezovska, O.2    Growdon, J.H.3    Hyman, B.T.4
  • 5
    • 34248190279 scopus 로고    scopus 로고
    • A beta oligomers - A decade of discovery
    • 10.1111/j.1471-4159.2006.04426.x. 17286590
    • A beta oligomers - a decade of discovery. DM Walsh DJ Selkoe, J Neurochem 2007 101 5 1172 1184 10.1111/j.1471-4159.2006.04426.x 17286590
    • (2007) J Neurochem , vol.101 , Issue.5 , pp. 1172-1184
    • Walsh, D.M.1    Selkoe, D.J.2
  • 6
    • 33748925716 scopus 로고    scopus 로고
    • Interventions for heart disease and their effects on Alzheimer's disease
    • 10.1179/016164106X130515. 16945215
    • Interventions for heart disease and their effects on Alzheimer's disease. B Wolozin MM Bednar, Neurol Res 2006 28 6 630 636 10.1179/016164106X130515 16945215
    • (2006) Neurol Res , vol.28 , Issue.6 , pp. 630-636
    • Wolozin, B.1    Bednar, M.M.2
  • 7
    • 0031054674 scopus 로고    scopus 로고
    • Brain infarction and the clinical expression of Alzheimer disease. The Nun Study
    • 10.1001/jama.277.10.813. 9052711
    • Brain infarction and the clinical expression of Alzheimer disease. The Nun Study. DA Snowdon LH Greiner JA Mortimer KP Riley PA Greiner WR Markesbery, Jama 1997 277 10 813 817 10.1001/jama.277.10.813 9052711
    • (1997) Jama , vol.277 , Issue.10 , pp. 813-817
    • Snowdon, D.A.1    Greiner, L.H.2    Mortimer, J.A.3    Riley, K.P.4    Greiner, P.A.5    Markesbery, W.R.6
  • 9
    • 0029832348 scopus 로고    scopus 로고
    • Expression of beta-amyloid precursor protein mRNAs following transient focal ischaemia
    • 10.1097/00001756-199611040-00064. 8981456
    • Expression of beta-amyloid precursor protein mRNAs following transient focal ischaemia. J Koistinaho I Pyykonen R Keinanen T Hokfelt, Neuroreport 1996 7 15-17 2727 2731 10.1097/00001756-199611040-00064 8981456
    • (1996) Neuroreport , vol.7 , Issue.15-17 , pp. 2727-2731
    • Koistinaho, J.1    Pyykonen, I.2    Keinanen, R.3    Hokfelt, T.4
  • 10
    • 0032972815 scopus 로고    scopus 로고
    • Progressive parenchymal deposition of β-amyloid precursor protein in rat brain following global cerebral ischemia
    • DOI 10.1007/s004010050999
    • Progressive parenchymal deposition of beta-amyloid precursor protein in rat brain following global cerebral ischemia. B Lin R Schmidt-Kastner R Busto MD Ginsberg, Acta Neuropathol (Berl) 1999 97 4 359 368 10.1007/s004010050999 (Pubitemid 29134516)
    • (1999) Acta Neuropathologica , vol.97 , Issue.4 , pp. 359-368
    • Lin, B.1    Schmidt-Kastner, R.2    Busto, R.3    Ginsberg, M.D.4
  • 11
    • 0036904555 scopus 로고    scopus 로고
    • Altered processing of amyloid precursor protein in the human neuroblastoma SH-SY5Y by chronic hypoxia
    • 10.1046/j.1471-4159.2002.01236.x. 12472881
    • Altered processing of amyloid precursor protein in the human neuroblastoma SH-SY5Y by chronic hypoxia. NJ Webster KN Green C Peers PF Vaughan, J Neurochem 2002 83 6 1262 1271 10.1046/j.1471-4159.2002.01236.x 12472881
    • (2002) J Neurochem , vol.83 , Issue.6 , pp. 1262-1271
    • Webster, N.J.1    Green, K.N.2    Peers, C.3    Vaughan, P.F.4
  • 12
    • 0142042435 scopus 로고    scopus 로고
    • Transient hypoxia causes Alzheimer-type molecular and biochemical abnormalities in cortical neurons: Potential strategies for neuroprotection
    • 12897406
    • Transient hypoxia causes Alzheimer-type molecular and biochemical abnormalities in cortical neurons: potential strategies for neuroprotection. GJ Chen J Xu SA Lahousse NL Caggiano SM de la Monte, J Alzheimers Dis 2003 5 3 209 228 12897406
    • (2003) J Alzheimers Dis , vol.5 , Issue.3 , pp. 209-228
    • Chen, G.J.1    Xu, J.2    Lahousse, S.A.3    Caggiano, N.L.4    De La Monte, S.M.5
  • 13
    • 64349114305 scopus 로고    scopus 로고
    • Hypoxia increases Abeta generation by altering beta- and gamma-cleavage of APP
    • 10.1016/j.neurobiolaging.2007.10.011. 18063223
    • Hypoxia increases Abeta generation by altering beta- and gamma-cleavage of APP. L Li X Zhang D Yang G Luo S Chen W Le, Neurobiol Aging 2009 30 7 1091 1098 10.1016/j.neurobiolaging.2007.10.011 18063223
    • (2009) Neurobiol Aging , vol.30 , Issue.7 , pp. 1091-1098
    • Li, L.1    Zhang, X.2    Yang, D.3    Luo, G.4    Chen, S.5    Le, W.6
  • 14
    • 33845505233 scopus 로고    scopus 로고
    • Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression
    • 10.1073/pnas.0606298103. 17121991
    • Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression. X Sun G He H Qing W Zhou F Dobie F Cai M Staufenbiel LE Huang W Song, Proc Natl Acad Sci USA 2006 103 49 18727 18732 10.1073/pnas.0606298103 17121991
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.49 , pp. 18727-18732
    • Sun, X.1    He, G.2    Qing, H.3    Zhou, W.4    Dobie, F.5    Cai, F.6    Staufenbiel, M.7    Huang, L.E.8    Song, W.9
  • 15
    • 34249727115 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation
    • 10.1074/jbc.M608856200. 17303576
    • Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation. X Zhang K Zhou R Wang J Cui SA Lipton FF Liao H Xu YW Zhang, J Biol Chem 2007 282 15 10873 10880 10.1074/jbc.M608856200 17303576
    • (2007) J Biol Chem , vol.282 , Issue.15 , pp. 10873-10880
    • Zhang, X.1    Zhou, K.2    Wang, R.3    Cui, J.4    Lipton, S.A.5    Liao, F.F.6    Xu, H.7    Zhang, Y.W.8
  • 16
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • 10.1038/nrc1187. 13130303
    • Targeting HIF-1 for cancer therapy. GL Semenza, Nat Rev Cancer 2003 3 10 721 732 10.1038/nrc1187 13130303
    • (2003) Nat Rev Cancer , vol.3 , Issue.10 , pp. 721-732
    • Semenza, G.L.1
  • 17
    • 33751169387 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 (HIF-1)
    • 10.1124/mol.106.027029. 16887934
    • Hypoxia-inducible factor-1 (HIF-1). Q Ke M Costa, Mol Pharmacol 2006 70 5 1469 1480 10.1124/mol.106.027029 16887934
    • (2006) Mol Pharmacol , vol.70 , Issue.5 , pp. 1469-1480
    • Ke, Q.1    Costa, M.2
  • 18
    • 0036710591 scopus 로고    scopus 로고
    • Signal transduction to hypoxia-inducible factor 1
    • 10.1016/S0006-2952(02)01168-1. 12213597
    • Signal transduction to hypoxia-inducible factor 1. G Semenza, Biochem Pharmacol 2002 64 5-6 993 998 10.1016/S0006-2952(02)01168-1 12213597
    • (2002) Biochem Pharmacol , vol.64 , Issue.5-6 , pp. 993-998
    • Semenza, G.1
  • 19
    • 0037008770 scopus 로고    scopus 로고
    • Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway
    • 10.1074/jbc.M204152200. 12032158
    • Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway. C Treins S Giorgetti-Peraldi J Murdaca GL Semenza E Van Obberghen, J Biol Chem 2002 277 31 27975 27981 10.1074/jbc.M204152200 12032158
    • (2002) J Biol Chem , vol.277 , Issue.31 , pp. 27975-27981
    • Treins, C.1    Giorgetti-Peraldi, S.2    Murdaca, J.3    Semenza, G.L.4    Van Obberghen, E.5
  • 20
    • 0037070223 scopus 로고    scopus 로고
    • Normoxic induction of the hypoxia-inducible factor 1alpha by insulin and interleukin-1beta involves the phosphatidylinositol 3-kinase pathway
    • 10.1016/S0014-5793(02)02247-0. 11852072
    • Normoxic induction of the hypoxia-inducible factor 1alpha by insulin and interleukin-1beta involves the phosphatidylinositol 3-kinase pathway. DP Stiehl W Jelkmann RH Wenger T Hellwig-Burgel, FEBS Lett 2002 512 1-3 157 162 10.1016/S0014-5793(02)02247-0 11852072
    • (2002) FEBS Lett , vol.512 , Issue.1-3 , pp. 157-162
    • Stiehl, D.P.1    Jelkmann, W.2    Wenger, R.H.3    Hellwig-Burgel, T.4
  • 21
    • 0037064010 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells
    • 10.1074/jbc.M203781200. 12149254
    • Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. R Fukuda K Hirota F Fan YD Jung LM Ellis GL Semenza, J Biol Chem 2002 277 41 38205 38211 10.1074/jbc.M203781200 12149254
    • (2002) J Biol Chem , vol.277 , Issue.41 , pp. 38205-38211
    • Fukuda, R.1    Hirota, K.2    Fan, F.3    Jung, Y.D.4    Ellis, L.M.5    Semenza, G.L.6
  • 22
    • 0032169214 scopus 로고    scopus 로고
    • Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha/ARNT
    • 10.1093/emboj/17.17.5085. 9724644
    • Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha/ARNT. E Zelzer Y Levy C Kahana BZ Shilo M Rubinstein B Cohen, Embo J 1998 17 17 5085 5094 10.1093/emboj/17.17.5085 9724644
    • (1998) Embo J , vol.17 , Issue.17 , pp. 5085-5094
    • Zelzer, E.1    Levy, Y.2    Kahana, C.3    Shilo, B.Z.4    Rubinstein, M.5    Cohen, B.6
  • 23
    • 33646436736 scopus 로고    scopus 로고
    • Insulin activates hypoxia-inducible factor-1alpha in human and rat vascular smooth muscle cells via phosphatidylinositol-3 kinase and mitogen-activated protein kinase pathways: Impairment in insulin resistance owing to defects in insulin signalling
    • 10.1007/s00125-006-0156-0. 16506055
    • Insulin activates hypoxia-inducible factor-1alpha in human and rat vascular smooth muscle cells via phosphatidylinositol-3 kinase and mitogen-activated protein kinase pathways: impairment in insulin resistance owing to defects in insulin signalling. G Doronzo I Russo L Mattiello C Riganti G Anfossi M Trovati, Diabetologia 2006 49 5 1049 1063 10.1007/s00125-006-0156-0 16506055
    • (2006) Diabetologia , vol.49 , Issue.5 , pp. 1049-1063
    • Doronzo, G.1    Russo, I.2    Mattiello, L.3    Riganti, C.4    Anfossi, G.5    Trovati, M.6
  • 24
    • 0035931493 scopus 로고    scopus 로고
    • Presenilin-2 (PS2) expression up-regulation in a model of retinopathy of prematurity and pathoangiogenesis
    • 10.1097/00001756-200101220-00019. 11201091
    • Presenilin-2 (PS2) expression up-regulation in a model of retinopathy of prematurity and pathoangiogenesis. WJ Lukiw WC Gordon EI Rogaev H Thompson NG Bazan, Neuroreport 2001 12 1 53 57 10.1097/00001756-200101220-00019 11201091
    • (2001) Neuroreport , vol.12 , Issue.1 , pp. 53-57
    • Lukiw, W.J.1    Gordon, W.C.2    Rogaev, E.I.3    Thompson, H.4    Bazan, N.G.5
  • 25
    • 0037207059 scopus 로고    scopus 로고
    • Presenilins in the heart: Presenilin-2 expression is increased by low glucose and by hypoxia in cardiac cells
    • 10.1016/S0167-0115(02)00225-2. 12468103
    • Presenilins in the heart: presenilin-2 expression is increased by low glucose and by hypoxia in cardiac cells. D Mohuczy K Qian MI Phillips, Regul Pept 2002 110 1 1 7 10.1016/S0167-0115(02)00225-2 12468103
    • (2002) Regul Pept , vol.110 , Issue.1 , pp. 1-7
    • Mohuczy, D.1    Qian, K.2    Phillips, M.I.3
  • 26
    • 37549007657 scopus 로고    scopus 로고
    • Altered expression of cyclooxygenase-2, presenilins and oxygen radical scavenging enzymes in a rat model of global perinatal asphyxia
    • 10.1016/j.expneurol.2007.09.014. 17963755
    • Altered expression of cyclooxygenase-2, presenilins and oxygen radical scavenging enzymes in a rat model of global perinatal asphyxia. P Piscopo A Bernardo G Calamandrei A Venerosi A Valanzano D Bianchi A Confaloni L Minghetti, Exp Neurol 2008 209 1 192 198 10.1016/j.expneurol.2007.09.014 17963755
    • (2008) Exp Neurol , vol.209 , Issue.1 , pp. 192-198
    • Piscopo, P.1    Bernardo, A.2    Calamandrei, G.3    Venerosi, A.4    Valanzano, A.5    Bianchi, D.6    Confaloni, A.7    Minghetti, L.8
  • 27
    • 3343005434 scopus 로고    scopus 로고
    • PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: Effects of FAD mutations
    • 10.1038/sj.emboj.7600251. 15192701
    • PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations. L Baki J Shioi P Wen Z Shao A Schwarzman M Gama-Sosa R Neve NK Robakis, Embo J 2004 23 13 2586 2596 10.1038/sj.emboj.7600251 15192701
    • (2004) Embo J , vol.23 , Issue.13 , pp. 2586-2596
    • Baki, L.1    Shioi, J.2    Wen, P.3    Shao, Z.4    Schwarzman, A.5    Gama-Sosa, M.6    Neve, R.7    Robakis, N.K.8
  • 28
    • 24744459453 scopus 로고    scopus 로고
    • Presenilins mediate phosphatidylinositol 3-kinase/AKT and ERK activation via select signaling receptors. Selectivity of PS2 in platelet-derived growth factor signaling
    • 10.1074/jbc.M500833200. 16014629
    • Presenilins mediate phosphatidylinositol 3-kinase/AKT and ERK activation via select signaling receptors. Selectivity of PS2 in platelet-derived growth factor signaling. DE Kang IS Yoon E Repetto T Busse N Yermian L Ie EH Koo, J Biol Chem 2005 280 36 31537 31547 10.1074/jbc.M500833200 16014629
    • (2005) J Biol Chem , vol.280 , Issue.36 , pp. 31537-31547
    • Kang, D.E.1    Yoon, I.S.2    Repetto, E.3    Busse, T.4    Yermian, N.5    Ie, L.6    Koo, E.H.7
  • 30
    • 4644263024 scopus 로고    scopus 로고
    • Potential roles for presenilin-1 in oxygen sensing and in glial-specific gene expression
    • 10.1097/00001756-200409150-00006. 15486475
    • Potential roles for presenilin-1 in oxygen sensing and in glial-specific gene expression. JG Cui PE Fraser P St George-Hyslop D Westaway WJ Lukiw, Neuroreport 2004 15 13 2025 2028 10.1097/00001756-200409150-00006 15486475
    • (2004) Neuroreport , vol.15 , Issue.13 , pp. 2025-2028
    • Cui, J.G.1    Fraser, P.E.2    St George-Hyslop, P.3    Westaway, D.4    Lukiw, W.J.5
  • 31
    • 0037203240 scopus 로고    scopus 로고
    • Differential display analysis of presenilin 1-deficient mouse brains
    • 10.1016/S0169-328X(02)00491-6. 12531515
    • Differential display analysis of presenilin 1-deficient mouse brains. J Liauw V Nguyen J Huang P St George-Hyslop R Rozmahel, Mol Brain Res 2002 109 1-2 56 62 10.1016/S0169-328X(02)00491-6 12531515
    • (2002) Mol Brain Res , vol.109 , Issue.1-2 , pp. 56-62
    • Liauw, J.1    Nguyen, V.2    Huang, J.3    St George-Hyslop, P.4    Rozmahel, R.5
  • 32
    • 3142523739 scopus 로고    scopus 로고
    • HIF-1: An oxygen and metal responsive transcription factor
    • 14726713
    • HIF-1: an oxygen and metal responsive transcription factor. P Maxwell K Salnikow, Cancer Biol Ther 2004 3 1 29 35 14726713
    • (2004) Cancer Biol Ther , vol.3 , Issue.1 , pp. 29-35
    • Maxwell, P.1    Salnikow, K.2
  • 33
    • 11144337759 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1: Regulation by hypoxic and non-hypoxic activators
    • 10.1016/j.biocel.2004.08.012. 15618010
    • Hypoxia-inducible factor 1: regulation by hypoxic and non-hypoxic activators. MA Dery MD Michaud DE Richard, Int J Biochem Cell Biol 2005 37 3 535 540 10.1016/j.biocel.2004.08.012 15618010
    • (2005) Int J Biochem Cell Biol , vol.37 , Issue.3 , pp. 535-540
    • Dery, M.A.1    Michaud, M.D.2    Richard, D.E.3
  • 34
    • 17844364429 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible factor (HIF)-1 activity and expression of HIF hydroxylases in response to insulin-like growth factor i
    • 10.1210/me.2004-0239. 15695372
    • Regulation of hypoxia-inducible factor (HIF)-1 activity and expression of HIF hydroxylases in response to insulin-like growth factor I. C Treins S Giorgetti-Peraldi J Murdaca MN Monthouel-Kartmann E Van Obberghen, Mol Endocrinol 2005 19 5 1304 1317 10.1210/me.2004-0239 15695372
    • (2005) Mol Endocrinol , vol.19 , Issue.5 , pp. 1304-1317
    • Treins, C.1    Giorgetti-Peraldi, S.2    Murdaca, J.3    Monthouel-Kartmann, M.N.4    Van Obberghen, E.5
  • 35
    • 7244242390 scopus 로고    scopus 로고
    • Chelation of cellular calcium modulates hypoxia-inducible gene expression through activation of hypoxia-inducible factor-1alpha
    • 10.1074/jbc.M313995200. 15322093
    • Chelation of cellular calcium modulates hypoxia-inducible gene expression through activation of hypoxia-inducible factor-1alpha. U Berchner-Pfannschmidt F Petrat K Doege B Trinidad P Freitag E Metzen H de Groot J Fandrey, J Biol Chem 2004 279 43 44976 44986 10.1074/jbc.M313995200 15322093
    • (2004) J Biol Chem , vol.279 , Issue.43 , pp. 44976-44986
    • Berchner-Pfannschmidt, U.1    Petrat, F.2    Doege, K.3    Trinidad, B.4    Freitag, P.5    Metzen, E.6    De Groot, H.7    Fandrey, J.8
  • 36
    • 3142512452 scopus 로고    scopus 로고
    • Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration
    • 10.1038/nm1065. 15272268
    • Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration. EH Koo R Kopan, Nat Med 2004 10 Suppl 26 33 10.1038/nm1065 15272268
    • (2004) Nat Med , vol.10 , Issue.SUPPL. , pp. 1926-1933
    • Koo, E.H.1    Kopan, R.2
  • 37
    • 34250874502 scopus 로고    scopus 로고
    • Generation of intracellular domain of insulin receptor tyrosine kinase by gamma-secretase
    • 10.1016/j.bbrc.2007.06.022. 17577576
    • Generation of intracellular domain of insulin receptor tyrosine kinase by gamma-secretase. K Kasuga H Kaneko M Nishizawa O Onodera T Ikeuchi, Biochem Biophys Res Commun 2007 360 1 90 96 10.1016/j.bbrc.2007.06.022 17577576
    • (2007) Biochem Biophys Res Commun , vol.360 , Issue.1 , pp. 90-96
    • Kasuga, K.1    Kaneko, H.2    Nishizawa, M.3    Onodera, O.4    Ikeuchi, T.5
  • 38
    • 34249664257 scopus 로고    scopus 로고
    • The insulin-like growth factor 1 (IGF-1) receptor is a substrate for gamma-secretase-mediated intramembrane proteolysis
    • 10.1016/j.bbrc.2007.05.062. 17524361
    • The insulin-like growth factor 1 (IGF-1) receptor is a substrate for gamma-secretase-mediated intramembrane proteolysis. B McElroy JC Powell JV McCarthy, Biochem Biophys Res Commun 2007 358 4 1136 1141 10.1016/j.bbrc.2007. 05.062 17524361
    • (2007) Biochem Biophys Res Commun , vol.358 , Issue.4 , pp. 1136-1141
    • McElroy, B.1    Powell, J.C.2    McCarthy, J.V.3
  • 39
    • 0141429160 scopus 로고    scopus 로고
    • A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations
    • 10.1016/j.cell.2003.08.008. 13678586
    • A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations. P Marambaud PH Wen A Dutt J Shioi A Takashima R Siman NK Robakis, Cell 2003 114 5 635 645 10.1016/j.cell.2003.08.008 13678586
    • (2003) Cell , vol.114 , Issue.5 , pp. 635-645
    • Marambaud, P.1    Wen, P.H.2    Dutt, A.3    Shioi, J.4    Takashima, A.5    Siman, R.6    Robakis, N.K.7
  • 40
    • 34247140171 scopus 로고    scopus 로고
    • Regulation of insulin receptor function
    • 10.1007/s00018-007-6359-9. 17347799
    • Regulation of insulin receptor function. JF Youngren, Cell Mol Life Sci 2007 64 7-8 873 891 10.1007/s00018-007-6359-9 17347799
    • (2007) Cell Mol Life Sci , vol.64 , Issue.7-8 , pp. 873-891
    • Youngren, J.F.1
  • 41
    • 0029051439 scopus 로고
    • Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
    • 10.1073/pnas.92.12.5510. 7539918
    • Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. GL Wang BH Jiang EA Rue GL Semenza, Proc Natl Acad Sci USA 1995 92 12 5510 5514 10.1073/pnas.92.12.5510 7539918
    • (1995) Proc Natl Acad Sci USA , vol.92 , Issue.12 , pp. 5510-5514
    • Wang, G.L.1    Jiang, B.H.2    Rue, E.A.3    Semenza, G.L.4
  • 42
    • 33947609757 scopus 로고    scopus 로고
    • The role of presenilin and its interacting proteins in the biogenesis of Alzheimer's beta amyloid
    • 10.1007/s11064-006-9131-x. 16944319
    • The role of presenilin and its interacting proteins in the biogenesis of Alzheimer's beta amyloid. G Verdile SE Gandy RN Martins, Neurochem Res 2007 32 4-5 609 623 10.1007/s11064-006-9131-x 16944319
    • (2007) Neurochem Res , vol.32 , Issue.4-5 , pp. 609-623
    • Verdile, G.1    Gandy, S.E.2    Martins, R.N.3
  • 43
    • 1642267052 scopus 로고    scopus 로고
    • Presenilin modulates Pen-2 levels posttranslationally by protecting it from proteasomal degradation
    • 10.1021/bi0361214. 15035625
    • Presenilin modulates Pen-2 levels posttranslationally by protecting it from proteasomal degradation. AS Crystal VA Morais RR Fortna D Carlin TC Pierson CA Wilson VM Lee RW Doms, Biochemistry 2004 43 12 3555 3563 10.1021/bi0361214 15035625
    • (2004) Biochemistry , vol.43 , Issue.12 , pp. 3555-3563
    • Crystal, A.S.1    Morais, V.A.2    Fortna, R.R.3    Carlin, D.4    Pierson, T.C.5    Wilson, C.A.6    Lee, V.M.7    Doms, R.W.8
  • 44
    • 33947242870 scopus 로고    scopus 로고
    • When loss is gain: Reduced presenilin proteolytic function leads to increased Abeta42/Abeta40. Talking Point on the role of presenilin mutations in Alzheimer disease
    • 10.1038/sj.embor.7400896. 17268504
    • When loss is gain: reduced presenilin proteolytic function leads to increased Abeta42/Abeta40. Talking Point on the role of presenilin mutations in Alzheimer disease. MS Wolfe, EMBO Rep 2007 8 2 136 140 10.1038/sj.embor.7400896 17268504
    • (2007) EMBO Rep , vol.8 , Issue.2 , pp. 136-140
    • Wolfe, M.S.1
  • 45
    • 33947201115 scopus 로고    scopus 로고
    • Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer disease
    • 10.1038/sj.embor.7400897. 17268505
    • Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer disease. B De Strooper, EMBO Rep 2007 8 2 141 146 10.1038/sj.embor.7400897 17268505
    • (2007) EMBO Rep , vol.8 , Issue.2 , pp. 141-146
    • De Strooper, B.1
  • 47
    • 0035142809 scopus 로고    scopus 로고
    • Determination of hypoxic region by hypoxia marker in developing mouse embryos in vivo: A possible signal for vessel development
    • 10.1002/1097-0177(20010201)22 0:2<175::AID-DVDY1101>3.0.CO;2-F. 11169851
    • Determination of hypoxic region by hypoxia marker in developing mouse embryos in vivo: a possible signal for vessel development. YM Lee CH Jeong SY Koo MJ Son HS Song SK Bae JA Raleigh HY Chung MA Yoo KW Kim, Dev Dyn 2001 220 2 175 186 10.1002/1097-0177(20010201)220:2<175::AID-DVDY1101>3.0.CO;2-F 11169851
    • (2001) Dev Dyn , vol.220 , Issue.2 , pp. 175-186
    • Lee, Y.M.1    Jeong, C.H.2    Koo, S.Y.3    Son, M.J.4    Song, H.S.5    Bae, S.K.6    Raleigh, J.A.7    Chung, H.Y.8    Yoo, M.A.9    Kim, K.W.10
  • 48
    • 33846403492 scopus 로고    scopus 로고
    • Pathological and physiological functions of presenilins
    • 10.1186/1750-1326-1-4. 16930451
    • Pathological and physiological functions of presenilins. KS Vetrivel YW Zhang H Xu G Thinakaran, Mol Neurodegener 2006 1 4 10.1186/1750-1326-1-4 16930451
    • (2006) Mol Neurodegener , vol.1 , pp. 4
    • Vetrivel, K.S.1    Zhang, Y.W.2    Xu, H.3    Thinakaran, G.4
  • 49
    • 2642555563 scopus 로고    scopus 로고
    • HIF1 and oxygen sensing in the brain
    • 10.1038/nrn1408. 15152194
    • HIF1 and oxygen sensing in the brain. FR Sharp M Bernaudin, Nat Rev Neurosci 2004 5 6 437 448 10.1038/nrn1408 15152194
    • (2004) Nat Rev Neurosci , vol.5 , Issue.6 , pp. 437-448
    • Sharp, F.R.1    Bernaudin, M.2
  • 50
    • 0345708353 scopus 로고    scopus 로고
    • The mammalian basic helix-loop-helix/PAS family of transcriptional regulators
    • 10.1016/S1357-2725(03)00211-5. 14643885
    • The mammalian basic helix-loop-helix/PAS family of transcriptional regulators. RJ Kewley ML Whitelaw A Chapman-Smith, Int J Biochem Cell Biol 2004 36 2 189 204 10.1016/S1357-2725(03)00211-5 14643885
    • (2004) Int J Biochem Cell Biol , vol.36 , Issue.2 , pp. 189-204
    • Kewley, R.J.1    Whitelaw, M.L.2    Chapman-Smith, A.3
  • 53
    • 0034645063 scopus 로고    scopus 로고
    • Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation
    • 10.1083/jcb.151.4.847. 11076969
    • Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation. AL Mah G Perry MA Smith MJ Monteiro, J Cell Biol 2000 151 4 847 862 10.1083/jcb.151.4.847 11076969
    • (2000) J Cell Biol , vol.151 , Issue.4 , pp. 847-862
    • Mah, A.L.1    Perry, G.2    Smith, M.A.3    Monteiro, M.J.4
  • 54
  • 55
    • 27744468749 scopus 로고    scopus 로고
    • Ubiquilin regulates presenilin endoproteolysis and modulates gamma-secretase components, Pen-2 and nicastrin
    • 15975090
    • Ubiquilin regulates presenilin endoproteolysis and modulates gamma-secretase components, Pen-2 and nicastrin. LK Massey AL Mah MJ Monteiro, Biochem J 2005 391 Pt 3 513 525 15975090
    • (2005) Biochem J , vol.391 , Issue.PART 3 , pp. 513-525
    • Massey, L.K.1    Mah, A.L.2    Monteiro, M.J.3
  • 56
    • 44349157891 scopus 로고    scopus 로고
    • Glucose and endoplasmic reticulum calcium channels regulate HIF-1beta via presenilin in pancreatic beta-cells
    • 10.1074/jbc.M710601200. 18174159
    • Glucose and endoplasmic reticulum calcium channels regulate HIF-1beta via presenilin in pancreatic beta-cells. V Dror TB Kalynyak Y Bychkivska MH Frey M Tee KD Jeffrey V Nguyen DS Luciani JD Johnson, J Biol Chem 2008 283 15 9909 9916 10.1074/jbc.M710601200 18174159
    • (2008) J Biol Chem , vol.283 , Issue.15 , pp. 9909-9916
    • Dror, V.1    Kalynyak, T.B.2    Bychkivska, Y.3    Frey, M.H.4    Tee, M.5    Jeffrey, K.D.6    Nguyen, V.7    Luciani, D.S.8    Johnson, J.D.9
  • 57
    • 0025847968 scopus 로고
    • Insulin receptors in the central nervous system: Localization, signalling mechanisms and functional aspects
    • 10.1016/0301-0082(91)90015-S. 1887067
    • Insulin receptors in the central nervous system: localization, signalling mechanisms and functional aspects. JW Unger JN Livingston AM Moss, Prog Neurobiol 1991 36 5 343 362 10.1016/0301-0082(91)90015-S 1887067
    • (1991) Prog Neurobiol , vol.36 , Issue.5 , pp. 343-362
    • Unger, J.W.1    Livingston, J.N.2    Moss, A.M.3
  • 58
    • 1242316296 scopus 로고    scopus 로고
    • Insulin and neurodegenerative disease: Shared and specific mechanisms
    • 10.1016/S1474-4422(04)00681-7. 14980532
    • Insulin and neurodegenerative disease: shared and specific mechanisms. S Craft GS Watson, Lancet Neurol 2004 3 3 169 178 10.1016/S1474-4422(04)00681-7 14980532
    • (2004) Lancet Neurol , vol.3 , Issue.3 , pp. 169-178
    • Craft, S.1    Watson, G.S.2
  • 59
    • 42249116015 scopus 로고    scopus 로고
    • Insulin, PKC signaling pathways and synaptic remodeling during memory storage and neuronal repair
    • 10.1016/j.ejphar.2008.01.051. 18402935
    • Insulin, PKC signaling pathways and synaptic remodeling during memory storage and neuronal repair. TJ Nelson MK Sun J Hongpaisan DL Alkon, Eur J Pharmacol 2008 585 1 76 87 10.1016/j.ejphar.2008.01.051 18402935
    • (2008) Eur J Pharmacol , vol.585 , Issue.1 , pp. 76-87
    • Nelson, T.J.1    Sun, M.K.2    Hongpaisan, J.3    Alkon, D.L.4
  • 60
    • 1842785189 scopus 로고    scopus 로고
    • Signaling by insulin-like growth factor 1 in brain
    • 10.1016/j.ejphar.2004.02.042. 15094071
    • Signaling by insulin-like growth factor 1 in brain. CA Bondy CM Cheng, Eur J Pharmacol 2004 490 1-3 25 31 10.1016/j.ejphar.2004.02.042 15094071
    • (2004) Eur J Pharmacol , vol.490 , Issue.1-3 , pp. 25-31
    • Bondy, C.A.1    Cheng, C.M.2
  • 61
    • 34347252649 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor i signalling in neurons
    • 10.2741/2306. 17485293
    • Insulin and insulin-like growth factor I signalling in neurons. D Davila J Piriz JL Trejo A Nunez I Torres-Aleman, Front Biosci 2007 12 3194 3202 10.2741/2306 17485293
    • (2007) Front Biosci , vol.12 , pp. 3194-3202
    • Davila, D.1    Piriz, J.2    Trejo, J.L.3    Nunez, A.4    Torres-Aleman, I.5
  • 62
    • 42949114366 scopus 로고    scopus 로고
    • Aging of the brain, neurotrophin signaling, and Alzheimer's disease: Is IGF1-R the common culprit?
    • 10.1016/j.neurobiolaging.2007.01.010. 17313996
    • Aging of the brain, neurotrophin signaling, and Alzheimer's disease: is IGF1-R the common culprit? L Puglielli, Neurobiol Aging 2008 29 6 795 811 10.1016/j.neurobiolaging.2007.01.010 17313996
    • (2008) Neurobiol Aging , vol.29 , Issue.6 , pp. 795-811
    • Puglielli, L.1
  • 63
    • 38449115019 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 in plasma and brain: Regulation in health and disease
    • 10.2741/2662. 17981530
    • Insulin-like growth factor-1 in plasma and brain: regulation in health and disease. C Sievers HJ Schneider GK Stalla, Front Biosci 2008 13 85 99 10.2741/2662 17981530
    • (2008) Front Biosci , vol.13 , pp. 85-99
    • Sievers, C.1    Schneider, H.J.2    Stalla, G.K.3
  • 64
    • 42249094013 scopus 로고    scopus 로고
    • Adiposity, hyperinsulinemia, diabetes and Alzheimer's disease: An epidemiological perspective
    • 10.1016/j.ejphar.2008.02.048. 18384771
    • Adiposity, hyperinsulinemia, diabetes and Alzheimer's disease: an epidemiological perspective. JA Luchsinger, Eur J Pharmacol 2008 585 1 119 129 10.1016/j.ejphar.2008.02.048 18384771
    • (2008) Eur J Pharmacol , vol.585 , Issue.1 , pp. 119-129
    • Luchsinger, J.A.1
  • 67
    • 0035871641 scopus 로고    scopus 로고
    • Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling
    • 11306609
    • Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling. L Gasparini GK Gouras R Wang RS Gross MF Beal P Greengard H Xu, J Neurosci 2001 21 8 2561 2570 11306609
    • (2001) J Neurosci , vol.21 , Issue.8 , pp. 2561-2570
    • Gasparini, L.1    Gouras, G.K.2    Wang, R.3    Gross, R.S.4    Beal, M.F.5    Greengard, P.6    Xu, H.7
  • 68
    • 34249851328 scopus 로고    scopus 로고
    • IGF-1-induced processing of the amyloid precursor protein family is mediated by different signaling pathways
    • 10.1074/jbc.M611183200. 17301053
    • IGF-1-induced processing of the amyloid precursor protein family is mediated by different signaling pathways. L Adlerz S Holback G Multhaup K Iverfeldt, J Biol Chem 2007 282 14 10203 10209 10.1074/jbc.M611183200 17301053
    • (2007) J Biol Chem , vol.282 , Issue.14 , pp. 10203-10209
    • Adlerz, L.1    Holback, S.2    Multhaup, G.3    Iverfeldt, K.4
  • 73
    • 0036917631 scopus 로고    scopus 로고
    • Serum insulin-like growth factor i regulates brain amyloid-beta levels
    • 10.1038/nm793. 12415260
    • Serum insulin-like growth factor I regulates brain amyloid-beta levels. E Carro JL Trejo T Gomez-Isla D LeRoith I Torres-Aleman, Nat Med 2002 8 12 1390 1397 10.1038/nm793 12415260
    • (2002) Nat Med , vol.8 , Issue.12 , pp. 1390-1397
    • Carro, E.1    Trejo, J.L.2    Gomez-Isla, T.3    Leroith, D.4    Torres-Aleman, I.5
  • 74
    • 33746215099 scopus 로고    scopus 로고
    • Therapeutic actions of insulin-like growth factor I on APP/PS2 mice with severe brain amyloidosis
    • DOI 10.1016/j.neurobiolaging.2005.06.015, PII S0197458005001892
    • Therapeutic actions of insulin-like growth factor I on APP/PS2 mice with severe brain amyloidosis. E Carro JL Trejo A Gerber H Loetscher J Torrado F Metzger I Torres-Aleman, Neurobiol Aging 2006 29 9 1250 1257 10.1016/j.neurobiolaging.2005.06.015 (Pubitemid 44088577)
    • (2006) Neurobiology of Aging , vol.27 , Issue.9 , pp. 1250-1257
    • Carro, E.1    Trejo, J.L.2    Gerber, A.3    Loetscher, H.4    Torrado, J.5    Metzger, F.6    Torres-Aleman, I.7
  • 75
    • 0034638270 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 and insulin mediate transient site-selective increases in tau phosphorylation in primary cortical neurons
    • 10.1016/S0306-4522(00)00200-1. 10938436
    • Insulin-like growth factor-1 and insulin mediate transient site-selective increases in tau phosphorylation in primary cortical neurons. M Lesort GV Johnson, Neuroscience 2000 99 2 305 316 10.1016/S0306-4522(00)00200-1 10938436
    • (2000) Neuroscience , vol.99 , Issue.2 , pp. 305-316
    • Lesort, M.1    Johnson, G.V.2
  • 76
    • 0032955426 scopus 로고    scopus 로고
    • Insulin transiently increases tau phosphorylation: Involvement of glycogen synthase kinase-3beta and Fyn tyrosine kinase
    • 10.1046/j.1471-4159.1999.0720576.x. 9930729
    • Insulin transiently increases tau phosphorylation: involvement of glycogen synthase kinase-3beta and Fyn tyrosine kinase. M Lesort RS Jope GV Johnson, J Neurochem 1999 72 2 576 584 10.1046/j.1471-4159.1999.0720576.x 9930729
    • (1999) J Neurochem , vol.72 , Issue.2 , pp. 576-584
    • Lesort, M.1    Jope, R.S.2    Johnson, G.V.3
  • 78
    • 23044481208 scopus 로고    scopus 로고
    • The effect of insulin deficiency on tau and neurofilament in the insulin knockout mouse
    • 10.1016/j.bbrc.2005.07.001. 16039605
    • The effect of insulin deficiency on tau and neurofilament in the insulin knockout mouse. R Schechter D Beju KE Miller, Biochem Biophys Res Commun 2005 334 4 979 986 10.1016/j.bbrc.2005.07.001 16039605
    • (2005) Biochem Biophys Res Commun , vol.334 , Issue.4 , pp. 979-986
    • Schechter, R.1    Beju, D.2    Miller, K.E.3
  • 81
    • 33845577779 scopus 로고    scopus 로고
    • The role of insulin and neurotrophic factor signaling in brain aging and Alzheimer's Disease
    • 10.1016/j.exger.2006.08.009. 17049785
    • The role of insulin and neurotrophic factor signaling in brain aging and Alzheimer's Disease. GM Cole SA Frautschy, Exp Gerontol 2007 42 1-2 10 21 10.1016/j.exger.2006.08.009 17049785
    • (2007) Exp Gerontol , vol.42 , Issue.1-2 , pp. 10-21
    • Cole, G.M.1    Frautschy, S.A.2
  • 82
    • 42249114008 scopus 로고    scopus 로고
    • Role of insulin metabolism disturbances in the development of Alzheimer disease: Mini review
    • 10.1177/1533317507312623. 18198237
    • Role of insulin metabolism disturbances in the development of Alzheimer disease: mini review. B Sabayan F Foroughinia A Mowla A Borhanihaghighi, Am J Alzheimers Dis Other Demen 2008 23 2 192 199 10.1177/1533317507312623 18198237
    • (2008) Am J Alzheimers Dis Other Demen , vol.23 , Issue.2 , pp. 192-199
    • Sabayan, B.1    Foroughinia, F.2    Mowla, A.3    Borhanihaghighi, A.4
  • 83
    • 77950460690 scopus 로고    scopus 로고
    • Presenilin transgenic mice as models of Alzheimer's disease
    • 10.1007/s00429-009-0227-3. 19921519
    • Presenilin transgenic mice as models of Alzheimer's disease. GA Elder MA Gama Sosa R De Gasperi DL Dickstein PR Hof, Brain Struct Funct 2010 214 2-3 127 143 10.1007/s00429-009-0227-3 19921519
    • (2010) Brain Struct Funct , vol.214 , Issue.2-3 , pp. 127-143
    • Elder, G.A.1    Gama Sosa, M.A.2    De Gasperi, R.3    Dickstein, D.L.4    Hof, P.R.5
  • 84
    • 0030779784 scopus 로고    scopus 로고
    • Skeletal and CNS defects in Presenilin-1-deficient mice
    • 10.1016/S0092-8674(00)80244-5. 9160754
    • Skeletal and CNS defects in Presenilin-1-deficient mice. J Shen RT Bronson DF Chen W Xia DJ Selkoe S Tonegawa, Cell 1997 89 4 629 639 10.1016/S0092-8674(00)80244-5 9160754
    • (1997) Cell , vol.89 , Issue.4 , pp. 629-639
    • Shen, J.1    Bronson, R.T.2    Chen, D.F.3    Xia, W.4    Selkoe, D.J.5    Tonegawa, S.6
  • 86
    • 34547226651 scopus 로고    scopus 로고
    • Interactions of primary neuroepithelial progenitor and brain endothelial cells: Distinct effect on neural progenitor maintenance and differentiation by soluble factors and direct contact
    • 10.1038/cr.2007.53. 17593907
    • Interactions of primary neuroepithelial progenitor and brain endothelial cells: distinct effect on neural progenitor maintenance and differentiation by soluble factors and direct contact. MA Gama Sosa R De Gasperi AB Rocher GM Perez K Simons DE Cruz PR Hof GA Elder, Cell Res 2007 17 7 619 626 10.1038/cr.2007.53 17593907
    • (2007) Cell Res , vol.17 , Issue.7 , pp. 619-626
    • Gama Sosa, M.A.1    De Gasperi, R.2    Rocher, A.B.3    Perez, G.M.4    Simons, K.5    Cruz, D.E.6    Hof, P.R.7    Elder, G.A.8
  • 87
    • 51549086925 scopus 로고    scopus 로고
    • Cortical development in the presenilin-1 null mutant mouse fails after splitting of the preplate and is not due to a failure of reelin-dependent signaling
    • 10.1002/dvdy.21661. 18729224
    • Cortical development in the presenilin-1 null mutant mouse fails after splitting of the preplate and is not due to a failure of reelin-dependent signaling. R De Gasperi MA Gama Sosa PH Wen J Li GM Perez T Curran GA Elder, Dev Dyn 2008 237 9 2405 2414 10.1002/dvdy.21661 18729224
    • (2008) Dev Dyn , vol.237 , Issue.9 , pp. 2405-2414
    • De Gasperi, R.1    Gama Sosa, M.A.2    Wen, P.H.3    Li, J.4    Perez, G.M.5    Curran, T.6    Elder, G.A.7
  • 88
    • 54249084924 scopus 로고    scopus 로고
    • Increased serotonin 2C receptor mRNA editing: A possible risk factor for suicide
    • 10.1038/sj.mp.4002081. 17848916
    • Increased serotonin 2C receptor mRNA editing: a possible risk factor for suicide. S Dracheva N Patel DA Woo SM Marcus LJ Siever V Haroutunian, Mol Psychiatry 2008 13 11 1001 1010 10.1038/sj.mp.4002081 17848916
    • (2008) Mol Psychiatry , vol.13 , Issue.11 , pp. 1001-1010
    • Dracheva, S.1    Patel, N.2    Woo, D.A.3    Marcus, S.M.4    Siever, L.J.5    Haroutunian, V.6
  • 89
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • 10.1006/meth.2001.1262. 11846609
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. KJ Livak TD Schmittgen, Methods 2001 25 4 402 408 10.1006/meth.2001.1262 11846609
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.