Mutations in zebrafish Lrp2 result in adult-onset ocular pathogenesis that models myopia and other risk factors for glaucoma

PLoS Genetics

Volumn 7, Issue 2, 2011, Pages

  Veth, Kerry N ^a   Willer, Jason R ^b   Collery, Ross F ^a   Gray, Matthew P ^a   Willer, Gregory B ^b   Wagner, Daniel S ^c   Mullins, Mary C ^d   Udvadia, Ava J ^e   Smith, Richard S ^f   John, Simon W M ^f   Gregg, Ronald G ^b   Link, Brian A ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b UNIVERSITY OF LOUISVILLE   (United States)

^c RICE UNIVERSITY   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e UNIVERSITY OF WISCONSIN MILWAUKEE   (United States)

^f HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MEGALIN; ZEBRAFISH PROTEIN;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; GENE MUTATION; GENETIC RISK; GLAUCOMA; INTRAOCULAR HYPERTENSION; MUTANT; MYOPIA; NONHUMAN; NONSENSE MUTATION; NUCLEOTIDE SEQUENCE; ONSET AGE; PATHOGENESIS; PHENOTYPE; RETINA GANGLION CELL; RISK FACTOR; ZEBRA FISH; AGING; AMINO ACID SEQUENCE; ANIMAL; APOPTOSIS; BUPHTHALMOS; CELL COUNT; CELL PROLIFERATION; CHEMISTRY; DISEASE MODEL; EYE; GENETICS; INTRAOCULAR PRESSURE; METABOLISM; MOLECULAR GENETICS; MUTATION; NERVE FIBER; OPTIC DISK; ORGAN SIZE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGICAL STRESS; ULTRASTRUCTURE; UPREGULATION;

ANIMALIA; DANIO RERIO; ERINACEIDAE;

AGING; AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; AXONS; BASE SEQUENCE; CELL COUNT; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; EYE; GLAUCOMA; HYDROPHTHALMOS; INTRAOCULAR PRESSURE; LDL-RECEPTOR RELATED PROTEIN 2; MOLECULAR SEQUENCE DATA; MUTATION; MYOPIA; OPTIC DISK; ORGAN SIZE; PHENOTYPE; RETINAL GANGLION CELLS; RISK FACTORS; STRESS, PHYSIOLOGICAL; UP-REGULATION; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 79952256057     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1001310     Document Type: Article

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