Incorporating epigenetic data into the risk assessment process for the toxic metals arsenic, cadmium, chromium, lead, and mercury: Strategies and challenges

Frontiers in Genetics

Volumn 5, Issue JUL, 2014, Pages

  Ray, Paul D ^a,b   Yosim, Andrew ^a   Fry, Rebecca C ^a,b  

^a University of North Carolina at Chapel Hill   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Disease; DNA methylation; Epigenetics; Epigenomics; Histone modification; miRNA; Risk assessment

Indexed keywords

ARSENIC; BRAIN DERIVED NEUROTROPHIC FACTOR; CADMIUM; CASPASE 10; CHROMIUM; CYTOKERATIN 7; DNA GLYCOSYLTRANSFERASE; DNA METHYLTRANSFERASE; EPIREGULIN; EXCISION REPAIR CROSS COMPLEMENTING PROTEIN 1; GLUCOCORTICOID INDUCED TUMOR NECROSIS FACTOR RECEPTOR; LEAD; MERCURY; METALLOTHIONEIN III; PROSTAGLANDIN SYNTHASE; PROTEIN MSH2; PROTEIN P53; THIOL ESTER HYDROLASE; XRCC1 PROTEIN; ZINC FINGER PROTEIN;

CARCINOGENESIS; CHROMATIN ASSEMBLY AND DISASSEMBLY; DNA DAMAGE CHECKPOINT; DNA METHYLATION; DNA REPAIR; DNA REPLICATION; DNA SEQUENCE; DOSE RESPONSE; ENVIRONMENTAL EXPOSURE; EPIGENETICS; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE SILENCING; HEALTH HAZARD; HEAVY METAL POISONING; HISTONE MODIFICATION; HUMAN; LIMIT OF DETECTION; MALIGNANT TRANSFORMATION; MRNA EXPRESSION ASSAY; OXIDATIVE STRESS; PROTEIN EXPRESSION; QUALITY ADJUSTED LIFE YEAR; REVIEW; RISK ASSESSMENT; RNA TRANSLATION; TOXIC WASTE; TRANSIENT EXPRESSION; WORLD HEALTH ORGANIZATION;

EID: 84906247013     PISSN: None     EISSN: 16648021     Source Type: Journal    
DOI: 10.3389/fgene.2014.00201     Document Type: Review

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