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Volumn 24, Issue 1, 2009, Pages 15-45

Neurotoxic effects and biomarkers of lead exposure: A review

Author keywords

Biological monitoring; Genotoxicity; Lead poisoning; Neurodevelopment; Neurotoxicity

Indexed keywords

BIOLOGICAL MARKER; CALCIUM; CALCIUM ION; GLUTAMIC ACID; LEAD; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NITRIC OXIDE SYNTHASE; PROTEIN KINASE C; REACTIVE OXYGEN METABOLITE;

EID: 65749089509     PISSN: 00487554     EISSN: None     Source Type: Journal    
DOI: 10.1515/REVEH.2009.24.1.15     Document Type: Review
Times cited : (682)

References (200)
  • 1
    • 65749096237 scopus 로고    scopus 로고
    • HazDat, Atlanta, GA: Centers for Disease Control and Prevention, Available at
    • Agency for Toxic Substances and Disease Registry. Hazardous Substance Release and Health Effects Database (HazDat). Atlanta, GA: Centers for Disease Control and Prevention, 2006. Available at: http://www.atsdr.cdc.gov/hazdat.html
    • (2006) Hazardous Substance Release and Health Effects Database
  • 2
    • 65749087779 scopus 로고    scopus 로고
    • Agency for Toxic Substances and Disease Registry. Toxicological profile for lead. Atlanta, GA, USA: US Department of Health and Human Services, Public Health Service, ATSDR, 2006. Available at: hptt://www.atsdr.cdc.gov. Accessed 22 Jan 2009.
    • Agency for Toxic Substances and Disease Registry. Toxicological profile for lead. Atlanta, GA, USA: US Department of Health and Human Services, Public Health Service, ATSDR, 2006. Available at: hptt://www.atsdr.cdc.gov. Accessed 22 Jan 2009.
  • 3
    • 65749112493 scopus 로고    scopus 로고
    • National Institute of Environmental Health Services. Lead. Research Triangle Park, NC, USA. Available at: http://www.niehs.nih.gov/health/ topics/agents/lead/index.cfm. Last revised 02 Jan 2009.
    • National Institute of Environmental Health Services. Lead. Research Triangle Park, NC, USA. Available at: http://www.niehs.nih.gov/health/ topics/agents/lead/index.cfm. Last revised 02 Jan 2009.
  • 4
    • 0001835555 scopus 로고
    • Exterior surface dust lead, interior house dust lead and childhood lead exposure in an urban environment
    • Hemphill D, ed, Columbia, MO: University of Missouri
    • Bornschein RL, Succop PA, Krafft KM, Clark CS, Peace B, Hammond PB. Exterior surface dust lead, interior house dust lead and childhood lead exposure in an urban environment. In: Hemphill D, ed. Trace substances in environmental health. Columbia, MO: University of Missouri, 1986.322-32.
    • (1986) Trace substances in environmental health , pp. 322-332
    • Bornschein, R.L.1    Succop, P.A.2    Krafft, K.M.3    Clark, C.S.4    Peace, B.5    Hammond, P.B.6
  • 5
    • 65749085231 scopus 로고    scopus 로고
    • Occupational Safety & Health Administration. Lead. 1910.1025. Washington, DC: OSHA, 2006. Available at: http://www.osha.gov/pls/ oshaweb/owadisp.show_document?p_table=STANDARDS&I_id=10030. Accessed 1 December 2006.
    • Occupational Safety & Health Administration. Lead. 1910.1025. Washington, DC: OSHA, 2006. Available at: http://www.osha.gov/pls/ oshaweb/owadisp.show_document?p_table=STANDARDS&I_id=10030. Accessed 1 December 2006.
  • 6
    • 65749104764 scopus 로고    scopus 로고
    • Occupational Safety & Health Administration, Washington, DC:, Available at:, Accessed 1 December 2006
    • Occupational Safety & Health Administration. Lead 1926.62. Washington, DC: OSHA, 2006. Available at: http://www.osha.gov/pls/ oshaweb/owadisp.showdocument?p_table=STANDARDS&p_id=10641. Accessed 1 December 2006.
    • (2006) Lead 1926.62
  • 7
    • 34147173975 scopus 로고    scopus 로고
    • Cumulative lead dose and cognitive function in adults: A review of studies that measured both blood lead and bone lead
    • Shib R, Hu H, Weisskopf MG, Schwartz BS. Cumulative lead dose and cognitive function in adults: a review of studies that measured both blood lead and bone lead. Environ Health Perspect 2007;115:483-92.
    • (2007) Environ Health Perspect , vol.115 , pp. 483-492
    • Shib, R.1    Hu, H.2    Weisskopf, M.G.3    Schwartz, B.S.4
  • 8
    • 65549129243 scopus 로고    scopus 로고
    • Lead toxicity: Does the critical level of lead resulting in adverse effects differ between adults and children?
    • Murata K, Iwata T, Dakeishi M, Karita K. Lead toxicity: does the critical level of lead resulting in adverse effects differ between adults and children? J Occup Health 2009;51:1-12.
    • (2009) J Occup Health , vol.51 , pp. 1-12
    • Murata, K.1    Iwata, T.2    Dakeishi, M.3    Karita, K.4
  • 9
    • 0037175508 scopus 로고    scopus 로고
    • Blood lead levels and mortality
    • Lustberg, M; Silbergeld, E. Blood lead levels and mortality. Arch Intern Med 2002;162(21):2443-9
    • (2002) Arch Intern Med , vol.162 , Issue.21 , pp. 2443-2449
    • Lustberg, M.1    Silbergeld, E.2
  • 11
    • 0019954892 scopus 로고
    • International seminar on the assessment of toxic agents at the workplace. Roles of ambient and biological monitoring. Luxembourg, 8-12 December, 1980
    • Berlin A, Yodaiken RE, Henman BA. International seminar on the assessment of toxic agents at the workplace. Roles of ambient and biological monitoring. Luxembourg, 8-12 December, 1980; Int Arch Occup Environ Health 1982;50:197-207.
    • (1982) Int Arch Occup Environ Health , vol.50 , pp. 197-207
    • Berlin, A.1    Yodaiken, R.E.2    Henman, B.A.3
  • 12
    • 0019402283 scopus 로고
    • Determination of lead in plasma and studies of its relationship to lead in erythrocytes
    • DeSilva PE. Determination of lead in plasma and studies of its relationship to lead in erythrocytes. Br J Ind Med 1981;38(3):209-17.
    • (1981) Br J Ind Med , vol.38 , Issue.3 , pp. 209-217
    • DeSilva, P.E.1
  • 13
    • 0029798991 scopus 로고    scopus 로고
    • Measurement by ICP-MS of lead in plasma and whole blood of lead workers and controls
    • Schütz A, Bergdahl IA, Ekholm A, Skerfving S. Measurement by ICP-MS of lead in plasma and whole blood of lead workers and controls. Occup Environ Med 1996;53:736-40.
    • (1996) Occup Environ Med , vol.53 , pp. 736-740
    • Schütz, A.1    Bergdahl, I.A.2    Ekholm, A.3    Skerfving, S.4
  • 14
    • 0030043111 scopus 로고    scopus 로고
    • Impact on blood lead in children and adults following relocation from their source of exposure and contribution of skeletal tissue to blood lead
    • Gulson BL, Mizon KJ, Korsch MJ, Horwarth D, Phillips A, Hall J. Impact on blood lead in children and adults following relocation from their source of exposure and contribution of skeletal tissue to blood lead. Bull Environ Contarn Toxicol 1996;56:543-50.
    • (1996) Bull Environ Contarn Toxicol , vol.56 , pp. 543-550
    • Gulson, B.L.1    Mizon, K.J.2    Korsch, M.J.3    Horwarth, D.4    Phillips, A.5    Hall, J.6
  • 15
    • 0029310657 scopus 로고
    • Contribution of tissue lead to bone lead in adult female subjects based on stable lead-isotope methods
    • Gulson BL, Mahaffey KR, Mizon KP, Korsch MJ, Cameron MA, Vimpani G. Contribution of tissue lead to bone lead in adult female subjects based on stable lead-isotope methods. J Lab Clin Med 1995;125:703-12.
    • (1995) J Lab Clin Med , vol.125 , pp. 703-712
    • Gulson, B.L.1    Mahaffey, K.R.2    Mizon, K.P.3    Korsch, M.J.4    Cameron, M.A.5    Vimpani, G.6
  • 17
    • 29144437220 scopus 로고    scopus 로고
    • A critical review of biomarkers; used for monitoring human exposure to lead: Advantages, limitations, and future needs
    • Barbosa Jr F, Tanus-Santos JE, Gerlach RF, Parsons PJ. A critical review of biomarkers; used for monitoring human exposure to lead: advantages, limitations, and future needs. Environ Health Perspect 2005;113(12)1669-74.
    • (2005) Environ Health Perspect , vol.113 , Issue.12 , pp. 1669-1674
    • Barbosa Jr, F.1    Tanus-Santos, J.E.2    Gerlach, R.F.3    Parsons, P.J.4
  • 18
    • 12744279380 scopus 로고    scopus 로고
    • A noninvasive isotopic approach to estimate the bone lead contribution to blood in children: Implication for assessing the efficacy of lead abatement
    • Gwiazda R, Campbell C, Smith D. A noninvasive isotopic approach to estimate the bone lead contribution to blood in children: implication for assessing the efficacy of lead abatement. Environ Health Perspect 2005;113:104-10.
    • (2005) Environ Health Perspect , vol.113 , pp. 104-110
    • Gwiazda, R.1    Campbell, C.2    Smith, D.3
  • 19
    • 0034996943 scopus 로고    scopus 로고
    • Time required for blood lead levels to decline in nonchelated children
    • Roberts JR, Reigart JR, Ebeling M, Hulsey TC. Time required for blood lead levels to decline in nonchelated children. Clin Toxicol 2001;39:153-60.
    • (2001) Clin Toxicol , vol.39 , pp. 153-160
    • Roberts, J.R.1    Reigart, J.R.2    Ebeling, M.3    Hulsey, T.C.4
  • 20
    • 0344666478 scopus 로고    scopus 로고
    • Environmental, dietary, demographic, and activity variables associated with biomarkers of exposure for benzene and lead
    • Roy A, Georgopoulos PG, Ouyang M, Freeman N, Lioy PJ. Environmental, dietary, demographic, and activity variables associated with biomarkers of exposure for benzene and lead. J Expo Anal Environ Epidemiol 2003;13(6):417-26
    • (2003) J Expo Anal Environ Epidemiol , vol.13 , Issue.6 , pp. 417-426
    • Roy, A.1    Georgopoulos, P.G.2    Ouyang, M.3    Freeman, N.4    Lioy, P.J.5
  • 21
    • 47949113714 scopus 로고    scopus 로고
    • Biomonitoring of lead exposure-alternatives to blood
    • Bergdahl IA, Skerfving S. Biomonitoring of lead exposure-alternatives to blood. J Toxicol Environ Health A. 2008;71(18):1235-43.
    • (2008) J Toxicol Environ Health A , vol.71 , Issue.18 , pp. 1235-1243
    • Bergdahl, I.A.1    Skerfving, S.2
  • 23
    • 0031888609 scopus 로고    scopus 로고
    • Bone lead as a biological marker in epidemiologic studies of chronic toxicity: Conceptual paradigms
    • Hu H, Rabinowitz M, Smith D. Bone lead as a biological marker in epidemiologic studies of chronic toxicity: conceptual paradigms. Environ Health Perspect 1998;106:1-8.
    • (1998) Environ Health Perspect , vol.106 , pp. 1-8
    • Hu, H.1    Rabinowitz, M.2    Smith, D.3
  • 24
    • 0028957351 scopus 로고
    • Physiologically based models for bone-seeking elements V: Lead absorption and disposition in childhood
    • O'Flaherty EJ. Physiologically based models for bone-seeking elements V: lead absorption and disposition in childhood. Toxicol Appl Pharmacol 1995;131:297-308.
    • (1995) Toxicol Appl Pharmacol , vol.131 , pp. 297-308
    • O'Flaherty, E.J.1
  • 25
    • 0028776394 scopus 로고
    • Direct measurement of lead in bone - a promising biomarker
    • Landrigan PJ, Todd AC. Direct measurement of lead in bone - a promising biomarker. JAMA 1994;271:239-40.
    • (1994) JAMA , vol.271 , pp. 239-240
    • Landrigan, P.J.1    Todd, A.C.2
  • 26
    • 0031660385 scopus 로고    scopus 로고
    • The influence of bone and blood lead on plasma lead levels in environmentally exposed adults
    • Hernandez-Avila M, Smith D, Meneses F, Sanin LH, Hu H. The influence of bone and blood lead on plasma lead levels in environmentally exposed adults. Environ Health Perspect 1998;106:473-7.
    • (1998) Environ Health Perspect , vol.106 , pp. 473-477
    • Hernandez-Avila, M.1    Smith, D.2    Meneses, F.3    Sanin, L.H.4    Hu, H.5
  • 28
    • 0027485058 scopus 로고
    • New approaches to monitoring environmental neurotoxins
    • Silbergeld EK. New approaches to monitoring environmental neurotoxins. Annals NY Acad Sci 1993;694:62-71.
    • (1993) Annals NY Acad Sci , vol.694 , pp. 62-71
    • Silbergeld, E.K.1
  • 29
    • 0025825582 scopus 로고    scopus 로고
    • Omokhodion FO, Crockford GW. Lead in sweat and its relationship to salivary and urinary levels in normal healthy subjects. Sci Total Environ 1991; 103:113-122.
    • Omokhodion FO, Crockford GW. Lead in sweat and its relationship to salivary and urinary levels in normal healthy subjects. Sci Total Environ 1991; 103:113-122.
  • 30
    • 0019515270 scopus 로고
    • Lead levels in saliva and in blood
    • Pan AY. Lead levels in saliva and in blood. J Toxicol Environ Health 1981;7:273-80.
    • (1981) J Toxicol Environ Health , vol.7 , pp. 273-280
    • Pan, A.Y.1
  • 31
    • 33645077063 scopus 로고    scopus 로고
    • Thaweboon S, Thaweboon B, Veerapradist W. Lead in saliva and its relationship to blood in the residents of Klity Village in Thailand. Southeast Asian J Trop Med Public Health 2005;36(6): 1576-9.
    • Thaweboon S, Thaweboon B, Veerapradist W. Lead in saliva and its relationship to blood in the residents of Klity Village in Thailand. Southeast Asian J Trop Med Public Health 2005;36(6): 1576-9.
  • 32
    • 33748686179 scopus 로고    scopus 로고
    • Evaluation of the use of salivary lead levels as a surrogate of blood lead or plasma lead levels in lead exposed subjects
    • Barbosa F Jr, Corrêa Rodrigues MH, Buzalaf MR, Krug FJ, Gerlach RF, Tanus-Santos JE. Evaluation of the use of salivary lead levels as a surrogate of blood lead or plasma lead levels in lead exposed subjects. Arch Toxicol 2006;80 (10):633-7.
    • (2006) Arch Toxicol , vol.80 , Issue.10 , pp. 633-637
    • Barbosa Jr, F.1    Corrêa Rodrigues, M.H.2    Buzalaf, M.R.3    Krug, F.J.4    Gerlach, R.F.5    Tanus-Santos, J.E.6
  • 33
    • 65749091368 scopus 로고    scopus 로고
    • Costa de Almeida GR, Umbelino de Freitas C, Barbosa F Jr, Tanus-Santos JE, Gerlach RF. Lead in saliva from lead-exposed and unexposed children. Sci Total Environ 2008;Nov 27. [Epub ahead of print]
    • Costa de Almeida GR, Umbelino de Freitas C, Barbosa F Jr, Tanus-Santos JE, Gerlach RF. Lead in saliva from lead-exposed and unexposed children. Sci Total Environ 2008;Nov 27. [Epub ahead of print]
  • 34
    • 0032864185 scopus 로고    scopus 로고
    • The independent contribution of bone and erythrocyte lead to urinary lead among middle-aged and elderly men: The normative aging study
    • Tsaih SW, Schwartz J, Lee ML, Amarasiriwardena C, Aro A, Sparrow D, et al. The independent contribution of bone and erythrocyte lead to urinary lead among middle-aged and elderly men: the normative aging study. Environ Health Perspect 1999;107:391-6.
    • (1999) Environ Health Perspect , vol.107 , pp. 391-396
    • Tsaih, S.W.1    Schwartz, J.2    Lee, M.L.3    Amarasiriwardena, C.4    Aro, A.5    Sparrow, D.6
  • 35
    • 0032745434 scopus 로고    scopus 로고
    • Urinary lead as a possible surrogate of blood lead among workers occupationally exposed to lead
    • Fukui Y, Miki M, Ukai H, Okamoto S, Takada S, Higashikawa K, et al. Urinary lead as a possible surrogate of blood lead among workers occupationally exposed to lead. Int Arch Occup Environ Health 1999;72(8):516-20.
    • (1999) Int Arch Occup Environ Health , vol.72 , Issue.8 , pp. 516-520
    • Fukui, Y.1    Miki, M.2    Ukai, H.3    Okamoto, S.4    Takada, S.5    Higashikawa, K.6
  • 36
    • 0025922859 scopus 로고
    • Lead in children's hair, as related to exposure in Tarragona province, Spain
    • Schumacher M, Domingo JL, Llobet JM, Corbella. Lead in children's hair, as related to exposure in Tarragona province, Spain. Sci Total Environ 1991; 104:167-77.
    • (1991) Sci Total Environ , vol.104 , pp. 167-177
    • Schumacher, M.1    Domingo, J.L.2    Llobet, J.M.3    Corbella4
  • 38
    • 0033888701 scopus 로고    scopus 로고
    • Relationship of lead and cadmium to essential elements in hair, teeth, and nails and of environmentally exposed people
    • Nowak B, Chmielnicka J. Relationship of lead and cadmium to essential elements in hair, teeth, and nails and of environmentally exposed people. Ecotoxicol Environ Safe 2000;46(3):265-74.
    • (2000) Ecotoxicol Environ Safe , vol.46 , Issue.3 , pp. 265-274
    • Nowak, B.1    Chmielnicka, J.2
  • 39
    • 0034735713 scopus 로고    scopus 로고
    • Application of double focusing sector field ICP-MS for multi-elemental characterization of human hair and nails. Part II: A study of the inhabitants of northern Sweden
    • Rodushkin I, Axelsson MD. Application of double focusing sector field ICP-MS for multi-elemental characterization of human hair and nails. Part II: a study of the inhabitants of northern Sweden. Sci Total Environ 2000;262:21-36.
    • (2000) Sci Total Environ , vol.262 , pp. 21-36
    • Rodushkin, I.1    Axelsson, M.D.2
  • 40
    • 0025745050 scopus 로고
    • Comparative increases of lead and barium with age in human tooth enamel, rib, and ulna
    • Maneakrichten M, Patterson C, Miller G, Settle D, Erel Y. Comparative increases of lead and barium with age in human tooth enamel, rib, and ulna. Sci Total Environ 1991;107:179-203.
    • (1991) Sci Total Environ , vol.107 , pp. 179-203
    • Maneakrichten, M.1    Patterson, C.2    Miller, G.3    Settle, D.4    Erel, Y.5
  • 41
    • 0025935177 scopus 로고    scopus 로고
    • Cleymaet R, Collys K, Retief DH, Michotte Y, Stop D, Taghon E, et al Relation between lead in surface tooth enamel, blood, and saliva from children residing in the vicinity of a non-ferrous metal plant in Belgium.Br J Ind Med 1991;48(10): 702-9.
    • Cleymaet R, Collys K, Retief DH, Michotte Y, Stop D, Taghon E, et al Relation between lead in surface tooth enamel, blood, and saliva from children residing in the vicinity of a non-ferrous metal plant in Belgium.Br J Ind Med 1991;48(10): 702-9.
  • 42
    • 65749099732 scopus 로고
    • Cytokinesis-block micronucleus techniques: A detailed description of the method and its application to genotoxicity studies in human populations
    • Fenech M. Cytokinesis-block micronucleus techniques: a detailed description of the method and its application to genotoxicity studies in human populations. Mutat Res 1993;161:193-8.
    • (1993) Mutat Res , vol.161 , pp. 193-198
    • Fenech, M.1
  • 43
    • 0031719640 scopus 로고    scopus 로고
    • Biomonitoring of workers exposed to lead. Genotoxic effects, its modulation by polyvitamin treatment and evaluation of induced radioresistance
    • Vaglenov A, Carbonell E, Marcos R. Biomonitoring of workers exposed to lead. Genotoxic effects, its modulation by polyvitamin treatment and evaluation of induced radioresistance. Mutat Res 1998;418:79-92.
    • (1998) Mutat Res , vol.418 , pp. 79-92
    • Vaglenov, A.1    Carbonell, E.2    Marcos, R.3
  • 44
    • 0036227655 scopus 로고    scopus 로고
    • Correlations of blood lead with DNA-protein cross-links and sister chromatid exchanges in lead workers
    • Wu FY, Chang PW, Wu CC, Kuo HW. Correlations of blood lead with DNA-protein cross-links and sister chromatid exchanges in lead workers. Cancer Epidemiol Biomarkers Prev 2002; 11:287-90,
    • (2002) Cancer Epidemiol Biomarkers Prev , vol.11 , pp. 287-290
    • Wu, F.Y.1    Chang, P.W.2    Wu, C.C.3    Kuo, H.W.4
  • 45
    • 33747368249 scopus 로고    scopus 로고
    • Blood-brain barrier: Structural components and function under physiologic and pathologic conditions
    • Persidsky Y, Ramirez SH, Haorah J, Kanmogne GD. Blood-brain barrier: structural components and function under physiologic and pathologic conditions. J Neuroimmun Pharmacol 2006;1(3): 223-36.
    • (2006) J Neuroimmun Pharmacol , vol.1 , Issue.3 , pp. 223-236
    • Persidsky, Y.1    Ramirez, S.H.2    Haorah, J.3    Kanmogne, G.D.4
  • 46
    • 22944483792 scopus 로고    scopus 로고
    • The blood-brain barrier/neurovascular unit in health and disease
    • Hawkins BT, Davis TP. The blood-brain barrier/neurovascular unit in health and disease. Pharmacol Rev 2005;57(2):173-85.
    • (2005) Pharmacol Rev , vol.57 , Issue.2 , pp. 173-185
    • Hawkins, B.T.1    Davis, T.P.2
  • 47
    • 0023944284 scopus 로고
    • Picomolar concentrations of lead stimulate brain protein kinase C
    • Markovac J, Goldstein GW. Picomolar concentrations of lead stimulate brain protein kinase C. Nature 1988;334:71-73.
    • (1988) Nature , vol.334 , pp. 71-73
    • Markovac, J.1    Goldstein, G.W.2
  • 50
    • 0027508421 scopus 로고
    • Evidence that lead acts as a calcium substitute in second messenger metabolism
    • Goldstein GW. Evidence that lead acts as a calcium substitute in second messenger metabolism. NeuroToxicology 1993;14:97-101.
    • (1993) NeuroToxicology , vol.14 , pp. 97-101
    • Goldstein, G.W.1
  • 51
    • 0028358608 scopus 로고
    • Phospholipid metabolism in neural microvascular endothelial cells after exposure to lead in vitro
    • Bressler J, Forman S, Goldstein GW. Phospholipid metabolism in neural microvascular endothelial cells after exposure to lead in vitro. Toxicol Appl Pharmacol 1994;126(2):352-60.
    • (1994) Toxicol Appl Pharmacol , vol.126 , Issue.2 , pp. 352-360
    • Bressler, J.1    Forman, S.2    Goldstein, G.W.3
  • 52
    • 0031752512 scopus 로고    scopus 로고
    • Low-level lead-induced neurotoxicity in children: An update on central nervous system effects
    • Finkelstein Y, Markowitz ME, Rosen JF. Low-level lead-induced neurotoxicity in children: an update on central nervous system effects. Brain Res Rev 1998;27(2):168-76.
    • (1998) Brain Res Rev , vol.27 , Issue.2 , pp. 168-176
    • Finkelstein, Y.1    Markowitz, M.E.2    Rosen, J.F.3
  • 53
    • 39549112477 scopus 로고    scopus 로고
    • Environmental stressors and violence: Lead and polychlorinated biphenyls
    • Hwang L. Environmental stressors and violence: lead and polychlorinated biphenyls. Rev Environ Health 2007;22(4):313-28.
    • (2007) Rev Environ Health , vol.22 , Issue.4 , pp. 313-328
    • Hwang, L.1
  • 54
    • 65749113108 scopus 로고    scopus 로고
    • Centers for Disease Control and Prevention (CDC). Managing elevated blood lead levels among young children: recommendations from the Advisory Committee on Childhood Lead Poisoning Prevention. Atlanta, GA: US Department of Health and Human Services, CDC; 2002.
    • Centers for Disease Control and Prevention (CDC). Managing elevated blood lead levels among young children: recommendations from the Advisory Committee on Childhood Lead Poisoning Prevention. Atlanta, GA: US Department of Health and Human Services, CDC; 2002.
  • 55
    • 0033599801 scopus 로고    scopus 로고
    • Braga MF, Pereira EF, Albuquerque EX. Nanomolar concentrations of lead inhibit glutamatergic and GABAergic transmission in hippocampal neurons. Brain Res 1999 24;826(1): 22-34.
    • Braga MF, Pereira EF, Albuquerque EX. Nanomolar concentrations of lead inhibit glutamatergic and GABAergic transmission in hippocampal neurons. Brain Res 1999 24;826(1): 22-34.
  • 57
    • 65749084803 scopus 로고    scopus 로고
    • Centers for Disease Control and Prevention (CDC). Preventing lead poisoning in young children. Atlanta, GA: US Department of Health and Human Services, CDC; 1991.
    • Centers for Disease Control and Prevention (CDC). Preventing lead poisoning in young children. Atlanta, GA: US Department of Health and Human Services, CDC; 1991.
  • 58
    • 0026744045 scopus 로고
    • Environmental exposure to lead and children's intelligence at the age of seven years. The Port Pirie Cohort Study
    • Baghurst PA, McMichael AJ, Wigg NR, Vimpani GV, Robertson EF, Roberts RJ, et al Environmental exposure to lead and children's intelligence at the age of seven years. The Port Pirie Cohort Study. N Engl J Med 1992;327:1279-84.
    • (1992) N Engl J Med , vol.327 , pp. 1279-1284
    • Baghurst, P.A.1    McMichael, A.J.2    Wigg, N.R.3    Vimpani, G.V.4    Robertson, E.F.5    Roberts, R.J.6
  • 59
    • 36049009963 scopus 로고    scopus 로고
    • Centers for Disease Control and Prevention Advisory Committee on Childhood Lead Poisoning Prevention. Interpreting and managing blood lead levels of less than 10 microg/dL in children and reducing childhood exposure to lead: Recommendations of the Centers for Disease Control and Prevention Advisory Committee on Childhood Lead Poisoning Prevention
    • Birms HJ, Campbell C, Brown MJ; Centers for Disease Control and Prevention Advisory Committee on Childhood Lead Poisoning Prevention. Interpreting and managing blood lead levels of less than 10 microg/dL in children and reducing childhood exposure to lead: Recommendations of the Centers for Disease Control and Prevention Advisory Committee on Childhood Lead Poisoning Prevention. Pediatrics 2007;120(5):e1285-98.
    • (2007) Pediatrics , vol.120 , Issue.5
    • Birms, H.J.1    Campbell, C.2    Brown, M.J.3
  • 60
    • 0018102537 scopus 로고
    • Placental transfer of lead, mercury, cadmium, and carbon monoxide in women: III. Factors influencing the accumulation of heavy metals in the placenta and the relationship between metal concentration in the placenta and in maternal and cord blood
    • Roels HA, Hubermont G, Buchet J, Lauwerys Rl. Placental transfer of lead, mercury, cadmium, and carbon monoxide in women: III. Factors influencing the accumulation of heavy metals in the placenta and the relationship between metal concentration in the placenta and in maternal and cord blood. Environ Res 1978;16:236-47.
    • (1978) Environ Res , vol.16 , pp. 236-247
    • Roels, H.A.1    Hubermont, G.2    Buchet, J.3    Lauwerys, R.4
  • 61
    • 0035067421 scopus 로고    scopus 로고
    • Lead exposure in pregnancy: A review of the literature and argument for routine prenatal screening
    • Gardella C. Lead exposure in pregnancy: a review of the literature and argument for routine prenatal screening. Obstet Gynecol Survey 2001;56:231-8.
    • (2001) Obstet Gynecol Survey , vol.56 , pp. 231-238
    • Gardella, C.1
  • 62
    • 0037294129 scopus 로고    scopus 로고
    • Maternal blood lead concentration, diet during pregnancy, and anthropometry predict neonatal blood lead in a socioeconomically disadvantaged population
    • Schell LM, Denham M, Stark AD, Gomez M, Ravenscroft J, Parsons PJ, et al Maternal blood lead concentration, diet during pregnancy, and anthropometry predict neonatal blood lead in a socioeconomically disadvantaged population. Environ Health Perspect 2003;111:195-200.
    • (2003) Environ Health Perspect , vol.111 , pp. 195-200
    • Schell, L.M.1    Denham, M.2    Stark, A.D.3    Gomez, M.4    Ravenscroft, J.5    Parsons, P.J.6
  • 66
    • 0023110134 scopus 로고
    • Longitudinal analyses of prenatal and postnatal lead exposure and early cognitive development
    • Bellinger D, Leviton A, Waternaux C, Needleman H, Rabinowitz M. Longitudinal analyses of prenatal and postnatal lead exposure and early cognitive development. N Engl J Med 1987; 316 (17):1037-43.
    • (1987) N Engl J Med , vol.316 , Issue.17 , pp. 1037-1043
    • Bellinger, D.1    Leviton, A.2    Waternaux, C.3    Needleman, H.4    Rabinowitz, M.5
  • 68
    • 33646348445 scopus 로고    scopus 로고
    • Reduced intellectual development in children with prenatal lead exposure
    • Schnaas L, Rothenberg SJ, Flores MF. Reduced intellectual development in children with prenatal lead exposure. Environ Health Perspect 2006;114 (5):791-7.
    • (2006) Environ Health Perspect , vol.114 , Issue.5 , pp. 791-797
    • Schnaas, L.1    Rothenberg, S.J.2    Flores, M.F.3
  • 69
    • 0026564273 scopus 로고
    • Health effects of lead at low exposure levels
    • Rosen JF. Health effects of lead at low exposure levels, Am J Dis Child 1992;146:1278-81.
    • (1992) Am J Dis Child , vol.146 , pp. 1278-1281
    • Rosen, J.F.1
  • 70
    • 22144464444 scopus 로고    scopus 로고
    • An international pooled analysis
    • et Low-level environmental lead exposure and children's intellectual function
    • Lanphear BP, Hornung R, Khoury J, Yolton K, Baghurst P, Bellinger DC, et Low-level environmental lead exposure and children's intellectual function: An international pooled analysis. Environ Health Perspect 2005;113(7):894-9.
    • (2005) Environ Health Perspect , vol.113 , Issue.7 , pp. 894-899
    • Lanphear, B.P.1    Hornung, R.2    Khoury, J.3    Yolton, K.4    Baghurst, P.5    Bellinger, D.C.6
  • 71
    • 33748430530 scopus 로고    scopus 로고
    • Longitudinal associations between blood lead concentrations lower than 10 microg/dL and neurobehavioral development in environmentally exposed children in Mexico City
    • Téllez-Rojo MM, Bellinger DC, Arroyo-Quiroz C, Lamadrid-Figueroa H, Mercado-Garcia A, Schnaas-Arrieta L, et al. Longitudinal associations between blood lead concentrations lower than 10 microg/dL and neurobehavioral development in environmentally exposed children in Mexico City. Pediatrics 118(2):e323-30.
    • Pediatrics , vol.118 , Issue.2
    • Téllez-Rojo, M.M.1    Bellinger, D.C.2    Arroyo-Quiroz, C.3    Lamadrid-Figueroa, H.4    Mercado-Garcia, A.5    Schnaas-Arrieta, L.6
  • 72
    • 44449122269 scopus 로고    scopus 로고
    • Association of prenatal and childhood blood lead concentrations with criminal arrests in early adulthood
    • Wright JP, Dietrich KN, Ri MD, Hornung RW, Wessel SD, Lanphear BP, et al Association of prenatal and childhood blood lead concentrations with criminal arrests in early adulthood. PLoS Med 2008;5(5):e101.
    • (2008) PLoS Med , vol.5 , Issue.5
    • Wright, J.P.1    Dietrich, K.N.2    Ri, M.D.3    Hornung, R.W.4    Wessel, S.D.5    Lanphear, B.P.6
  • 75
    • 0018092643 scopus 로고
    • Metabolism of lead-210 in juvenile and adult Rhesus monkeys Macaca mulatta
    • Pounds JG, Marlar RJ, Allen JR. Metabolism of lead-210 in juvenile and adult Rhesus monkeys Macaca mulatta. Bull Environ Contam Toxicol 1978;19:684-91.
    • (1978) Bull Environ Contam Toxicol , vol.19 , pp. 684-691
    • Pounds, J.G.1    Marlar, R.J.2    Allen, J.R.3
  • 76
    • 0019465560 scopus 로고
    • Kinetic characterization of an in vitro lead transport across the rat small intestine
    • Aungst BJ, Fung HL. Kinetic characterization of an in vitro lead transport across the rat small intestine. Toxicol Appl Pharmacol 1981;61:38-47.
    • (1981) Toxicol Appl Pharmacol , vol.61 , pp. 38-47
    • Aungst, B.J.1    Fung, H.L.2
  • 77
    • 0015338115 scopus 로고
    • Effect of age on gastrointestinal absorption (Fe, Sr, lead) in the rat
    • Forbes GB, Reina JC. Effect of age on gastrointestinal absorption (Fe, Sr, lead) in the rat. J Nutr 1972;102:647-52.
    • (1972) J Nutr , vol.102 , pp. 647-652
    • Forbes, G.B.1    Reina, J.C.2
  • 79
    • 36049009963 scopus 로고    scopus 로고
    • Interpreting and managing blood lead levels of less than 10 μg/dL in children and reducing childhood exposures to lead. Recommendations of Centers for Disease Control and Prevention Advisory Committee on Childhood Lead Poisoning Prevention
    • for the Advisory Committee on Childhood Lead Poisoning Prevention
    • Binns HJ, Campbell C, Brown MJ, for the Advisory Committee on Childhood Lead Poisoning Prevention. Interpreting and managing blood lead levels of less than 10 μg/dL in children and reducing childhood exposures to lead. Recommendations of Centers for Disease Control and Prevention Advisory Committee on Childhood Lead Poisoning Prevention. Pediatrics 2007; 120 (5):e1285-e1298
    • (2007) Pediatrics , vol.120 , Issue.5
    • Binns, H.J.1    Campbell, C.2    Brown, M.J.3
  • 81
    • 33645783986 scopus 로고    scopus 로고
    • Centers for Disease Control and Prevention CDC, Atlanta, GA: US Department of Health and Human Services CDC
    • Centers for Disease Control and Prevention (CDC). Preventing lead poisoning in young children. Atlanta, GA: US Department of Health and Human Services CDC, 2005.
    • (2005) Preventing lead poisoning in young children
  • 82
    • 0034756495 scopus 로고    scopus 로고
    • Effects of metals on the nervous system of humans and animals
    • Carpenter DO. Effects of metals on the nervous system of humans and animals. Int J Occup Med Environ Health 2001;14(3):209-18.
    • (2001) Int J Occup Med Environ Health , vol.14 , Issue.3 , pp. 209-218
    • Carpenter, D.O.1
  • 83
    • 33644701023 scopus 로고    scopus 로고
    • Lead exposure in children: Prevention, detection, and management
    • American Academy of Pediatrics Committee on Environmental Health
    • American Academy of Pediatrics Committee on Environmental Health. Lead exposure in children: prevention, detection, and management. Pediatrics 2005;116:1036-46.
    • (2005) Pediatrics , vol.116 , pp. 1036-1046
  • 84
    • 1842583585 scopus 로고    scopus 로고
    • Bellinger DC. Lead. Pediatrics 2004;113:1016-22.
    • (2004) Pediatrics , vol.113 , pp. 1016-1022
    • Lead, B.D.C.1
  • 86
    • 0041842629 scopus 로고    scopus 로고
    • Intellectual impairment and blood lead levels
    • Bellinger DC, Needleman HL. Intellectual impairment and blood lead levels. N Engl J Med 2003;349:500-2.
    • (2003) N Engl J Med , vol.349 , pp. 500-502
    • Bellinger, D.C.1    Needleman, H.L.2
  • 87
    • 0037451908 scopus 로고    scopus 로고
    • Exposure to lead in children - how low is low enough?
    • Rogan WJ, Ware JH. Exposure to lead in children - how low is low enough? N Engl J Med 2003;348:1515-6.
    • (2003) N Engl J Med , vol.348 , pp. 1515-1516
    • Rogan, W.J.1    Ware, J.H.2
  • 88
    • 0028171514 scopus 로고
    • Environmental lead and children's intelligence: A systematic review of the epidemiological evidence
    • Pocock SJ, Smith M, Baghurst P. Environmental lead and children's intelligence: A systematic review of the epidemiological evidence. Br Med J 1994;309:1189-97.
    • (1994) Br Med J , vol.309 , pp. 1189-1197
    • Pocock, S.J.1    Smith, M.2    Baghurst, P.3
  • 90
    • 0029899315 scopus 로고    scopus 로고
    • Lead cytotoxicity in primary cultured rat astrocytes and Schwann cells
    • Tang HW, Yan HL, Hu XH, Leang YX, Shen XY. Lead cytotoxicity in primary cultured rat astrocytes and Schwann cells. J Appl Toxicol 1996;16: 187-96.
    • (1996) J Appl Toxicol , vol.16 , pp. 187-196
    • Tang, H.W.1    Yan, H.L.2    Hu, X.H.3    Leang, Y.X.4    Shen, X.Y.5
  • 91
    • 0032092333 scopus 로고    scopus 로고
    • Magnetic resonance imaging and spectroscopy of regional brain structure in a 10-year-old boy with elevated blood lead levels
    • Trope I, Lopez-Villegas D, Lenkinski RE. Magnetic resonance imaging and spectroscopy of regional brain structure in a 10-year-old boy with elevated blood lead levels. Pediatrics 1998;101(6):E7.
    • (1998) Pediatrics , vol.101 , Issue.6
    • Trope, I.1    Lopez-Villegas, D.2    Lenkinski, R.E.3
  • 94
    • 65749086026 scopus 로고    scopus 로고
    • Needleman HL. History of lead poisoning in the world. In: George AM, ed. Lead Poisoning Prevention and treatment: Implementing a National Program in Developing Countries. Proc. of the International Conference on Lead Poisoning Prevention and Treatment. February 8-10, 1999, Banglore, India;17-25. Available at http://www.leadpoison.net/general/ history.htm. Accessed 17 January 2009.
    • Needleman HL. History of lead poisoning in the world. In: George AM, ed. Lead Poisoning Prevention and treatment: Implementing a National Program in Developing Countries. Proc. of the International Conference on Lead Poisoning Prevention and Treatment. February 8-10, 1999, Banglore, India;17-25. Available at http://www.leadpoison.net/general/ history.htm. Accessed 17 January 2009.
  • 95
    • 33746078438 scopus 로고    scopus 로고
    • Involvement of environmental mercury and lead in the etiology of neurodegenerative diseases
    • Monnet-Tschudi F, Zurich M-G, Boschat C, Corbaz A, Honegger P. Involvement of environmental mercury and lead in the etiology of neurodegenerative diseases. Rev Environ Health 2006;21(2):105-17.
    • (2006) Rev Environ Health , vol.21 , Issue.2 , pp. 105-117
    • Monnet-Tschudi, F.1    Zurich, M.-G.2    Boschat, C.3    Corbaz, A.4    Honegger, P.5
  • 98
    • 0031827147 scopus 로고    scopus 로고
    • Neurotoxicity in young adults 20 years after childhood exposure to lead: The Bunker Hill experience
    • Stokes L, Letz R, Gerr F, Kolczak M, McNeil FE, Chettle DR, et al Neurotoxicity in young adults 20 years after childhood exposure to lead: the Bunker Hill experience. Occup Environ Med 1998;55: 507-16.
    • (1998) Occup Environ Med , vol.55 , pp. 507-516
    • Stokes, L.1    Letz, R.2    Gerr, F.3    Kolczak, M.4    McNeil, F.E.5    Chettle, D.R.6
  • 99
    • 0027302661 scopus 로고
    • Residual cognitive deficits 50 years after lead poisoning during childhood
    • White RF, Diamond R, Proctor S, Morey C, Hu H. Residual cognitive deficits 50 years after lead poisoning during childhood. Br J Ind Med 1993; 50:613-22.
    • (1993) Br J Ind Med , vol.50 , pp. 613-622
    • White, R.F.1    Diamond, R.2    Proctor, S.3    Morey, C.4    Hu, H.5
  • 100
    • 0017740152 scopus 로고
    • Cerebellar calcification: A possible marker of lead poisoning
    • Tonge JI, Burry AF, Saal JR. Cerebellar calcification: a possible marker of lead poisoning. Pathology 1977;9(4):289-300.
    • (1977) Pathology , vol.9 , Issue.4 , pp. 289-300
    • Tonge, J.I.1    Burry, A.F.2    Saal, J.R.3
  • 102
    • 0025950672 scopus 로고
    • Neurologic and psychiatric manifestations of lead poisoning in adults
    • Schroter C, Schroter H, and Huffman G. Neurologic and psychiatric manifestations of lead poisoning in adults. Fortschr Neurol Psychiat 1991;59(10):413-24.
    • (1991) Fortschr Neurol Psychiat , vol.59 , Issue.10 , pp. 413-424
    • Schroter, C.1    Schroter, H.2    Huffman, G.3
  • 103
    • 0027368512 scopus 로고
    • Schizophrenia: Into the next millennium
    • Jones B. Schizophrenia: Into the next millennium. Can J Psychiat 1993;38(3):567-9.
    • (1993) Can J Psychiat , vol.38 , Issue.3 , pp. 567-569
    • Jones, B.1
  • 104
  • 105
    • 0025678759 scopus 로고
    • Lead-induced behavioral impairment on a spatial discrimination reversal task in monkeys during different periods of development
    • Rice DC. Lead-induced behavioral impairment on a spatial discrimination reversal task in monkeys during different periods of development. Appl Pharmacol 1990;106:327-33.
    • (1990) Appl Pharmacol , vol.106 , pp. 327-333
    • Rice, D.C.1
  • 106
    • 0027445751 scopus 로고
    • Lead-induced changes in learning: Evidence for behavioral mechanisms from experimental animal studies
    • Rice DC. Lead-induced changes in learning: evidence for behavioral mechanisms from experimental animal studies. Neurotoxicology 1993;14: 167-78.
    • (1993) Neurotoxicology , vol.14 , pp. 167-178
    • Rice, D.C.1
  • 107
    • 0007836065 scopus 로고
    • Effect of lead on schedule-controlled behavior in monkeys
    • Seiden LS, Balster RL, eds, New York, NY, USA: Alan R. Liss
    • Rice DC. Effect of lead on schedule-controlled behavior in monkeys. In: Seiden LS, Balster RL, eds. Behavioral Pharmacology: The Current Status, New York, NY, USA: Alan R. Liss, 1985; 473-86.
    • (1985) Behavioral Pharmacology: The Current Status , pp. 473-486
    • Rice, D.C.1
  • 108
    • 0026728651 scopus 로고
    • Behavioral effects of lead in monkeys tested during infancy and adulthood
    • Rice DC. Behavioral effects of lead in monkeys tested during infancy and adulthood, Neurotoxicol Teratol 1992;14:235-45.
    • (1992) Neurotoxicol Teratol , vol.14 , pp. 235-245
    • Rice, D.C.1
  • 109
    • 0035970752 scopus 로고    scopus 로고
    • Enriched environment during development is protective against lead-induced neurotoxicity
    • Schneider JS, Lee MH, Anderson DW, Zuck L, Lidksy TI. Enriched environment during development is protective against lead-induced neurotoxicity. Brain Res 2001;896:48-55.
    • (2001) Brain Res , vol.896 , pp. 48-55
    • Schneider, J.S.1    Lee, M.H.2    Anderson, D.W.3    Zuck, L.4    Lidksy, T.I.5
  • 111
    • 26444616243 scopus 로고    scopus 로고
    • Young brains on lead: Adult neurological consequences
    • Pabello NG, Bolivar VJ. Young brains on lead: adult neurological consequences. Toxicol Sci 2005; 86 (2):211-13.
    • (2005) Toxicol Sci , vol.86 , Issue.2 , pp. 211-213
    • Pabello, N.G.1    Bolivar, V.J.2
  • 112
    • 0033399263 scopus 로고    scopus 로고
    • Chronic lead intoxication affects the myelin membrane status in the central nervous system (CNS) of adult rats
    • Dabrowska-Bouta B, Sulkowski G, Bartosz G, Walski M, Rafalowska U. Chronic lead intoxication affects the myelin membrane status in the central nervous system (CNS) of adult rats. J Mol Neurosci 1999;13:127-39.
    • (1999) J Mol Neurosci , vol.13 , pp. 127-139
    • Dabrowska-Bouta, B.1    Sulkowski, G.2    Bartosz, G.3    Walski, M.4    Rafalowska, U.5
  • 113
    • 0032997813 scopus 로고    scopus 로고
    • Toxic effects of lead on the blood brain barrier in rats
    • Ruan SY, Gu Z-w, Toxic effects of lead on the blood brain barrier in rats. J Occup Health 1999; 41:39-42.
    • (1999) J Occup Health , vol.41 , pp. 39-42
    • Ruan, S.Y.1    Gu, Z.-W.2
  • 114
    • 1342275834 scopus 로고    scopus 로고
    • Energy dispersive X-ray analysis in studying the permeability of blood-brain barrier caused by lead in rats]
    • Ruan S, Gu Z, Yang Y. [Energy dispersive X-ray analysis in studying the permeability of blood-brain barrier caused by lead in rats] Zhonghua Yu Fang Yi Xue Za Zhi. 1999;33(2):107-9.
    • (1999) Zhonghua Yu Fang Yi Xue Za Zhi , vol.33 , Issue.2 , pp. 107-109
    • Ruan, S.1    Gu, Z.2    Yang, Y.3
  • 115
    • 33846904766 scopus 로고    scopus 로고
    • Wang Q, Luo W, Zheng W, Liu Y, Xu H, Zheng G, et al. Iron supplement prevents lead-induced disruption of the blood-brain barrier during rat development. Toxicol Appl Pharmacol 2007;15: 219(1):33-41.
    • Wang Q, Luo W, Zheng W, Liu Y, Xu H, Zheng G, et al. Iron supplement prevents lead-induced disruption of the blood-brain barrier during rat development. Toxicol Appl Pharmacol 2007;15: 219(1):33-41.
  • 117
    • 0030964555 scopus 로고    scopus 로고
    • Functional alterations and apoptotic cell death in the retina following developmental or adult lead exposure
    • Fox DA, Campbell ML, Blocker YS. Functional alterations and apoptotic cell death in the retina following developmental or adult lead exposure. Neurotoxicology 1997;18:645-54.
    • (1997) Neurotoxicology , vol.18 , pp. 645-654
    • Fox, D.A.1    Campbell, M.L.2    Blocker, Y.S.3
  • 118
    • 0034697363 scopus 로고    scopus 로고
    • Lead and calcium produce rod photoreceptor cell apoptosis by opening the mitochondrial permeability transition pore
    • He L, Poblenz AT, Medrano CJ, Fox DA. Lead and calcium produce rod photoreceptor cell apoptosis by opening the mitochondrial permeability transition pore. J Biol Chem 2000;275: 12175-84.
    • (2000) J Biol Chem , vol.275 , pp. 12175-12184
    • He, L.1    Poblenz, A.T.2    Medrano, C.J.3    Fox, D.A.4
  • 119
    • 58149147335 scopus 로고    scopus 로고
    • Lead-induced oxidative stress adversely affects health of the occupational workers
    • Khan D, Qayyum S, Saleem S, Khan F. Lead-induced oxidative stress adversely affects health of the occupational workers. Toxicol Ind Health 2008;24(9):611-8.
    • (2008) Toxicol Ind Health , vol.24 , Issue.9 , pp. 611-618
    • Khan, D.1    Qayyum, S.2    Saleem, S.3    Khan, F.4
  • 121
    • 0034027280 scopus 로고    scopus 로고
    • Lead promotes hydroxyl radical generation and lipid peroxidation in cultured aortic endothelial cells
    • Ding Y, Gonick HC, Vaziri ND. Lead promotes hydroxyl radical generation and lipid peroxidation in cultured aortic endothelial cells. Am J Hypertens 2000;13(5 Pt 1):552-5.
    • (2000) Am J Hypertens , vol.13 , Issue.5 PART 1 , pp. 552-555
    • Ding, Y.1    Gonick, H.C.2    Vaziri, N.D.3
  • 122
    • 42749085617 scopus 로고    scopus 로고
    • Toxic effects of perinatal lead exposure on the brain of rats: Involvement of oxidative stress and the beneficial role of antioxidants
    • Antonio-García MT, Massó-Gonzalez EL. Toxic effects of perinatal lead exposure on the brain of rats: involvement of oxidative stress and the beneficial role of antioxidants. Food Chem Toxicol. 2008;46(6):2089-95.
    • (2008) Food Chem Toxicol , vol.46 , Issue.6 , pp. 2089-2095
    • Antonio-García, M.T.1    Massó-Gonzalez, E.L.2
  • 123
    • 33745903081 scopus 로고    scopus 로고
    • Mechanisms of lead toxicity: The effect of lead on oxidant/ antioxidant balance
    • Patrick L. Mechanisms of lead toxicity: The effect of lead on oxidant/ antioxidant balance. Altern Med Rev 2006;11(2)114-26.
    • (2006) Altern Med Rev , vol.11 , Issue.2 , pp. 114-126
    • Patrick, L.1
  • 124
    • 0002556021 scopus 로고    scopus 로고
    • Pathophysiology of lead poisoning
    • Pueschel SM, Linakis JG, Anderson AC, eds, Baltimore, MD: P.H. Brookes;
    • Anderson AC, Pueschel SM, Linakis JG. Pathophysiology of lead poisoning. In: Pueschel SM, Linakis JG, Anderson AC, eds. Lead poisoning in children. Baltimore, MD: P.H. Brookes; 1996;75-96.
    • (1996) Lead poisoning in children , pp. 75-96
    • Anderson, A.C.1    Pueschel, S.M.2    Linakis, J.G.3
  • 125
    • 0037227997 scopus 로고    scopus 로고
    • Lead neurotoxicity in children: Basic mechanisms and clinical correlates
    • Lidsky TI, Schneider JS. Lead neurotoxicity in children: basic mechanisms and clinical correlates. Brain 2003;126(1):5-19.
    • (2003) Brain , vol.126 , Issue.1 , pp. 5-19
    • Lidsky, T.I.1    Schneider, J.S.2
  • 126
    • 0027433553 scopus 로고
    • Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid
    • Beal MF, Brouillet E, Jenkins BG, Ferrante JG, Kowall NW, Miller JM, et al Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid. J Neurosci 1993;13:4181-92.
    • (1993) J Neurosci , vol.13 , pp. 4181-4192
    • Beal, M.F.1    Brouillet, E.2    Jenkins, B.G.3    Ferrante, J.G.4    Kowall, N.W.5    Miller, J.M.6
  • 127
    • 0042536473 scopus 로고    scopus 로고
    • Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity
    • Arundine M, Tymianski M. Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity. Cell Calcium 2003;34(4-5):325-37.
    • (2003) Cell Calcium , vol.34 , Issue.4-5 , pp. 325-337
    • Arundine, M.1    Tymianski, M.2
  • 128
    • 0037452854 scopus 로고    scopus 로고
    • Glutamate receptor function in learning and memory
    • Riedel G, Platt B, Micheau J. Glutamate receptor function in learning and memory. Behav Brain Res 2003;140(1-2):1-47.
    • (2003) Behav Brain Res , vol.140 , Issue.1-2 , pp. 1-47
    • Riedel, G.1    Platt, B.2    Micheau, J.3
  • 130
    • 0042477712 scopus 로고    scopus 로고
    • FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons
    • Gilley J, Coffer PJ, Ham J. FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons. J Cell Biol 2003;162:613-22.
    • (2003) J Cell Biol , vol.162 , pp. 613-622
    • Gilley, J.1    Coffer, P.J.2    Ham, J.3
  • 131
    • 0036086130 scopus 로고    scopus 로고
    • Free radicals in the physiological control of cell function
    • Droge, W. Free radicals in the physiological control of cell function. Physiol Rev 2002;82:47-95.
    • (2002) Physiol Rev , vol.82 , pp. 47-95
    • Droge, W.1
  • 133
    • 1642483509 scopus 로고    scopus 로고
    • Neurodegenerative diseases and oxidative stress
    • Emerit J, Edeas M, Bricaire F. Neurodegenerative diseases and oxidative stress. Biomed Pharmacother 2004;58(1):39-46.
    • (2004) Biomed Pharmacother , vol.58 , Issue.1 , pp. 39-46
    • Emerit, J.1    Edeas, M.2    Bricaire, F.3
  • 134
    • 0032473367 scopus 로고    scopus 로고
    • Molecular biology of glutamate receptors in the central nervous system and their role in excitotoxicity, oxidative stress and aging
    • Michaelis EK. Molecular biology of glutamate receptors in the central nervous system and their role in excitotoxicity, oxidative stress and aging. Prog Neurobiol 1998;54:369-415.
    • (1998) Prog Neurobiol , vol.54 , pp. 369-415
    • Michaelis, E.K.1
  • 136
    • 0035211681 scopus 로고    scopus 로고
    • Atroglia as metal depots: Molecular mechanisms for metal accumulation, storage and release
    • Tiffany-Castiglioni E, Qian Y. Atroglia as metal depots: molecular mechanisms for metal accumulation, storage and release. NeuroToxicology 2001; 22(5):577-592
    • (2001) NeuroToxicology , vol.22 , Issue.5 , pp. 577-592
    • Tiffany-Castiglioni, E.1    Qian, Y.2
  • 137
    • 0032816902 scopus 로고    scopus 로고
    • Differential ability of astroglia and neuronal cells to accumulate lead: Dependence on cell type and on degree of differentiation
    • Lindahl LS, Bird L, Legare ME, Mikeska G, Bratton GR, Tiffany-Castiglioni E. Differential ability of astroglia and neuronal cells to accumulate lead: dependence on cell type and on degree of differentiation. Toxicol Sci 1999;50: 236-43.
    • (1999) Toxicol Sci , vol.50 , pp. 236-243
    • Lindahl, L.S.1    Bird, L.2    Legare, M.E.3    Mikeska, G.4    Bratton, G.R.5    Tiffany-Castiglioni, E.6
  • 138
    • 0023258018 scopus 로고
    • Lead toxicity in primary cultured cerebral astrocytes and cerebellar granular neurons
    • Holtzman D, Olson JE, DeVries C, Bensch K. Lead toxicity in primary cultured cerebral astrocytes and cerebellar granular neurons. Toxicol Appl Pharmacol 1987;89:211-25.
    • (1987) Toxicol Appl Pharmacol , vol.89 , pp. 211-225
    • Holtzman, D.1    Olson, J.E.2    DeVries, C.3    Bensch, K.4
  • 139
    • 0018382256 scopus 로고
    • Fine structural localization of glutamine synthetase in astrocytes in rat brain
    • Norenberg MD, Martinez-Hernandez A. Fine structural localization of glutamine synthetase in astrocytes in rat brain. Brain Res 1979;161:303-10.
    • (1979) Brain Res , vol.161 , pp. 303-310
    • Norenberg, M.D.1    Martinez-Hernandez, A.2
  • 140
    • 0023751255 scopus 로고
    • Use of an in vitro system to study the effects of lead on astrocyte-endothelial cell interactions: A model for studying toxic injury to the blood-brain barrier
    • Gebhart AM, Goldstein GW. Use of an in vitro system to study the effects of lead on astrocyte-endothelial cell interactions: a model for studying toxic injury to the blood-brain barrier. Toxicol Appl Pharmacol 1988;94(2):191-206.
    • (1988) Toxicol Appl Pharmacol , vol.94 , Issue.2 , pp. 191-206
    • Gebhart, A.M.1    Goldstein, G.W.2
  • 141
    • 0000138025 scopus 로고
    • Developmental neurobiology of lead toxicity
    • Needlmann HL, ed, Boca Raton, FL: CRC
    • Goldstein GW. Developmental neurobiology of lead toxicity. In: Needlmann HL, ed. Human lead exposure, Boca Raton, FL: CRC, 1992;191-208.
    • (1992) Human lead exposure , pp. 191-208
    • Goldstein, G.W.1
  • 142
    • 0027317818 scopus 로고
    • Lead increases inositol 1,4,5-triphosphate levels but does not interfere with calcium transients in primary rat astrocytes
    • Dave V, Vitarella D, Aschner JL, Fletcher P, Kimelberg HK, Aschner M. Lead increases inositol 1,4,5-triphosphate levels but does not interfere with calcium transients in primary rat astrocytes Brain Res 1993;618:9-18.
    • (1993) Brain Res , vol.618 , pp. 9-18
    • Dave, V.1    Vitarella, D.2    Aschner, J.L.3    Fletcher, P.4    Kimelberg, H.K.5    Aschner, M.6
  • 143
    • 0027383420 scopus 로고
    • Permeability of the blood-brain barrier to lead
    • Bradbury MW, Deane R. Permeability of the blood-brain barrier to lead. Neurotoxicology 1993; 14:131-6.
    • (1993) Neurotoxicology , vol.14 , pp. 131-136
    • Bradbury, M.W.1    Deane, R.2
  • 144
    • 0030931426 scopus 로고    scopus 로고
    • Lead uptake in brain capillary endothelial cells: Activation by calcium store depletion
    • Kerper LE, Hinkle PM. Lead uptake in brain capillary endothelial cells: activation by calcium store depletion. Toxicol Appl Pharmacol 1997; 146:127-33.
    • (1997) Toxicol Appl Pharmacol , vol.146 , pp. 127-133
    • Kerper, L.E.1    Hinkle, P.M.2
  • 145
    • 0030888687 scopus 로고    scopus 로고
    • Cellular uptake of lead is activated by depletion of intracellular calcium stores
    • Kerper LE, Hinkle PM. Cellular uptake of lead is activated by depletion of intracellular calcium stores. J Biol Chem 1997;272:8346-52.
    • (1997) J Biol Chem , vol.272 , pp. 8346-8352
    • Kerper, L.E.1    Hinkle, P.M.2
  • 147
    • 33947427428 scopus 로고    scopus 로고
    • Early lead exposure increases the leakage of the blood-cerebrospinal fluid barrier in vitro
    • Shi LZ, Zheng W. Early lead exposure increases the leakage of the blood-cerebrospinal fluid barrier in vitro. Hum Exp Toxicol 2007;26(3): 159-67.
    • (2007) Hum Exp Toxicol , vol.26 , Issue.3 , pp. 159-167
    • Shi, L.Z.1    Zheng, W.2
  • 148
    • 2942522639 scopus 로고    scopus 로고
    • Presynaptic disruption of transmitter release by lead
    • Suszkiw JB. Presynaptic disruption of transmitter release by lead. Neurotoxicology. 2004;25(4):599-604.
    • (2004) Neurotoxicology , vol.25 , Issue.4 , pp. 599-604
    • Suszkiw, J.B.1
  • 149
    • 0028987874 scopus 로고
    • Relationships between lead-induced learning impairments and changes in dopaminergic, cholinergic, and glutamatergic neurotransmitter system functions
    • Cory-Slechta DA. Relationships between lead-induced learning impairments and changes in dopaminergic, cholinergic, and glutamatergic neurotransmitter system functions. Ann Rev Pharmacol Toxicol 1995;35:391-415.
    • (1995) Ann Rev Pharmacol Toxicol , vol.35 , pp. 391-415
    • Cory-Slechta, D.A.1
  • 150
    • 22844433441 scopus 로고    scopus 로고
    • Study on the neurotoxic effects of low-level lead exposure in rats
    • Zhu ZW, Yang RL, Dong GJ, Zhao ZY. Study on the neurotoxic effects of low-level lead exposure in rats. J Zhejiang Univ Sci B 2005;6(7):686-92.
    • (2005) J Zhejiang Univ Sci B , vol.6 , Issue.7 , pp. 686-692
    • Zhu, Z.W.1    Yang, R.L.2    Dong, G.J.3    Zhao, Z.Y.4
  • 151
    • 0028811653 scopus 로고
    • Protein Kinase C: Structure, function, and regulation
    • NewtonAC. Protein Kinase C: Structure, function, and regulation. JBC 1995;270(48)28495-8.
    • (1995) JBC , vol.270 , Issue.48 , pp. 28495-28498
    • NewtonAC1
  • 152
    • 0023091203 scopus 로고
    • Down regulation of protein kinase C in neuronal cells: Effects on neurotransmitter release
    • Matthies HJG, Palfrey HC, Himing LD, Miller RJ. Down regulation of protein kinase C in neuronal cells: effects on neurotransmitter release. J Neurosci 1987;7:1198-206.
    • (1987) J Neurosci , vol.7 , pp. 1198-1206
    • Matthies, H.J.G.1    Palfrey, H.C.2    Himing, L.D.3    Miller, R.J.4
  • 153
    • 0024497102 scopus 로고
    • Translocation and activation of protein kinase C in striatal neurons in primary culture: Relationship to phorphol dibutyrate actions on the inositol phosphate generating system and neurotransmitter release
    • Weiss S, Ellis J, Hendly DD, Lenox RH. Translocation and activation of protein kinase C in striatal neurons in primary culture: relationship to phorphol dibutyrate actions on the inositol phosphate generating system and neurotransmitter release. J Neurochem 1989;52:530-6.
    • (1989) J Neurochem , vol.52 , pp. 530-536
    • Weiss, S.1    Ellis, J.2    Hendly, D.D.3    Lenox, R.H.4
  • 154
    • 0023043778 scopus 로고    scopus 로고
    • Akers RF, Lovinger DM, Colley D, Linden D, Routenberg A. Translocation of protein kinase C activity after LTP may mediate hippocampal synaptic plasticity. 1986;Science 231:587-9.
    • Akers RF, Lovinger DM, Colley D, Linden D, Routenberg A. Translocation of protein kinase C activity after LTP may mediate hippocampal synaptic plasticity. 1986;Science 231:587-9.
  • 155
    • 0026340841 scopus 로고
    • A tale of two contingent protein kinase C activators: Both neutral and acidic lipids regulate synaptic plasticity and information storage
    • Routtenberg A. A tale of two contingent protein kinase C activators: both neutral and acidic lipids regulate synaptic plasticity and information storage. Prog Brain Res 1991;89:249-61.
    • (1991) Prog Brain Res , vol.89 , pp. 249-261
    • Routtenberg, A.1
  • 156
    • 0024815156 scopus 로고
    • Modulation of ion channel activity: A key function of the protein kinase C enzyme family
    • Shearman MS, Sekiguchi K, Nishizuka Y. Modulation of ion channel activity: a key function of the protein kinase C enzyme family. Pharmacol Rev 1989;41:211-47.
    • (1989) Pharmacol Rev , vol.41 , pp. 211-247
    • Shearman, M.S.1    Sekiguchi, K.2    Nishizuka, Y.3
  • 157
    • 0026447428 scopus 로고
    • Inhibition of astroglia-induced endothelial differentiation by inorganic lead: A role for protein kinase C
    • Laterra J, Bressler JP, Indurti RR, Belloni-Olivi L, Goldstein GW. Inhibition of astroglia-induced endothelial differentiation by inorganic lead: a role for protein kinase C. Proc Natl Acad Sci USA 1992;89:10748-52.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 10748-10752
    • Laterra, J.1    Bressler, J.P.2    Indurti, R.R.3    Belloni-Olivi, L.4    Goldstein, G.W.5
  • 158
    • 0032957270 scopus 로고    scopus 로고
    • Protein kinase C in rat brain is altered by developmental lead exposure
    • Chon HH, Ma T, Ho IK. Protein kinase C in rat brain is altered by developmental lead exposure. Neurochem Res 1999.24:415-21.
    • (1999) Neurochem Res , vol.24 , pp. 415-421
    • Chon, H.H.1    Ma, T.2    Ho, I.K.3
  • 159
    • 0025351941 scopus 로고
    • Hippocampal protein kinase C activity is reduced in poor spatial learners
    • Wehner JM, Sleight S, Upchurch M. Hippocampal protein kinase C activity is reduced in poor spatial learners. Brain Res 1990;523:181-7.
    • (1990) Brain Res , vol.523 , pp. 181-187
    • Wehner, J.M.1    Sleight, S.2    Upchurch, M.3
  • 160
    • 0031853418 scopus 로고    scopus 로고
    • Age-related alteration of PKC, a key enzyme in memory processes: Physiological and pathological examples
    • Pascale A, Govoni S, Battaini F. Age-related alteration of PKC, a key enzyme in memory processes: physiological and pathological examples. Mol Neurobiol 1998;16:49-62.
    • (1998) Mol Neurobiol , vol.16 , pp. 49-62
    • Pascale, A.1    Govoni, S.2    Battaini, F.3
  • 161
    • 7444256727 scopus 로고    scopus 로고
    • Protein kinase C overactivity impairs prefrontal cortical regulation of working memory
    • Birnbaum SG, Yuan PX, Wang M, Vijayraghavan S, Bloom AK, Davis DJ, et al. Protein kinase C overactivity impairs prefrontal cortical regulation of working memory. Science 2004;306(5697):882-4
    • (2004) Science , vol.306 , Issue.5697 , pp. 882-884
    • Birnbaum, S.G.1    Yuan, P.X.2    Wang, M.3    Vijayraghavan, S.4    Bloom, A.K.5    Davis, D.J.6
  • 162
    • 0036175369 scopus 로고    scopus 로고
    • Protein kinase C activity and the relations between blood lead and neurobehavioral function in lead workers
    • Hwang KY, Lee BK, Bressler JP, Bolla KI, Stewart WF, Schwartz BS. Protein kinase C activity and the relations between blood lead and neurobehavioral function in lead workers. Environ Health Perspect 2002;110(2):133-8.
    • (2002) Environ Health Perspect , vol.110 , Issue.2 , pp. 133-138
    • Hwang, K.Y.1    Lee, B.K.2    Bressler, J.P.3    Bolla, K.I.4    Stewart, W.F.5    Schwartz, B.S.6
  • 163
    • 84879790289 scopus 로고    scopus 로고
    • Wang FS, Liu ZH, Zhang JS, Di JR. [Effects of lead exposure on protein kinase C and calmodulin expression in hippocampus and neurobehavioral function of baby rats] Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2008;26(3):139-42. In Chinese.
    • Wang FS, Liu ZH, Zhang JS, Di JR. [Effects of lead exposure on protein kinase C and calmodulin expression in hippocampus and neurobehavioral function of baby rats] Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2008;26(3):139-42. In Chinese.
  • 164
    • 0032550160 scopus 로고    scopus 로고
    • Hippocampal NMDA receptor mRNA undergoes subunit specific changes during developmental lead exposure
    • Guilarte TR, McGlothan JL. Hippocampal NMDA receptor mRNA undergoes subunit specific changes during developmental lead exposure. Brain Res 1998;790(1-2):98-107
    • (1998) Brain Res , vol.790 , Issue.1-2 , pp. 98-107
    • Guilarte, T.R.1    McGlothan, J.L.2
  • 165
    • 65749101124 scopus 로고    scopus 로고
    • Effect of prenatal lead exposure on the gene transcription and protein expression level of POU-domain protein Brn-3a in different regions of offspring rat brain]
    • In Chinese
    • Chang W, Xie H, Chen X.[Effect of prenatal lead exposure on the gene transcription and protein expression level of POU-domain protein Brn-3a in different regions of offspring rat brain] Wei Sheng Yan Jiu 2008;37(4):385-8. In Chinese.
    • (2008) Wei Sheng Yan Jiu , vol.37 , Issue.4 , pp. 385-388
    • Chang, W.1    Xie, H.2    Chen, X.3
  • 166
    • 39049182329 scopus 로고    scopus 로고
    • Song B, Han CC, Sun X, Peng L, Niu YJ. [Effects of prenatal exposure to low level, lead on learning and memory of rats' offspring] Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2006; 24(7):399-402. In Chinese.
    • Song B, Han CC, Sun X, Peng L, Niu YJ. [Effects of prenatal exposure to low level, lead on learning and memory of rats' offspring] Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2006; 24(7):399-402. In Chinese.
  • 167
    • 84879790753 scopus 로고    scopus 로고
    • Yin J, Niu YJ, Zhang R, Song B, Cheng JX. [Effects of prenatal exposure to low level lead on expression of GAP-43 in hippocampus of rat's offspring] Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2008;26(4):208-11. In Chinese.
    • Yin J, Niu YJ, Zhang R, Song B, Cheng JX. [Effects of prenatal exposure to low level lead on expression of GAP-43 in hippocampus of rat's offspring] Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2008;26(4):208-11. In Chinese.
  • 168
    • 0034685739 scopus 로고    scopus 로고
    • In vitro aberrant gene expression as the indicator of lead-induced neurotoxicity in U-373MG cells
    • Liu MY, Hsieh WC, Yang BC. In vitro aberrant gene expression as the indicator of lead-induced neurotoxicity in U-373MG cells. Toxicol 2007; 147(1):59-64.
    • (2007) Toxicol , vol.147 , Issue.1 , pp. 59-64
    • Liu, M.Y.1    Hsieh, W.C.2    Yang, B.C.3
  • 169
    • 0034523449 scopus 로고    scopus 로고
    • Lead exposure alters Egr-1 DNA-binding in the neonatal rat brain
    • Reddy GR, Zawia NH. Lead exposure alters Egr-1 DNA-binding in the neonatal rat brain. Int J Dev Neurosci 2000;18:791-5.
    • (2000) Int J Dev Neurosci , vol.18 , pp. 791-795
    • Reddy, G.R.1    Zawia, N.H.2
  • 170
    • 0024873545 scopus 로고
    • Characteristics of lead adaptation in a rat kidney cell line. I. Uptake and subcellular and subnuclear distribution of lead
    • Hitzfeld B, Taylor DM. Characteristics of lead adaptation in a rat kidney cell line. I. Uptake and subcellular and subnuclear distribution of lead. Mol Toxicol 1989;2:151-62.
    • (1989) Mol Toxicol , vol.2 , pp. 151-162
    • Hitzfeld, B.1    Taylor, D.M.2
  • 171
    • 0032733074 scopus 로고    scopus 로고
    • Lead inhibition of DNA-binding mechanism of Cys2His2 zinc finger proteins
    • Hanas JS, Rodgers JS, Bantle JA, Cheng YG. Lead inhibition of DNA-binding mechanism of Cys2His2 zinc finger proteins. Mol Pharmacol 1999;56:982-988.
    • (1999) Mol Pharmacol , vol.56 , pp. 982-988
    • Hanas, J.S.1    Rodgers, J.S.2    Bantle, J.A.3    Cheng, Y.G.4
  • 172
    • 0032524391 scopus 로고    scopus 로고
    • Sp1 as a target site for metal-induced perturbations of transcriptional regulation of developmental brain gene expression
    • Zawia NH, Sharan R, Brydie M, Oyama T, Crumpton T. Sp1 as a target site for metal-induced perturbations of transcriptional regulation of developmental brain gene expression. Brain Res Dev Brain Res 1998;107:291-8.
    • (1998) Brain Res Dev Brain Res , vol.107 , pp. 291-298
    • Zawia, N.H.1    Sharan, R.2    Brydie, M.3    Oyama, T.4    Crumpton, T.5
  • 173
    • 65749104561 scopus 로고    scopus 로고
    • Crumpton T, Atkins DS, Zawia NH, and Barone Jr S. lead, inorganic. In: Spencer PS, Schaumburg HH, Ludolph AC, eds. Experimental and clinical neurotoxicology. 2nd edition. New York: Oxford University Press; 2000;708-20.
    • Crumpton T, Atkins DS, Zawia NH, and Barone Jr S. lead, inorganic. In: Spencer PS, Schaumburg HH, Ludolph AC, eds. Experimental and clinical neurotoxicology. 2nd edition. New York: Oxford University Press; 2000;708-20.
  • 174
    • 0034075931 scopus 로고    scopus 로고
    • Genetic susceptibility to lead poisoning
    • Onalaja AO, Claudio L. Genetic susceptibility to lead poisoning. Environ Health Perspect 2000;108 (1):23-28.
    • (2000) Environ Health Perspect , vol.108 , Issue.1 , pp. 23-28
    • Onalaja, A.O.1    Claudio, L.2
  • 175
    • 0028545107 scopus 로고
    • Low-level lead exposure and cognitive function in children
    • Bellinger D, Dietrich KN. Low-level lead exposure and cognitive function in children. Pediatr Ann 1994;23:600-5.
    • (1994) Pediatr Ann , vol.23 , pp. 600-605
    • Bellinger, D.1    Dietrich, K.N.2
  • 176
    • 36749073876 scopus 로고    scopus 로고
    • Lead burden and psychiatric symptoms and the modifying influence of the delta-aminolevulinic acid dehydratase (ALAD) polymorphism: The VA Normative Aging Study
    • Rajan P, Kelsey KT, Schwartz JD, Bellinger DC, Weuve J, Sparrow D, et al. Lead burden and psychiatric symptoms and the modifying influence of the delta-aminolevulinic acid dehydratase (ALAD) polymorphism: the VA Normative Aging Study. Am J Epidemiol 2007;166(12):1400-8.
    • (2007) Am J Epidemiol , vol.166 , Issue.12 , pp. 1400-1408
    • Rajan, P.1    Kelsey, K.T.2    Schwartz, J.D.3    Bellinger, D.C.4    Weuve, J.5    Sparrow, D.6
  • 177
    • 0032526114 scopus 로고    scopus 로고
    • Relation of nutrition to bone lead and blood lead levels in middle-aged to elderly men. The Normative Aging Study
    • Cheng Y, Willett WC, Schwartz J, Sparrow D, Weiss S, Hu H. Relation of nutrition to bone lead and blood lead levels in middle-aged to elderly men. The Normative Aging Study. Am J Epidemiol 1998;147:1162-74.
    • (1998) Am J Epidemiol , vol.147 , pp. 1162-1174
    • Cheng, Y.1    Willett, W.C.2    Schwartz, J.3    Sparrow, D.4    Weiss, S.5    Hu, H.6
  • 178
    • 0033677264 scopus 로고    scopus 로고
    • Associations of blood lead, dimercaptosuccinic acid-chelatable lead and
    • Schwartz BS, Lee BK, Lee GS, Stewart WF, Simon D, Kelsey K, et al Associations of blood lead, dimercaptosuccinic acid-chelatable lead and tibia lead with polymorphisms in the vitamin D receptor and [delta]-aminolevulinic acid dehydrase genes. Environ Health Perspect 2000;108:949-54.
    • (2000) Environ Health Perspect , vol.108 , pp. 949-954
    • Schwartz, B.S.1    Lee, B.K.2    Lee, G.S.3    Stewart, W.F.4    Simon, D.5    Kelsey, K.6
  • 180
    • 0027524171 scopus 로고
    • The genotoxicity of lead
    • Winder C, Bonin T. The genotoxicity of lead. Mutat Res 1993;285:117-24.
    • (1993) Mutat Res , vol.285 , pp. 117-124
    • Winder, C.1    Bonin, T.2
  • 181
    • 0019827255 scopus 로고
    • Chromosome aberrations and sister chromatid exchanges in lead-exposed workers
    • Mäki-Paakkanen J, Sorsa M, Vainio H. Chromosome aberrations and sister chromatid exchanges in lead-exposed workers. Hereditas 1981;94:269-75.
    • (1981) Hereditas , vol.94 , pp. 269-275
    • Mäki-Paakkanen, J.1    Sorsa, M.2    Vainio, H.3
  • 182
    • 0017107026 scopus 로고
    • Cytogenetic investigations in volunteers ingesting inorganic lead
    • Bulsma JB, De France HF. 1976. Cytogenetic investigations in volunteers ingesting inorganic lead. Int Arch Occup Environ Health 28:145-8.
    • (1976) Int Arch Occup Environ Health , vol.28 , pp. 145-148
    • Bulsma, J.B.1    De France, H.F.2
  • 183
    • 0015963682 scopus 로고
    • Absence of significant chromosome damage in males occupationally exposed to lead
    • O'Riordan ML, Evans HJ, 1974. Absence of significant chromosome damage in males occupationally exposed to lead. Nature 247: 50-53.
    • (1974) Nature , vol.247 , pp. 50-53
    • O'Riordan, M.L.1    Evans, H.J.2
  • 186
    • 0036227655 scopus 로고    scopus 로고
    • Correlations of blood lead with DNA-protein cross-links and sister chromatid exchanges in lead workers
    • Wu FY, Chang PW, Wu CC, Kuo HW. Correlations of blood lead with DNA-protein cross-links and sister chromatid exchanges in lead workers. Cancer Epidemiol Biomarkers Prev 2002; 11:287-90.
    • (2002) Cancer Epidemiol Biomarkers Prev , vol.11 , pp. 287-290
    • Wu, F.Y.1    Chang, P.W.2    Wu, C.C.3    Kuo, H.W.4
  • 187
    • 0034902493 scopus 로고    scopus 로고
    • Correlation between lead exposure indicators and sister chromatid exchange (SCE) frequencies in lymphocytes from inorganic lead exposed workers
    • Duydu Y, Süzen HS, Aydin A, Cander O, Uysal H, Işimer A, et al. Correlation between lead exposure indicators and sister chromatid exchange (SCE) frequencies in lymphocytes from inorganic lead exposed workers. Arch Environ Contam Toxicol 2001;41(2):241-6.
    • (2001) Arch Environ Contam Toxicol , vol.41 , Issue.2 , pp. 241-246
    • Duydu, Y.1    Süzen, H.S.2    Aydin, A.3    Cander, O.4    Uysal, H.5    Işimer, A.6
  • 189
    • 25844528250 scopus 로고    scopus 로고
    • Genotoxicity effect of chronic lead exposure assessed using the comet assay]
    • In Polish
    • Steinmetz-Beck A, Szahidewicz-Krupska E, Beck B, Poreba R, Andrzejak R. Genotoxicity effect of chronic lead exposure assessed using the comet assay] Med Pr 2005;56(4):295-302. In Polish.
    • (2005) Med Pr , vol.56 , Issue.4 , pp. 295-302
    • Steinmetz-Beck, A.1    Szahidewicz-Krupska, E.2    Beck, B.3    Poreba, R.4    Andrzejak, R.5
  • 190
    • 0037170677 scopus 로고    scopus 로고
    • Lead induced DNA strand breaks in lymphocytes of exposed workers: Role of reactive oxygen species and protein kinase C
    • Fracasso ME, Perbellini L, Soldà S, Talamini G, Franceschetti P. Lead induced DNA strand breaks in lymphocytes of exposed workers: Role of reactive oxygen species and protein kinase C. Mutat Res 2002;515:159-69.
    • (2002) Mutat Res , vol.515 , pp. 159-169
    • Fracasso, M.E.1    Perbellini, L.2    Soldà, S.3    Talamini, G.4    Franceschetti, P.5
  • 191
    • 0031719640 scopus 로고    scopus 로고
    • Biomonitoring of workers exposed to lead. Genotoxic effects, its modulation by polyvitamin treatment and evaluation of induced radioresistance
    • Vaglenov A, Carbonell E, Marcos R. Biomonitoring of workers exposed to lead. Genotoxic effects, its modulation by polyvitamin treatment and evaluation of induced radioresistance. Mutat Res 1998;418:79-92.
    • (1998) Mutat Res , vol.418 , pp. 79-92
    • Vaglenov, A.1    Carbonell, E.2    Marcos, R.3
  • 193
    • 33744540272 scopus 로고    scopus 로고
    • Evaluating the genotoxic effects of workers exposed to lead using micronucleus assay, comet assay and TCR gene mutation test
    • Chen Z, Lou J, Chen S, Zheng W, Wu W, Jin L, et al. Evaluating the genotoxic effects of workers exposed to lead using micronucleus assay, comet assay and TCR gene mutation test. Toxicology 2006;223(3):219-26.
    • (2006) Toxicology , vol.223 , Issue.3 , pp. 219-226
    • Chen, Z.1    Lou, J.2    Chen, S.3    Zheng, W.4    Wu, W.5    Jin, L.6
  • 194
    • 33749640354 scopus 로고    scopus 로고
    • The influence of environmental exposure to complex mixtures including PAHs and lead on genotoxic effects in children living in Upper Silesia, Poland
    • Mielzyńska D, Siwińska E, Kapka L, Szyfter K, Knudsen LE, Merlo DF. The influence of environmental exposure to complex mixtures including PAHs and lead on genotoxic effects in children living in Upper Silesia, Poland. Mutagenesis 2006;21(5):295-304.
    • (2006) Mutagenesis , vol.21 , Issue.5 , pp. 295-304
    • Mielzyńska, D.1    Siwińska, E.2    Kapka, L.3    Szyfter, K.4    Knudsen, L.E.5    Merlo, D.F.6
  • 195
    • 0025230371 scopus 로고
    • Indirect mechanism of lead induced genotoxicity in cultured mammalian cells
    • Hartwig A, Schlepegrell I, Beyersmann D. Indirect mechanism of lead induced genotoxicity in cultured mammalian cells. Mutat Res 1990;241: 75-82.
    • (1990) Mutat Res , vol.241 , pp. 75-82
    • Hartwig, A.1    Schlepegrell, I.2    Beyersmann, D.3
  • 196
    • 1542300180 scopus 로고    scopus 로고
    • Lead acetate genotoxicity on human melanoma cells in vitro
    • Poma A, Pittaluga E, Tucci A. Lead acetate genotoxicity on human melanoma cells in vitro. Melanoma Res 2003;13(6):563-566.
    • (2003) Melanoma Res , vol.13 , Issue.6 , pp. 563-566
    • Poma, A.1    Pittaluga, E.2    Tucci, A.3
  • 199
    • 0032051941 scopus 로고    scopus 로고
    • The genetic effect of environmental lead
    • Johonsor, FM. The genetic effect of environmental lead. Mutat Res 1998;410:123-40.
    • (1998) Mutat Res , vol.410 , pp. 123-140
    • Johonsor, F.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.