Genotoxicity of arsenical compounds

International Journal of Hygiene and Environmental Health

Volumn 203, Issue 3, 2001, Pages 249-262

  Gebel, T W ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

Arsenic; Dose response; Genotoxicity; Mutagenicity; Sublinearity

Indexed keywords

ARSENIC DERIVATIVE; DNA; DRINKING WATER; MUTAGENIC AGENT;

BACTERIAL MUTATION; BIOLOGICAL MONITORING; CARCINOGENICITY; CHROMOSOME ABERRATION; DNA DAMAGE; GENOTOXICITY; HUMAN; LONG TERM EXPOSURE; MAMMAL CELL; MICRONUCLEUS TEST; MUTAGENICITY; NONHUMAN; OCCUPATIONAL EXPOSURE; OXIDATIVE STRESS; POINT MUTATION; REVIEW; RISK ASSESSMENT; SISTER CHROMATID EXCHANGE; TOXICOKINETICS; WATER CONTAMINATION;

BACTERIA (MICROORGANISMS); MAMMALIA;

EID: 0035082717     PISSN: 14384639     EISSN: None     Source Type: Journal    
DOI: 10.1078/S1438-4639(04)70036-X     Document Type: Review

References (101)

1. Chromosome aberrations in workers exposed to arsenic
2. Relationship of urinary arsenic to intake estimates and a biomarker of effect, bladder cell micronuclei
3. Infrequent p53 mutations in arsenic-related skin lesions
4. Arsenic speciation in the Environment
5. Modification of clastogenicity of three known clastogens by garlic extract in mice in vivo
6. Modulating influence of inorganic arsenic on the recombinogenic and mutagenic action of ionizing radiation and alkylating agents in Drosophila melanogaster
7. In vivo studies in male mice on the mutagenic effects of inorganic arsenic
8. Chromosomal aberrations in peripheral blood lymphocytes from native Andean women and children from northwestern Argentina exposed to arsenic in drinking water
9. Identification of aneuploidy-inducing agents using cytokinesis-blocked human lymphocytes and an anti-kinetochore antibody
10. Metabolites of arsenic induced tetraploids and mitotic arrest in cultured cells
11. Squalene inhibits sodium arsenite-induced sister chromatid exchanges and micronuclei in Chinese hamster ovary-K1 cells
12. Arsenic and antimony: Comparative approach on mechanistic toxicology
13. Suppression of arsenic-induced chromosome mutagenicity by antimony
14. Comparative and environmental genotoxicity of antimony and arsenic
15. Arsenic can mediate skin neoplasia by chronic stimulation of keratinocyte-derived growth factors
16. Cytogenetic effects in human exposure to arsenic
17. Aneugenic effects of some metal compounds assessed by chromosome counting in MRC-5 human cells
18. Induction of chromatid breaks and tetraploidy in Chinese hamster ovary cells by treatment with sodium arsenite during the G2 phase
19. Arsenic disrupts cellular levels of p53 and mdm2: A potential mechanism of carcinogenesis
20. Sister chromatid exchanges in human peripheral blood lymphocytes after ingestion of high doses of arsenicals
21. Effects of arsenic exposure on the frequency of HPRT-mutant lymphocytes in a population of copper roasters in Antofagasta, Chile: A pilot study
22. Interaction of arsenic(III) with nucleotide excision repair in UV- irradiated human fibroblasts
23. Mutagenicity of arsenic in mammalian cells: Role of reactive oxygen species
24. Arsenic[III] and heavy metal ions induce intrachromosomal homologous recombination in the hprt gene of V79 Chinese hamster cells
25. Arsenic-related Bowen's disease and paraquat-related skin cancerous lesions show no detectable ras and p53 gene alterations
26. Mutational spectrum of p53 gene in arsenic-related skin cancers from the blackfoot disease endemic area of Taiwan
27. Arsenic toxicity is enzyme specific and its effects on ligation are not caused by the direct inhibition of DNA repair enzymes
28. Cycloheximide suppresses the enhancing effect of sodium arsenite on the clastogenicity of ethyl methanesulphonate
29. Is the human carcinogen arsenic carcinogenic to laboratory animals?
30. Different modes of action of sodium arsenite, 3-aminobenzamide, and caffeine on the enhancement of ethyl methanesulfonate clastogenicity
31. Genotoxic effects of sodium arsenite on human cells
32. Tumorigenic effect of dimethyl-arsinic acid in the rat
33. A comparative study on acute toxicity of methylarsonic acid, dimethylarsinic acid, and tetramethylarsine oxide in mice
34. Aneuploidy induced by dimethylarsinic acid in mouse bone marrow cells
35. Effect of trivalent and pentavalent arsenic in causing chromosome alterations in cultured Chinese hamster ovary (CHO) cells
36. Genotoxicity of selected metal compounds in the SOS chromotest
37. Induction by inorganic metal salts of sister chromatid exchanges and chromosome aberrations in human and Syrian hamster cells
38. Expression of heme oxygenase in arsenic-resistant human lung adenocarcinoma cells
39. Modulation of cellular antioxidant defense activities by sodium arsenite in human fibroblasts
40. Sodium arsenite enhances the cytotoxicity, clastogenicity, and 6-thioguanine-resistant mutagenicity of ultraviolet light in Chinese hamster ovary cells
41. Differential cytotoxicity of sodium arsenite in human fibroblasts and Chinese hamster ovary cells
42. Sodium arsenite potentiates the clastogenicity and mutagenicity of DNA crosslinking agents
43. Comparison of arsenic-induced cell transformation, cytotoxicity, mutation and cytogenetic effects in Syrian hamster embryo cells in culture
44. Induction of gene amplification by arsenic
45. Differential effects of pre- and posttreatment of sodium arsenite on the genotoxicity of methyl methanesulfonate in Chinese hamster ovary cells
46. Sister-chromatid exchange (SCE) among individuals chronically exposed to arsenic in drinking water
47. Arsenic uptake and metabolism by liver cells is dependent on arsenic oxidation state
48. Inhibition of DNA ligase activity by arsenite: A possible mechanism of its comutagenesis
49. Comutagenesis of sodium arsenite with ultraviolet radiation in Chinese hamster V79 cells
50. Association between the clastogenic effect in peripheral lymphocytes and human exposure to arsenic through drinking water
51. Arsenic alters cytosine methylation patterns of the promoter of the tumor suppressor gene p53 in human lung cells: A model for a mechanism of carcinogenesis
52. Biotransformation of dimethylarsinic acid in mouse, hamster and man
53. The role of oxidative DNA damage in human arsenic carcinogenesis: Detection of 8-hydroxy-2′-deoxyguanosine in arsenic-related Bowen's disease
54. Decrease in bladder cell micronucleus prevalence after intervention to lower the concentration of arsenic in drinking water
55. Micronuclei in exfoliated bladder cells among individuals chronically exposed to arsenic in drinking water
56. Use of the fluorescent micronucleus assay to detect the genotoxic effects of radiation and arsenic exposure in exfoliated human epithelial cells
57. Genotoxicity of arsenic and its methylated metabolites
58. Relative genotoxic potency of arsenic and its methylated metabolites
59. Comparative studies of chromosomal aberration induced by trivalent and pentavalent arsenic
60. Occupational and Environmental risks in and around a smelter in northern Sweden. VII. Reanalysis and follow-up of chromosomal aberrations in workers exposed to arsenic
61. Is the genotoxic effect of arsenic mediated by oxygen free radicals?
62. Occupational and Environmental risks in and around a smelter in northern Sweden. II. Chromosomal aberrations in workers exposed to arsenic
63. Chromosome aberrations in cultured human lymphocytes exposed to trivalent and pentavalent arsenic
64. Lymphocyte proliferation kinetics and genotoxic findings in a pilot study on individuals chronically exposed to arsenic in Mexico
65. Induction of chromosomal aberrations in cultured human fibroblasts by inorganic and organic arsenic compounds and the different roles of glutathione in such induction
66. Monomethylarsonous acid (MMA(III)) is more toxic than arsenite in Chang human hepatocytes
67. Arsenic in aquatic organisms: A review, emphasizing chemical speciation
68. Disruption of microtubule assembly and spindle formation as a mechanism for the induction of aneuploid cells by sodium arsenite and vanadium pentoxide
69. Variation in arsenic-induced sister chromatid exchange in human lymphocytes and lymphoblastoid cell lines
70. Absence of arsenite mutagenicity in E. coli and Chinese hamster cells
71. Expression cloning for arsenite-resistance resulted in isolation of tumor-suppressor fau cDNA: Possible involvement of the ubiquitin system in arsenic carcinogenesis
72. Dietary garlic extract in modifying clastogenic effects of inorganic arsenic in mice: Two-generation studies
73. Implications of arsenic genotoxicity for dose response of carcinogenic effects
74. Heterogeneity of the DNA damage provoked by antimony and arsenic
75. Mutational spectrum in the p53 gene in bladder tumors from the endemic area of black foot disease in Taiwan
76. Mechanisms of arsenic carcinogenicity: Genetic or epigenetic mechanisms?
77. Arsenic mediates cell proliferation and gene expression in the bladder epithelium: Association with activating protein-1 transactivation
78. Disposition of 14C and/or 74As-cacodylic acid in rats after intravenous, intratracheal, or peroral administration
79. Comparative toxicity or trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells
80. A chemical hypothesis for arsenic methylation in mammals
81. Effect of hepatic methyl donor status on urinary excretion and DNA damage in B6C3F1 mice treated with sodium arsenite
82. Arsenite as the probable active species in the human carcinogenicity of arsenic: Mouse micronucleus assays on Na and K arsenite, orpiment, and Fowler's solution
83. Tissue distribution and retention of 74As-dimethylarsinic acid in mice and rats
84. Chromosome studies in human subjects chronically exposed to arsenic in drinking water
85. Studies of cytogenetic effects of sodium arsenicals on mammalian cells in vitro
86. Active oxygen species are involved in the induction of micronuclei by arsenite in XRS-5 cells
87. Glutathione peroxidase and catalase modulate the genotoxicity of arsenite
88. Increased micronuclei in exfoliated bladder cells of individuals who chronically ingest arsenic-contaminated water in Nevada
89. Specificity of arsenite in potentiating cytogenetic damage induced by the DNA crosslinking agent diepoxybutane
90. Inhibition of poly(ADP-ribose) polymerase by arsenite
91. Possible carcinogenic potential of dimethylarsinic acid as assessed in rat in vivo models: A review
92. Dimethylated arsenics induce DNA strand breaks in lung via the production of active oxygen in mice
93. Exposure to dimethylarsinic acid, a main metabolite of inorganic arsenics, strongly promotes tumorigenesis initiated by 4-nitroquinoline-1-oxide in the lungs of mice
94. Induction of lung-specific DNA damage by metabolically methylated arsenics via the production of free radicals
95. Crosslink formation between DNA and nuclear proteins by in vivo and in vitro exposure of cells to dimethyl-arsinic acid
96. Metabolism and excretion of orally administered dimethylarsinic acid in the hamster
97. Sodium arsenite disturbs mitosis and induces chromosome loss in human fibroblasts
98. The urinary excretion of arsenic metabolites after a single oral administration of dimethyl-arsinic acid to rats
99. Association of arsenic-induced malignant transformation with DNA hypomethylation and aberrant gene expression