Tumor suppressor gene inactivation during cadmium-induced malignant transformation of human prostate cells correlates with overexpression of de Novo DNA methyltransferase

Environmental Health Perspectives

Volumn 115, Issue 10, 2007, Pages 1454-1459

  Benbrahim Tallaa, Lamia ^a   Waterland, Robert A ^b   Dill, Anna L ^a   Webber, Mukta M ^c   Waalkes, Michael P ^a  

^a National Cancer Institute   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

Cadmium; Carcinogenesis; DNA methylation; DNMT3b; p16; Prostate; RASSF1A

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; CADMIUM; DNA METHYLTRANSFERASE 3B; GENOMIC DNA; PROCAINAMIDE; PROTEIN P16; RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A;

ARTICLE; CONTROLLED STUDY; DEMETHYLATION; ENZYME ACTIVITY; EPITHELIUM CELL; GENE EXPRESSION; GENE INACTIVATION; GENE OVEREXPRESSION; GENE SILENCING; GENETIC CORRELATION; HUMAN; HUMAN CELL; MALIGNANT TRANSFORMATION; PRIORITY JOURNAL; PROMOTER REGION; PROSTATE CANCER; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR GENE; WESTERN BLOTTING;

CADMIUM; CARCINOGENS, ENVIRONMENTAL; CASE-CONTROL STUDIES; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; EPITHELIAL CELLS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENES, TUMOR SUPPRESSOR; HUMANS; MALE; PROSTATE; UP-REGULATION;

EID: 35448974533     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.10207     Document Type: Article

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