Analysis of aberrant methylation in DNA repair genes during malignant transformation of human bronchial epithelial cells induced by cadmium

Toxicological Sciences

Volumn 125, Issue 2, 2012, Pages 412-417

  Zhou, Zhi heng ^a   Lei, Yi xiong ^a   Wang, Cai xia ^b  

^a GUANGZHOU MEDICAL UNIVERSITY   (China)

^b First Hospital of Guangzhou   (China)

Author keywords

5 aza 2' deoxycytidine; DNA methylation; DNA repair genes; Human bronchial epithelial cells (16HBE)

Indexed keywords

BETA ACTIN; CADMIUM; DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3A; EXCISION REPAIR CROSS COMPLEMENTING PROTEIN 1; MESSENGER RNA; PROTEIN MSH2; XRCC1 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DNA METHYLATION; DNA REPAIR; EPIGENETICS; EPITHELIUM CELL; GENE OVEREXPRESSION; GENE SILENCING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; PROMOTER REGION; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

MUS MUSCULUS;

EID: 84862909045     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfr320     Document Type: Article

References (38)

1. Balaghi, M., and Wagner, C. (1993). DNA methylation in folate deficiency: Use of CpG methylase. Biochem. Biophys. Res. Commun. 93, 1184-1190.
2. Baylin, S. B., Herman, J. G., Graff, J. R., Vertino, P. M., and Issa, J. P. (1998). Alterations in DNA methylation: A fundamental aspect of neoplasia. Adv. Cancer Res. 72, 141-196.
3. Baylin, S. B., and Ohm, J. E. (2006). Epigenetic gene silencing in cancer-A mechanism for early oncogenic pathway addiction? Nat. Rev. Cancer 6, 107-116.
4. Belinsky, S. A., Nikula, K. J., Baylin, S. B., and Issa, J. P. (1996). Increased cytosine DNA-methyltransferase activity is target-cell-specific and an early event in lung cancer. Proc. Natl. Acad. Sci. U.S.A. 93, 4045-4050.
5. Benbrahim-Tallaa, L., Waterland, R. A., Dill, A. L., Webber, M. M., and Waalkes, M. P. (2007). Tumor suppressor gene inactivation during cadmium-induced malignant transformation of human prostate cells correlates with overexpression of de novo DNA methyltransferase. Environ. Health Perspect. 115, 1454-1459.
6. Brenner, C., and Fuks, F. (2006). DNA methyltransferases: Facts, clues, mysteries. Curr. Top. Microbiol. Immunol. 301, 45-66.
7. Calvisi, D. F., Ladu, S., Gorden, A., Farina, M., Lee, J. S., Conner, E. A., Schroeder, I., Factor, V. M., and Thorgeirsson, S. S. (2007). Mechanistic and prognostic significance of aberrant methylation in the molecular pathogenesis of human hepatocellular carcinoma. J. Clin. Invest. 117, 2713-2722.
8. Chen, T., Ueda, Y., Dodge, J. E., Wang, Z., and Li, E. (2003). Establishment and maintenance of genomic methylation patterns in mouse embryonic stem cells by Dnmt3a and Dnmt3b. Mol. Cell. Biol. 23, 5594-5605.
9. Choi, J. H., Park, S. H., Park, J., Park, B. G., Cha, S. J., Kong, K. H., Lee, K. H., and Park, A. J. (2007). Site-specific methylation of CpG nucleotides in the hTERT promoter region can control the expression of hTERT during malignant progression of colorectal carcinoma. Biochem. Biophys. Res. Commun. 361, 615-620.
10. Etoh, T., Kanai, Y., Ushijima, S., Nakagawa, T., Nakanishi, Y., Sasako, M., Kitano, S., and Hirohashi, S. (2004). Increased DNA methyltransferase 1 (DNMT1) protein expression correlates significantly with poorer tumor differentiation and frequent DNA hypermethylation of multiple CpG islands in gastric cancers. Am. J. Pathol. 164, 689-699.
11. Hake, S. B., Xiao, A., and Allis, C. D. (2007). Linking the epigenetic 'language' of covalent histone modifications to cancer. Br. J. Cancer 96(Suppl.), R31-R39.
12. Hart, B. A., Lee, C. H., Shukla, G. S., Shukla, A., Osier, M., Eneman, J. D., and Chiu, J. F. (1999). Characterization of cadmium-induced apoptosis in rat lung epithelial cells: Evidence for the participation of oxidant stress. Toxicology 133, 43-58.
13. Herceg, Z. (2007). Epigenetics and cancer: Towards an evaluation of the impact of environmental and dietary factors. Mutagenesis 22, 91-103.
14. International Agency for Research on Cancer (IARC). (1993). Beryllium, Cadmium, Mercury and Exposures in the Glass Manufacturing Industry, Vol. 58, pp. 119-238. International Agency for Research on Cancer, Lyon, France.
15. Jones, P. A., and Baylin, S. B. (2007). The epigenomics of cancer. Cell 128, 683-692.
16. Kasprzak, K. S. (2002). Oxidative DNA and protein damage in metal-induced toxicity and carcinogenesis. Free Radic. Biol. Med. 32, 958-967.
17. Kim, G. D., Ni, J., Kelesoglu, N., Roberts, R. J., and Pradhan, S. (2002). Cooperation and communication between the human maintenance and de novo DNA (cytosine-5) methyltransferases. EMBO J. 21, 4183-4195.
18. Klaassen, C. D., Liu, J., and Choudhuri, S. (1999). Metallothionein: An intracellular protein to protect against cadmium toxicity. Annu. Rev. Pharmacol. Toxicol. 39, 267-294.
19. Klein, G. (2005). Epigenetics: Surveillance team against cancer. Nature 434, 150.
20. Koyu, A., Gokcimen, A., Ozguner, F., Bayram, D. S., and Kocak, A. (2006). Evaluation of the effects of cadmium on rat liver. Mol. Cell. Biochem. 20, 1-5
21. Lei, Y. X., Wei, L., Wang, M., Wu, G. R., and Li, M. (2008). Malignant transformation and abnormal expression of eukaryotic initiation factor during human bronchial epithelial cells induced by cadmium chloride. Biomed. Environ. Sci. 21, 332-338.
22. McCabe, M. T., Low, J. A., Daignault, S., Imperiale, M. J., Wojno, K. J., and Day, M. L. (2006). Inhibition of DNA methyltransferase activity prevents tumorigenesis in a mouse model of prostate cancer. Cancer Res. 66, 385-392.
23. Misra, R. R., Smith, G. T., and Waalkes, M. P. (1998). Evaluation of the direct genotoxic potential of cadmium in four different rodent cell lines. Toxicology 126, 103-114.
24. Nordberg, G., Jin, T., Bernard, A., Fierens, S., Buchet, J. P., Ye, T., Kong, Q., and Wang, H. (2002). Low bone density and renal dysfunction following environmental cadmium exposure in China. Ambio 31, 478-481.
25. Okano, M., Bell, D. W., Haber, D. A., and Li, E. (1999). DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99, 247-257.
26. Pogribny, P., and James, S. J. (2002). De novo methylation of the p16INK4A gene in early preneoplastic liver and tumors induced by folate/methyl deficiency in rats. Cancer Lett. 187, 69-75.
27. Rhee, I., Bachman, K. E., Park, B. H., Jair, K. W., Yen, R. W., Schuebel, K. E., Cui, H., Feinberg, A. P., Lengauer, C., Kinzler, K. W., et al. (2002). DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Nature 416, 552-556.
28. Rhee, I., Jair, K. W., Yen, R. W., Lengauer, C., Herman, J. G., Kinzler, K. W., Vogelstein, B., Baylin, S. B., and Schuebel, K. E. (2000). CpG methylation is maintained in human cancer cells lacking DNMT1. Nature 404, 1003-1007.
29. Robert, M. F., Morin, S., Beaulieu, N., Gauthier, F., Chute, I. C., Barsalou, A., and MacLeod, A. R. (2003). DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells. Nat. Genet. 33, 61-65.
30. Satarug, S., Baker, J. R., Urbenjapol, S., Haswell-Elkins, M., Reilly, P. E. B., Williams, D. J., and Moore, M. R. (2003). A global perspective on cadmium pollution and toxicity in non-occupationally exposed population. Toxicol. Lett. 137, 65-83.
31. Schöpfer, J., Drasch, G., and Schrauzer, G. N. (2010). Selenium and cadmium levels and ratios in prostates, livers, and kidneys of nonsmokers and smokers. Biol. Trace Elem. Res. 134, 180-187.
32. Shimizu, K., Onishi, M., Sugata, E., Sokuza, Y., Mori, C., Nishikawa, T., Honoki, K., and Tsujiuchi, T. (2007). Disturbance of DNA methylation patterns in the early phase of hepatocarcinogenesis induced by a cholinedeficient l-amino acid-defined diet in rats. Cancer Sci. 98, 1318-1322.
33. Sibani, S., Melnyk, S., Pogribny, I. P., Wang, W., Hiou-Tim, F., Deng, L., Trasler, J., James, S. J., and Rozen, R. (2002). Studies of methionine cycle intermediates (SAM, SAH), DNA methylation and the impact of folate deficiency on tumor numbers in Min mice. Carcinogenesis 23, 61-65.
34. Suzuki, M., Sunaga, N., Shames, D. S., Toyooka, S., Gazdar, A. F., and Minna, J. D. (2004). RNA interference-mediated knockdown of DNA methyltransferase 1 leads to promoter demethylation and gene reexpression in human lung and breast cancer cells. Cancer Res. 64, 3137-3143.
35. Swaddiwudhipong, W., Mahasakpan, P., Funkhiew, T., and Limpatanachote, P. (2010). Changes in cadmium exposure among persons living in cadmiumcontaminated areas in northwestern Thailand: A five-year follow-up. J. Med. Assoc. Thail. 93, 1217-1222.
36. Waalkes, M. P. (2003). Cadmium carcinogenesis. Mutat. Res. 533, 107-120.
37. Waalkes, M. P., and Poirier, L. A. (1984). In vitro cadmium-DNA interactions: Cooperativity of cadmium binding and competitive antagonism by calcium. Toxicol. Appl. Pharmacol. 75, 539-546.
38. Wu, 1/25/2012J., Issa, J. P., Herman, J., Bassett, D. E., Jr., Nelkin, B. D., and Baylin, S. B. (1993). Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells. Proc. Natl. Acad. Sci. U.S.A. 90, 8891-8895.