Effect of cadmium on cortisol production and 11β-hydroxysteroid dehydrogenase 2 expression by cultured human choriocarcinoma cells (JEG-3)

Toxicology in Vitro

Volumn 24, Issue 6, 2010, Pages 1532-1537

  Ronco, Ana Maria ^a   Llaguno, Emanuel ^a   Epuñan, Maria Jose ^a   Llanos, Miguel N ^a  

^a UNIVERSITY OF CHILE   (Chile)

Author keywords

11 HSD2; Cadmium; Cortisol; DNA methylation; JEG 3

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 2; CADMIUM; HYDROCORTISONE;

ARTICLE; CELL CULTURE; CELL VIABILITY; CHORIOCARCINOMA; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HYDROCORTISONE RELEASE; METHYLATION; PROMOTER REGION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RADIOIMMUNOASSAY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2; CADMIUM COMPOUNDS; CELL LINE, TUMOR; CELL SURVIVAL; CHORIOCARCINOMA; DNA METHYLATION; ENVIRONMENTAL POLLUTANTS; GENE EXPRESSION; GENE SILENCING; HUMANS; HYDROCORTISONE; RNA, MESSENGER;

EID: 77956174214     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2010.07.003     Document Type: Article

References (39)

1. Alikhani-Koopaei R., Fouladkou F., Frey F.J., Frey B.M. Epigenetic regulation of 11ß-hydroxysteroid dehydrogenase type 2 expression. Journal Clinical Investigation 2004, 114:1146-1157.
2. Baccarelli A., Bollati V. Epigenetics and environmental chemicals. Current Opinion in Pediatrics 2009, 21:243-251.
3. Baserga M., Kaur R., Hale M.A., Bares A., Yu X., Callaway C.W., McKnight R.A., Lane R.H. Fetal growth restriction alters transcription factor binding and epigenetic mechanisms of renal 11β-hydroxysteroid dehydrogenase type 2 in a sex-specific manner. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology (April 28, 2010) 2010, 10.1152/ajpregu.00122.2010.
4. Bhattacharyya M.H., Wilson A.K., Rajan S.S., Jonah M. Biochemical pathways in cadmium toxicity. Molecular Biology and Toxicology of Metals 2000, 1-74. Taylor and Francis, London. R.K. Zalup, J. Joropatnick (Eds.).
5. Burton P.J., Waddell B.J. Dual function of 11 beta-hydroxysteroid dehydrogenase in placenta: modulating placental glucocorticoid passage and local steroid action. Biology of Reproduction 1999, 60:234-240.
6. Clark S.J., Frommer M. Laboratory Methods for the Detection of Mutations and Polymorphisms in DNA 1997, 151-162. CRC Press, Boca Raton, FL. T. GR (Ed.).
7. Esteller M., Herman J.G. Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours. Journal of Pathology 2002, 196:1-7.
8. Feinberg A.P., Vogelstein B. Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature 1983, 301:89-92.
9. Friso S., Pizzolo F., Choi S.-W., Guarini P., Castagna A., Ravagnani V., Carletto A., Pattini P., Corrocher R., Olivieri O. Epigenetic control of 11 beta-hydroxysteroid dehydrogenase 2 gene promoter is related to human hypertension. Atherosclerosis 2008, 199:323-327.
10. Goodman J.I., Watson R.E. Altered DNA methylation: a secondary mechanism involved in carcinogenesis. Annual Review of Pharmacology and Toxicology 2002, 42:501-525.
11. Hardy D.B., Pereria L.E., Yang K. Prostaglandins and leukotriene B4 are potent inhibitors of 11(-hydroxysteroid dehydrogenase type 2 activity in human choriocarcinoma JEG-3 cells. Biology of Reproduction 1999, 61:40-45.
12. Henson M.C., Chedrese P.J. Endocrine disruption by cadmium, a common environmental toxicant with paradoxical effects on reproduction. Experimental Biology and Medicine 2004, 229:383-392.
13. Herman, J.G., Graff, J.R., Myohanen, S., Nelkin, B.D., Baylin, S.B., 1996. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proceeding of the National Academy of Sciences, USA 93, 9821-9826.
14. Hirsch S., Ronco A.M., Guerrero-Bosagna C., de la Maza M.P., Leiva L., Barrera G., Llanos M., Alliende M.A., Silva F., Bunout D. Methylation status in healthy subjects with normal and high serum folate concentration. Nutrition 2008, 24:1103-1109.
15. Jiang G., Xub L., Songa S., Zhua C., Wu K., Zhang L., Wu L. Effects of long-term low-dose cadmium exposure on genomic DNA methylation in human embryo lung fibroblast cells. Toxicology 2008, 244:49-55.
16. Kajantie E., Feldt K., Räikkönen K., Phillips D.I., Osmond C., Heinonen K., Pesonen A.K., Andersson S., Barker D.J., Eriksson J.G. Body size at birth predicts hypothalamic-pituitary-adrenal axis response to psychosocial stress at age 60 to 70 years. Journal Clinical Endocrinology and Metabolism 2007, 92:4094-4100.
17. Krozowski Z., MaGuire J.A., Stein-Oakley A.N., Dowling J., Smith R.E., Andrews R.K. Immunohistochemical localization of the 11 beta-hydroxysteroid dehydrogenase type II enzyme in human kidney and placenta. Journal Clinical Endocrinology and Metabolism 1995, 80:2203-2209.
18. Lee Y.W., Broday L., Costa M. Effects of nickel on DNA methyltransferase activity and genomic DNA methylation levels. Mutation Research 1998, 415:213-218.
19. Llanos M.N., Ronco A.M. Fetal growth restriction is related to placental levels of cadmium, lead and arsenic but not with antioxidant activities. Reproductive Toxicology 2009, 27:88-92.
20. Mc Ternan C.L., Draper N., Nicholson H., Chalder S.M., Driver P., Hewison M., Kilby M.D., Stewart P.M. Reduced placental 11 beta-hydroxysteroid dehydrogenase type 2 mRNA levels in human pregnancies complicated by intrauterine growth restriction: an analysis of possible mechanisms. Journal Clinical Endocrinology and Metabolism 2001, 86:4979-4983.
21. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. Journal of Immunological Methods 1983, 65:55-63.
22. Murphy V.E., Zakar T., Smith R., Giles W.B., Gibson P.G., Clifton V.L. Reduced 11 beta-hydroxysteroid dehydrogenase type 2 activity is associated with decreased birth weight centile in pregnancies complicated by asthma. Journal Clinical Endocrinology and Metabolism 2002, 87:1660-1668.
23. Ozanne S.E., Constancia M. Mechanisms of disease: the developmental origins of disease and the role of the epigenotype. Nature clinical practice. Endocrinology and Metabolism 2007, 3:539-546.
24. Pepe G.J., Burch M.G., Albrecht E.D. Expression of the 11beta-hydroxysteroid dehydrogenase types 1 and 2 proteins in human and baboon placental syncytiotrophoblast. Placenta 1999, 20:575-582.
25. Ronco A.M., Valdés K., Marcus D., Llanos M. The mechanism for lindane-induced inhibition of steroidogenesis in cultured rat Leydig cells. Toxicology 2001, 159:99-106.
26. Ronco A.M., Arguello G., Munoz L., Gras N., Llanos M. Metals content in placentas from moderate cigarette consumers. Correlation with newborn birth weight. Biometals 2005, 18:233-241.
27. Ronco A.M., Urrutia M., Montenegro M., Llanos M.N. Cadmium exposure during pregnancy reduces birth weight and increases maternal and foetal glucocorticoids. Toxicology Letters 2009, 188:186-191.
28. Seckl J.R., Holmes M.C. Mechanisms of disease: glucocorticoids, their placentalmetabolism and fetal programming of adult pathophysiology. Nature clinical practice. Endocrinology and Metabolism 2007, 3:479-488.
29. Stewart P.M., Rogerson F.M., Mason J.I. Type 2 11 beta-hydroxysteroid dehydrogenase messenger ribonucleic acid and activity in human placenta and fetal membranes: its relationship to birth weight and putative role in fetal adrenal steroidogenesis. Journal Clinical Endocrinology and Metabolism 1995, 80:885-890.
30. Szyf M. The early life environment and the epigenome. Biochimica et Biophysica Acta 2009, 1790:878-885.
31. Takiguchi M., Achanzar W.E., Qu W., Li G., Waalkes M.P. Effects of cadmium on DNA-(Cytosine-5) methyltransferase activity and DNA methylation status during cadmium-induced cellular transformation. Experimental Cell Research 2003, 286:355-365.
32. Tate P.H., Bird A.P. Effects of DNA methylation on DNA-binding proteins and gene expression. Current Opinion in Genetics and Development 1993, 3:226-231.
33. Tremblay J., Hardy D.B., Pereira L.E., Yang K. Retinoic acid stimulates the expression of 11b-hydroxysteroid dehydrogenase type 2 in human choriocarcinoma JEG-3 cells. Biology of Reproduction 1999, 60:541-545.
34. Waalkes M.P. Cadmium carcinogenesis in review. Journal of Inorganic Biochemistry 2000, 79:241-244.
35. Waisberg M., Joseph P., Hale B., Beyersmann D. Molecular and cellular mechanisms of cadmium carcinogenesis. Toxicology 2003, 192:95-117.
36. Warnecke P., Clark S. DNA methylation profile of the mouse skeletal alpha-actin promoter during development and differentiation. Molecular and Cellular Biology 1999, 19:164-172.
37. Yang K. Placental 11 beta-hydroxysteroid dehydrogenase: barrier to maternal glucocorticoids. Reviews of Reproduction 1997, 2:129-132.
38. Yang K., Julan L., Rubio F., Sharma A., Guan H. Cadmium reduces 11(-hydroxysteroid dehydrogenase type 2 activity and expression in human placental trophoblast cells. American Journal of Physiology Endocrinology and Metabolism 2006, 290:E135-E142.
39. Zhao, C.K., Young, M.R., Diwan, B.A., Coogan, T.P., Waalkes, M.P., 1997. Association of arsenic-induced malignant transformation with DNA hypomethylation and aberrant gene expression. Proceeding of the National Academy of Sciences, USA 94, 10907-10912.