-
1
-
-
84859778293
-
MTOR signaling in growth control and disease
-
Laplante, M. and Sabatini, D.M. (2012) mTOR signaling in growth control and disease. Cell 149, 274-293
-
(2012)
Cell
, vol.149
, pp. 274-293
-
-
Laplante, M.1
Sabatini, D.M.2
-
2
-
-
84879943324
-
Evolutionarily conserved regulation of TOR signalling
-
Takahara, T. and Maeda, T. (2013) Evolutionarily conserved regulation of TOR signalling. J. Biochem. 154, 1-10
-
(2013)
J. Biochem.
, vol.154
, pp. 1-10
-
-
Takahara, T.1
Maeda, T.2
-
3
-
-
32044465506
-
TOR signaling in growth and metabolism
-
Wullschleger, S., Loewith, R., and Hall, M.N. (2006) TOR signaling in growth and metabolism. Cell 124, 471-484
-
(2006)
Cell
, vol.124
, pp. 471-484
-
-
Wullschleger, S.1
Loewith, R.2
Hall, M.N.3
-
4
-
-
34347220473
-
Defining the role of mTOR in cancer
-
Guertin, D.A. and Sabatini, D.M. (2007) Defining the role of mTOR in cancer. Cancer Cell 12, 9-22
-
(2007)
Cancer Cell
, vol.12
, pp. 9-22
-
-
Guertin, D.A.1
Sabatini, D.M.2
-
5
-
-
84880709668
-
MTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin
-
Kang, S.A., Pacold, M.E., Cervantes, C.L., Lim, D., Lou, H.J., Ottina, K., Gray, N.S., Turk, B.E., Yaffe, M.B., and Sabatini, D.M. (2013) mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin. Science 341, 1236566
-
(2013)
Science
, vol.341
, pp. 1236566
-
-
Kang, S.A.1
Pacold, M.E.2
Cervantes, C.L.3
Lim, D.4
Lou, H.J.5
Ottina, K.6
Gray, N.S.7
Turk, B.E.8
Yaffe, M.B.9
Sabatini, D.M.10
-
6
-
-
0037623417
-
GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR
-
Kim, D.H., Sarbassov, D.D., Ali, S.M., Latek, R.R., Guntur, K.V., Erdjument-Bromage, H., Tempst, P., and Sabatini, D.M. (2003) GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Mol. Cell 11, 895-904
-
(2003)
Mol. Cell
, vol.11
, pp. 895-904
-
-
Kim, D.H.1
Sarbassov, D.D.2
Ali, S.M.3
Latek, R.R.4
Guntur, K.V.5
Erdjument-Bromage, H.6
Tempst, P.7
Sabatini, D.M.8
-
7
-
-
67349241955
-
DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival
-
Peterson, T.R., Laplante, M., Thoreen, C.C., Sancak, Y., Kang, S.A., Kuehl, W.M., Gray, N.S., and Sabatini, D.M. (2009) DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. Cell 137, 873-886
-
(2009)
Cell
, vol.137
, pp. 873-886
-
-
Peterson, T.R.1
Laplante, M.2
Thoreen, C.C.3
Sancak, Y.4
Kang, S.A.5
Kuehl, W.M.6
Gray, N.S.7
Sabatini, D.M.8
-
8
-
-
77953800576
-
Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly
-
Kaizuka, T., Hara, T., Oshiro, N., Kikkawa, U., Yonezawa, K., Takehana, K., Iemura, S., Natsume, T., and Mizushima, N. (2010) Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly. J. Biol. Chem. 285, 20109-20116
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 20109-20116
-
-
Kaizuka, T.1
Hara, T.2
Oshiro, N.3
Kikkawa, U.4
Yonezawa, K.5
Takehana, K.6
Iemura, S.7
Natsume, T.8
Mizushima, N.9
-
9
-
-
0037178781
-
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
-
Hara, K., Maruki, Y., Long, X., Yoshino, K., Oshiro, N., Hidayat, S., Tokunaga, C., Avruch, J., and Yonezawa, K. (2002) Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell 110, 177-189
-
(2002)
Cell
, vol.110
, pp. 177-189
-
-
Hara, K.1
Maruki, Y.2
Long, X.3
Yoshino, K.4
Oshiro, N.5
Hidayat, S.6
Tokunaga, C.7
Avruch, J.8
Yonezawa, K.9
-
10
-
-
0037178786
-
MTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
-
Kim, D.H., Sarbassov, D.D., Ali, S.M., King, J.E., Latek, R.R., Erdjument-Bromage, H., Tempst, P., and Sabatini, D.M. (2002) mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 110, 163-175
-
(2002)
Cell
, vol.110
, pp. 163-175
-
-
Kim, D.H.1
Sarbassov, D.D.2
Ali, S.M.3
King, J.E.4
Latek, R.R.5
Erdjument-Bromage, H.6
Tempst, P.7
Sabatini, D.M.8
-
11
-
-
33947264077
-
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
-
Sancak, Y., Thoreen, C.C., Peterson, T.R., Lindquist, R.A., Kang, S.A., Spooner, E., Carr, S.A., and Sabatini, D.M. (2007) PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase. Mol. Cell 25, 903-915
-
(2007)
Mol. Cell
, vol.25
, pp. 903-915
-
-
Sancak, Y.1
Thoreen, C.C.2
Peterson, T.R.3
Lindquist, R.A.4
Kang, S.A.5
Spooner, E.6
Carr, S.A.7
Sabatini, D.M.8
-
12
-
-
7944235758
-
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
-
Jacinto, E., Loewith, R., Schmidt, A., Lin, S., Ruegg, M.A., Hall, A., and Hall, M.N. (2004) Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat. Cell Biol. 6, 1122-1128
-
(2004)
Nat. Cell Biol.
, vol.6
, pp. 1122-1128
-
-
Jacinto, E.1
Loewith, R.2
Schmidt, A.3
Lin, S.4
Ruegg, M.A.5
Hall, A.6
Hall, M.N.7
-
13
-
-
3342895823
-
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
-
Sarbassov, D.D., Ali, S.M., Kim, D.H., Guertin, D.A., Latek, R.R., Erdjument-Bromage, H., Tempst, P., and Sabatini, D.M. (2004) Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr. Biol. 14, 1296-1302
-
(2004)
Curr. Biol.
, vol.14
, pp. 1296-1302
-
-
Sarbassov, D.D.1
Ali, S.M.2
Kim, D.H.3
Guertin, D.A.4
Latek, R.R.5
Erdjument-Bromage, H.6
Tempst, P.7
Sabatini, D.M.8
-
14
-
-
33749076673
-
SIN1/ MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity
-
Jacinto, E., Facchinetti, V., Liu, D., Soto, N., Wei, S., Jung, S.Y., Huang, Q., Qin, J., and Su, B. (2006) SIN1/ MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell 127, 125-137
-
(2006)
Cell
, vol.127
, pp. 125-137
-
-
Jacinto, E.1
Facchinetti, V.2
Liu, D.3
Soto, N.4
Wei, S.5
Jung, S.Y.6
Huang, Q.7
Qin, J.8
Su, B.9
-
15
-
-
34347210090
-
Identification of protor as a novel rictor-binding component of mTOR complex-2
-
Pearce, L.R., Huang, X., Boudeau, J., Pawlowski, R., Wullschleger, S., Deak, M., Ibrahim, A.F., Gourlay, R., Magnuson, M.A., and Alessi, D.R. (2007) Identification of protor as a novel rictor-binding component of mTOR complex-2. Biochem. J. 405, 513-522
-
(2007)
Biochem. J.
, vol.405
, pp. 513-522
-
-
Pearce, L.R.1
Huang, X.2
Boudeau, J.3
Pawlowski, R.4
Wullschleger, S.5
Deak, M.6
Ibrahim, A.F.7
Gourlay, R.8
Magnuson, M.A.9
Alessi, D.R.10
-
16
-
-
43249124698
-
PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis
-
Thedieck, K., Polak, P., Kim, M.L., Molle, K.D., Cohen, A., Jeno, P., Arrieumerlou, C., and Hall, M.N. (2007) PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis. PLoS One 2, e1217
-
(2007)
PLoS One
, vol.2
-
-
Thedieck, K.1
Polak, P.2
Kim, M.L.3
Molle, K.D.4
Cohen, A.5
Jeno, P.6
Arrieumerlou, C.7
Hall, M.N.8
-
17
-
-
84860527756
-
A unifying model for mTORC1-mediated regulation of mRNA translation
-
Thoreen, C.C., Chantranupong, L., Keys, H.R., Wang, T., Gray, N.S., and Sabatini, D.M. (2012) A unifying model for mTORC1-mediated regulation of mRNA translation. Nature 485, 109-113
-
(2012)
Nature
, vol.485
, pp. 109-113
-
-
Thoreen, C.C.1
Chantranupong, L.2
Keys, H.R.3
Wang, T.4
Gray, N.S.5
Sabatini, D.M.6
-
18
-
-
66449083078
-
ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy
-
Ganley, I.G., Lam du, H., Wang, J., Ding, X., Chen, S., and Jiang, X. (2009) ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy. J Biol. Chem. 284, 12297-12305
-
(2009)
J Biol. Chem.
, vol.284
, pp. 12297-12305
-
-
Ganley, I.G.1
Lam Du, H.2
Wang, J.3
Ding, X.4
Chen, S.5
Jiang, X.6
-
19
-
-
65249119430
-
Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy
-
Hosokawa, N., Hara, T., Kaizuka, T., Kishi, C., Takamura, A., Miura, Y., Iemura, S., Natsume, T., Takehana, K., Yamada, N., Guan, J.L., Oshiro, N., and Mizushima, N. (2009) Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. Mol. Biol. Cell 20, 1981-1991
-
(2009)
Mol. Biol. Cell
, vol.20
, pp. 1981-1991
-
-
Hosokawa, N.1
Hara, T.2
Kaizuka, T.3
Kishi, C.4
Takamura, A.5
Miura, Y.6
Iemura, S.7
Natsume, T.8
Takehana, K.9
Yamada, N.10
Guan, J.L.11
Oshiro, N.12
Mizushima, N.13
-
20
-
-
79961165137
-
MTOR complex 1 regulates lipin 1 localization to control the SREBP pathway
-
Peterson, T.R., Sengupta, S.S., Harris, T.E., Carmack, A.E., Kang, S.A., Balderas, E., Guertin, D.A., Madden, K.L., Carpenter, A.E., Finck, B.N., and Sabatini, D.M. (2011) mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway. Cell 146, 408-420
-
(2011)
Cell
, vol.146
, pp. 408-420
-
-
Peterson, T.R.1
Sengupta, S.S.2
Harris, T.E.3
Carmack, A.E.4
Kang, S.A.5
Balderas, E.6
Guertin, D.A.7
Madden, K.L.8
Carpenter, A.E.9
Finck, B.N.10
Sabatini, D.M.11
-
21
-
-
79958696694
-
The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling
-
Hsu, P.P., Kang, S.A., Rameseder, J., Zhang, Y., Ottina, K.A., Lim, D., Peterson, T.R., Choi, Y., Gray, N.S., Yaffe, M.B., Marto, J.A., and Sabatini, D.M. (2011) The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332, 1317-1322
-
(2011)
Science
, vol.332
, pp. 1317-1322
-
-
Hsu, P.P.1
Kang, S.A.2
Rameseder, J.3
Zhang, Y.4
Ottina, K.A.5
Lim, D.6
Peterson, T.R.7
Choi, Y.8
Gray, N.S.9
Yaffe, M.B.10
Marto, J.A.11
Sabatini, D.M.12
-
22
-
-
79958696336
-
Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling
-
Yu, Y., Yoon, S.O., Poulogiannis, G., Yang, Q., Ma, X.M., Villen, J., Kubica, N., Hoffman, G.R., Cantley, L.C., Gygi, S.P., and Blenis, J. (2011) Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 332, 1322-1326
-
(2011)
Science
, vol.332
, pp. 1322-1326
-
-
Yu, Y.1
Yoon, S.O.2
Poulogiannis, G.3
Yang, Q.4
Ma, X.M.5
Villen, J.6
Kubica, N.7
Hoffman, G.R.8
Cantley, L.C.9
Gygi, S.P.10
Blenis, J.11
-
23
-
-
28844434558
-
MTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes
-
Hresko, R.C. and Mueckler, M. (2005) mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes. J. Biol. Chem. 280, 40406-40416
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 40406-40416
-
-
Hresko, R.C.1
Mueckler, M.2
-
24
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
Sarbassov, D.D., Guertin, D.A., Ali, S.M., and Sabatini, D.M. (2005) Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307, 1098-1101
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
25
-
-
58649092475
-
MTOR complex 2 (mTORC2) controls hydrophobic motifphosphorylation and activation of serum-and glucocorticoid-induced protein kinase 1 (SGK1)
-
Garcia-Martinez, J.M. and Alessi, D.R. (2008) mTOR complex 2 (mTORC2) controls hydrophobic motifphosphorylation and activation of serum-and glucocorticoid-induced protein kinase 1 (SGK1). Biochem. J. 416, 375-385
-
(2008)
Biochem. J.
, vol.416
, pp. 375-385
-
-
Garcia-Martinez, J.M.1
Alessi, D.R.2
-
26
-
-
77951768486
-
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
-
Sancak, Y., Bar-Peled, L., Zoncu, R., Markhard, A.L., Nada, S., and Sabatini, D.M. (2010) Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell 141, 290-303
-
(2010)
Cell
, vol.141
, pp. 290-303
-
-
Sancak, Y.1
Bar-Peled, L.2
Zoncu, R.3
Markhard, A.L.4
Nada, S.5
Sabatini, D.M.6
-
27
-
-
45849105156
-
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
-
Sancak, Y., Peterson, T.R., Shaul, Y.D., Lindquist, R.A., Thoreen, C.C., Bar-Peled, L., and Sabatini, D.M. (2008) The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science 320, 1496-1501
-
(2008)
Science
, vol.320
, pp. 1496-1501
-
-
Sancak, Y.1
Peterson, T.R.2
Shaul, Y.D.3
Lindquist, R.A.4
Thoreen, C.C.5
Bar-Peled, L.6
Sabatini, D.M.7
-
28
-
-
80555143078
-
MTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase
-
Zoncu, R., Bar-Peled, L., Efeyan, A., Wang, S., Sancak, Y., and Sabatini, D.M. (2011) mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase. Science 334, 678-683
-
(2011)
Science
, vol.334
, pp. 678-683
-
-
Zoncu, R.1
Bar-Peled, L.2
Efeyan, A.3
Wang, S.4
Sancak, Y.5
Sabatini, D.M.6
-
29
-
-
84894212463
-
Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2
-
Demetriades, C., Doumpas, N., and Teleman, A.A. (2014) Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2. Cell 156, 786-799
-
(2014)
Cell
, vol.156
, pp. 786-799
-
-
Demetriades, C.1
Doumpas, N.2
Teleman, A.A.3
-
30
-
-
84894114029
-
Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome
-
Menon, S., Dibble, C.C., Talbott, G., Hoxhaj, G., Valvezan, A.J., Takahashi, H., Cantley, L.C., and Manning, B.D. (2014) Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome. Cell 156, 771-785
-
(2014)
Cell
, vol.156
, pp. 771-785
-
-
Menon, S.1
Dibble, C.C.2
Talbott, G.3
Hoxhaj, G.4
Valvezan, A.J.5
Takahashi, H.6
Cantley, L.C.7
Manning, B.D.8
-
31
-
-
0028360374
-
A mammalian protein targeted by G1-arresting rapamycin-receptor complex
-
Brown, E.J., Albers, M.W., Shin, T.B., Ichikawa, K., Keith, C.T., Lane, W.S., and Schreiber, S.L. (1994) A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature 369, 756-758
-
(1994)
Nature
, vol.369
, pp. 756-758
-
-
Brown, E.J.1
Albers, M.W.2
Shin, T.B.3
Ichikawa, K.4
Keith, C.T.5
Lane, W.S.6
Schreiber, S.L.7
-
32
-
-
0028239893
-
RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs
-
Sabatini, D.M., Erdjument-Bromage, H., Lui, M., Tempst, P., and Snyder, S.H. (1994) RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell 78, 35-43
-
(1994)
Cell
, vol.78
, pp. 35-43
-
-
Sabatini, D.M.1
Erdjument-Bromage, H.2
Lui, M.3
Tempst, P.4
Snyder, S.H.5
-
33
-
-
0028950217
-
Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells
-
Sabers, C.J., Martin, M.M., Brunn, G.J., Williams, J.M., Dumont, F.J., Wiederrecht, G., and Abraham, R.T. (1995) Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells. J. Biol. Chem. 270, 815-822
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 815-822
-
-
Sabers, C.J.1
Martin, M.M.2
Brunn, G.J.3
Williams, J.M.4
Dumont, F.J.5
Wiederrecht, G.6
Abraham, R.T.7
-
34
-
-
0026748870
-
Cyclosporin A FK-506, and rapamycin: Pharmacologic probes of lymphocyte signal transduction
-
Sigal, N.H. and Dumont, F.J. (1992) Cyclosporin A, FK-506, and rapamycin: pharmacologic probes of lymphocyte signal transduction. Annu. Rev. Immunol. 10, 519-560
-
(1992)
Annu. Rev. Immunol.
, vol.10
, pp. 519-560
-
-
Sigal, N.H.1
Dumont, F.J.2
-
35
-
-
84859117806
-
Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity
-
Lamming, D.W., Ye, L., Katajisto, P., Goncalves, M.D., Saitoh, M., Stevens, D.M., Davis, J.G., Salmon, A.B., Richardson, A., Ahima, R.S., Guertin, D.A., Sabatini, D.M., and Baur, J.A. (2012) Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science 335, 1638-1643
-
(2012)
Science
, vol.335
, pp. 1638-1643
-
-
Lamming, D.W.1
Ye, L.2
Katajisto, P.3
Goncalves, M.D.4
Saitoh, M.5
Stevens, D.M.6
Davis, J.G.7
Salmon, A.B.8
Richardson, A.9
Ahima, R.S.10
Guertin, D.A.11
Sabatini, D.M.12
Baur, J.A.13
-
36
-
-
33646023695
-
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
-
Sarbassov, D.D., Ali, S.M., Sengupta, S., Sheen, J.H., Hsu, P.P., Bagley, A.F., Markhard, A.L., and Sabatini, D.M. (2006) Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB, Mol. Cell 22, 159-168
-
(2006)
Mol. Cell
, vol.22
, pp. 159-168
-
-
Sarbassov, D.D.1
Ali, S.M.2
Sengupta, S.3
Sheen, J.H.4
Hsu, P.P.5
Bagley, A.F.6
Markhard, A.L.7
Sabatini, D.M.8
-
37
-
-
33646376411
-
Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
-
Yilmaz, O.H., Valdez, R., Theisen, B.K., Guo, W., Ferguson, D.O., Wu, H., and Morrison, S.J. (2006) Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature 441, 475-482
-
(2006)
Nature
, vol.441
, pp. 475-482
-
-
Yilmaz, O.H.1
Valdez, R.2
Theisen, B.K.3
Guo, W.4
Ferguson, D.O.5
Wu, H.6
Morrison, S.J.7
-
38
-
-
78049496814
-
MTOR activation induces tumor suppressors that inhibit leukemogenesis and deplete hematopoietic stem cells after Pten deletion
-
Lee, J.Y., Nakada, D., Yilmaz, O.H., Tothova, Z., Joseph, N.M., Lim, M.S., Gilliland, D.G., and Morrison, S.J. (2010) mTOR activation induces tumor suppressors that inhibit leukemogenesis and deplete hematopoietic stem cells after Pten deletion. Cell Stem Cell 7, 593-605
-
(2010)
Cell Stem Cell
, vol.7
, pp. 593-605
-
-
Lee, J.Y.1
Nakada, D.2
Yilmaz, O.H.3
Tothova, Z.4
Joseph, N.M.5
Lim, M.S.6
Gilliland, D.G.7
Morrison, S.J.8
-
39
-
-
70350729488
-
Overexpression of Rheb2 enhances mouse hematopoietic progenitor cell growth while impairing stem cell repopulation
-
Campbell, T.B., Basu, S., Hangoc, G., Tao, W., and Broxmeyer, H.E. (2009) Overexpression of Rheb2 enhances mouse hematopoietic progenitor cell growth while impairing stem cell repopulation. Blood 114, 3392-3401
-
(2009)
Blood
, vol.114
, pp. 3392-3401
-
-
Campbell, T.B.1
Basu, S.2
Hangoc, G.3
Tao, W.4
Broxmeyer, H.E.5
-
40
-
-
53349091768
-
TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species
-
Chen, C., Liu, Y., Liu, R., Ikenoue, T., Guan, K.L., Liu, Y., and Zheng, P. (2008) TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species. J. Exp. Med. 205, 2397-2408
-
(2008)
J. Exp. Med.
, vol.205
, pp. 2397-2408
-
-
Chen, C.1
Liu, Y.2
Liu, R.3
Ikenoue, T.4
Guan, K.L.5
Liu, Y.6
Zheng, P.7
-
41
-
-
58049196780
-
MTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization
-
Gan, B., Sahin, E., Jiang, S., Sanchez-Aguilera, A., Scott, K.L., Chin, L., Williams, D.A., Kwiatkowski, D.J., and DePinho, R.A. (2008) mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization. Proc. Natl Acad. Sci. U. S. A. 105, 19384-19389
-
(2008)
Proc. Natl Acad. Sci. U. S. A.
, vol.105
, pp. 19384-19389
-
-
Gan, B.1
Sahin, E.2
Jiang, S.3
Sanchez-Aguilera, A.4
Scott, K.L.5
Chin, L.6
Williams, D.A.7
Kwiatkowski, D.J.8
Depinho, R.A.9
-
42
-
-
84866082606
-
MTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis
-
Kalaitzidis, D., Sykes, S.M., Wang, Z., Punt, N., Tang, Y., Ragu, C., Sinha, A.U., Lane, S.W., Souza, A.L., Clish, C.B., Anastasiou, D., Gilliland, D.G., Scadden, D.T., Guertin, D.A., and Armstrong, S.A. (2012) mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis. Cell Stem Cell 11, 429-439
-
(2012)
Cell Stem Cell
, vol.11
, pp. 429-439
-
-
Kalaitzidis, D.1
Sykes, S.M.2
Wang, Z.3
Punt, N.4
Tang, Y.5
Ragu, C.6
Sinha, A.U.7
Lane, S.W.8
Souza, A.L.9
Clish, C.B.10
Anastasiou, D.11
Gilliland, D.G.12
Scadden, D.T.13
Guertin, D.A.14
Armstrong, S.A.15
-
43
-
-
84866064701
-
Temporal changes in PTEN and mTORC2 regulation of hematopoietic stem cell self-renewal and leukemia suppression
-
Magee, J.A., Ikenoue, T., Nakada, D., Lee, J.Y., Guan, K.L., and Morrison, S.J. (2012) Temporal changes in PTEN and mTORC2 regulation of hematopoietic stem cell self-renewal and leukemia suppression. Cell Stem Cell 11, 415-428
-
(2012)
Cell Stem Cell
, vol.11
, pp. 415-428
-
-
Magee, J.A.1
Ikenoue, T.2
Nakada, D.3
Lee, J.Y.4
Guan, K.L.5
Morrison, S.J.6
-
44
-
-
84870866912
-
Maintenance of hematopoietic stem cells through regulation of Wnt and mTOR pathways
-
Huang, J., Nguyen-McCarty, M., Hexner, E.O., Danet-Desnoyers, G., and Klein, P.S. (2012) Maintenance of hematopoietic stem cells through regulation of Wnt and mTOR pathways. Nat. Med. 18, 1778-1785
-
(2012)
Nat. Med.
, vol.18
, pp. 1778-1785
-
-
Huang, J.1
Nguyen-Mccarty, M.2
Hexner, E.O.3
Danet-Desnoyers, G.4
Klein, P.S.5
-
45
-
-
84861833364
-
MTORC1 is essential for leukemia propagation but not stem cell self-renewal
-
Hoshii, T., Tadokoro, Y., Naka, K., Ooshio, T., Muraguchi, T., Sugiyama, N., Soga, T., Araki, K., Yamamura, K., and Hirao, A. (2012) mTORC1 is essential for leukemia propagation but not stem cell self-renewal. J. Clin. Invest. 122, 2114-2129
-
(2012)
J. Clin. Invest.
, vol.122
, pp. 2114-2129
-
-
Hoshii, T.1
Tadokoro, Y.2
Naka, K.3
Ooshio, T.4
Muraguchi, T.5
Sugiyama, N.6
Soga, T.7
Araki, K.8
Yamamura, K.9
Hirao, A.10
-
46
-
-
84883639503
-
Mouse gene targeting reveals an essential role of mTOR in hematopoietic stem cell engraftment and hematopoiesis
-
Guo, F., Zhang, S., Grogg, M., Cancelas, J.A., Varney, M.E., Starczynowski, D.T., Du, W., Yang, J.Q., Liu, W., Thomas, G., Kozma, S., Pang, Q., and Zheng, Y. (2013) Mouse gene targeting reveals an essential role of mTOR in hematopoietic stem cell engraftment and hematopoiesis. Haematologica 98, 1353-1358
-
(2013)
Haematologica
, vol.98
, pp. 1353-1358
-
-
Guo, F.1
Zhang, S.2
Grogg, M.3
Cancelas, J.A.4
Varney, M.E.5
Starczynowski, D.T.6
Du, W.7
Yang, J.Q.8
Liu, W.9
Thomas, G.10
Kozma, S.11
Pang, Q.12
Zheng, Y.13
-
47
-
-
84896304723
-
Loss of mTOR complex 1 induces developmental blockage in early Tlymphopoiesis and eradicates T-cell acute lymphoblastic leukemia cells
-
Hoshii, T., Kasada, A., Hatakeyama, T., Ohtani, M., Tadokoro, Y., Naka, K., Ikenoue, T., Ikawa, T., Kawamoto, H., Fehling, H.J., Araki, K., Yamamura, K.I., Matsuda, S., and Hirao, A. (2014) Loss of mTOR complex 1 induces developmental blockage in early Tlymphopoiesis and eradicates T-cell acute lymphoblastic leukemia cells. Proc. Natl Acad. Sci. U. S. A. 111, 3805-3810
-
(2014)
Proc. Natl Acad. Sci. U. S. A.
, vol.111
, pp. 3805-3810
-
-
Hoshii, T.1
Kasada, A.2
Hatakeyama, T.3
Ohtani, M.4
Tadokoro, Y.5
Naka, K.6
Ikenoue, T.7
Ikawa, T.8
Kawamoto, H.9
Fehling, H.J.10
Araki, K.11
Yamamura, K.I.12
Matsuda, S.13
Hirao, A.14
-
48
-
-
84881236410
-
Positive feedback between PU.1 and the cell cycle controls myeloid differentiation
-
Kueh, H.Y., Champhekar, A., Nutt, S.L., Elowitz, M.B., and Rothenberg, E.V. (2013) Positive feedback between PU.1 and the cell cycle controls myeloid differentiation. Science 341, 670-673
-
(2013)
Science
, vol.341
, pp. 670-673
-
-
Kueh, H.Y.1
Champhekar, A.2
Nutt, S.L.3
Elowitz, M.B.4
Rothenberg, E.V.5
-
49
-
-
33745013651
-
Intracellular network of phosphatidylinositol 3-kinase, mammalian target of the rapamycin/70 kDa ribosomal S6 kinase 1, and mitogen-activated protein kinases pathways for regulating mycobacteria-induced IL-23 expression in human macrophages
-
Yang, C.S., Song, C.H., Lee, J.S., Jung, S.B., Oh, J.H., Park, J., Kim, H.J., Park, J.K., Paik, T.H., and Jo, E.K. (2006) Intracellular network of phosphatidylinositol 3-kinase, mammalian target of the rapamycin/70 kDa ribosomal S6 kinase 1, and mitogen-activated protein kinases pathways for regulating mycobacteria-induced IL-23 expression in human macrophages. Cell. Microbiol. 8, 1158-1171
-
(2006)
Cell. Microbiol.
, vol.8
, pp. 1158-1171
-
-
Yang, C.S.1
Song, C.H.2
Lee, J.S.3
Jung, S.B.4
Oh, J.H.5
Park, J.6
Kim, H.J.7
Park, J.K.8
Paik, T.H.9
Jo, E.K.10
-
50
-
-
54949109311
-
The TSC-mTOR signaling pathway regulates the innate inflammatory response
-
Weichhart, T., Costantino, G., Poglitsch, M., Rosner, M., Zeyda, M., Stuhlmeier, K.M., Kolbe, T., Stulnig, T.M., Horl, W.H., Hengstschlager, M., Muller, M., and Saemann, M.D. (2008) The TSC-mTOR signaling pathway regulates the innate inflammatory response. Immunity 29, 565-577
-
(2008)
Immunity
, vol.29
, pp. 565-577
-
-
Weichhart, T.1
Costantino, G.2
Poglitsch, M.3
Rosner, M.4
Zeyda, M.5
Stuhlmeier, K.M.6
Kolbe, T.7
Stulnig, T.M.8
Horl, W.H.9
Hengstschlager, M.10
Muller, M.11
Saemann, M.D.12
-
51
-
-
84889249320
-
The TSC-mTOR pathway regulates macrophage polarization
-
Byles, V., Covarrubias, A.J., Ben-Sahra, I., Lamming, D.W., Sabatini, D.M., Manning, B.D., and Horng, T. (2013) The TSC-mTOR pathway regulates macrophage polarization. Nat. Commun. 4, 2834
-
(2013)
Nat. Commun.
, vol.4
, pp. 2834
-
-
Byles, V.1
Covarrubias, A.J.2
Ben-Sahra, I.3
Lamming, D.W.4
Sabatini, D.M.5
Manning, B.D.6
Horng, T.7
-
52
-
-
84872300827
-
Langerhans cell homeostasis in mice is dependent on mTORC1 but not mTORC2 function
-
Kellersch, B. and Brocker, T. (2013) Langerhans cell homeostasis in mice is dependent on mTORC1 but not mTORC2 function. Blood 121, 298-307
-
(2013)
Blood
, vol.121
, pp. 298-307
-
-
Kellersch, B.1
Brocker, T.2
-
53
-
-
84861157347
-
Cutting edge: MTORC1 in intestinal CD11c+ CD11b+ dendritic cells regulates intestinal homeostasis by promoting IL-10 production
-
Ohtani, M., Hoshii, T., Fujii, H., Koyasu, S., Hirao, A., and Matsuda, S. (2012) Cutting edge: mTORC1 in intestinal CD11c+ CD11b+ dendritic cells regulates intestinal homeostasis by promoting IL-10 production. J. Immunol. 188, 4736-4740
-
(2012)
J. Immunol.
, vol.188
, pp. 4736-4740
-
-
Ohtani, M.1
Hoshii, T.2
Fujii, H.3
Koyasu, S.4
Hirao, A.5
Matsuda, S.6
-
54
-
-
84890288918
-
Tuberous sclerosis 1 (Tsc1)-dependent metabolic checkpoint controls development of dendritic cells
-
Wang, Y., Huang, G., Zeng, H., Yang, K., Lamb, R.F., and Chi, H. (2013) Tuberous sclerosis 1 (Tsc1)-dependent metabolic checkpoint controls development of dendritic cells. Proc. Natl Acad. Sci. U. S. A. 110, E4894-E4903
-
(2013)
Proc. Natl Acad. Sci. U. S. A.
, vol.110
-
-
Wang, Y.1
Huang, G.2
Zeng, H.3
Yang, K.4
Lamb, R.F.5
Chi, H.6
-
55
-
-
79251569252
-
Constitutive reductions in mTOR alter cell size, immune cell development, and antibody production
-
Zhang, S., Readinger, J.A., DuBois, W., Janka-Junttila, M., Robinson, R., Pruitt, M., Bliskovsky, V., Wu, J.Z., Sakakibara, K., Patel, J., Parent, C.A., Tessarollo, L., Schwartzberg, P.L., and Mock, B.A. (2011) Constitutive reductions in mTOR alter cell size, immune cell development, and antibody production. Blood 117, 1228-1238
-
(2011)
Blood
, vol.117
, pp. 1228-1238
-
-
Zhang, S.1
Readinger, J.A.2
Dubois, W.3
Janka-Junttila, M.4
Robinson, R.5
Pruitt, M.6
Bliskovsky, V.7
Wu, J.Z.8
Sakakibara, K.9
Patel, J.10
Parent, C.A.11
Tessarollo, L.12
Schwartzberg, P.L.13
Mock, B.A.14
-
56
-
-
84864818063
-
A critical role for Rictor in T lymphopoiesis
-
Tang, F., Wu, Q., Ikenoue, T., Guan, K.L., Liu, Y., and Zheng, P. (2012) A critical role for Rictor in T lymphopoiesis. J. Immunol. 189, 1850-1857
-
(2012)
J. Immunol.
, vol.189
, pp. 1850-1857
-
-
Tang, F.1
Wu, Q.2
Ikenoue, T.3
Guan, K.L.4
Liu, Y.5
Zheng, P.6
-
57
-
-
84861719535
-
Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia
-
Lee, K., Nam, K.T., Cho, S.H., Gudapati, P., Hwang, Y., Park, D.S., Potter, R., Chen, J., Volanakis, E., and Boothby, M. (2012) Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia. J. Exp. Med. 209, 713-728
-
(2012)
J. Exp. Med.
, vol.209
, pp. 713-728
-
-
Lee, K.1
Nam, K.T.2
Cho, S.H.3
Gudapati, P.4
Hwang, Y.5
Park, D.S.6
Potter, R.7
Chen, J.8
Volanakis, E.9
Boothby, M.10
-
58
-
-
66949173728
-
The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment
-
Delgoffe, G.M., Kole, T.P., Zheng, Y., Zarek, P.E., Matthews, K.L., Xiao, B., Worley, P.F., Kozma, S.C., and Powell, J.D. (2009) The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity 30, 832-844
-
(2009)
Immunity
, vol.30
, pp. 832-844
-
-
Delgoffe, G.M.1
Kole, T.P.2
Zheng, Y.3
Zarek, P.E.4
Matthews, K.L.5
Xiao, B.6
Worley, P.F.7
Kozma, S.C.8
Powell, J.D.9
-
59
-
-
79952985551
-
The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2
-
Delgoffe, G.M., Pollizzi, K.N., Waickman, A.T., Heikamp, E., Meyers, D.J., Horton, M.R., Xiao, B., Worley, P.F., and Powell, J.D. (2011) The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2. Nat. Immunol. 12, 295-303
-
(2011)
Nat. Immunol.
, vol.12
, pp. 295-303
-
-
Delgoffe, G.M.1
Pollizzi, K.N.2
Waickman, A.T.3
Heikamp, E.4
Meyers, D.J.5
Horton, M.R.6
Xiao, B.7
Worley, P.F.8
Powell, J.D.9
-
60
-
-
84878238075
-
Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways
-
Kim, J.S., Sklarz, T., Banks, L.B., Gohil, M., Waickman, A.T., Skuli, N., Krock, B.L., Luo, C.T., Hu, W., Pollizzi, K.N., Li, M.O., Rathmell, J.C., Birnbaum, M.J., Powell, J.D., Jordan, M.S., and Koretzky, G.A. (2013) Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways. Nat. Immunol. 14, 611-618
-
(2013)
Nat. Immunol.
, vol.14
, pp. 611-618
-
-
Kim, J.S.1
Sklarz, T.2
Banks, L.B.3
Gohil, M.4
Waickman, A.T.5
Skuli, N.6
Krock, B.L.7
Luo, C.T.8
Hu, W.9
Pollizzi, K.N.10
Li, M.O.11
Rathmell, J.C.12
Birnbaum, M.J.13
Powell, J.D.14
Jordan, M.S.15
Koretzky, G.A.16
-
61
-
-
84890137621
-
T cell exit from quiescence and differentiation into Th2 cells depend on Raptor-mTORC1-mediated metabolic reprogramming
-
Yang, K., Shrestha, S., Zeng, H., Karmaus, P.W., Neale, G., Vogel, P., Guertin, D.A., Lamb, R.F., and Chi, H. (2013) T cell exit from quiescence and differentiation into Th2 cells depend on Raptor-mTORC1-mediated metabolic reprogramming. Immunity 39, 1043-1056
-
(2013)
Immunity
, vol.39
, pp. 1043-1056
-
-
Yang, K.1
Shrestha, S.2
Zeng, H.3
Karmaus, P.W.4
Neale, G.5
Vogel, P.6
Guertin, D.A.7
Lamb, R.F.8
Chi, H.9
-
62
-
-
77953897189
-
Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways
-
Lee, K., Gudapati, P., Dragovic, S., Spencer, C., Joyce, S., Killeen, N., Magnuson, M.A., and Boothby, M. (2010) Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways. Immunity 32, 743-753
-
(2010)
Immunity
, vol.32
, pp. 743-753
-
-
Lee, K.1
Gudapati, P.2
Dragovic, S.3
Spencer, C.4
Joyce, S.5
Killeen, N.6
Magnuson, M.A.7
Boothby, M.8
-
63
-
-
84861134382
-
PI3K-Akt-mTORC1-S6K1/2 axis controls Th17 differentiation by regulating Gfi1 expression and nuclear translocation of RORgamma
-
Kurebayashi, Y., Nagai, S., Ikejiri, A., Ohtani, M., Ichiyama, K., Baba, Y., Yamada, T., Egami, S., Hoshii, T., Hirao, A., Matsuda, S., and Koyasu, S. (2012) PI3K-Akt-mTORC1-S6K1/2 axis controls Th17 differentiation by regulating Gfi1 expression and nuclear translocation of RORgamma. Cell Rep. 1, 360-373
-
(2012)
Cell Rep.
, vol.1
, pp. 360-373
-
-
Kurebayashi, Y.1
Nagai, S.2
Ikejiri, A.3
Ohtani, M.4
Ichiyama, K.5
Baba, Y.6
Yamada, T.7
Egami, S.8
Hoshii, T.9
Hirao, A.10
Matsuda, S.11
Koyasu, S.12
-
64
-
-
0345732640
-
MTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E
-
Fingar, D.C., Richardson, C.J., Tee, A.R., Cheatham, L., Tsou, C., and Blenis, J. (2004) mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E. Mol. Cell. Biol. 24, 200-216
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 200-216
-
-
Fingar, D.C.1
Richardson, C.J.2
Tee, A.R.3
Cheatham, L.4
Tsou, C.5
Blenis, J.6
-
65
-
-
77952967459
-
MTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs
-
Dowling, R.J., Topisirovic, I., Alain, T., Bidinosti, M., Fonseca, B.D., Petroulakis, E., Wang, X., Larsson, O., Selvaraj, A., Liu, Y., Kozma, S.C., Thomas, G., and Sonenberg, N. (2010) mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs. Science 328, 1172-1176
-
(2010)
Science
, vol.328
, pp. 1172-1176
-
-
Dowling, R.J.1
Topisirovic, I.2
Alain, T.3
Bidinosti, M.4
Fonseca, B.D.5
Petroulakis, E.6
Wang, X.7
Larsson, O.8
Selvaraj, A.9
Liu, Y.10
Kozma, S.C.11
Thomas, G.12
Sonenberg, N.13
-
66
-
-
84881192927
-
MTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function
-
Zeng, H., Yang, K., Cloer, C., Neale, G., Vogel, P., and Chi, H. (2013) mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function. Nature 499, 485-490
-
(2013)
Nature
, vol.499
, pp. 485-490
-
-
Zeng, H.1
Yang, K.2
Cloer, C.3
Neale, G.4
Vogel, P.5
Chi, H.6
-
67
-
-
84890040690
-
TSC1 regulates the balance between effector and regulatory T cells
-
Park, Y., Jin, H.S., Lopez, J., Elly, C., Kim, G., Murai, M., Kronenberg, M., and Liu, Y.C. (2013) TSC1 regulates the balance between effector and regulatory T cells. J. Clin. Invest. 123, 5165-5178
-
(2013)
J. Clin. Invest.
, vol.123
, pp. 5165-5178
-
-
Park, Y.1
Jin, H.S.2
Lopez, J.3
Elly, C.4
Kim, G.5
Murai, M.6
Kronenberg, M.7
Liu, Y.C.8
-
68
-
-
80052277906
-
Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1
-
Dang, E.V., Barbi, J., Yang, H.Y., Jinasena, D., Yu, H., Zheng, Y., Bordman, Z., Fu, J., Kim, Y., Yen, H.R., Luo, W., Zeller, K., Shimoda, L., Topalian, S.L., Semenza, G.L., Dang, C.V., Pardoll, D.M., and Pan, F. (2011) Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1. Cell 146, 772-784
-
(2011)
Cell
, vol.146
, pp. 772-784
-
-
Dang, E.V.1
Barbi, J.2
Yang, H.Y.3
Jinasena, D.4
Yu, H.5
Zheng, Y.6
Bordman, Z.7
Fu, J.8
Kim, Y.9
Yen, H.R.10
Luo, W.11
Zeller, K.12
Shimoda, L.13
Topalian, S.L.14
Semenza, G.L.15
Dang, C.V.16
Pardoll, D.M.17
Pan, F.18
-
69
-
-
79960369458
-
HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
-
Shi, L.Z., Wang, R., Huang, G., Vogel, P., Neale, G., Green, D.R., and Chi, H. (2011) HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. J. Exp. Med. 208, 1367-1376
-
(2011)
J. Exp. Med.
, vol.208
, pp. 1367-1376
-
-
Shi, L.Z.1
Wang, R.2
Huang, G.3
Vogel, P.4
Neale, G.5
Green, D.R.6
Chi, H.7
-
70
-
-
67650074206
-
MTOR regulates memory CD8 T-cell differentiation
-
Araki, K., Turner, A.P., Shaffer, V.O., Gangappa, S., Keller, S.A., Bachmann, M.F., Larsen, C.P., and Ahmed, R. (2009) mTOR regulates memory CD8 T-cell differentiation. Nature 460, 108-112
-
(2009)
Nature
, vol.460
, pp. 108-112
-
-
Araki, K.1
Turner, A.P.2
Shaffer, V.O.3
Gangappa, S.4
Keller, S.A.5
Bachmann, M.F.6
Larsen, C.P.7
Ahmed, R.8
-
71
-
-
74649085700
-
The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin
-
Rao, R.R., Li, Q., Odunsi, K., and Shrikant, P.A. (2010) The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin. Immunity 32, 67-78
-
(2010)
Immunity
, vol.32
, pp. 67-78
-
-
Rao, R.R.1
Li, Q.2
Odunsi, K.3
Shrikant, P.A.4
-
72
-
-
84871861969
-
PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells
-
Finlay, D.K., Rosenzweig, E., Sinclair, L.V., Feijoo-Carnero, C., Hukelmann, J.L., Rolf, J., Panteleyev, A.A., Okkenhaug, K., and Cantrell, D.A. (2012) PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells. J. Exp. Med. 209, 2441-2453
-
(2012)
J. Exp. Med.
, vol.209
, pp. 2441-2453
-
-
Finlay, D.K.1
Rosenzweig, E.2
Sinclair, L.V.3
Feijoo-Carnero, C.4
Hukelmann, J.L.5
Rolf, J.6
Panteleyev, A.A.7
Okkenhaug, K.8
Cantrell, D.A.9
-
73
-
-
84886721392
-
Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch
-
Gubser, P.M., Bantug, G.R., Razik, L., Fischer, M., Dimeloe, S., Hoenger, G., Durovic, B., Jauch, A., and Hess, C. (2013) Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch. Nat. Immunol. 14, 1064-1072
-
(2013)
Nat. Immunol.
, vol.14
, pp. 1064-1072
-
-
Gubser, P.M.1
Bantug, G.R.2
Razik, L.3
Fischer, M.4
Dimeloe, S.5
Hoenger, G.6
Durovic, B.7
Jauch, A.8
Hess, C.9
-
74
-
-
77955488179
-
Sin1-mTORC2 suppresses rag and il7r gene expression through Akt2 in B cells
-
Lazorchak, A.S., Liu, D., Facchinetti, V., Di Lorenzo, A., Sessa, W.C., Schatz, D.G., and Su, B. (2010) Sin1-mTORC2 suppresses rag and il7r gene expression through Akt2 in B cells. Mol. Cell 39, 433-443
-
(2010)
Mol. Cell
, vol.39
, pp. 433-443
-
-
Lazorchak, A.S.1
Liu, D.2
Facchinetti, V.3
Di Lorenzo, A.4
Sessa, W.C.5
Schatz, D.G.6
Su, B.7
-
75
-
-
77953247731
-
Akt1 and Akt2 promote peripheral Bcell maturation and survival
-
Calamito, M., Juntilla, M.M., Thomas, M., Northrup, D.L., Rathmell, J., Birnbaum, M.J., Koretzky, G., and Allman, D. (2010) Akt1 and Akt2 promote peripheral Bcell maturation and survival. Blood 115, 4043-4050
-
(2010)
Blood
, vol.115
, pp. 4043-4050
-
-
Calamito, M.1
Juntilla, M.M.2
Thomas, M.3
Northrup, D.L.4
Rathmell, J.5
Birnbaum, M.J.6
Koretzky, G.7
Allman, D.8
-
76
-
-
44049091757
-
Foxo1 directly regulates the transcription of recombination-activating genes during B cell development
-
Amin, R.H. and Schlissel, M.S. (2008) Foxo1 directly regulates the transcription of recombination-activating genes during B cell development. Nat. Immunol. 9, 613-622
-
(2008)
Nat. Immunol.
, vol.9
, pp. 613-622
-
-
Amin, R.H.1
Schlissel, M.S.2
-
77
-
-
58449102260
-
Foxo1 links homing and survival of naïve T cells by regulating L-selectin CCR7 and interleukin 7 receptor
-
Kerdiles, Y.M., Beisner, D.R., Tinoco, R., Dejean, A.S., Castrillon, D.H., DePinho, R.A., and Hedrick, S.M. (2009) Foxo1 links homing and survival of naïve T cells by regulating L-selectin, CCR7 and interleukin 7 receptor. Nat. Immunol. 10, 176-184
-
(2009)
Nat. Immunol.
, vol.10
, pp. 176-184
-
-
Kerdiles, Y.M.1
Beisner, D.R.2
Tinoco, R.3
Dejean, A.S.4
Castrillon, D.H.5
Depinho, R.A.6
Hedrick, S.M.7
-
78
-
-
84881399035
-
B cell-specific deficiencies in mTOR limit humoral immune responses
-
Zhang, S., Pruitt, M., Tran, D., Du Bois, W., Zhang, K., Patel, R., Hoover, S., Simpson, R.M., Simmons, J., Gary, J., Snapper, C.M., Casellas, R., and Mock, B.A. (2013) B cell-specific deficiencies in mTOR limit humoral immune responses. J. Immunol. 191, 1692-1703
-
(2013)
J. Immunol.
, vol.191
, pp. 1692-1703
-
-
Zhang, S.1
Pruitt, M.2
Tran, D.3
Du Bois, W.4
Zhang, K.5
Patel, R.6
Hoover, S.7
Simpson, R.M.8
Simmons, J.9
Gary, J.10
Snapper, C.M.11
Casellas, R.12
Mock, B.A.13
-
79
-
-
79960724234
-
Direct activation of mTOR in B lymphocytes confers impairment in B-cell maturation andloss of marginal zone B cells
-
Benhamron, S. and Tirosh, B. (2011) Direct activation of mTOR in B lymphocytes confers impairment in B-cell maturation andloss of marginal zone B cells. Eur. J. Immunol. 41, 2390-2396
-
(2011)
Eur. J. Immunol.
, vol.41
, pp. 2390-2396
-
-
Benhamron, S.1
Tirosh, B.2
-
80
-
-
80052276420
-
AKT/ FOXO signaling enforces reversible differentiation blockade in myeloid leukemias
-
Sykes, S.M., Lane, S.W., Bullinger, L., Kalaitzidis, D., Yusuf, R., Saez, B., Ferraro, F., Mercier, F., Singh, H., Brumme, K.M., Acharya, S.S., Scholl, C., Tothova, Z., Attar, E.C., Frohling, S., DePinho, R.A., Armstrong, S.A., Gilliland, D.G., and Scadden, D.T. (2011) AKT/ FOXO signaling enforces reversible differentiation blockade in myeloid leukemias. Cell 146, 697-708
-
(2011)
Cell
, vol.146
, pp. 697-708
-
-
Sykes, S.M.1
Lane, S.W.2
Bullinger, L.3
Kalaitzidis, D.4
Yusuf, R.5
Saez, B.6
Ferraro, F.7
Mercier, F.8
Singh, H.9
Brumme, K.M.10
Acharya, S.S.11
Scholl, C.12
Tothova, Z.13
Attar, E.C.14
Frohling, S.15
Depinho, R.A.16
Armstrong, S.A.17
Gilliland, D.G.18
Scadden, D.T.19
-
81
-
-
49449108291
-
MTORC1 promotes survival through translational control of Mcl-1
-
Mills, J.R., Hippo, Y., Robert, F., Chen, S.M., Malina, A., Lin, C.J., Trojahn, U., Wendel, H.G., Charest, A., Bronson, R.T., Kogan, S.C., Nadon, R., Housman, D.E., Lowe, S.W., and Pelletier, J. (2008) mTORC1 promotes survival through translational control of Mcl-1. Proc. Natl Acad. Sci. U. S. A. 105, 10853-10858
-
(2008)
Proc. Natl Acad. Sci. U. S. A.
, vol.105
, pp. 10853-10858
-
-
Mills, J.R.1
Hippo, Y.2
Robert, F.3
Chen, S.M.4
Malina, A.5
Lin, C.J.6
Trojahn, U.7
Wendel, H.G.8
Charest, A.9
Bronson, R.T.10
Kogan, S.C.11
Nadon, R.12
Housman, D.E.13
Lowe, S.W.14
Pelletier, J.15
-
82
-
-
84862740330
-
Inhibition of the mTORC2 and chaperone pathways to treat leukemia
-
Zhang, F., Lazorchak, A.S., Liu, D., Chen, F., and Su, B. (2012) Inhibition of the mTORC2 and chaperone pathways to treat leukemia. Blood 119, 6080-6088
-
(2012)
Blood
, vol.119
, pp. 6080-6088
-
-
Zhang, F.1
Lazorchak, A.S.2
Liu, D.3
Chen, F.4
Su, B.5
|