메뉴 건너뛰기




Volumn 110, Issue 50, 2013, Pages

Tuberous sclerosis 1 (Tsc1)-dependent metabolic checkpoint controls development of dendritic cells

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN P 15095; INTERLEUKIN 12P35; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; MYC PROTEIN; PROTEIN; RHEB PROTEIN; TAMOXIFEN; TUBEROUS SCLEROSIS 1 PROTEIN; UNCLASSIFIED DRUG;

EID: 84890288918     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1308905110     Document Type: Article
Times cited : (77)

References (62)
  • 1
    • 84866562625 scopus 로고    scopus 로고
    • Metabolic checkpoints in activated T cells
    • Wang R, Green DR (2012) Metabolic checkpoints in activated T cells. Nat Immunol 13(10):907-915.
    • (2012) Nat Immunol , vol.13 , Issue.10 , pp. 907-915
    • Wang, R.1    Green, D.R.2
  • 3
    • 84876758617 scopus 로고    scopus 로고
    • Metabolic pathways in immune cell activation and quiescence
    • Pearce EL, Pearce EJ (2013) Metabolic pathways in immune cell activation and quiescence. Immunity 38(4):633-643.
    • (2013) Immunity , vol.38 , Issue.4 , pp. 633-643
    • Pearce, E.L.1    Pearce, E.J.2
  • 4
    • 84255199079 scopus 로고    scopus 로고
    • The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation
    • Wang R, et al. (2011) The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation. Immunity 35(6):871-882.
    • (2011) Immunity , vol.35 , Issue.6 , pp. 871-882
    • Wang, R.1
  • 5
    • 79960369458 scopus 로고    scopus 로고
    • HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
    • Shi LZ, et al. (2011) HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. J Exp Med 208(7):1367-1376.
    • (2011) J Exp Med , vol.208 , Issue.7 , pp. 1367-1376
    • Shi, L.Z.1
  • 6
    • 79953172571 scopus 로고    scopus 로고
    • + T cell subsets
    • + T cell subsets. J Immunol 186(6):3299-3303.
    • (2011) J Immunol , vol.186 , Issue.6 , pp. 3299-3303
    • Michalek, R.D.1
  • 7
    • 46149098344 scopus 로고    scopus 로고
    • LXR signaling couples sterol metabolism to proliferation in the acquired immune response
    • Bensinger SJ, et al. (2008) LXR signaling couples sterol metabolism to proliferation in the acquired immune response. Cell 134(1):97-111.
    • (2008) Cell , vol.134 , Issue.1 , pp. 97-111
    • Bensinger, S.J.1
  • 8
    • 84876684375 scopus 로고    scopus 로고
    • Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity
    • Kidani Y, et al. (2013) Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity. Nat Immunol 14(5):489-499.
    • (2013) Nat Immunol , vol.14 , Issue.5 , pp. 489-499
    • Kidani, Y.1
  • 9
    • 67650096912 scopus 로고    scopus 로고
    • Enhancing CD8 T-cell memory by modulating fatty acid metabolism
    • Pearce EL, et al. (2009) Enhancing CD8 T-cell memory by modulating fatty acid metabolism. Nature 460(7251):103-107
    • (2009) Nature , vol.460 , Issue.7251 , pp. 103-107
    • Pearce, E.L.1
  • 10
    • 84856183120 scopus 로고    scopus 로고
    • + T cell memory development
    • + T cell memory development. Immunity 36(1):68-78.
    • (2012) Immunity , vol.36 , Issue.1 , pp. 68-78
    • Van Der Windt, G.J.1
  • 11
    • 84865197492 scopus 로고    scopus 로고
    • Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells
    • Everts B, et al. (2012) Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells. Blood 120(7):1422-1431.
    • (2012) Blood , vol.120 , Issue.7 , pp. 1422-1431
    • Everts, B.1
  • 12
    • 77954735369 scopus 로고    scopus 로고
    • Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation
    • Krawczyk CM, et al. (2010) Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation. Blood 115(23):4742-4749.
    • (2010) Blood , vol.115 , Issue.23 , pp. 4742-4749
    • Krawczyk, C.M.1
  • 13
    • 77956958947 scopus 로고    scopus 로고
    • Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
    • Masters SL, et al. (2010) Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes. Nat Immunol 11(10):897-904.
    • (2010) Nat Immunol , vol.11 , Issue.10 , pp. 897-904
    • Masters, S.L.1
  • 14
    • 84876285741 scopus 로고    scopus 로고
    • Succinate is an inflammatory signal that induces IL-1β through HIF-1α
    • Tannahill GM, et al. (2013) Succinate is an inflammatory signal that induces IL-1β through HIF-1α. Nature 496(7444):238-242.
    • (2013) Nature , vol.496 , Issue.7444 , pp. 238-242
    • Tannahill, G.M.1
  • 15
    • 84859778293 scopus 로고    scopus 로고
    • mTOR signaling in growth control and disease
    • Laplante M, Sabatini DM (2012) mTOR signaling in growth control and disease. Cell 149(2):274-293.
    • (2012) Cell , vol.149 , Issue.2 , pp. 274-293
    • Laplante, M.1    Sabatini, D.M.2
  • 16
    • 77955483125 scopus 로고    scopus 로고
    • Activation of a metabolic gene regulatory network downstream of mTOR complex 1
    • Düvel K, et al. (2010) Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Mol Cell 39(2):171-183.
    • (2010) Mol Cell , vol.39 , Issue.2 , pp. 171-183
    • Düvel, K.1
  • 17
    • 84860237060 scopus 로고    scopus 로고
    • Regulation and function of mTOR signalling in T cell fate decisions
    • Chi H (2012) Regulation and function of mTOR signalling in T cell fate decisions. Nat Rev Immunol 12(5):325-338.
    • (2012) Nat Rev Immunol , vol.12 , Issue.5 , pp. 325-338
    • Chi, H.1
  • 19
  • 20
    • 54949109311 scopus 로고    scopus 로고
    • The TSC-mTOR signaling pathway regulates the innate inflammatory response
    • Weichhart T, et al. (2008) The TSC-mTOR signaling pathway regulates the innate inflammatory response. Immunity 29(4):565-577.
    • (2008) Immunity , vol.29 , Issue.4 , pp. 565-577
    • Weichhart, T.1
  • 21
    • 50949130076 scopus 로고    scopus 로고
    • Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells
    • Ohtani M, et al. (2008) Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells. Blood 112(3):635-643.
    • (2008) Blood , vol.112 , Issue.3 , pp. 635-643
    • Ohtani, M.1
  • 22
    • 58149352480 scopus 로고    scopus 로고
    • Mammalian target of rapamycin (mTOR) orchestrates the defense program of innate immune cells
    • Schmitz F, et al. (2008) Mammalian target of rapamycin (mTOR) orchestrates the defense program of innate immune cells. Eur J Immunol 38(11):2981-2992.
    • (2008) Eur J Immunol , vol.38 , Issue.11 , pp. 2981-2992
    • Schmitz, F.1
  • 23
    • 77958126087 scopus 로고    scopus 로고
    • A versatile role of mammalian target of rapamycin in human dendritic cell function and differentiation
    • Haidinger M, et al. (2010) A versatile role of mammalian target of rapamycin in human dendritic cell function and differentiation. J Immunol 185(7):3919-3931.
    • (2010) J Immunol , vol.185 , Issue.7 , pp. 3919-3931
    • Haidinger, M.1
  • 24
    • 84861157347 scopus 로고    scopus 로고
    • + dendritic cells regulates intestinal homeostasis by promoting IL-10 production
    • + dendritic cells regulates intestinal homeostasis by promoting IL-10 production. J Immunol 188(10):4736-4740.
    • (2012) J Immunol , vol.188 , Issue.10 , pp. 4736-4740
    • Ohtani, M.1
  • 25
    • 52549127241 scopus 로고    scopus 로고
    • Toll-like receptor-mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway
    • Cao W, et al. (2008) Toll-like receptor-mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway. Nat Immunol 9(10):1157-1164.
    • (2008) Nat Immunol , vol.9 , Issue.10 , pp. 1157-1164
    • Cao, W.1
  • 26
    • 84865435212 scopus 로고    scopus 로고
    • Inhibition of mechanistic target of rapamycin promotes dendritic cell activation and enhances therapeutic autologous vaccination in mice
    • Amiel E, et al. (2012) Inhibition of mechanistic target of rapamycin promotes dendritic cell activation and enhances therapeutic autologous vaccination in mice. J Immunol 189(5):2151-2158.
    • (2012) J Immunol , vol.189 , Issue.5 , pp. 2151-2158
    • Amiel, E.1
  • 27
    • 77958470125 scopus 로고    scopus 로고
    • Mammalian target of rapamycin controls dendritic cell development downstream of Flt3 ligand signaling
    • Sathaliyawala T, et al. (2010) Mammalian target of rapamycin controls dendritic cell development downstream of Flt3 ligand signaling. Immunity 33(4):597-606.
    • (2010) Immunity , vol.33 , Issue.4 , pp. 597-606
    • Sathaliyawala, T.1
  • 28
    • 77954748989 scopus 로고    scopus 로고
    • + T-cell stimulatory and differentiation capacity of myeloid DCs after exposure to LPS
    • + T-cell stimulatory and differentiation capacity of myeloid DCs after exposure to LPS. Blood 115(23):4758-4769.
    • (2010) Blood , vol.115 , Issue.23 , pp. 4758-4769
    • Turnquist, H.R.1
  • 29
    • 84879316492 scopus 로고    scopus 로고
    • Murine dendritic cell rapamycin-resistant and rictor-independent mTOR controls IL-10, B7-H1, and regulatory T-cell induction
    • Rosborough BR, et al. (2013) Murine dendritic cell rapamycin-resistant and rictor-independent mTOR controls IL-10, B7-H1, and regulatory T-cell induction. Blood 121(18):3619-3630.
    • (2013) Blood , vol.121 , Issue.18 , pp. 3619-3630
    • Rosborough, B.R.1
  • 30
    • 56249147509 scopus 로고    scopus 로고
    • Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation
    • Choo AY, Yoon SO, Kim SG, Roux PP, Blenis J (2008) Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation. Proc Natl Acad Sci USA 105(45):17414-17419.
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.45 , pp. 17414-17419
    • Choo, A.Y.1    Yoon, S.O.2    Kim, S.G.3    Roux, P.P.4    Blenis, J.5
  • 31
    • 33646023695 scopus 로고    scopus 로고
    • Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
    • Sarbassov DD, et al. (2006) Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol Cell 22(2):159-168.
    • (2006) Mol Cell , vol.22 , Issue.2 , pp. 159-168
    • Sarbassov, D.D.1
  • 32
    • 79952985551 scopus 로고    scopus 로고
    • The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2
    • Delgoffe GM, et al. (2011) The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2. Nat Immunol 12(4):295-303.
    • (2011) Nat Immunol , vol.12 , Issue.4 , pp. 295-303
    • Delgoffe, G.M.1
  • 33
    • 65249089638 scopus 로고    scopus 로고
    • In vivo analysis of dendritic cell development and homeostasis
    • Liu K, et al. (2009) In vivo analysis of dendritic cell development and homeostasis. Science 324(5925):392-397.
    • (2009) Science , vol.324 , Issue.5925 , pp. 392-397
    • Liu, K.1
  • 34
    • 77349124883 scopus 로고    scopus 로고
    • Origin and development of dendritic cells
    • Liu K, Nussenzweig MC (2010) Origin and development of dendritic cells. Immunol Rev 234(1):45-54.
    • (2010) Immunol Rev , vol.234 , Issue.1 , pp. 45-54
    • Liu, K.1    Nussenzweig, M.C.2
  • 35
    • 84875528275 scopus 로고    scopus 로고
    • The dendritic cell lineage: Ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting
    • Merad M, Sathe P, Helft J, Miller J, Mortha A (2013) The dendritic cell lineage: Ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting. Annu Rev Immunol 31:563-604.
    • (2013) Annu Rev Immunol , vol.31 , pp. 563-604
    • Merad, M.1    Sathe, P.2    Helft, J.3    Miller, J.4    Mortha, A.5
  • 36
    • 53349091768 scopus 로고    scopus 로고
    • TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species
    • Chen C, et al. (2008) TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species. J Exp Med 205(10):2397-2408.
    • (2008) J Exp Med , vol.205 , Issue.10 , pp. 2397-2408
    • Chen, C.1
  • 37
    • 58049196780 scopus 로고    scopus 로고
    • mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization
    • Gan B, et al. (2008) mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization. Proc Natl Acad Sci USA 105(49):19384-19389.
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.49 , pp. 19384-19389
    • Gan, B.1
  • 38
    • 30344444770 scopus 로고    scopus 로고
    • A clonogenic bone marrow progenitor specific for macrophages and dendritic cells
    • Fogg DK, et al. (2006) A clonogenic bone marrow progenitor specific for macrophages and dendritic cells. Science 311(5757):83-87.
    • (2006) Science , vol.311 , Issue.5757 , pp. 83-87
    • Fogg, D.K.1
  • 39
    • 33846408655 scopus 로고    scopus 로고
    • Monocytes give rise to mucosal, but not splenic, conventional dendritic cells
    • Varol C, et al. (2007) Monocytes give rise to mucosal, but not splenic, conventional dendritic cells. J Exp Med 204(1):171-180.
    • (2007) J Exp Med , vol.204 , Issue.1 , pp. 171-180
    • Varol, C.1
  • 40
    • 44049097818 scopus 로고    scopus 로고
    • The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues
    • Waskow C, et al. (2008) The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues. Nat Immunol 9(6):676-683.
    • (2008) Nat Immunol , vol.9 , Issue.6 , pp. 676-683
    • Waskow, C.1
  • 41
    • 80051997049 scopus 로고    scopus 로고
    • The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function
    • Yang K, Neale G, Green DR, He W, Chi H (2011) The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function. Nat Immunol 12(9):888-897.
    • (2011) Nat Immunol , vol.12 , Issue.9 , pp. 888-897
    • Yang, K.1    Neale, G.2    Green, D.R.3    He, W.4    Chi, H.5
  • 42
    • 77953767101 scopus 로고    scopus 로고
    • Programmed cell death of dendritic cells in immune regulation
    • Chen M, Wang J (2010) Programmed cell death of dendritic cells in immune regulation. Immunol Rev 236(1):11-27.
    • (2010) Immunol Rev , vol.236 , Issue.1 , pp. 11-27
    • Chen, M.1    Wang, J.2
  • 43
    • 58049209834 scopus 로고    scopus 로고
    • Inflammatory signals in dendritic cell activation and the induction of adaptive immunity
    • Joffre O, Nolte MA, Spörri R, Reis e Sousa C (2009) Inflammatory signals in dendritic cell activation and the induction of adaptive immunity. Immunol Rev 227(1):234-247.
    • (2009) Immunol Rev , vol.227 , Issue.1 , pp. 234-247
    • Joffre, O.1    Nolte, M.A.2    Spörri, R.3    Reis E Sousa, C.4
  • 44
    • 77952313777 scopus 로고    scopus 로고
    • Differentiation of effector CD4 T cell populations
    • Zhu J, Yamane H, Paul WE (2010) Differentiation of effector CD4 T cell populations. Annu Rev Immunol 28:445-489.
    • (2010) Annu Rev Immunol , vol.28 , pp. 445-489
    • Zhu, J.1    Yamane, H.2    Paul, W.E.3
  • 45
    • 50049116472 scopus 로고    scopus 로고
    • SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth
    • Porstmann T, et al. (2008) SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth. Cell Metab 8(3):224-236.
    • (2008) Cell Metab , vol.8 , Issue.3 , pp. 224-236
    • Porstmann, T.1
  • 46
    • 79960960007 scopus 로고    scopus 로고
    • Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways
    • Yecies JL, et al. (2011) Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways. Cell Metab 14(1):21-32.
    • (2011) Cell Metab , vol.14 , Issue.1 , pp. 21-32
    • Yecies, J.L.1
  • 47
    • 79953177846 scopus 로고    scopus 로고
    • Tuberous sclerosis complex-1 deficiency attenuates diet-induced hepatic lipid accumulation
    • Kenerson HL, Yeh MM, Yeung RS (2011) Tuberous sclerosis complex-1 deficiency attenuates diet-induced hepatic lipid accumulation. PLoS One 6(3):e18075.
    • (2011) PLoS One , vol.6 , Issue.3
    • Kenerson, H.L.1    Yeh, M.M.2    Yeung, R.S.3
  • 48
    • 44949215822 scopus 로고    scopus 로고
    • The TSC1-TSC2 complex is required for proper activation of mTOR complex 2
    • Huang J, Dibble CC, Matsuzaki M, Manning BD (2008) The TSC1-TSC2 complex is required for proper activation of mTOR complex 2. Mol Cell Biol 28(12):4104-4115.
    • (2008) Mol Cell Biol , vol.28 , Issue.12 , pp. 4104-4115
    • Huang, J.1    Dibble, C.C.2    Matsuzaki, M.3    Manning, B.D.4
  • 49
    • 80054721266 scopus 로고    scopus 로고
    • Regulation of T-cell survival and mitochondrial homeostasis by TSC1
    • O' Brien TF, et al. (2011) Regulation of T-cell survival and mitochondrial homeostasis by TSC1. Eur J Immunol 41(11):3361-3370.
    • (2011) Eur J Immunol , vol.41 , Issue.11 , pp. 3361-3370
    • O'Brien, T.F.1
  • 50
    • 84857398190 scopus 로고    scopus 로고
    • + T cell survival and homeostasis in mice
    • + T cell survival and homeostasis in mice. PLoS One 7(2):e30592.
    • (2012) PLoS One , vol.7 , Issue.2
    • Zhang, L.1
  • 51
    • 42949139481 scopus 로고    scopus 로고
    • AMPK phosphorylation of raptor mediates a metabolic checkpoint
    • Gwinn DM, et al. (2008) AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell 30(2):214-226.
    • (2008) Mol Cell , vol.30 , Issue.2 , pp. 214-226
    • Gwinn, D.M.1
  • 52
    • 84880103374 scopus 로고    scopus 로고
    • Critical role of the tumor suppressor tuberous sclerosis complex 1 in dendritic cell activation of CD4 T cells by promoting MHC class II expression via IRF4 and CIITA
    • Pan H, et al. (2013) Critical role of the tumor suppressor tuberous sclerosis complex 1 in dendritic cell activation of CD4 T cells by promoting MHC class II expression via IRF4 and CIITA. J Immunol 191(2):699-707.
    • (2013) J Immunol , vol.191 , Issue.2 , pp. 699-707
    • Pan, H.1
  • 53
    • 33845999615 scopus 로고    scopus 로고
    • Essential role for nuclear PTEN in maintaining chromosomal integrity
    • Shen WH, et al. (2007) Essential role for nuclear PTEN in maintaining chromosomal integrity. Cell 128(1):157-170.
    • (2007) Cell , vol.128 , Issue.1 , pp. 157-170
    • Shen, W.H.1
  • 54
    • 78651427865 scopus 로고    scopus 로고
    • Rheb1 is required for mTORC1 and myelination in postnatal brain development
    • Zou J, et al. (2011) Rheb1 is required for mTORC1 and myelination in postnatal brain development. Dev Cell 20(1):97-108.
    • (2011) Dev Cell , vol.20 , Issue.1 , pp. 97-108
    • Zou, J.1
  • 55
    • 78649874959 scopus 로고    scopus 로고
    • Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells
    • Gan B, et al. (2010) Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells. Nature 468(7324):701-704.
    • (2010) Nature , vol.468 , Issue.7324 , pp. 701-704
    • Gan, B.1
  • 56
    • 78649851511 scopus 로고    scopus 로고
    • The Lkb1 metabolic sensor maintains haematopoietic stem cell survival
    • Gurumurthy S, et al. (2010) The Lkb1 metabolic sensor maintains haematopoietic stem cell survival. Nature 468(7324):659-663.
    • (2010) Nature , vol.468 , Issue.7324 , pp. 659-663
    • Gurumurthy, S.1
  • 57
    • 78649811793 scopus 로고    scopus 로고
    • Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells
    • Nakada D, Saunders TL, Morrison SJ (2010) Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells. Nature 468(7324):653-658.
    • (2010) Nature , vol.468 , Issue.7324 , pp. 653-658
    • Nakada, D.1    Saunders, T.L.2    Morrison, S.J.3
  • 58
    • 78049496814 scopus 로고    scopus 로고
    • mTOR activation induces tumor suppressors that inhibit leukemogenesis and deplete hematopoietic stem cells after Pten deletion
    • Lee JY, et al. (2010) mTOR activation induces tumor suppressors that inhibit leukemogenesis and deplete hematopoietic stem cells after Pten deletion. Cell Stem Cell 7(5):593-605.
    • (2010) Cell Stem Cell , vol.7 , Issue.5 , pp. 593-605
    • Lee, J.Y.1
  • 59
    • 84860333507 scopus 로고    scopus 로고
    • The role of tuberous sclerosis complex 1 in regulating innate immunity
    • Pan H, O'Brien TF, Zhang P, Zhong XP (2012) The role of tuberous sclerosis complex 1 in regulating innate immunity. J Immunol 188(8):3658-3666.
    • (2012) J Immunol , vol.188 , Issue.8 , pp. 3658-3666
    • Pan, H.1    O'Brien, T.F.2    Zhang, P.3    Zhong, X.P.4
  • 60
    • 79960463300 scopus 로고    scopus 로고
    • Signaling by the phosphatase MKP-1 in dendritic cells imprints distinct effector and regulatory T cell fates
    • Huang G, Wang Y, Shi LZ, Kanneganti TD, Chi H (2011) Signaling by the phosphatase MKP-1 in dendritic cells imprints distinct effector and regulatory T cell fates. Immunity 35(1):45-58.
    • (2011) Immunity , vol.35 , Issue.1 , pp. 45-58
    • Huang, G.1    Wang, Y.2    Shi, L.Z.3    Kanneganti, T.D.4    Chi, H.5
  • 61
    • 84863119109 scopus 로고    scopus 로고
    • Transforming growth factor beta-activated kinase 1 (TAK1)-dependent checkpoint in the survival of dendritic cells promotes immune homeostasis and function
    • Wang Y, et al. (2012) Transforming growth factor beta-activated kinase 1 (TAK1)-dependent checkpoint in the survival of dendritic cells promotes immune homeostasis and function. Proc Natl Acad Sci USA 109(6):E343-E352.
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.6
    • Wang, Y.1
  • 62
    • 84855929741 scopus 로고    scopus 로고
    • Signaling via the kinase p38α programs dendritic cells to drive TH17 differentiation and autoimmune inflammation
    • Huang G, et al. (2012) Signaling via the kinase p38α programs dendritic cells to drive TH17 differentiation and autoimmune inflammation. Nat Immunol 13(2):152-161.
    • (2012) Nat Immunol , vol.13 , Issue.2 , pp. 152-161
    • Huang, G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.