-
1
-
-
0034489805
-
The role of Ras and other low molecular weight guanine nucleotide (GTP)-binding proteins during hematopoietic cell differentiation
-
Scheele JS, Ripple D, Lubbert M. The role of ras and other low molecular weight guanine nucleotide (GTP)-binding proteins during hematopoietic cell differentiation. Cell Mol Life Sci. 2000;57(13-14):1950-1963. (Pubitemid 32102589)
-
(2000)
Cellular and Molecular Life Sciences
, vol.57
, Issue.13-14
, pp. 1950-1963
-
-
Scheele, J.S.1
Rapple, D.2
Lubbert, M.3
-
2
-
-
34247348615
-
G12D expression induces hyperproliferation and aberrant signaling in primary hematopoietic stem/progenitor cells
-
DOI 10.1182/blood-2006-09-047530
-
Van Meter ME, Diaz-Flores E, Archard JA, et al. K-RasG12D expression induces hyperproliferation and aberrant signaling in primary hematopoietic stem/progenitor cells. Blood. 2007;109(9):3945-3952. (Pubitemid 46641747)
-
(2007)
Blood
, vol.109
, Issue.9
, pp. 3945-3952
-
-
Van Meter, M.E.M.1
Diaz-Flores, E.2
Archard, J.A.3
Passegue, E.4
Irish, J.M.5
Kotecha, N.6
Nolan, G.P.7
Shannon, K.8
Braun, B.S.9
-
3
-
-
0345743699
-
Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder
-
DOI 10.1073/pnas.0307203101
-
Braun BS, Tuveson DA, Kong N, et al. Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder. Proc Natl Acad Sci U S A. 2004;101(2):597-602. (Pubitemid 38084682)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.2
, pp. 597-602
-
-
Braun, B.S.1
Tuveson, D.A.2
Kong, N.3
Le, D.T.4
Kogan, S.C.5
Rozmus, J.6
Le Beau, M.M.7
Jacks, T.E.8
Shannon, K.M.9
-
4
-
-
4444350859
-
+ hematopoietic progenitor cells into myeloid differentiation and proliferation both in vitro and in the NOD/SCID mouse
-
DOI 10.1016/j.exphem.2004.06.001, PII S0301472X04002000
-
Shen SW, Dolnikov A, Passioura T, et al. Mutant N-ras preferentially drives human CD34+ hematopoietic progenitor cells into myeloid differentiation and proliferation both in vitro and in the NOD/SCID mouse. Exp Hematol. 2004;32(9):852-860. (Pubitemid 39166032)
-
(2004)
Experimental Hematology
, vol.32
, Issue.9
, pp. 852-860
-
-
Shen, S.W.1
Dolnikov, A.2
Passioura, T.3
Millington, M.4
Wotherspoon, S.5
Rice, A.6
MacKenzie, K.L.7
Symonds, G.8
-
5
-
-
11144356354
-
Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects
-
Tuveson DA, Shaw AT, Willis NA, et al. Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. Cancer Cell. 2004;5(4):375-387.
-
(2004)
Cancer Cell
, vol.5
, Issue.4
, pp. 375-387
-
-
Tuveson, D.A.1
Shaw, A.T.2
Willis, N.A.3
-
6
-
-
18244363103
-
K-Ras is essential for normal fetal liver erythropoiesis
-
DOI 10.1182/blood-2004-05-2021
-
Khalaf WF, White H, Wenning MJ, Orazi A, Kapur R, Ingram DA. K-Ras is essential for normal fetal liver erythropoiesis. Blood. 2005;105(9):3538-3541. (Pubitemid 40628197)
-
(2005)
Blood
, vol.105
, Issue.9
, pp. 3538-3541
-
-
Khalaf, W.F.1
White, H.2
Wenning, M.J.3
Orazi, A.4
Kapur, R.5
Ingram, D.A.6
-
7
-
-
0033559734
-
Mutant N-ras induces myeloproliferative disorders and apoptosis in bone marrow repopulated mice
-
MacKenzie KL, Dolnikov A, Millington M, Shounan Y, Symonds G. Mutant N-ras induces myeloproliferative disorders and apoptosis in bone marrow repopulated mice. Blood. 1999;93(6):2043-2056. (Pubitemid 29128508)
-
(1999)
Blood
, vol.93
, Issue.6
, pp. 2043-2056
-
-
MacKenzie, K.L.1
Dolnikov, A.2
Millington, M.3
Shounan, Y.4
Symonds, G.5
-
8
-
-
24744465206
-
The farnesyl transferase inhibitor (FTI) SCH66336 (lonafarnib) inhibits Rheb farnesylation and mTOR signaling: Role in FTI enhancement of taxane and tamoxifen anti-tumor activity
-
DOI 10.1074/jbc.M503763200
-
Basso AD, Mirza A, Liu G, Long BJ, Bishop WR, Kirschmeier P. The farnesyl transferase inhibitor (FTI) SCH66336 (lonafarnib) inhibits Rheb farnesylation and mTOR signaling: role in FTI enhancement of taxane and tamoxifen anti-tumor activity. J Biol Chem. 2005;280(35):31101-31108. (Pubitemid 41291845)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.35
, pp. 31101-31108
-
-
Basso, A.D.1
Mirza, A.2
Liu, G.3
Long, B.J.4
Bishop, W.R.5
Kirschmeier, P.6
-
9
-
-
27944503577
-
Identification and characterization of RHEBL1, a novel member of Ras family, which activates transcriptional activities of NF-kappa B
-
DOI 10.1007/s11033-005-0984-x
-
Yuan J, Shan Y, Chen X, et al. Identification and characterization of RHEBL1, a novel member of Ras family, which activates transcriptional activities of NF-kappa B. Mol Biol Rep. 2005;32(4):205-214. (Pubitemid 41674319)
-
(2005)
Molecular Biology Reports
, vol.32
, Issue.4
, pp. 205-214
-
-
Yuan, J.1
Shan, Y.2
Chen, X.3
Tang, W.4
Luo, K.5
Ni, J.6
Wan, B.7
Yu, L.8
-
10
-
-
0037130961
-
A stem cell molecular signature
-
Ivanova NB, Dimos JT, Schaniel C, Hackney JA, Moore KA, Lemischka IR. A stem cell molecular signature. Science. 2002;298(5593):601-604.
-
(2002)
Science
, vol.298
, Issue.5593
, pp. 601-604
-
-
Ivanova, N.B.1
Dimos, J.T.2
Schaniel, C.3
Hackney, J.A.4
Moore, K.A.5
Lemischka, I.R.6
-
11
-
-
24044442298
-
Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1
-
DOI 10.1016/j.febslet.2005.07.054, PII S0014579305009154
-
Tee AR, Blenis J, Proud CG. Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1. FEBS Lett. 2005;579(21):4763-4768. (Pubitemid 41218660)
-
(2005)
FEBS Letters
, vol.579
, Issue.21
, pp. 4763-4768
-
-
Tee, A.R.1
Blenis, J.2
Proud, C.G.3
-
12
-
-
32044465506
-
TOR signaling in growth and metabolism
-
Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell. 2006;124(3):471-484.
-
(2006)
Cell
, vol.124
, Issue.3
, pp. 471-484
-
-
Wullschleger, S.1
Loewith, R.2
Hall, M.N.3
-
13
-
-
2342545519
-
Target of rapamycin (TOR): An integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
-
DOI 10.1038/sj.onc.1207542
-
Fingar DC, Blenis J. Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene. 2004;23(18):3151-3171. (Pubitemid 38638827)
-
(2004)
Oncogene
, vol.23
, Issue.18
, pp. 3151-3171
-
-
Fingar, D.C.1
Blenis, J.2
-
14
-
-
28844473256
-
S6 kinase 2 potentiates interleukin-3-driven cell proliferation
-
DOI 10.1189/jlb.0405225
-
Cruz R, Hedden L, Boyer D, Kharas MG, Fruman DA, Lee-Fruman KK. S6 kinase 2 potentiates interleukin-3-driven cell proliferation. J Leukoc Biol. 2005;78(6):1378-1385. (Pubitemid 41779244)
-
(2005)
Journal of Leukocyte Biology
, vol.78
, Issue.6
, pp. 1378-1385
-
-
Cruz, R.1
Hedden, L.2
Boyer, D.3
Kharas, M.G.4
Fruman, D.A.5
Lee-Fruman, K.K.6
-
15
-
-
33644769115
-
Mammalian target of rapamycin (mTOR) regulates both proliferation of megakaryocyte progenitors and late stages of megakaryocyte differentiation
-
DOI 10.1182/blood-2005-07-3005
-
Raslova H, Baccini V, Loussaief L, et al. Mammalian target of rapamycin (mTOR) regulates both proliferation of megakaryocyte progenitors and late stages of megakaryocyte differentiation. Blood. 2006;107(6):2303-2310. (Pubitemid 43345548)
-
(2006)
Blood
, vol.107
, Issue.6
, pp. 2303-2310
-
-
Raslova, H.1
Baccini, V.2
Loussaief, L.3
Comba, B.4
Larghero, J.5
Debili, N.6
Vainchenker, W.7
-
16
-
-
11844295983
-
Inhibition of PI3K, mTOR and MEK signaling pathways promotes rapid apoptosis in B-lineage ALL in the presence of stromal cell support
-
Bertrand FE, Spengemen JD, Shelton JG, McCubrey JA. Inhibition of PI3K, mTOR and MEK signaling pathways promotes rapid apoptosis in B-lineage ALL in the presence of stromal cell support. Leukemia. 2005;19(1):98-102.
-
(2005)
Leukemia
, vol.19
, Issue.1
, pp. 98-102
-
-
Bertrand, F.E.1
Spengemen, J.D.2
Shelton, J.G.3
McCubrey, J.A.4
-
17
-
-
28844480101
-
MTOR regulates cell survival after etoposide treatment in primary AML cells
-
DOI 10.1182/blood-2004-11-4468
-
Xu Q, Thompson JE, Carroll M. mTOR regulates cell survival after etoposide treatment in primary AML cells. Blood. 2005;106(13):4261-4268. (Pubitemid 41775935)
-
(2005)
Blood
, vol.106
, Issue.13
, pp. 4261-4268
-
-
Xu, Q.1
Thompson, J.E.2
Carroll, M.3
-
18
-
-
28544444116
-
Synergistic effect of targeting mTOR by rapamycin and depleting ATP by inhibition of glycolysis in lymphoma and leukemia cells
-
DOI 10.1038/sj.leu.2403968, PII 2403968
-
Xu RH, Pelicano H, Zhang H, Giles FJ, Keating MJ, Huang P. Synergistic effect of targeting mTOR by rapamycin and depleting ATP by inhibition of glycolysis in lymphoma and leukemia cells. Leukemia. 2005;19(12):2153-2158. (Pubitemid 41741609)
-
(2005)
Leukemia
, vol.19
, Issue.12
, pp. 2153-2158
-
-
Xu, R.-H.1
Pelicano, H.2
Zhang, H.3
Giles, F.J.4
Keating, M.J.5
Huang, P.6
-
19
-
-
34249308840
-
The Akt/mammalian target of rapamycin signal transduction pathway is activated in high-risk myelodysplastic syndromes and influences cell survival and proliferation
-
DOI 10.1158/0008-5472.CAN-06-4409
-
Follo MY, Mongiorgi S, Bosi C, et al. The Akt/ mammalian target of rapamycin signal transduction pathway is activated in high-risk myelodysplastic syndromes and influences cell survival and proliferation. Cancer Res. 2007;67(9):4287-4294. (Pubitemid 46815076)
-
(2007)
Cancer Research
, vol.67
, Issue.9
, pp. 4287-4294
-
-
Follo, M.Y.1
Mongiorgi, S.2
Bosi, C.3
Cappellini, A.4
Finelli, C.5
Chiarini, F.6
Papa, V.7
Libra, M.8
Martinelli, G.9
Cocco, L.10
Martelli, A.M.11
-
20
-
-
33645505599
-
Mammalian target of rapamycin is required for thrombopoietin- induced proliferation of megakaryocyte progenitors
-
Drayer AL, Olthof SG, Vellenga E. Mammalian target of rapamycin is required for thrombopoietin- induced proliferation of megakaryocyte progenitors. Stem Cells. 2006;24(1):105-114.
-
(2006)
Stem Cells
, vol.24
, Issue.1
, pp. 105-114
-
-
Drayer, A.L.1
Olthof, S.G.2
Vellenga, E.3
-
21
-
-
33646376411
-
Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
-
DOI 10.1038/nature04703, PII NATURE04703
-
Yilmaz OH, Valdez R, Theisen BK, et al. Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature. 2006;441(7092):475-482. (Pubitemid 44050144)
-
(2006)
Nature
, vol.441
, Issue.7092
, pp. 475-482
-
-
Yilmaz, O.H.1
Valdez, R.2
Theisen, B.K.3
Guo, W.4
Ferguson, D.O.5
Wu, H.6
Morrison, S.J.7
-
22
-
-
33747888507
-
Shp-2 heterozygous hematopoietic stem cells have deficient repopulating ability due to diminished self-renewal
-
Chan RJ, Li Y, Hass MN, et al. Shp-2 heterozygous hematopoietic stem cells have deficient repopulating ability due to diminished self-renewal. Exp Hematol. 2006;34(9):1230-1239.
-
(2006)
Exp Hematol
, vol.34
, Issue.9
, pp. 1230-1239
-
-
Chan, R.J.1
Li, Y.2
Hass, M.N.3
-
23
-
-
0034629129
-
Hematopoietic stem cell quiescence maintained by p21(cip1/waf1)
-
DOI 10.1126/science.287.5459.1804
-
Cheng T, Rodrigues N, Shen H, et al. Hematopoietic stem cell quiescence maintained by p21cip1/waf1. Science. 2000;287(5459):1804-1808. (Pubitemid 30143963)
-
(2000)
Science
, vol.287
, Issue.5459
, pp. 1804-1809
-
-
Cheng, T.1
Rodrigues, N.2
Shen, H.3
Yang, Y.-G.4
Dombkowski, D.5
Sykes, M.6
Scadden, D.T.7
-
24
-
-
28544436371
-
Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates
-
DOI 10.1084/jem.20050967
-
Passegue E, Wagers AJ, Giuriato S, Anderson WC, Weissman IL. Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates. J Exp Med. 2005;202(11):1599-1611. (Pubitemid 41746605)
-
(2005)
Journal of Experimental Medicine
, vol.202
, Issue.11
, pp. 1599-1611
-
-
Passegue, E.1
Wagers, A.J.2
Giuriato, S.3
Anderson, W.C.4
Weissman, I.L.5
-
25
-
-
8144220648
-
Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cells
-
DOI 10.1038/sj.emboj.7600419
-
Zeng H, Yucel R, Kosan C, Klein-Hitpass L, Moroy T. Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cells. EMBO J. 2004;23(20):4116-4125. (Pubitemid 39472432)
-
(2004)
EMBO Journal
, vol.23
, Issue.20
, pp. 4116-4125
-
-
Zeng, H.1
Yucel, R.2
Kosan, C.3
Klein-Hitpass, L.4
Moroy, T.5
-
26
-
-
1642433054
-
SDF-1alpha/CXCL 12 enhances retroviral-mediated gene transfer into immature subsets of human and murine hematopietic progenitor cells
-
DOI 10.1038/sj.gt.3302127
-
Tao W, Hangoc G, Cooper S, Broxmeyer HE. SDF-1alpha/CXCL12 enhances retroviral-mediated gene transfer into immature subsets of human and murine hematopoietic progenitor cells. Gene Ther. 2004;11(1):61-69. (Pubitemid 38111389)
-
(2004)
Gene Therapy
, vol.11
, Issue.1
, pp. 61-69
-
-
Tao, W.1
Hangoc, G.2
Cooper, S.3
Broxmeyer, H.E.4
-
27
-
-
0037218576
-
Transgenic expression of stromal cell-derived factor-1/CXC chemokine ligand 12 enhances myeloid progenitor cell survival/antiapoptosis in vitro in response to growth factor withdrawal and enhances myelopoiesis in vivo
-
Broxmeyer HE, Cooper S, Kohli L, et al. Transgenic expression of stromal cell-derived factor-1/ CXC chemokine ligand 12 enhances myeloid progenitor cell survival/antiapoptosis in vitro in response to growth factor withdrawal and enhances myelopoiesis in vivo. J Immunol. 2003;170(1):421-429. (Pubitemid 36026167)
-
(2003)
Journal of Immunology
, vol.170
, Issue.1
, pp. 421-429
-
-
Broxmeyer, H.E.1
Cooper, S.2
Kohli, L.3
Hangoc, G.4
Lee, Y.5
Mantel, C.6
Clapp, D.W.7
Kim, C.H.8
-
28
-
-
0038500953
-
Stromal cell-derived factor-1/CXCL12 directly enhances survival/antiapoptosis of myeloid progenitor cells through CXCR4 and Galphai proteins and enhances engraftment of competitive, repopulating stem cells
-
DOI 10.1189/jlb.1002495
-
Broxmeyer HE, Kohli L, Kim CH, et al. Stromal cell-derived factor-1/CXCL12 directly enhances survival/antiapoptosis of myeloid progenitor cells through CXCR4 and G(alpha)i proteins and enhances engraftment of competitive, repopulating stem cells. J Leukoc Biol. 2003;73(5):630-638. (Pubitemid 38040476)
-
(2003)
Journal of Leukocyte Biology
, vol.73
, Issue.5
, pp. 630-638
-
-
Broxmeyer, H.E.1
Kohli, L.2
Kim, C.H.3
Lee, Y.4
Mantel, C.5
Cooper, S.6
Hangoc, G.7
Shaheen, M.8
Li, X.9
Clapp, D.W.10
-
29
-
-
4043117769
-
Modulation of hematopoietic stem cell homing and engraftment by CD26
-
Christopherson KW 2nd, Hangoc G, Mantel CR, Broxmeyer HE. Modulation of hematopoietic stem cell homing and engraftment by CD26. Science. 2004;305(5686):1000-1003.
-
(2004)
Science
, vol.305
, Issue.5686
, pp. 1000-1003
-
-
Christopherson II, K.W.1
Hangoc, G.2
Mantel, C.R.3
Broxmeyer, H.E.4
-
30
-
-
20944440068
-
Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist
-
Broxmeyer HE, Orschell CM, Clapp DW, et al. Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist. J Exp Med. 2005;201(8):1307-1318.
-
(2005)
J Exp Med
, vol.201
, Issue.8
, pp. 1307-1318
-
-
Broxmeyer, H.E.1
Orschell, C.M.2
Clapp, D.W.3
-
31
-
-
3142757865
-
Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent
-
DOI 10.1074/jbc.M402591200
-
Karbowniczek M, Cash T, Cheung M, Robertson GP, Astrinidis A, Henske EP. Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent. J Biol Chem. 2004;279(29):29930-29937. (Pubitemid 38937912)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.29
, pp. 29930-29937
-
-
Karbowniczek, M.1
Cash, T.2
Cheung, M.3
Robertson, G.P.4
Astrinidis, A.5
Henske, E.P.6
|