메뉴 건너뛰기




Volumn 33, Issue , 2014, Pages 52-62

Hedgehog and its circuitous journey from producing to target cells

Author keywords

Cytonemes; Hh gradient; Hh processing; Hh recycling

Indexed keywords

FLOTILLIN 2; LIPID; LIPOPROTEIN; OLIGOMER; PROTEIN; PROTEIN SCUBE 2; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG;

EID: 84905572370     PISSN: 10849521     EISSN: 10963634     Source Type: Journal    
DOI: 10.1016/j.semcdb.2014.06.016     Document Type: Review
Times cited : (31)

References (156)
  • 1
    • 0019133661 scopus 로고
    • Mutations affecting segment number and polarity in Drosophila
    • Nüsslein-Volhard C., Wieschaus E. Mutations affecting segment number and polarity in Drosophila. Nature 1980, 287:795-801.
    • (1980) Nature , vol.287 , pp. 795-801
    • Nüsslein-Volhard, C.1    Wieschaus, E.2
  • 2
    • 0027756145 scopus 로고
    • Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity
    • Echelard Y., Epstein D.J., St-Jacques B., Shen L., Mohler J., McMahon J.A., et al. Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell 1993, 75:1417-1430.
    • (1993) Cell , vol.75 , pp. 1417-1430
    • Echelard, Y.1    Epstein, D.J.2    St-Jacques, B.3    Shen, L.4    Mohler, J.5    McMahon, J.A.6
  • 3
    • 79956308325 scopus 로고    scopus 로고
    • Mechanisms and functions of Hedgehog signalling across the metazoa
    • Ingham P.W., Nakano Y., Seger C. Mechanisms and functions of Hedgehog signalling across the metazoa. Nat Rev Genet 2011, 12:393-406.
    • (2011) Nat Rev Genet , vol.12 , pp. 393-406
    • Ingham, P.W.1    Nakano, Y.2    Seger, C.3
  • 4
    • 4043122029 scopus 로고    scopus 로고
    • Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning
    • Ahn S., Joyner A.L. Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning. Cell 2004, 118:505-516.
    • (2004) Cell , vol.118 , pp. 505-516
    • Ahn, S.1    Joyner, A.L.2
  • 5
    • 3142696904 scopus 로고    scopus 로고
    • The limb bud Shh-Fgf feedback loop is terminated by expansion of former ZPA cells
    • Scherz P.J., Harfe B.D., McMahon A.P., Tabin C.J. The limb bud Shh-Fgf feedback loop is terminated by expansion of former ZPA cells. Science 2004, 305:396-399.
    • (2004) Science , vol.305 , pp. 396-399
    • Scherz, P.J.1    Harfe, B.D.2    McMahon, A.P.3    Tabin, C.J.4
  • 6
    • 0037418830 scopus 로고    scopus 로고
    • The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance
    • Charron F., Stein E., Jeong J., McMahon A.P., Tessier-Lavigne M. The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance. Cell 2003, 113:11-23.
    • (2003) Cell , vol.113 , pp. 11-23
    • Charron, F.1    Stein, E.2    Jeong, J.3    McMahon, A.P.4    Tessier-Lavigne, M.5
  • 7
    • 58149347652 scopus 로고    scopus 로고
    • Autonomous and non-autonomous Shh signalling mediate the in vivo growth and guidance of mouse retinal ganglion cell axons
    • Sanchez-Camacho C., Bovolenta P. Autonomous and non-autonomous Shh signalling mediate the in vivo growth and guidance of mouse retinal ganglion cell axons. Development 2008, 135:3531-3541.
    • (2008) Development , vol.135 , pp. 3531-3541
    • Sanchez-Camacho, C.1    Bovolenta, P.2
  • 8
    • 77958617639 scopus 로고    scopus 로고
    • Xenopus sonic hedgehog guides retinal axons along the optic tract
    • Gordon L., Mansh M., Kinsman H., Morris A.R. Xenopus sonic hedgehog guides retinal axons along the optic tract. Dev Dyn 2010, 239:2921-2932.
    • (2010) Dev Dyn , vol.239 , pp. 2921-2932
    • Gordon, L.1    Mansh, M.2    Kinsman, H.3    Morris, A.R.4
  • 9
    • 70349631211 scopus 로고    scopus 로고
    • Sonic hedgehog is a chemoattractant for midbrain dopaminergic axons
    • Hammond R., Blaess S., Abeliovich A. Sonic hedgehog is a chemoattractant for midbrain dopaminergic axons. PLoS ONE 2009, 4:e7007.
    • (2009) PLoS ONE , vol.4
    • Hammond, R.1    Blaess, S.2    Abeliovich, A.3
  • 10
    • 73949110776 scopus 로고    scopus 로고
    • Sonic hedgehog induces response of commissural axons to Semaphorin repulsion during midline crossing
    • Parra L.M., Zou Y. Sonic hedgehog induces response of commissural axons to Semaphorin repulsion during midline crossing. Nat Neurosci 2010, 13:29-35.
    • (2010) Nat Neurosci , vol.13 , pp. 29-35
    • Parra, L.M.1    Zou, Y.2
  • 11
    • 84869840135 scopus 로고    scopus 로고
    • 14-3-3 proteins regulate a cell-intrinsic switch from sonic hedgehog-mediated commissural axon attraction to repulsion after midline crossing
    • Yam P.T., Kent C.B., Morin S., Farmer W.T., Alchini R., Lepelletier L., et al. 14-3-3 proteins regulate a cell-intrinsic switch from sonic hedgehog-mediated commissural axon attraction to repulsion after midline crossing. Neuron 2012, 76:735-749.
    • (2012) Neuron , vol.76 , pp. 735-749
    • Yam, P.T.1    Kent, C.B.2    Morin, S.3    Farmer, W.T.4    Alchini, R.5    Lepelletier, L.6
  • 12
    • 77954055939 scopus 로고    scopus 로고
    • Shaping morphogen gradients by proteoglycans
    • Yan D., Lin X. Shaping morphogen gradients by proteoglycans. Cold Spring Harb Perspect Biol 2009, 1:a002493.
    • (2009) Cold Spring Harb Perspect Biol , vol.1
    • Yan, D.1    Lin, X.2
  • 13
    • 0029750190 scopus 로고    scopus 로고
    • Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein
    • Vortkamp A., Lee K., Lanske B., Segre G.V., Kronenberg H.M., Tabin C.J. Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein. Science 1996, 273:613-622.
    • (1996) Science , vol.273 , pp. 613-622
    • Vortkamp, A.1    Lee, K.2    Lanske, B.3    Segre, G.V.4    Kronenberg, H.M.5    Tabin, C.J.6
  • 14
    • 9344241375 scopus 로고    scopus 로고
    • PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth
    • Lanske B., Karaplis A.C., Lee K., Luz A., Vortkamp A., Pirro A., et al. PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth. Science 1996, 273:663-666.
    • (1996) Science , vol.273 , pp. 663-666
    • Lanske, B.1    Karaplis, A.C.2    Lee, K.3    Luz, A.4    Vortkamp, A.5    Pirro, A.6
  • 15
    • 0028837742 scopus 로고
    • Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo
    • Bitgood M.J., McMahon A.P. Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev Biol 1995, 172:126-138.
    • (1995) Dev Biol , vol.172 , pp. 126-138
    • Bitgood, M.J.1    McMahon, A.P.2
  • 16
    • 0033709190 scopus 로고    scopus 로고
    • Desert hedgehog (Dhh) gene is required in the mouse testis for formation of adult-type Leydig cells and normal development of peritubular cells and seminiferous tubules
    • Clark A.M., Garland K.K., Russell L.D. Desert hedgehog (Dhh) gene is required in the mouse testis for formation of adult-type Leydig cells and normal development of peritubular cells and seminiferous tubules. Biol Reprod 2000, 63:1825-1838.
    • (2000) Biol Reprod , vol.63 , pp. 1825-1838
    • Clark, A.M.1    Garland, K.K.2    Russell, L.D.3
  • 17
    • 0033754159 scopus 로고    scopus 로고
    • A novel mutation of desert hedgehog in a patient with 46,XY partial gonadal dysgenesis accompanied by minifascicular neuropathy
    • Umehara F., Tate G., Itoh K., Yamaguchi N., Douchi T., Mitsuya T., et al. A novel mutation of desert hedgehog in a patient with 46,XY partial gonadal dysgenesis accompanied by minifascicular neuropathy. Am J Hum Genet 2000, 67:1302-1305.
    • (2000) Am J Hum Genet , vol.67 , pp. 1302-1305
    • Umehara, F.1    Tate, G.2    Itoh, K.3    Yamaguchi, N.4    Douchi, T.5    Mitsuya, T.6
  • 18
    • 84887256489 scopus 로고    scopus 로고
    • Cytonemes are required for the establishment of a normal Hedgehog morphogen gradient in Drosophila epithelia
    • Bischoff M., Gradilla A.C., Seijo I., Andres G., Rodriguez-Navas C., Gonzalez-Mendez L., et al. Cytonemes are required for the establishment of a normal Hedgehog morphogen gradient in Drosophila epithelia. Nat Cell Biol 2013, 15:1269-1281.
    • (2013) Nat Cell Biol , vol.15 , pp. 1269-1281
    • Bischoff, M.1    Gradilla, A.C.2    Seijo, I.3    Andres, G.4    Rodriguez-Navas, C.5    Gonzalez-Mendez, L.6
  • 19
    • 51949097274 scopus 로고    scopus 로고
    • Hhat is a palmitoylacyltransferase with specificity for N-palmitoylation of Sonic Hedgehog
    • Buglino J.A., Resh M.D. Hhat is a palmitoylacyltransferase with specificity for N-palmitoylation of Sonic Hedgehog. J Biol Chem 2008, 283:22076-22088.
    • (2008) J Biol Chem , vol.283 , pp. 22076-22088
    • Buglino, J.A.1    Resh, M.D.2
  • 20
    • 0035860538 scopus 로고    scopus 로고
    • Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal
    • Chamoun Z., Mann R.K., Nellen D., von Kessler D.P., Bellotto M., Beachy P.A., et al. Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal. Science 2001, 293:2080-2084.
    • (2001) Science , vol.293 , pp. 2080-2084
    • Chamoun, Z.1    Mann, R.K.2    Nellen, D.3    von Kessler, D.P.4    Bellotto, M.5    Beachy, P.A.6
  • 21
    • 15444359695 scopus 로고    scopus 로고
    • Identification of a palmitic acid-modified form of human Sonic hedgehog
    • Pepinsky R.B., Zeng C., Wen D., Rayhorn P., Baker D.P., Williams K.P., et al. Identification of a palmitic acid-modified form of human Sonic hedgehog. J Biol Chem 1998, 273:14037-14045.
    • (1998) J Biol Chem , vol.273 , pp. 14037-14045
    • Pepinsky, R.B.1    Zeng, C.2    Wen, D.3    Rayhorn, P.4    Baker, D.P.5    Williams, K.P.6
  • 22
    • 79952433637 scopus 로고    scopus 로고
    • Processing and turnover of the Hedgehog protein in the endoplasmic reticulum
    • Chen X., Tukachinsky H., Huang C.H., Jao C., Chu Y.R., Tang H.Y., et al. Processing and turnover of the Hedgehog protein in the endoplasmic reticulum. J Cell Biol 2011, 192:825-838.
    • (2011) J Cell Biol , vol.192 , pp. 825-838
    • Chen, X.1    Tukachinsky, H.2    Huang, C.H.3    Jao, C.4    Chu, Y.R.5    Tang, H.Y.6
  • 23
    • 0035694931 scopus 로고    scopus 로고
    • Distinct roles of central missing and dispatched in sending the Hedgehog signal
    • Amanai K., Jiang J. Distinct roles of central missing and dispatched in sending the Hedgehog signal. Development 2001, 128:5119-5127.
    • (2001) Development , vol.128 , pp. 5119-5127
    • Amanai, K.1    Jiang, J.2
  • 24
    • 0035942989 scopus 로고    scopus 로고
    • Sightless has homology to transmembrane acyltransferases and is required to generate active Hedgehog protein
    • Lee J.D., Treisman J.E. Sightless has homology to transmembrane acyltransferases and is required to generate active Hedgehog protein. Curr Biol 2001, 11:1147-1152.
    • (2001) Curr Biol , vol.11 , pp. 1147-1152
    • Lee, J.D.1    Treisman, J.E.2
  • 25
    • 0036339605 scopus 로고    scopus 로고
    • Rasp, a putative transmembrane acyltransferase, is required for Hedgehog signaling
    • Micchelli C.A., The I., Selva E., Mogila V., Perrimon N. Rasp, a putative transmembrane acyltransferase, is required for Hedgehog signaling. Development 2002, 129:843-851.
    • (2002) Development , vol.129 , pp. 843-851
    • Micchelli, C.A.1    The, I.2    Selva, E.3    Mogila, V.4    Perrimon, N.5
  • 26
    • 1842853184 scopus 로고    scopus 로고
    • Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates
    • Chen M.H., Li Y.J., Kawakami T., Xu S.M., Chuang P.T. Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates. Genes Dev 2004, 18:641-659.
    • (2004) Genes Dev , vol.18 , pp. 641-659
    • Chen, M.H.1    Li, Y.J.2    Kawakami, T.3    Xu, S.M.4    Chuang, P.T.5
  • 27
    • 77955293319 scopus 로고    scopus 로고
    • Identification of conserved regions and residues within Hedgehog acyltransferase critical for palmitoylation of Sonic Hedgehog
    • Buglino J.A., Resh M.D. Identification of conserved regions and residues within Hedgehog acyltransferase critical for palmitoylation of Sonic Hedgehog. PLoS ONE 2010, 5:e11195.
    • (2010) PLoS ONE , vol.5
    • Buglino, J.A.1    Resh, M.D.2
  • 28
    • 0029844192 scopus 로고    scopus 로고
    • Cholesterol modification of hedgehog signaling proteins in animal development
    • Porter J.A., Young K.E., Beachy P.A. Cholesterol modification of hedgehog signaling proteins in animal development. Science 1996, 274:255-259.
    • (1996) Science , vol.274 , pp. 255-259
    • Porter, J.A.1    Young, K.E.2    Beachy, P.A.3
  • 29
    • 16144368562 scopus 로고    scopus 로고
    • Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly
    • Belloni E., Muenke M., Roessler E., Traverso G., Siegel-Bartelt J., Frumkin A., et al. Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly. Nat Genet 1996, 14:353-356.
    • (1996) Nat Genet , vol.14 , pp. 353-356
    • Belloni, E.1    Muenke, M.2    Roessler, E.3    Traverso, G.4    Siegel-Bartelt, J.5    Frumkin, A.6
  • 30
    • 28044441095 scopus 로고    scopus 로고
    • Molecular mechanisms of Sonic hedgehog mutant effects in holoprosencephaly
    • Maity T., Fuse N., Beachy P.A. Molecular mechanisms of Sonic hedgehog mutant effects in holoprosencephaly. Proc Natl Acad Sci U S A 2005, 102:17026-17031.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 17026-17031
    • Maity, T.1    Fuse, N.2    Beachy, P.A.3
  • 31
    • 73349088745 scopus 로고    scopus 로고
    • The mutational spectrum of holoprosencephaly-associated changes within the SHH gene in humans predicts loss-of-function through either key structural alterations of the ligand or its altered synthesis
    • Roessler E., El-Jaick K.B., Dubourg C., Velez J.I., Solomon B.D., Pineda-Alvarez D.E., et al. The mutational spectrum of holoprosencephaly-associated changes within the SHH gene in humans predicts loss-of-function through either key structural alterations of the ligand or its altered synthesis. Hum Mutat 2009, 30:E921-E935.
    • (2009) Hum Mutat , vol.30
    • Roessler, E.1    El-Jaick, K.B.2    Dubourg, C.3    Velez, J.I.4    Solomon, B.D.5    Pineda-Alvarez, D.E.6
  • 33
    • 77449105629 scopus 로고    scopus 로고
    • The full-length unprocessed hedgehog protein is an active signaling molecule
    • Tokhunts R., Singh S., Chu T., D'Angelo G., Baubet V., Goetz J.A., et al. The full-length unprocessed hedgehog protein is an active signaling molecule. J Biol Chem 2010, 285:2562-2568.
    • (2010) J Biol Chem , vol.285 , pp. 2562-2568
    • Tokhunts, R.1    Singh, S.2    Chu, T.3    D'Angelo, G.4    Baubet, V.5    Goetz, J.A.6
  • 34
    • 0012466695 scopus 로고    scopus 로고
    • Inhibition of sonic hedgehog autoprocessing in cultured mammalian cells by sterol deprivation
    • Guy R.K. Inhibition of sonic hedgehog autoprocessing in cultured mammalian cells by sterol deprivation. Proc Natl Acad Sci U S A 2000, 97:7307-7312.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 7307-7312
    • Guy, R.K.1
  • 35
    • 0032498234 scopus 로고    scopus 로고
    • Protein splicing of inteins and hedgehog autoproteolysis: structure, function, and evolution
    • Perler F.B. Protein splicing of inteins and hedgehog autoproteolysis: structure, function, and evolution. Cell 1998, 92:1-4.
    • (1998) Cell , vol.92 , pp. 1-4
    • Perler, F.B.1
  • 36
    • 2942742564 scopus 로고    scopus 로고
    • Novel lipid modifications of secreted protein signals
    • Mann R.K., Beachy P.A. Novel lipid modifications of secreted protein signals. Annu Rev Biochem 2004, 73:891-923.
    • (2004) Annu Rev Biochem , vol.73 , pp. 891-923
    • Mann, R.K.1    Beachy, P.A.2
  • 37
    • 33646111433 scopus 로고    scopus 로고
    • A C-terminal motif targets Hedgehog to axons, coordinating assembly of the Drosophila eye and brain
    • Chu T., Chiu M., Zhang E., Kunes S. A C-terminal motif targets Hedgehog to axons, coordinating assembly of the Drosophila eye and brain. Dev Cell 2006, 10:635-646.
    • (2006) Dev Cell , vol.10 , pp. 635-646
    • Chu, T.1    Chiu, M.2    Zhang, E.3    Kunes, S.4
  • 38
    • 33244463974 scopus 로고    scopus 로고
    • Hedgehog lipid modifications are required for Hedgehog stabilization in the extracellular matrix
    • Callejo A., Torroja C., Quijada L., Guerrero I. Hedgehog lipid modifications are required for Hedgehog stabilization in the extracellular matrix. Development 2006, 133:471-483.
    • (2006) Development , vol.133 , pp. 471-483
    • Callejo, A.1    Torroja, C.2    Quijada, L.3    Guerrero, I.4
  • 40
    • 0037321854 scopus 로고    scopus 로고
    • Cholesterol modification of hedgehog is required for trafficking and movement, revealing an asymmetric cellular response to hedgehog
    • Gallet A., Rodriguez R., Ruel L., Therond P.P. Cholesterol modification of hedgehog is required for trafficking and movement, revealing an asymmetric cellular response to hedgehog. Dev Cell 2003, 4:191-204.
    • (2003) Dev Cell , vol.4 , pp. 191-204
    • Gallet, A.1    Rodriguez, R.2    Ruel, L.3    Therond, P.P.4
  • 41
    • 33244482560 scopus 로고    scopus 로고
    • Cholesterol modification is necessary for controlled planar long-range activity of Hedgehog in Drosophila epithelia
    • Gallet A., Ruel L., Staccini-Lavenant L., Therond P.P. Cholesterol modification is necessary for controlled planar long-range activity of Hedgehog in Drosophila epithelia. Development 2006, 133:407-418.
    • (2006) Development , vol.133 , pp. 407-418
    • Gallet, A.1    Ruel, L.2    Staccini-Lavenant, L.3    Therond, P.P.4
  • 42
    • 34250875089 scopus 로고    scopus 로고
    • Region-specific requirement for cholesterol modification of sonic hedgehog in patterning the telencephalon and spinal cord
    • Huang X., Litingtung Y., Chiang C. Region-specific requirement for cholesterol modification of sonic hedgehog in patterning the telencephalon and spinal cord. Development 2007, 134:2095-2105.
    • (2007) Development , vol.134 , pp. 2095-2105
    • Huang, X.1    Litingtung, Y.2    Chiang, C.3
  • 43
    • 0035337027 scopus 로고    scopus 로고
    • An acylatable residue of Hedgehog is differentially required in Drosophila and mouse limb development
    • Lee J.D., Kraus P., Gaiano N., Nery S., Kohtz J., Fishell G., et al. An acylatable residue of Hedgehog is differentially required in Drosophila and mouse limb development. Dev Biol 2001, 233:122-136.
    • (2001) Dev Biol , vol.233 , pp. 122-136
    • Lee, J.D.1    Kraus, P.2    Gaiano, N.3    Nery, S.4    Kohtz, J.5    Fishell, G.6
  • 44
    • 0035368725 scopus 로고    scopus 로고
    • Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1
    • Lewis P.M., Dunn M.P., McMahon J.A., Logan M., Martin J.F., St-Jacques B., et al. Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1. Cell 2001, 105:599-612.
    • (2001) Cell , vol.105 , pp. 599-612
    • Lewis, P.M.1    Dunn, M.P.2    McMahon, J.A.3    Logan, M.4    Martin, J.F.5    St-Jacques, B.6
  • 45
    • 33646247878 scopus 로고    scopus 로고
    • Cholesterol modification restricts the spread of Shh gradient in the limb bud
    • Li Y., Zhang H., Litingtung Y., Chiang C. Cholesterol modification restricts the spread of Shh gradient in the limb bud. Proc Natl Acad Sci U S A 2006, 103:6548-6553.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 6548-6553
    • Li, Y.1    Zhang, H.2    Litingtung, Y.3    Chiang, C.4
  • 46
    • 0033490535 scopus 로고    scopus 로고
    • Functional antagonists of sonic hedgehog reveal the importance of the N terminus for activity
    • Williams K.P., Rayhorn P., Chi-Rosso G., Garber E.A., Strauch K.L., Horan G.S., et al. Functional antagonists of sonic hedgehog reveal the importance of the N terminus for activity. J Cell Sci 1999, 112(Pt 23):4405-4414.
    • (1999) J Cell Sci , vol.112 , Issue.Pt 23 , pp. 4405-4414
    • Williams, K.P.1    Rayhorn, P.2    Chi-Rosso, G.3    Garber, E.A.4    Strauch, K.L.5    Horan, G.S.6
  • 47
    • 0034931149 scopus 로고    scopus 로고
    • N-terminal fatty-acylation of sonic hedgehog enhances the induction of rodent ventral forebrain neurons
    • Kohtz J.D., Lee H.Y., Gaiano N., Segal J., Ng E., Larson T., et al. N-terminal fatty-acylation of sonic hedgehog enhances the induction of rodent ventral forebrain neurons. Development 2001, 128:2351-2363.
    • (2001) Development , vol.128 , pp. 2351-2363
    • Kohtz, J.D.1    Lee, H.Y.2    Gaiano, N.3    Segal, J.4    Ng, E.5    Larson, T.6
  • 48
    • 84871596524 scopus 로고    scopus 로고
    • An emerging role of Sonic hedgehog shedding as a modulator of heparan sulfate interactions
    • Ohlig S., Pickhinke U., Sirko S., Bandari S., Hoffmann D., Dreier R., et al. An emerging role of Sonic hedgehog shedding as a modulator of heparan sulfate interactions. J Biol Chem 2012, 287:43708-43719.
    • (2012) J Biol Chem , vol.287 , pp. 43708-43719
    • Ohlig, S.1    Pickhinke, U.2    Sirko, S.3    Bandari, S.4    Hoffmann, D.5    Dreier, R.6
  • 49
    • 27644487457 scopus 로고    scopus 로고
    • HMGCoA reductase potentiates hedgehog signaling in Drosophila melanogaster
    • Deshpande G., Schedl P. HMGCoA reductase potentiates hedgehog signaling in Drosophila melanogaster. Dev Cell 2005, 9:629-638.
    • (2005) Dev Cell , vol.9 , pp. 629-638
    • Deshpande, G.1    Schedl, P.2
  • 52
    • 84965080920 scopus 로고    scopus 로고
    • Absolute requirement of cholesterol binding for Hedgehog gradient formation in Drosophila
    • Ducuing A., Mollereau B., Axelrod J.D., Vincent S. Absolute requirement of cholesterol binding for Hedgehog gradient formation in Drosophila. Biol Open 2013, 2:596-604.
    • (2013) Biol Open , vol.2 , pp. 596-604
    • Ducuing, A.1    Mollereau, B.2    Axelrod, J.D.3    Vincent, S.4
  • 53
    • 34249798211 scopus 로고    scopus 로고
    • Quantitative analysis of Hedgehog gradient formation using an inducible expression system
    • Su V.F., Jones K.A., Brodsky M., The I. Quantitative analysis of Hedgehog gradient formation using an inducible expression system. BMC Dev Biol 2007, 7:43.
    • (2007) BMC Dev Biol , vol.7 , pp. 43
    • Su, V.F.1    Jones, K.A.2    Brodsky, M.3    The, I.4
  • 54
    • 2942593888 scopus 로고    scopus 로고
    • The cholesterol membrane anchor of the Hedgehog protein confers stable membrane association to lipid-modified proteins
    • Peters C., Wolf A., Wagner M., Kuhlmann J., Waldmann H. The cholesterol membrane anchor of the Hedgehog protein confers stable membrane association to lipid-modified proteins. Proc Natl Acad Sci U S A 2004, 101:8531-8536.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 8531-8536
    • Peters, C.1    Wolf, A.2    Wagner, M.3    Kuhlmann, J.4    Waldmann, H.5
  • 55
    • 0033597141 scopus 로고    scopus 로고
    • Association of sterol- and glycosylphosphatidylinositol-linked proteins with Drosophila raft lipid microdomains
    • Rietveld A., Neutz S., Simons K., Eaton S. Association of sterol- and glycosylphosphatidylinositol-linked proteins with Drosophila raft lipid microdomains. J Biol Chem 1999, 274:12049-12054.
    • (1999) J Biol Chem , vol.274 , pp. 12049-12054
    • Rietveld, A.1    Neutz, S.2    Simons, K.3    Eaton, S.4
  • 56
    • 0033598964 scopus 로고    scopus 로고
    • Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells
    • Burke R., Nellen D., Bellotto M., Hafen E., Senti K.A., Dickson B.J., et al. Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells. Cell 1999, 99:803-815.
    • (1999) Cell , vol.99 , pp. 803-815
    • Burke, R.1    Nellen, D.2    Bellotto, M.3    Hafen, E.4    Senti, K.A.5    Dickson, B.J.6
  • 57
    • 0036922902 scopus 로고    scopus 로고
    • Mouse dispatched mutants fail to distribute hedgehog proteins and are defective in hedgehog signaling
    • Kawakami T., Kawcak T., Li Y.J., Zhang W., Hu Y., Chuang P.T. Mouse dispatched mutants fail to distribute hedgehog proteins and are defective in hedgehog signaling. Development 2002, 129:5753-5765.
    • (2002) Development , vol.129 , pp. 5753-5765
    • Kawakami, T.1    Kawcak, T.2    Li, Y.J.3    Zhang, W.4    Hu, Y.5    Chuang, P.T.6
  • 58
    • 0037020216 scopus 로고    scopus 로고
    • Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched
    • Ma Y., Erkner A., Gong R., Yao S., Taipale J., Basler K., et al. Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched. Cell 2002, 111:63-75.
    • (2002) Cell , vol.111 , pp. 63-75
    • Ma, Y.1    Erkner, A.2    Gong, R.3    Yao, S.4    Taipale, J.5    Basler, K.6
  • 59
    • 79961221518 scopus 로고    scopus 로고
    • Dispatched mediates Hedgehog basolateral release to form the long-range morphogenetic gradient in the Drosophila wing disk epithelium
    • Callejo A., Bilioni A., Mollica E., Gorfinkiel N., Andres G., Ibanez C., et al. Dispatched mediates Hedgehog basolateral release to form the long-range morphogenetic gradient in the Drosophila wing disk epithelium. Proc Natl Acad Sci U S A 2011, 108:12591-12598.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 12591-12598
    • Callejo, A.1    Bilioni, A.2    Mollica, E.3    Gorfinkiel, N.4    Andres, G.5    Ibanez, C.6
  • 60
    • 84864048458 scopus 로고    scopus 로고
    • Scube activity is necessary for Hedgehog signal transduction in vivo
    • Johnson J.L., Hall T.E., Dyson J.M., Sonntag C., Ayers K., Berger S., et al. Scube activity is necessary for Hedgehog signal transduction in vivo. Dev Biol 2012, 368:193-202.
    • (2012) Dev Biol , vol.368 , pp. 193-202
    • Johnson, J.L.1    Hall, T.E.2    Dyson, J.M.3    Sonntag, C.4    Ayers, K.5    Berger, S.6
  • 62
    • 18044366926 scopus 로고    scopus 로고
    • The you gene encodes an EGF-CUB protein essential for Hedgehog signaling in zebrafish
    • Woods I.G., Talbot W.S. The you gene encodes an EGF-CUB protein essential for Hedgehog signaling in zebrafish. PLoS Biol 2005, 3:e66.
    • (2005) PLoS Biol , vol.3
    • Woods, I.G.1    Talbot, W.S.2
  • 63
    • 84862594879 scopus 로고    scopus 로고
    • Scube/You activity mediates release of dually lipid-modified Hedgehog signal in soluble form
    • Creanga A., Glenn T.D., Mann R.K., Saunders A.M., Talbot W.S., Beachy P.A. Scube/You activity mediates release of dually lipid-modified Hedgehog signal in soluble form. Genes Dev 2012, 26:1312-1325.
    • (2012) Genes Dev , vol.26 , pp. 1312-1325
    • Creanga, A.1    Glenn, T.D.2    Mann, R.K.3    Saunders, A.M.4    Talbot, W.S.5    Beachy, P.A.6
  • 64
    • 84865783630 scopus 로고    scopus 로고
    • Dispatched and scube mediate the efficient secretion of the cholesterol-modified hedgehog ligand
    • Tukachinsky H., Kuzmickas R.P., Jao C.Y., Liu J., Salic A. Dispatched and scube mediate the efficient secretion of the cholesterol-modified hedgehog ligand. Cell Rep 2012, 2:308-320.
    • (2012) Cell Rep , vol.2 , pp. 308-320
    • Tukachinsky, H.1    Kuzmickas, R.P.2    Jao, C.Y.3    Liu, J.4    Salic, A.5
  • 65
    • 79958198050 scopus 로고    scopus 로고
    • Sonic hedgehog shedding results in functional activation of the solubilized protein
    • Ohlig S., Farshi P., Pickhinke U., van den Boom J., Hoing S., Jakuschev S., et al. Sonic hedgehog shedding results in functional activation of the solubilized protein. Dev Cell 2011, 20:764-774.
    • (2011) Dev Cell , vol.20 , pp. 764-774
    • Ohlig, S.1    Farshi, P.2    Pickhinke, U.3    van den Boom, J.4    Hoing, S.5    Jakuschev, S.6
  • 66
    • 84875452685 scopus 로고    scopus 로고
    • Secretion and signaling activities of lipoprotein-associated hedgehog and non-sterol-modified hedgehog in flies and mammals
    • Palm W., Swierczynska M.M., Kumari V., Ehrhart-Bornstein M., Bornstein S.R., Eaton S. Secretion and signaling activities of lipoprotein-associated hedgehog and non-sterol-modified hedgehog in flies and mammals. PLoS Biol 2013, 11:e1001505.
    • (2013) PLoS Biol , vol.11
    • Palm, W.1    Swierczynska, M.M.2    Kumari, V.3    Ehrhart-Bornstein, M.4    Bornstein, S.R.5    Eaton, S.6
  • 67
    • 18344378499 scopus 로고    scopus 로고
    • Lipoprotein particles are required for Hedgehog and Wingless signalling
    • Panakova D., Sprong H., Marois E., Thiele C., Eaton S. Lipoprotein particles are required for Hedgehog and Wingless signalling. Nature 2005, 435:58-65.
    • (2005) Nature , vol.435 , pp. 58-65
    • Panakova, D.1    Sprong, H.2    Marois, E.3    Thiele, C.4    Eaton, S.5
  • 68
    • 0032474837 scopus 로고    scopus 로고
    • Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion
    • Bellaiche Y., The I., Perrimon N. Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion. Nature 1998, 394:85-88.
    • (1998) Nature , vol.394 , pp. 85-88
    • Bellaiche, Y.1    The, I.2    Perrimon, N.3
  • 69
    • 0031711921 scopus 로고    scopus 로고
    • Expression and properties of wild-type and mutant forms of the Drosophila sex comb on midleg (SCM) repressor protein
    • Bornemann D., Miller E., Simon J. Expression and properties of wild-type and mutant forms of the Drosophila sex comb on midleg (SCM) repressor protein. Genetics 1998, 150:675-686.
    • (1998) Genetics , vol.150 , pp. 675-686
    • Bornemann, D.1    Miller, E.2    Simon, J.3
  • 70
    • 1342341864 scopus 로고    scopus 로고
    • Three Drosophila EXT genes shape morphogen gradients through synthesis of heparan sulfate proteoglycans
    • Takei Y., Ozawa Y., Sato M., Watanabe A., Tabata T. Three Drosophila EXT genes shape morphogen gradients through synthesis of heparan sulfate proteoglycans. Development 2004, 131:73-82.
    • (2004) Development , vol.131 , pp. 73-82
    • Takei, Y.1    Ozawa, Y.2    Sato, M.3    Watanabe, A.4    Tabata, T.5
  • 71
    • 0033212987 scopus 로고    scopus 로고
    • Hedgehog movement is regulated through tout velu-dependent synthesis of a heparan sulfate proteoglycan
    • The I., Bellaiche Y., Perrimon N. Hedgehog movement is regulated through tout velu-dependent synthesis of a heparan sulfate proteoglycan. Mol Cell 1999, 4:633-639.
    • (1999) Mol Cell , vol.4 , pp. 633-639
    • The, I.1    Bellaiche, Y.2    Perrimon, N.3
  • 72
    • 0034704824 scopus 로고    scopus 로고
    • Wingless gradient formation in the Drosophila wing
    • Strigini M., Cohen S.M. Wingless gradient formation in the Drosophila wing. Curr Biol 2000, 10:293-300.
    • (2000) Curr Biol , vol.10 , pp. 293-300
    • Strigini, M.1    Cohen, S.M.2
  • 73
    • 77951896697 scopus 로고    scopus 로고
    • The long-range activity of Hedgehog is regulated in the apical extracellular space by the glypican Dally and the hydrolase Notum
    • Ayers K.L., Gallet A., Staccini-Lavenant L., Therond P.P. The long-range activity of Hedgehog is regulated in the apical extracellular space by the glypican Dally and the hydrolase Notum. Dev Cell 2010, 18:605-620.
    • (2010) Dev Cell , vol.18 , pp. 605-620
    • Ayers, K.L.1    Gallet, A.2    Staccini-Lavenant, L.3    Therond, P.P.4
  • 75
    • 84875056033 scopus 로고    scopus 로고
    • Balancing Hedgehog, a retention and release equilibrium given by Dally, Ihog, Boi and shifted/DmWif
    • Bilioni A., Sánchez-Hernández D., Callejo A., Gradilla A.C., Ibanez C., Mollica E., et al. Balancing Hedgehog, a retention and release equilibrium given by Dally, Ihog, Boi and shifted/DmWif. Dev Biol 2013, 376:198-212.
    • (2013) Dev Biol , vol.376 , pp. 198-212
    • Bilioni, A.1    Sánchez-Hernández, D.2    Callejo, A.3    Gradilla, A.C.4    Ibanez, C.5    Mollica, E.6
  • 76
    • 81855183845 scopus 로고    scopus 로고
    • Barcoding Hedgehog for intracellular transport
    • Kornberg T.B. Barcoding Hedgehog for intracellular transport. Sci Signal 2011, 4:pe44.
    • (2011) Sci Signal , vol.4
    • Kornberg, T.B.1
  • 77
    • 0033168456 scopus 로고    scopus 로고
    • Is dynamin a regular motor or a master regulator
    • van der Bliek A.M. Is dynamin a regular motor or a master regulator. Trends Cell Biol 1999, 9:253-254.
    • (1999) Trends Cell Biol , vol.9 , pp. 253-254
    • van der Bliek, A.M.1
  • 79
    • 73649106563 scopus 로고    scopus 로고
    • Evidence for a role of vertebrate Disp1 in long-range Shh signaling
    • Etheridge L.A., Crawford T.Q., Zhang S., Roelink H. Evidence for a role of vertebrate Disp1 in long-range Shh signaling. Development 2010, 137:133-140.
    • (2010) Development , vol.137 , pp. 133-140
    • Etheridge, L.A.1    Crawford, T.Q.2    Zhang, S.3    Roelink, H.4
  • 80
    • 13344284705 scopus 로고    scopus 로고
    • Mouse Disp1 is required in sonic hedgehog-expressing cells for paracrine activity of the cholesterol-modified ligand
    • Tian H., Jeong J., Harfe B.D., Tabin C.J., McMahon A.P. Mouse Disp1 is required in sonic hedgehog-expressing cells for paracrine activity of the cholesterol-modified ligand. Development 2005, 132:133-142.
    • (2005) Development , vol.132 , pp. 133-142
    • Tian, H.1    Jeong, J.2    Harfe, B.D.3    Tabin, C.J.4    McMahon, A.P.5
  • 81
    • 0032538989 scopus 로고    scopus 로고
    • The monomeric guanosine triphosphatase rab4 controls an essential step on the pathway of receptor-mediated antigen processing in B cells
    • Lazzarino D.A., Blier P., Mellman I. The monomeric guanosine triphosphatase rab4 controls an essential step on the pathway of receptor-mediated antigen processing in B cells. J Exp Med 1998, 188:1769-1774.
    • (1998) J Exp Med , vol.188 , pp. 1769-1774
    • Lazzarino, D.A.1    Blier, P.2    Mellman, I.3
  • 82
    • 0034282429 scopus 로고    scopus 로고
    • Ferguson SS. beta 2-adrenergic receptor internalization, endosomal sorting, and plasma membrane recycling are regulated by rab GTPases
    • Seachrist J.L., Anborgh P.H. Ferguson SS. beta 2-adrenergic receptor internalization, endosomal sorting, and plasma membrane recycling are regulated by rab GTPases. J Biol Chem 2000, 275:27221-27228.
    • (2000) J Biol Chem , vol.275 , pp. 27221-27228
    • Seachrist, J.L.1    Anborgh, P.H.2
  • 83
    • 38549141572 scopus 로고    scopus 로고
    • Cellular cholesterol trafficking and compartmentalization
    • Ikonen E. Cellular cholesterol trafficking and compartmentalization. Nat Rev Mol Cell Biol 2008, 9:125-138.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 125-138
    • Ikonen, E.1
  • 85
    • 43049138477 scopus 로고    scopus 로고
    • Cellular trafficking of the glypican Dally-like is required for full-strength Hedgehog signaling and wingless transcytosis
    • Gallet A., Staccini-Lavenant L., Therond P.P. Cellular trafficking of the glypican Dally-like is required for full-strength Hedgehog signaling and wingless transcytosis. Dev Cell 2008, 14:712-725.
    • (2008) Dev Cell , vol.14 , pp. 712-725
    • Gallet, A.1    Staccini-Lavenant, L.2    Therond, P.P.3
  • 86
    • 84878392551 scopus 로고    scopus 로고
    • Specialized filopodia direct long-range transport of SHH during vertebrate tissue patterning
    • Sanders T.A., Llagostera E., Barna M. Specialized filopodia direct long-range transport of SHH during vertebrate tissue patterning. Nature 2013, 497:628-632.
    • (2013) Nature , vol.497 , pp. 628-632
    • Sanders, T.A.1    Llagostera, E.2    Barna, M.3
  • 87
    • 84893267054 scopus 로고    scopus 로고
    • Cytonemes as specialized signaling filopodia
    • Kornberg T.B., Roy S. Cytonemes as specialized signaling filopodia. Development 2014, 141:729-736.
    • (2014) Development , vol.141 , pp. 729-736
    • Kornberg, T.B.1    Roy, S.2
  • 88
    • 79954580548 scopus 로고    scopus 로고
    • Specificity of Drosophila cytonemes for distinct signaling pathways
    • Roy S., Hsiung F., Kornberg T.B. Specificity of Drosophila cytonemes for distinct signaling pathways. Science 2011, 332:354-358.
    • (2011) Science , vol.332 , pp. 354-358
    • Roy, S.1    Hsiung, F.2    Kornberg, T.B.3
  • 89
    • 25644439969 scopus 로고    scopus 로고
    • Dependence of Drosophila wing imaginal disc cytonemes on Decapentaplegic
    • Hsiung F., Ramirez-Weber F.A., Iwaki D.D., Kornberg T.B. Dependence of Drosophila wing imaginal disc cytonemes on Decapentaplegic. Nature 2005, 437:560-563.
    • (2005) Nature , vol.437 , pp. 560-563
    • Hsiung, F.1    Ramirez-Weber, F.A.2    Iwaki, D.D.3    Kornberg, T.B.4
  • 90
    • 0035265822 scopus 로고    scopus 로고
    • Yb modulates the divisions of both germline and somatic stem cells through piwi- and hh-mediated mechanisms in the Drosophila ovary
    • King F.J., Szakmary A., Cox D.N., Lin H. Yb modulates the divisions of both germline and somatic stem cells through piwi- and hh-mediated mechanisms in the Drosophila ovary. Mol Cell 2001, 7:497-508.
    • (2001) Mol Cell , vol.7 , pp. 497-508
    • King, F.J.1    Szakmary, A.2    Cox, D.N.3    Lin, H.4
  • 91
    • 84859958093 scopus 로고    scopus 로고
    • Cytoneme-mediated delivery of hedgehog regulates the expression of bone morphogenetic proteins to maintain germline stem cells in Drosophila
    • Rojas-Rios P., Guerrero I., Gonzalez-Reyes A. Cytoneme-mediated delivery of hedgehog regulates the expression of bone morphogenetic proteins to maintain germline stem cells in Drosophila. PLoS Biol 2012, 10:e1001298.
    • (2012) PLoS Biol , vol.10
    • Rojas-Rios, P.1    Guerrero, I.2    Gonzalez-Reyes, A.3
  • 92
    • 13244292984 scopus 로고    scopus 로고
    • Shifted, the Drosophila ortholog of Wnt inhibitory factor-1, controls the distribution and movement of Hedgehog
    • Glise B., Miller C.A., Crozatier M., Halbisen M.A., Wise S., Olson D.J., et al. Shifted, the Drosophila ortholog of Wnt inhibitory factor-1, controls the distribution and movement of Hedgehog. Dev Cell 2005, 8:255-266.
    • (2005) Dev Cell , vol.8 , pp. 255-266
    • Glise, B.1    Miller, C.A.2    Crozatier, M.3    Halbisen, M.A.4    Wise, S.5    Olson, D.J.6
  • 93
    • 13244257603 scopus 로고    scopus 로고
    • The Drosophila ortholog of the human Wnt inhibitor factor Shifted controls the diffusion of lipid-modified Hedgehog
    • Gorfinkiel N., Sierra J., Callejo A., Ibanez C., Guerrero I. The Drosophila ortholog of the human Wnt inhibitor factor Shifted controls the diffusion of lipid-modified Hedgehog. Dev Cell 2005, 8:241-253.
    • (2005) Dev Cell , vol.8 , pp. 241-253
    • Gorfinkiel, N.1    Sierra, J.2    Callejo, A.3    Ibanez, C.4    Guerrero, I.5
  • 94
    • 34250764364 scopus 로고    scopus 로고
    • Toutvelu, a regulator of heparan sulfate proteoglycan biosynthesis, controls guidance cues for germ-cell migration
    • Deshpande G., Sethi N., Schedl P. toutvelu, a regulator of heparan sulfate proteoglycan biosynthesis, controls guidance cues for germ-cell migration. Genetics 2007, 176:905-912.
    • (2007) Genetics , vol.176 , pp. 905-912
    • Deshpande, G.1    Sethi, N.2    Schedl, P.3
  • 95
    • 84884684581 scopus 로고    scopus 로고
    • The hedgehog pathway gene shifted functions together with the hmgcr-dependent isoprenoid biosynthetic pathway to orchestrate germ cell migration
    • Deshpande G., Zhou K., Wan J.Y., Friedrich J., Jourjine N., Smith D., et al. The hedgehog pathway gene shifted functions together with the hmgcr-dependent isoprenoid biosynthetic pathway to orchestrate germ cell migration. PLoS Genet 2013, 9:e1003720.
    • (2013) PLoS Genet , vol.9
    • Deshpande, G.1    Zhou, K.2    Wan, J.Y.3    Friedrich, J.4    Jourjine, N.5    Smith, D.6
  • 96
    • 38749109672 scopus 로고    scopus 로고
    • GFP reconstitution across synaptic partners (GRASP) defines cell contacts and synapses in living nervous systems
    • Feinberg E.H., Vanhoven M.K., Bendesky A., Wang G., Fetter R.D., Shen K., et al. GFP reconstitution across synaptic partners (GRASP) defines cell contacts and synapses in living nervous systems. Neuron 2008, 57:353-363.
    • (2008) Neuron , vol.57 , pp. 353-363
    • Feinberg, E.H.1    Vanhoven, M.K.2    Bendesky, A.3    Wang, G.4    Fetter, R.D.5    Shen, K.6
  • 97
    • 59849096398 scopus 로고    scopus 로고
    • Motor control in a Drosophila taste circuit
    • Gordon M.D., Scott K. Motor control in a Drosophila taste circuit. Neuron 2009, 61:373-384.
    • (2009) Neuron , vol.61 , pp. 373-384
    • Gordon, M.D.1    Scott, K.2
  • 98
    • 84891652285 scopus 로고    scopus 로고
    • Cytoneme-mediated contact-dependent transport of the Drosophila decapentaplegic signaling protein
    • Roy S., Huang H., Liu S., Kornberg T.B. Cytoneme-mediated contact-dependent transport of the Drosophila decapentaplegic signaling protein. Science 2014, 343(6173):1244624.
    • (2014) Science , vol.343 , Issue.6173 , pp. 1244624
    • Roy, S.1    Huang, H.2    Liu, S.3    Kornberg, T.B.4
  • 99
    • 84901386977 scopus 로고    scopus 로고
    • Communicating by touch - neurons are not alone
    • Kornberg T.B., Roy S. Communicating by touch - neurons are not alone. Cell Biol 2014, 24(6):370-376.
    • (2014) Cell Biol , vol.24 , Issue.6 , pp. 370-376
    • Kornberg, T.B.1    Roy, S.2
  • 100
    • 33646035770 scopus 로고    scopus 로고
    • The ihog cell-surface proteins bind Hedgehog and mediate pathway activation
    • Yao S., Lum L., Beachy P. The ihog cell-surface proteins bind Hedgehog and mediate pathway activation. Cell 2006, 125:343-357.
    • (2006) Cell , vol.125 , pp. 343-357
    • Yao, S.1    Lum, L.2    Beachy, P.3
  • 101
    • 73549083198 scopus 로고    scopus 로고
    • Genetic and biochemical definition of the Hedgehog receptor
    • Zheng X., Mann R.K., Sever N., Beachy P.A. Genetic and biochemical definition of the Hedgehog receptor. Genes Dev 2010, 24:57-71.
    • (2010) Genes Dev , vol.24 , pp. 57-71
    • Zheng, X.1    Mann, R.K.2    Sever, N.3    Beachy, P.A.4
  • 102
    • 77956814604 scopus 로고    scopus 로고
    • Interactions between Hedgehog proteins and their binding partners come into view
    • Beachy P.A., Hymowitz S.G., Lazarus R.A., Leahy D.J., Siebold C. Interactions between Hedgehog proteins and their binding partners come into view. Genes Dev 2010, 24:2001-2012.
    • (2010) Genes Dev , vol.24 , pp. 2001-2012
    • Beachy, P.A.1    Hymowitz, S.G.2    Lazarus, R.A.3    Leahy, D.J.4    Siebold, C.5
  • 103
    • 77953080875 scopus 로고    scopus 로고
    • The cell-surface proteins Dally-like and Ihog differentially regulate Hedgehog signaling strength and range during development
    • Yan D., Wu Y., Yang Y., Belenkaya T.Y., Tang X., Lin X. The cell-surface proteins Dally-like and Ihog differentially regulate Hedgehog signaling strength and range during development. Development 2010, 137:2033-2044.
    • (2010) Development , vol.137 , pp. 2033-2044
    • Yan, D.1    Wu, Y.2    Yang, Y.3    Belenkaya, T.Y.4    Tang, X.5    Lin, X.6
  • 104
    • 84876336644 scopus 로고    scopus 로고
    • Drosophila miR-932 modulates hedgehog signaling by targeting its co-receptor Brother of ihog
    • Gao L., Wu L., Hou X., Zhang Q., Zhang F., Ye X., et al. Drosophila miR-932 modulates hedgehog signaling by targeting its co-receptor Brother of ihog. Dev Biol 2013, 377:166-176.
    • (2013) Dev Biol , vol.377 , pp. 166-176
    • Gao, L.1    Wu, L.2    Hou, X.3    Zhang, Q.4    Zhang, F.5    Ye, X.6
  • 105
  • 106
    • 84870696628 scopus 로고    scopus 로고
    • The Drosophila WIF1 homolog shifted maintains glypican-independent Hedgehog signaling and interacts with the Hedgehog co-receptors Ihog and Boi
    • Avanesov A., Blair S.S. The Drosophila WIF1 homolog shifted maintains glypican-independent Hedgehog signaling and interacts with the Hedgehog co-receptors Ihog and Boi. Development 2013, 140:107-116.
    • (2013) Development , vol.140 , pp. 107-116
    • Avanesov, A.1    Blair, S.S.2
  • 107
    • 84859199011 scopus 로고    scopus 로고
    • The role of glypicans in Wnt inhibitory factor-1 activity and the structural basis of Wif1's effects on Wnt and Hedgehog signaling
    • Avanesov A., Honeyager S.M., Malicki J., Blair S.S. The role of glypicans in Wnt inhibitory factor-1 activity and the structural basis of Wif1's effects on Wnt and Hedgehog signaling. PLoS Genet 2012, 8:e1002503.
    • (2012) PLoS Genet , vol.8
    • Avanesov, A.1    Honeyager, S.M.2    Malicki, J.3    Blair, S.S.4
  • 108
    • 84866516428 scopus 로고    scopus 로고
    • The WIF domain of the human and Drosophila Wif-1 secreted factors confers specificity for Wnt or Hedgehog
    • Sánchez-Hernández D., Sierra J., Ortigao-Farias J.R., Guerrero I. The WIF domain of the human and Drosophila Wif-1 secreted factors confers specificity for Wnt or Hedgehog. Development 2012, 139:3849-3858.
    • (2012) Development , vol.139 , pp. 3849-3858
    • Sánchez-Hernández, D.1    Sierra, J.2    Ortigao-Farias, J.R.3    Guerrero, I.4
  • 110
    • 84855780818 scopus 로고    scopus 로고
    • Perturbation of zebrafish swimbladder development by enhancing Wnt signaling in Wif1 morphants
    • Yin A., Korzh V., Gong Z. Perturbation of zebrafish swimbladder development by enhancing Wnt signaling in Wif1 morphants. Biochim Biophys Acta 2012, 1823:236-244.
    • (2012) Biochim Biophys Acta , vol.1823 , pp. 236-244
    • Yin, A.1    Korzh, V.2    Gong, Z.3
  • 111
    • 20044362899 scopus 로고    scopus 로고
    • The zebrafish-secreted matrix protein you/scube2 is implicated in long-range regulation of hedgehog signaling
    • Kawakami A., Nojima Y., Toyoda A., Takahoko M., Satoh M., Tanaka H., et al. The zebrafish-secreted matrix protein you/scube2 is implicated in long-range regulation of hedgehog signaling. Curr Biol 2005, 15:480-488.
    • (2005) Curr Biol , vol.15 , pp. 480-488
    • Kawakami, A.1    Nojima, Y.2    Toyoda, A.3    Takahoko, M.4    Satoh, M.5    Tanaka, H.6
  • 112
    • 68749106005 scopus 로고    scopus 로고
    • Isolation and characterization of a secreted, cell-surface glycoprotein SCUBE2 from humans
    • Tsai M.T., Cheng C.J., Lin Y.C., Chen C.C., Wu A.R., Wu M.T., et al. Isolation and characterization of a secreted, cell-surface glycoprotein SCUBE2 from humans. Biochem J 2009, 422:119-128.
    • (2009) Biochem J , vol.422 , pp. 119-128
    • Tsai, M.T.1    Cheng, C.J.2    Lin, Y.C.3    Chen, C.C.4    Wu, A.R.5    Wu, M.T.6
  • 113
    • 4644317326 scopus 로고    scopus 로고
    • Synergistic and antagonistic roles of the Sonic hedgehog N- and C-terminal lipids
    • Feng J., White B., Tyurina O.V., Guner B., Larson T., Lee H.Y., et al. Synergistic and antagonistic roles of the Sonic hedgehog N- and C-terminal lipids. Development 2004, 131:4357-4370.
    • (2004) Development , vol.131 , pp. 4357-4370
    • Feng, J.1    White, B.2    Tyurina, O.V.3    Guner, B.4    Larson, T.5    Lee, H.Y.6
  • 114
    • 33645228803 scopus 로고    scopus 로고
    • A highly conserved amino-terminal region of sonic hedgehog is required for the formation of its freely diffusible multimeric form
    • Goetz J.A., Singh S., Suber L.M., Kull F.J., Robbins D.J. A highly conserved amino-terminal region of sonic hedgehog is required for the formation of its freely diffusible multimeric form. J Biol Chem 2006, 281:4087-4093.
    • (2006) J Biol Chem , vol.281 , pp. 4087-4093
    • Goetz, J.A.1    Singh, S.2    Suber, L.M.3    Kull, F.J.4    Robbins, D.J.5
  • 115
    • 70450242729 scopus 로고    scopus 로고
    • Heparan sulfate and transglutaminase activity are required for the formation of covalently cross-linked hedgehog oligomers
    • Dierker T., Dreier R., Migone M., Hamer S., Grobe K. Heparan sulfate and transglutaminase activity are required for the formation of covalently cross-linked hedgehog oligomers. J Biol Chem 2009, 284:32562-32571.
    • (2009) J Biol Chem , vol.284 , pp. 32562-32571
    • Dierker, T.1    Dreier, R.2    Migone, M.3    Hamer, S.4    Grobe, K.5
  • 116
    • 38949159320 scopus 로고    scopus 로고
    • Reggie-1/flotillin-2 promotes secretion of the long-range signalling forms of Wingless and Hedgehog in Drosophila
    • Katanaev V.L., Solis G.P., Hausmann G., Buestorf S., Katanayeva N., Schrock Y., et al. Reggie-1/flotillin-2 promotes secretion of the long-range signalling forms of Wingless and Hedgehog in Drosophila. EMBO J 2008, 27:509-521.
    • (2008) EMBO J , vol.27 , pp. 509-521
    • Katanaev, V.L.1    Solis, G.P.2    Hausmann, G.3    Buestorf, S.4    Katanayeva, N.5    Schrock, Y.6
  • 117
    • 34250870665 scopus 로고    scopus 로고
    • Lipoprotein-heparan sulfate interactions in the Hh pathway
    • Eugster C., Panakova D., Mahmoud A., Eaton S. Lipoprotein-heparan sulfate interactions in the Hh pathway. Dev Cell 2007, 13:57-71.
    • (2007) Dev Cell , vol.13 , pp. 57-71
    • Eugster, C.1    Panakova, D.2    Mahmoud, A.3    Eaton, S.4
  • 118
    • 38949218488 scopus 로고    scopus 로고
    • Patched, the receptor of Hedgehog, is a lipoprotein receptor
    • Callejo A., Culi J., Guerrero I. Patched, the receptor of Hedgehog, is a lipoprotein receptor. Proc Natl Acad Sci U S A 2008, 105:912-917.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 912-917
    • Callejo, A.1    Culi, J.2    Guerrero, I.3
  • 119
    • 0029810885 scopus 로고    scopus 로고
    • Molecular characterization and developmental expression of a retinoid- and fatty acid-binding glycoprotein from Drosophila. A putative lipophorin
    • Kutty R.K., Kutty G., Kambadur R., Duncan T., Koonin E.V., Rodriguez I.R., et al. Molecular characterization and developmental expression of a retinoid- and fatty acid-binding glycoprotein from Drosophila. A putative lipophorin. J Biol Chem 1996, 271:20641-20649.
    • (1996) J Biol Chem , vol.271 , pp. 20641-20649
    • Kutty, R.K.1    Kutty, G.2    Kambadur, R.3    Duncan, T.4    Koonin, E.V.5    Rodriguez, I.R.6
  • 120
    • 0030239984 scopus 로고    scopus 로고
    • The precursor protein of the structural apolipoproteins of lipophorin: cDNA and deduced amino acid sequence
    • Sundermeyer K., Hendricks J.K., Prasad S.V., Wells M.A. The precursor protein of the structural apolipoproteins of lipophorin: cDNA and deduced amino acid sequence. Insect Biochem Mol Biol 1996, 26:735-738.
    • (1996) Insect Biochem Mol Biol , vol.26 , pp. 735-738
    • Sundermeyer, K.1    Hendricks, J.K.2    Prasad, S.V.3    Wells, M.A.4
  • 122
    • 77955382127 scopus 로고    scopus 로고
    • Lipoprotein particles cross the blood-brain barrier in Drosophila
    • Brankatschk M., Eaton S. Lipoprotein particles cross the blood-brain barrier in Drosophila. J Neurosci 2010, 30:10441-10447.
    • (2010) J Neurosci , vol.30 , pp. 10441-10447
    • Brankatschk, M.1    Eaton, S.2
  • 123
    • 70349829157 scopus 로고    scopus 로고
    • Trans-synaptic transmission of vesicular Wnt signals through Evi/Wntless
    • Korkut C., Ataman B., Ramachandran P., Ashley J., Barria R., Gherbesi N., et al. Trans-synaptic transmission of vesicular Wnt signals through Evi/Wntless. Cell 2009, 139:393-404.
    • (2009) Cell , vol.139 , pp. 393-404
    • Korkut, C.1    Ataman, B.2    Ramachandran, P.3    Ashley, J.4    Barria, R.5    Gherbesi, N.6
  • 124
    • 84930483835 scopus 로고    scopus 로고
    • Classification, functions, and clinical relevance of extracellular vesicles
    • van der Pol E., Boing A.N., Harrison P., Sturk A., Nieuwland R. Classification, functions, and clinical relevance of extracellular vesicles. Pharmacol Rev 2012, 64:676-705.
    • (2012) Pharmacol Rev , vol.64 , pp. 676-705
    • van der Pol, E.1    Boing, A.N.2    Harrison, P.3    Sturk, A.4    Nieuwland, R.5
  • 125
    • 33745280126 scopus 로고    scopus 로고
    • The V0-ATPase mediates apical secretion of exosomes containing Hedgehog-related proteins in Caenorhabditis elegans
    • Liegeois S., Benedetto A., Garnier J.M., Schwab Y., Labouesse M. The V0-ATPase mediates apical secretion of exosomes containing Hedgehog-related proteins in Caenorhabditis elegans. J Cell Biol 2006, 173:949-961.
    • (2006) J Cell Biol , vol.173 , pp. 949-961
    • Liegeois, S.1    Benedetto, A.2    Garnier, J.M.3    Schwab, Y.4    Labouesse, M.5
  • 126
    • 18744406718 scopus 로고    scopus 로고
    • FGF-induced vesicular release of Sonic hedgehog and retinoic acid in leftward nodal flow is critical for left-right determination
    • Tanaka Y., Okada Y., Hirokawa N. FGF-induced vesicular release of Sonic hedgehog and retinoic acid in leftward nodal flow is critical for left-right determination. Nature 2005, 435:172-177.
    • (2005) Nature , vol.435 , pp. 172-177
    • Tanaka, Y.1    Okada, Y.2    Hirokawa, N.3
  • 127
    • 0024468746 scopus 로고
    • The Drosophila patched gene encodes a putative membrane protein required for segmental patterning
    • Hooper J.E., Scott M.P. The Drosophila patched gene encodes a putative membrane protein required for segmental patterning. Cell 1989, 59:751-765.
    • (1989) Cell , vol.59 , pp. 751-765
    • Hooper, J.E.1    Scott, M.P.2
  • 128
    • 0024440611 scopus 로고
    • A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched
    • Nakano Y., Guerrero I., Hidalgo A., Taylor A., Whittle J.R.S., Ingham P.W. A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched. Nature 1989, 341:508-513.
    • (1989) Nature , vol.341 , pp. 508-513
    • Nakano, Y.1    Guerrero, I.2    Hidalgo, A.3    Taylor, A.4    Whittle, J.R.S.5    Ingham, P.W.6
  • 129
    • 0033170990 scopus 로고    scopus 로고
    • The RND permease superfamily: an ancient, ubiquitous and diverse family that includes human disease and development proteins
    • Tseng T.T., Gratwick K.S., Kollman J., Park D., Nies D.H., Goffeau A., et al. The RND permease superfamily: an ancient, ubiquitous and diverse family that includes human disease and development proteins. J Mol Microbiol Biotechnol 1999, 1:107-125.
    • (1999) J Mol Microbiol Biotechnol , vol.1 , pp. 107-125
    • Tseng, T.T.1    Gratwick, K.S.2    Kollman, J.3    Park, D.4    Nies, D.H.5    Goffeau, A.6
  • 130
    • 0033613253 scopus 로고    scopus 로고
    • Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for patched
    • Fuse N., Maiti T., Wang B., Porter J.A., Hall T.M., Leahy D.J., et al. Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for patched. Proc Natl Acad Sci U S A 1999, 96:10992-10999.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 10992-10999
    • Fuse, N.1    Maiti, T.2    Wang, B.3    Porter, J.A.4    Hall, T.M.5    Leahy, D.J.6
  • 131
    • 33748690784 scopus 로고    scopus 로고
    • The C-terminal tail of the Hedgehog receptor Patched regulates both localization and turnover
    • Lu X., Liu S., Kornberg T.B. The C-terminal tail of the Hedgehog receptor Patched regulates both localization and turnover. Genes Dev 2006, 20:2539-2551.
    • (2006) Genes Dev , vol.20 , pp. 2539-2551
    • Lu, X.1    Liu, S.2    Kornberg, T.B.3
  • 132
    • 0029948270 scopus 로고    scopus 로고
    • Biochemical evidence that patched is the Hedgehog receptor
    • Marigo V., Davey R.A., Zuo Y., Cunningham J.M., Tabin C.J. Biochemical evidence that patched is the Hedgehog receptor. Nature 1996, 384:176-179.
    • (1996) Nature , vol.384 , pp. 176-179
    • Marigo, V.1    Davey, R.A.2    Zuo, Y.3    Cunningham, J.M.4    Tabin, C.J.5
  • 133
    • 0011102935 scopus 로고    scopus 로고
    • The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog
    • Stone D.M., Hynes M., Armanini M., Swanson T.A., Gu Q., Johnson R.L., et al. The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature 1996, 384:129-134.
    • (1996) Nature , vol.384 , pp. 129-134
    • Stone, D.M.1    Hynes, M.2    Armanini, M.3    Swanson, T.A.4    Gu, Q.5    Johnson, R.L.6
  • 134
    • 0030297553 scopus 로고    scopus 로고
    • Dual roles for patched in sequestering and transducing Hedgehog
    • Chen Y., Struhl G. Dual roles for patched in sequestering and transducing Hedgehog. Cell 1996, 87:553-563.
    • (1996) Cell , vol.87 , pp. 553-563
    • Chen, Y.1    Struhl, G.2
  • 135
    • 0030027059 scopus 로고    scopus 로고
    • Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog
    • Goodrich L.V., Johnson R.L., Milenkovic L., McMahon J.A., Scott M.P. Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog. Genes Dev 1996, 10:301-312.
    • (1996) Genes Dev , vol.10 , pp. 301-312
    • Goodrich, L.V.1    Johnson, R.L.2    Milenkovic, L.3    McMahon, J.A.4    Scott, M.P.5
  • 136
    • 79958207835 scopus 로고    scopus 로고
    • Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function
    • Allen B.L., Song J.Y., Izzi L., Althaus I.W., Kang J.S., Charron F., et al. Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function. Dev Cell 2011, 20:775-787.
    • (2011) Dev Cell , vol.20 , pp. 775-787
    • Allen, B.L.1    Song, J.Y.2    Izzi, L.3    Althaus, I.W.4    Kang, J.S.5    Charron, F.6
  • 137
    • 79958210024 scopus 로고    scopus 로고
    • Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation
    • Izzi L., Levesque M., Morin S., Laniel D., Wilkes B.C., Mille F., et al. Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation. Dev Cell 2011, 20:788-801.
    • (2011) Dev Cell , vol.20 , pp. 788-801
    • Izzi, L.1    Levesque, M.2    Morin, S.3    Laniel, D.4    Wilkes, B.C.5    Mille, F.6
  • 138
    • 34249007279 scopus 로고    scopus 로고
    • The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development
    • Allen B.L., Tenzen T., McMahon A.P. The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development. Genes Dev 2007, 21:1244-1257.
    • (2007) Genes Dev , vol.21 , pp. 1244-1257
    • Allen, B.L.1    Tenzen, T.2    McMahon, A.P.3
  • 139
    • 34249011892 scopus 로고    scopus 로고
    • Gas1 extends the range of Hedgehog action by facilitating its signaling
    • Martinelli D.C., Fan C.M. Gas1 extends the range of Hedgehog action by facilitating its signaling. Genes Dev 2007, 21:1231-1243.
    • (2007) Genes Dev , vol.21 , pp. 1231-1243
    • Martinelli, D.C.1    Fan, C.M.2
  • 140
    • 33751078546 scopus 로고    scopus 로고
    • Boc is a receptor for sonic hedgehog in the guidance of commissural axons
    • Okada A., Charron F., Morin S., Shin D.S., Wong K., Fabre P.J., et al. Boc is a receptor for sonic hedgehog in the guidance of commissural axons. Nature 2006, 444:369-373.
    • (2006) Nature , vol.444 , pp. 369-373
    • Okada, A.1    Charron, F.2    Morin, S.3    Shin, D.S.4    Wong, K.5    Fabre, P.J.6
  • 141
    • 33646103902 scopus 로고    scopus 로고
    • The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice
    • Tenzen T., Allen B.L., Cole F., Kang J.S., Krauss R.S., McMahon A.P. The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice. Dev Cell 2006, 10:647-656.
    • (2006) Dev Cell , vol.10 , pp. 647-656
    • Tenzen, T.1    Allen, B.L.2    Cole, F.3    Kang, J.S.4    Krauss, R.S.5    McMahon, A.P.6
  • 142
    • 33646120095 scopus 로고    scopus 로고
    • Cdo functions at multiple points in the Sonic Hedgehog pathway, and Cdo-deficient mice accurately model human holoprosencephaly
    • Zhang W., Kang J.S., Cole F., Yi M.J., Krauss R.S. Cdo functions at multiple points in the Sonic Hedgehog pathway, and Cdo-deficient mice accurately model human holoprosencephaly. Dev Cell 2006, 10:657-665.
    • (2006) Dev Cell , vol.10 , pp. 657-665
    • Zhang, W.1    Kang, J.S.2    Cole, F.3    Yi, M.J.4    Krauss, R.S.5
  • 143
    • 54049122121 scopus 로고    scopus 로고
    • The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla
    • McLellan J.S., Zheng X., Hauk G., Ghirlando R., Beachy P.A., Leahy D.J. The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla. Nature 2008, 455:979-983.
    • (2008) Nature , vol.455 , pp. 979-983
    • McLellan, J.S.1    Zheng, X.2    Hauk, G.3    Ghirlando, R.4    Beachy, P.A.5    Leahy, D.J.6
  • 144
    • 0030602796 scopus 로고    scopus 로고
    • The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal
    • Alcedo J., Ayzenzon M., Von Ohlen T., Noll M., Hooper J.E. The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal. Cell 1996, 86:221-232.
    • (1996) Cell , vol.86 , pp. 221-232
    • Alcedo, J.1    Ayzenzon, M.2    Von Ohlen, T.3    Noll, M.4    Hooper, J.E.5
  • 145
    • 0029784223 scopus 로고    scopus 로고
    • Smoothened encodes a receptor-like serpentine protein required for hedgehog signalling
    • van den Heuvel M., Ingham P.W. smoothened encodes a receptor-like serpentine protein required for hedgehog signalling. Nature 1996, 382:547-551.
    • (1996) Nature , vol.382 , pp. 547-551
    • van den Heuvel, M.1    Ingham, P.W.2
  • 146
    • 77954935312 scopus 로고    scopus 로고
    • Hedgehog signaling uses lipid metabolism to tune smoothened activation
    • Yang Y., Lin X. Hedgehog signaling uses lipid metabolism to tune smoothened activation. Dev Cell 2010, 19:3-4.
    • (2010) Dev Cell , vol.19 , pp. 3-4
    • Yang, Y.1    Lin, X.2
  • 147
    • 0033580269 scopus 로고    scopus 로고
    • Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein
    • Chuang P.T., McMahon A.P. Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein. Nature 1999, 397:617-621.
    • (1999) Nature , vol.397 , pp. 617-621
    • Chuang, P.T.1    McMahon, A.P.2
  • 148
    • 77950538817 scopus 로고    scopus 로고
    • Dally-like core protein and its mammalian homologues mediate stimulatory and inhibitory effects on Hedgehog signal response
    • Williams E.H., Pappano W.N., Saunders A.M., Kim M.S., Leahy D.J., Beachy P.A. Dally-like core protein and its mammalian homologues mediate stimulatory and inhibitory effects on Hedgehog signal response. Proc Natl Acad Sci U S A 2010, 107:5869-5874.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 5869-5874
    • Williams, E.H.1    Pappano, W.N.2    Saunders, A.M.3    Kim, M.S.4    Leahy, D.J.5    Beachy, P.A.6
  • 149
    • 80051991015 scopus 로고    scopus 로고
    • Structure of the protein core of the glypican Dally-like and localization of a region important for hedgehog signaling
    • Kim M.S., Saunders A.M., Hamaoka B.Y., Beachy P.A., Leahy D.J. Structure of the protein core of the glypican Dally-like and localization of a region important for hedgehog signaling. Proc Natl Acad Sci U S A 2011, 108:13112-13117.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 13112-13117
    • Kim, M.S.1    Saunders, A.M.2    Hamaoka, B.Y.3    Beachy, P.A.4    Leahy, D.J.5
  • 150
    • 80052629780 scopus 로고    scopus 로고
    • DSulfatase-1 fine-tunes Hedgehog patterning activity through a novel regulatory feedback loop
    • Wojcinski A., Nakato H., Soula C., Glise B. DSulfatase-1 fine-tunes Hedgehog patterning activity through a novel regulatory feedback loop. Dev Biol 2011, 358:168-180.
    • (2011) Dev Biol , vol.358 , pp. 168-180
    • Wojcinski, A.1    Nakato, H.2    Soula, C.3    Glise, B.4
  • 152
    • 84883722622 scopus 로고    scopus 로고
    • Heparan sulfate proteoglycans containing a glypican 5 core and 2-O-sulfo-iduronic acid function as Sonic Hedgehog co-receptors to promote proliferation
    • Witt R.M., Hecht M.L., Pazyra-Murphy M.F., Cohen S.M., Noti C., van Kuppevelt T.H., et al. Heparan sulfate proteoglycans containing a glypican 5 core and 2-O-sulfo-iduronic acid function as Sonic Hedgehog co-receptors to promote proliferation. J Biol Chem 2013, 288:26275-26288.
    • (2013) J Biol Chem , vol.288 , pp. 26275-26288
    • Witt, R.M.1    Hecht, M.L.2    Pazyra-Murphy, M.F.3    Cohen, S.M.4    Noti, C.5    van Kuppevelt, T.H.6
  • 154
    • 84455173121 scopus 로고    scopus 로고
    • Two distinct sites in sonic Hedgehog combine for heparan sulfate interactions and cell signaling functions
    • Chang S.C., Mulloy B., Magee A.I., Couchman J.R. Two distinct sites in sonic Hedgehog combine for heparan sulfate interactions and cell signaling functions. J Biol Chem 2011, 286:44391-44402.
    • (2011) J Biol Chem , vol.286 , pp. 44391-44402
    • Chang, S.C.1    Mulloy, B.2    Magee, A.I.3    Couchman, J.R.4
  • 155
    • 0036341998 scopus 로고    scopus 로고
    • Cerebellar proteoglycans regulate sonic hedgehog responses during development
    • Rubin J.B., Choi Y., Segal R.A. Cerebellar proteoglycans regulate sonic hedgehog responses during development. Development 2002, 129:2223-2232.
    • (2002) Development , vol.129 , pp. 2223-2232
    • Rubin, J.B.1    Choi, Y.2    Segal, R.A.3
  • 156
    • 43049097898 scopus 로고    scopus 로고
    • Glypican-3 inhibits Hedgehog signaling during development by competing with patched for Hedgehog binding
    • Capurro M.I., Xu P., Shi W., Li F., Jia A., Filmus J. Glypican-3 inhibits Hedgehog signaling during development by competing with patched for Hedgehog binding. Dev Cell 2008, 14:700-711.
    • (2008) Dev Cell , vol.14 , pp. 700-711
    • Capurro, M.I.1    Xu, P.2    Shi, W.3    Li, F.4    Jia, A.5    Filmus, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.