-
1
-
-
77955266904
-
AMPK activation represses the human gene promoter of the cardiac isoform of acetyl-CoA carboxylase: Role of nuclear respiratory factor-1
-
Adam T, Opie LH, Essop MF (2010) AMPK activation represses the human gene promoter of the cardiac isoform of acetyl-CoA carboxylase: role of nuclear respiratory factor-1. Biochem Biophys Res Commun 398(3):495-499
-
(2010)
Biochem Biophys Res Commun
, vol.398
, Issue.3
, pp. 495-499
-
-
Adam, T.1
Opie, L.H.2
Essop, M.F.3
-
3
-
-
69449106873
-
Autophagy is required for extension of yeast chronological life span by rapamycin
-
Alvers A et al (2009) Autophagy is required for extension of yeast chronological life span by rapamycin. Autophagy 5(6):847-849
-
(2009)
Autophagy
, vol.5
, Issue.6
, pp. 847-849
-
-
Alvers, A.1
-
4
-
-
20244376316
-
Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients
-
DOI 10.1007/s00125-004-1627-9
-
Anello M et al (2005) Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients. Diabetologia 48(2):282-289 (Pubitemid 40543300)
-
(2005)
Diabetologia
, vol.48
, Issue.2
, pp. 282-289
-
-
Anello, M.1
Lupi, R.2
Spampinato, D.3
Piro, S.4
Masini, M.5
Boggi, U.6
Del, P.S.7
Rabuazzo, A.M.8
Purrello, F.9
Marchetti, P.10
-
5
-
-
0036797633
-
Inclusion-body myositis and myopathies: Different etiologies, possibly similar pathogenic mechanisms
-
DOI 10.1097/00019052-200210000-00002
-
Askanas V, Engel W (2002) Inclusion-body myositis and myopathies: different etiologies, possibly similar pathogenic mechanisms. Curr Opin Neurol 15(5):525-531 (Pubitemid 35176686)
-
(2002)
Current Opinion in Neurology
, vol.15
, Issue.5
, pp. 525-531
-
-
Askanas, V.1
Engel, W.K.2
-
6
-
-
21344463770
-
Sequestosome 1/p62 shuttles polyubiquitinated tau for proteasomal degradation
-
f27f4e63-a010-5926-f8b4-116f27f87842
-
Babu J, Geetha T, Wooten M (2005) Sequestosome 1/p62 shuttles polyubiquitinated tau for proteasomal degradation. J Neurochem 94(f27f4e63-a010-5926-f8b4-116f27f87842):192-395
-
(2005)
J Neurochem
, vol.94
, pp. 192-395
-
-
Babu, J.1
Geetha, T.2
Wooten, M.3
-
7
-
-
80855138775
-
Clearance of p16(Ink4a)-positive senescent cells delays ageing-associated disorders
-
Baker D et al (2011) Clearance of p16(Ink4a)-positive senescent cells delays ageing-associated disorders. Nature 479:232-236
-
(2011)
Nature
, vol.479
, pp. 232-236
-
-
Baker, D.1
-
8
-
-
80052277569
-
Genetic activation of Nrf2 signaling is sufficient to ameliorate neurodegenerative phenotypes in a Drosophilamodel of Parkinson's disease
-
29b98216-6e5f-44c2-693d-1f4bd0dc641e
-
Barone M, Sykiotis G, Bohmann D (2011) Genetic activation of Nrf2 signaling is sufficient to ameliorate neurodegenerative phenotypes in a Drosophilamodel of Parkinson's disease. Dis Models Mech 4(29b98216-6e5f-44c2- 693d-1f4bd0dc641e):701-708
-
(2011)
Dis Models Mech
, vol.4
, pp. 701-708
-
-
Barone, M.1
Sykiotis, G.2
Bohmann, D.3
-
9
-
-
84866316014
-
Astrocyte senescence as a component of Alzheimer's disease
-
Bhat R et al (2012) Astrocyte senescence as a component of Alzheimer's disease. PLoS One 7(9)
-
(2012)
PLoS One
, vol.7
, Issue.9
-
-
Bhat, R.1
-
10
-
-
77956875648
-
Stress-induced senescence in human and rodent astrocytes
-
Bitto A et al (2010a) Stress-induced senescence in human and rodent astrocytes. Exp Cell Res 316:2961-2968
-
(2010)
Exp Cell Res
, vol.316
, pp. 2961-2968
-
-
Bitto, A.1
-
11
-
-
77958611244
-
Long-term IGF-I exposure decreases autophagy and cell viability
-
Bitto A et al (2010b) Long-term IGF-I exposure decreases autophagy and cell viability. PLoS One 5(9)
-
(2010)
PLoS One
, vol.5
, Issue.9
-
-
Bitto, A.1
-
12
-
-
27944504351
-
p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
-
DOI 10.1083/jcb.200507002
-
Bjorkoy G et al (2005) p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J Cell Biol 171(4):603-614 (Pubitemid 41668720)
-
(2005)
Journal of Cell Biology
, vol.171
, Issue.4
, pp. 603-614
-
-
Bjorkoy, G.1
Lamark, T.2
Brech, A.3
Outzen, H.4
Perander, M.5
Overvatn, A.6
Stenmark, H.7
Johansen, T.8
-
13
-
-
84862986470
-
Analysis of neural subtypes reveals selective mitochondrial dysfunction in dopaminergic neurons from parkin mutants
-
Burman J et al (2012) Analysis of neural subtypes reveals selective mitochondrial dysfunction in dopaminergic neurons from parkin mutants. Proc Natl Acad Sci U S A 109(26):10438-10443
-
(2012)
Proc Natl Acad Sci U S a
, vol.109
, Issue.26
, pp. 10438-10443
-
-
Burman, J.1
-
14
-
-
43149107699
-
Functional mitochondria are required for alpha-synuclein toxicity in aging yeast
-
Buttner S et al (2008) Functional mitochondria are required for alpha-synuclein toxicity in aging yeast. J Biol Chem 283(12):7554-7560
-
(2008)
J Biol Chem
, vol.283
, Issue.12
, pp. 7554-7560
-
-
Buttner, S.1
-
15
-
-
79959776029
-
Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells
-
Cao K et al (2011) Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells. Sci Transl Med 3(89)
-
(2011)
Sci Transl Med
, vol.3
, Issue.89
-
-
Cao, K.1
-
16
-
-
80053553801
-
Mitochondria and the aging heart
-
Chaudhary K, El-Sikhry H, Seubert J (2011) Mitochondria and the aging heart. JGC 8(3):159-167
-
(2011)
JGC
, vol.8
, Issue.3
, pp. 159-167
-
-
Chaudhary, K.1
El-Sikhry, H.2
Seubert, J.3
-
17
-
-
39449108917
-
The Atg1 kinase complex is involved in the regulation of protein recruitment to initiate sequestering vesicle formation for nonspecific autophagy in Saccharomyces cerevisiae
-
DOI 10.1091/mbc.E07-08-0826
-
Cheong H et al (2008) The Atg1 kinase complex is involved in the regulation of protein recruitment to initiate sequestering vesicle formation for nonspecific autophagy in Saccharomyces cerevisiae. Mol Biol Cell 19(2):668-681 (Pubitemid 351272154)
-
(2008)
Molecular Biology of the Cell
, vol.19
, Issue.2
, pp. 668-681
-
-
Cheong, H.1
Nair, U.2
Geng, J.3
Klionsky, D.J.4
-
18
-
-
84877628647
-
Autophagy in human health and disease
-
Choi A, Ryter S, Levine B (2013) Autophagy in human health and disease. N Engl J Med 368(7):651-662
-
(2013)
N Engl J Med
, vol.368
, Issue.7
, pp. 651-662
-
-
Choi, A.1
Ryter, S.2
Levine, B.3
-
19
-
-
77952781968
-
Physical and functional interaction of sequestosome 1 with Keap1 regulates the Keap1-Nrf2 cell defense pathway
-
81009124-2876-05da-270c-84b2eb4bf664
-
Copple I et al (2010) Physical and functional interaction of sequestosome 1 with Keap1 regulates the Keap1-Nrf2 cell defense pathway. J Biol Chem 285(81009124-2876-05da-270c-84b2eb4bf664):16782-16790
-
(2010)
J Biol Chem
, vol.285
, pp. 16782-16790
-
-
Copple, I.1
-
20
-
-
56349168452
-
Autophagy and aging: Keeping that old broom working
-
Cuervo A (2008) Autophagy and aging: keeping that old broom working. TIG 24(12):604-612
-
(2008)
TIG
, vol.24
, Issue.12
, pp. 604-612
-
-
Cuervo, A.1
-
21
-
-
0026429550
-
Polymyositis, dermatomyositis and inclusion-body myositis
-
Dalakas M (1991) Polymyositis, dermatomyositis and inclusion-body myositis. N Engl J Med 325(21):1487-1498
-
(1991)
N Engl J Med
, vol.325
, Issue.21
, pp. 1487-1498
-
-
Dalakas, M.1
-
22
-
-
0038329255
-
Ageing-related changes in the in vivo function of rat liver macroautophagy and proteolysis
-
DOI 10.1016/S0531-5565(03)00002-0
-
Del Roso A et al (2003) Ageing-related changes in the in vivo function of rat liver macroautophagy and proteolysis. Exp Gerontol 38(5):519-527 (Pubitemid 36549038)
-
(2003)
Experimental Gerontology
, vol.38
, Issue.5
, pp. 519-527
-
-
Del, R.A.1
Vittorini, S.2
Cavallini, G.3
Donati, A.4
Gori, Z.5
Masini, M.6
Pollera, M.7
Bergamini, E.8
-
23
-
-
67649316033
-
Rapamycin decelerates cellular senescence
-
Demidenko ZN et al (2009) Rapamycin decelerates cellular senescence. Cell Cycle 8(12):1888-1895
-
(2009)
Cell Cycle
, vol.8
, Issue.12
, pp. 1888-1895
-
-
Demidenko, Z.N.1
-
24
-
-
58649099395
-
Age-associated oxidative damage to the p62 promoter: Implications for Alzheimer disease
-
23d068fb-0594-c642-03d0-07ddf3c86ab0
-
Du Y et al (2009a) Age-associated oxidative damage to the p62 promoter: implications for Alzheimer disease. Free Radic Biol Med 46(23d068fb-0594-c642- 03d0-07ddf3c86ab0):492-993
-
(2009)
Free Radic Biol Med
, vol.46
, pp. 492-993
-
-
Du, Y.1
-
25
-
-
67649491039
-
Oxidative damage to the promoter region of SQSTM1/p62 is common to neurodegenerative disease
-
685e8d56-503b-eab5-c2b8-07dd602f3f7f
-
Du Y, Wooten M, Wooten M (2009b) Oxidative damage to the promoter region of SQSTM1/p62 is common to neurodegenerative disease. Neurobiol Dis 35(685e8d56-503b-eab5-c2b8-07dd602f3f7f):302-312
-
(2009)
Neurobiol Dis
, vol.35
, pp. 302-312
-
-
Du, Y.1
Wooten, M.2
Wooten, M.3
-
26
-
-
81455128284
-
Diagnostic value of markers of muscle degeneration in sporadic inclusion body myositis
-
edited by the Gaetano Conte Academy for the study of striated muscle diseases.
-
Dubourg O et al (2011) Diagnostic value of markers of muscle degeneration in sporadic inclusion body myositis. Acta myologica: myopathies and cardiomyopathies: official journal of the Mediterranean Society of Myology / edited by the Gaetano Conte Academy for the study of striated muscle diseases. 30(2):103-108
-
(2011)
Acta Myologica: Myopathies and Cardiomyopathies: Official Journal of the Mediterranean Society of Myology
, vol.30
, Issue.2
, pp. 103-108
-
-
Dubourg, O.1
-
27
-
-
80053586265
-
p62 is a key regulator of nutrient sensing in the mTORC1 pathway
-
Duran A et al (2011) p62 is a key regulator of nutrient sensing in the mTORC1 pathway. Mol Cell 44(1):134-146
-
(2011)
Mol Cell
, vol.44
, Issue.1
, pp. 134-146
-
-
Duran, A.1
-
28
-
-
77955352128
-
Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy
-
a2b5697d-a785-653c-42b7-84b2eb17c4d1
-
Fan W et al (2010) Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy. Autophagy 6(a2b5697d-a785-653c-42b7-84b2eb17c4d1)
-
(2010)
Autophagy
, vol.6
-
-
Fan, W.1
-
29
-
-
0021128369
-
Age-dependent structural changes in the myocardium of rats. A quantitative light- and electron-microscopic study on the right and left chamber wall
-
DOI 10.1016/0047-6374(84)90080-0
-
Frenzel H, Feimann J (1984) Age-dependent structural changes in the myocardium of rats. A quantitative light- and electronmicroscopic study on the right and left chamber wall. Mech Ageing Dev 27(1):29-41 (Pubitemid 14038221)
-
(1984)
Mechanisms of Ageing and Development
, vol.27
, Issue.1
, pp. 29-41
-
-
Frenzel, H.1
Feimann, J.2
-
30
-
-
0037070216
-
Structure and functional properties of the ubiquitin binding protein p62
-
24344ce0-5262-a90c-1802-fc2e2b0a525f
-
Geetha T, Wooten M (2002) Structure and functional properties of the ubiquitin binding protein p62. FEBS Lett 512(24344ce0-5262-a90c-1802- fc2e2b0a525f):19-43
-
(2002)
FEBS Lett
, vol.512
, pp. 19-43
-
-
Geetha, T.1
Wooten, M.2
-
31
-
-
26944484011
-
Lysine 63 polyubiquitination of the nerve growth factor receptor TrkA directs internalization and signaling
-
1db9e0fb-5676-7dcd-89aa-116f27f72f5c
-
Geetha T, Jiang J, Wooten M (2005) Lysine 63 polyubiquitination of the nerve growth factor receptor TrkA directs internalization and signaling. Mol Cell 20(1db9e0fb-5676-7dcd-89aa-116f27f72f5c):301-313
-
(2005)
Mol Cell
, vol.20
, pp. 301-313
-
-
Geetha, T.1
Jiang, J.2
Wooten, M.3
-
32
-
-
47749148062
-
p62 serves as a shuttling factor for TrkA interaction with the proteasome
-
f569f091-6fb4-2905-c0a9-1b280377cbcc
-
Geetha T et al (2008) p62 serves as a shuttling factor for TrkA interaction with the proteasome. Biochem Biophys Res Commun 374(f569f091-6fb4- 2905-c0a9-1b280377cbcc):33-40
-
(2008)
Biochem Biophys Res Commun
, vol.374
, pp. 33-40
-
-
Geetha, T.1
-
33
-
-
75949130828
-
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
-
Geisler S et al (2010a) PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nat Cell Biol 12(2):119-131
-
(2010)
Nat Cell Biol
, vol.12
, Issue.2
, pp. 119-131
-
-
Geisler, S.1
-
34
-
-
77957673363
-
The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations
-
Geisler S et al (2010b) The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations. Autophagy 6(7):871-878
-
(2010)
Autophagy
, vol.6
, Issue.7
, pp. 871-878
-
-
Geisler, S.1
-
35
-
-
51049118332
-
The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. 'Protein modifications: Beyond the usual suspects' review series
-
Geng J, Klionsky D (2008) The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. 'Protein modifications: beyond the usual suspects' review series. EMBO Rep 9(9):859-864
-
(2008)
EMBO Rep
, vol.9
, Issue.9
, pp. 859-864
-
-
Geng, J.1
Klionsky, D.2
-
36
-
-
84856951239
-
Mitochondrial autophagy in cells with mtDNA mutations results from synergistic loss of transmembrane potential and mTORC1 inhibition
-
Gilkerson R, et al. (2011) Mitochondrial autophagy in cells with mtDNA mutations results from synergistic loss of transmembrane potential and mTORC1 inhibition. Human Mol Genet 21(5):978-990
-
(2011)
Human Mol Genet
, vol.21
, Issue.5
, pp. 978-990
-
-
Gilkerson, R.1
-
37
-
-
84862271583
-
Pancreatic function, type 2 diabetes, and metabolism in aging
-
94bf4f10-7e61-8f0d-47cb-395213c68671
-
Gong Z, Muzumdar R (2012) Pancreatic function, type 2 diabetes, and metabolism in aging. Int J Endocrinol 2012(94bf4f10-7e61-8f0d-47cb-395213c68671) :320482
-
(2012)
Int J Endocrinol
, vol.2012
, pp. 320482
-
-
Gong, Z.1
Muzumdar, R.2
-
38
-
-
77749301510
-
Recent advances in understanding the molecular basis of Paget disease of bone
-
e67bfe6b-8256-f35a-f589-fc0dcd60d5a1
-
Goode A, Layfield R (2010) Recent advances in understanding the molecular basis of Paget disease of bone. J Clin Pathol 63(e67bfe6b-8256-f35a-f589- fc0dcd60d5a1):199-402
-
(2010)
J Clin Pathol
, vol.63
, pp. 199-402
-
-
Goode, A.1
Layfield, R.2
-
39
-
-
84865354347
-
IGF-I enhances cellular senescence via the reactive oxygen species-p53 pathway
-
Handayaningsih A-E et al. (2012) IGF-I enhances cellular senescence via the reactive oxygen species-p53 pathway. Biochem Biophys Res Commun 425(2):478-484
-
(2012)
Biochem Biophys Res Commun
, vol.425
, Issue.2
, pp. 478-484
-
-
Handayaningsih, A.-E.1
-
40
-
-
40149105890
-
A role for autophagy in the extension of lifespan by dietary restriction in C. elegans
-
Hansen M et al (2008) A role for autophagy in the extension of lifespan by dietary restriction in C. elegans. PLoS Genet 4(2):e24
-
(2008)
PLoS Genet
, vol.4
, Issue.2
-
-
Hansen, M.1
-
41
-
-
0142213542
-
The free radical theory of aging
-
Harman D (2003) The free radical theory of aging. Antioxid Redox Signal 5(5):557-561
-
(2003)
Antioxid Redox Signal
, vol.5
, Issue.5
, pp. 557-561
-
-
Harman, D.1
-
42
-
-
72549095406
-
Regulation mechanisms and signaling pathways of autophagy
-
He C, Klionsky D (2009) Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet 43:67-93
-
(2009)
Annu Rev Genet
, vol.43
, pp. 67-93
-
-
He, C.1
Klionsky, D.2
-
43
-
-
84871011474
-
An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast
-
Hughes A, Gottschling D (2012) An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast. Nature 492(7428):261-265
-
(2012)
Nature
, vol.492
, Issue.7428
, pp. 261-265
-
-
Hughes, A.1
Gottschling, D.2
-
44
-
-
84863878834
-
Inclusion body myositis coexisting with hypertrophic cardiomyopathy: An autopsy study
-
Inamori Y et al (2012) Inclusion body myositis coexisting with hypertrophic cardiomyopathy: an autopsy study. NMD 22(8):747-754
-
(2012)
NMD
, vol.22
, Issue.8
, pp. 747-754
-
-
Inamori, Y.1
-
45
-
-
78651282673
-
p62 Targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding
-
35dd33bb-6bd5-d6ad-3d10-fcbe10fbbcb6
-
Itakura E, Mizushima N (2011) p62 Targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding. J Cell Biol 192(35dd33bb-6bd5-d6ad-3d10-fcbe10fbbcb6):17-44
-
(2011)
J Cell Biol
, vol.192
, pp. 17-44
-
-
Itakura, E.1
Mizushima, N.2
-
46
-
-
59249089394
-
Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG
-
Itakura E et al (2008) Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. Mol Biol Cell 19(12):5360-5372
-
(2008)
Mol Biol Cell
, vol.19
, Issue.12
, pp. 5360-5372
-
-
Itakura, E.1
-
47
-
-
77954599053
-
p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription
-
Jain A et al (2010) p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription. J Biol Chem 285(29):22576-22591
-
(2010)
J Biol Chem
, vol.285
, Issue.29
, pp. 22576-22591
-
-
Jain, A.1
-
48
-
-
78751704988
-
Age-associated alterations of the neuromuscular junction
-
Jang Y, Van Remmen H (2011) Age-associated alterations of the neuromuscular junction. Exp Gerontol 46(2-3):193-198
-
(2011)
Exp Gerontol
, vol.46
, Issue.2-3
, pp. 193-198
-
-
Jang, Y.1
Van Remmen, H.2
-
49
-
-
65549085701
-
Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling
-
Jin Z et al (2009) Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling. Cell 137(4):721-735
-
(2009)
Cell
, vol.137
, Issue.4
, pp. 721-735
-
-
Jin, Z.1
-
50
-
-
79952355107
-
Selective autophagy mediated by autophagic adapter proteins
-
Johansen T, Lamark T (2011) Selective autophagy mediated by autophagic adapter proteins. Autophagy 7(3):279-296
-
(2011)
Autophagy
, vol.7
, Issue.3
, pp. 279-296
-
-
Johansen, T.1
Lamark, T.2
-
51
-
-
0029894586
-
Molecular cloning of a phosphotyrosine-independent ligand of the p56lck SH2 domain
-
529cf5e6-37c8-49cb-37e6-008f126febd7
-
Joung I, Strominger J, Shin J (1996) Molecular cloning of a phosphotyrosine-independent ligand of the p56lck SH2 domain. Proc Natl Acad Sci U S A 93(529cf5e6-37c8-49cb-37e6-008f126febd7):5991-5996
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 5991-5996
-
-
Joung, I.1
Strominger, J.2
Shin, J.3
-
52
-
-
65249176304
-
ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery
-
Jung C et al (2009) ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol Biol Cell 20(7):1992-2003
-
(2009)
Mol Biol Cell
, vol.20
, Issue.7
, pp. 1992-2003
-
-
Jung, C.1
-
53
-
-
79961194820
-
Autophagy impairment induces premature senescence in primary human fibroblasts
-
Kang HT et al (2011) Autophagy impairment induces premature senescence in primary human fibroblasts. PLoS One 6(8):e23367
-
(2011)
PLoS One
, vol.6
, Issue.8
-
-
Kang, H.T.1
-
55
-
-
48649085816
-
Regulation of TORC1 by Rag GTPases in nutrient response
-
552acb39-f20a-30f5-80fb-6f46f5589ac8
-
Kim E et al (2008) Regulation of TORC1 by Rag GTPases in nutrient response. Nat Cell Biol 10(552acb39-f20a-30f5-80fb-6f46f5589ac8):935-980
-
(2008)
Nat Cell Biol
, vol.10
, pp. 935-980
-
-
Kim, E.1
-
56
-
-
79551598347
-
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
-
Kim J et al (2011) AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol 13(2):132-141
-
(2011)
Nat Cell Biol
, vol.13
, Issue.2
, pp. 132-141
-
-
Kim, J.1
-
57
-
-
60849099049
-
A role for NBR1 in autophagosomal degradation of ubiquitinated substrates
-
Kirkin V et al (2009) A role for NBR1 in autophagosomal degradation of ubiquitinated substrates. Mol Cell 33(4):505-516
-
(2009)
Mol Cell
, vol.33
, Issue.4
, pp. 505-516
-
-
Kirkin, V.1
-
58
-
-
0025253098
-
Age-related changes in the anatomy of the normal human heart
-
Kitzman D, Edwards W (1990) Age-related changes in the anatomy of the normal human heart. J Gerontol 45(2):9
-
(1990)
J Gerontol
, vol.45
, Issue.2
, pp. 9
-
-
Kitzman, D.1
Edwards, W.2
-
59
-
-
0017763799
-
Aging in the nematode Caenorhabditis elegans: Major biological and environmental factors influencing life span
-
Klass M (1977) Aging in the nematode Caenorhabditis elegans: major biological and environmental factors influencing life span. Mech Ageing Dev 6(6):413-429
-
(1977)
Mech Ageing Dev
, vol.6
, Issue.6
, pp. 413-429
-
-
Klass, M.1
-
60
-
-
79251498807
-
Protein homeostasis and aging: The importance of exquisite quality control
-
Koga H, Kaushik S, Cuervo A (2011) Protein homeostasis and aging: the importance of exquisite quality control. Ageing Res Rev 10(2):205-215
-
(2011)
Ageing Res Rev
, vol.10
, Issue.2
, pp. 205-215
-
-
Koga, H.1
Kaushik, S.2
Cuervo, A.3
-
61
-
-
36849089101
-
Homeostatic Levels of p62 Control Cytoplasmic Inclusion Body Formation in Autophagy-Deficient Mice
-
DOI 10.1016/j.cell.2007.10.035, PII S0092867407013542
-
Komatsu M et al (2007) Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell 131(6):1149-1163 (Pubitemid 350235021)
-
(2007)
Cell
, vol.131
, Issue.6
, pp. 1149-1163
-
-
Komatsu, M.1
Waguri, S.2
Koike, M.3
Sou, Y.-s.4
Ueno, T.5
Hara, T.6
Mizushima, N.7
Iwata, J.-i.8
Ezaki, J.9
Murata, S.10
Hamazaki, J.11
Nishito, Y.12
Iemura, S.-i.13
Natsume, T.14
Yanagawa, T.15
Uwayama, J.16
Warabi, E.17
Yoshida, H.18
Ishii, T.19
Kobayashi, A.20
Yamamoto, M.21
Yue, Z.22
Uchiyama, Y.23
Kominami, E.24
Tanaka, K.25
more..
-
62
-
-
77649265091
-
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
-
Komatsu M et al (2010) The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nat Cell Biol 12(3):213-223
-
(2010)
Nat Cell Biol
, vol.12
, Issue.3
, pp. 213-223
-
-
Komatsu, M.1
-
64
-
-
60549093730
-
Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates
-
47c733bb-2560-6596-2d60-07bda3a4c8b9
-
Korolchuk V et al (2009) Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates. Mol Cell 33(47c733bb-2560-6596-2d60- 07bda3a4c8b9):517-544
-
(2009)
Mol Cell
, vol.33
, pp. 517-544
-
-
Korolchuk, V.1
-
65
-
-
0035919837
-
Ubiquitin-binding protein p62 is present in neuronal and glial inclusions in human tauopathies and synucleinopathies
-
Kuusisto E, Salminen A, Alafuzoff I (2001) Ubiquitin-binding protein p62 is present in neuronal and glial inclusions in human tauopathies and synucleinopathies. Neuroreport 12(10):2085-2090 (Pubitemid 32646250)
-
(2001)
NeuroReport
, vol.12
, Issue.10
, pp. 2085-2090
-
-
Kuusisto, E.1
Salminen, A.2
Alafuzoff, I.3
-
66
-
-
0036284021
-
Early accumulation of p62 in neurofibrillary tangles in Alzheimer's disease: Possible role in tangle formation
-
3bceda89-d3ed-f98e-1484-07daef4daadc
-
Kuusisto E, Salminen A, Alafuzoff I (2002) Early accumulation of p62 in neurofibrillary tangles in Alzheimer's disease: possible role in tangle formation. Neuropathol Appl Neurobiol 28(3bceda89-d3ed-f98e-1484-07daef4daadc): 228-265
-
(2002)
Neuropathol Appl Neurobiol
, vol.28
, pp. 228-265
-
-
Kuusisto, E.1
Salminen, A.2
Alafuzoff, I.3
-
67
-
-
84863041323
-
Assurance of mitochondrial integrity and mammalian longevity by the p62-Keap1-Nrf2-Nqo1 cascade
-
e6cd8e22-20d2-22e1-d21de3874e265257
-
Kwon J et al (2012) Assurance of mitochondrial integrity and mammalian longevity by the p62-Keap1-Nrf2-Nqo1 cascade. EMBO Rep 13(e6cd8e22-20d2-22e1- d21de3874e265257):150-156
-
(2012)
EMBO Rep
, vol.13
, pp. 150-156
-
-
Kwon, J.1
-
68
-
-
84878919090
-
The aging respiratory system - pulmonary structure, function and neural control
-
Lalley P (2013) The aging respiratory system - pulmonary structure, function and neural control. Respir Physiol Neurobiol 187:199-210
-
(2013)
Respir Physiol Neurobiol
, vol.187
, pp. 199-210
-
-
Lalley, P.1
-
69
-
-
0141445968
-
Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins
-
4a65a5a4-71cb-2ade-e9ee-fc2e2b09dbc8
-
Lamark T et al (2003) Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins. J Biol Chem 278(4a65a5a4-71cb-2ade- e9ee-fc2e2b09dbc8):34568-34649
-
(2003)
J Biol Chem
, vol.278
, pp. 34568-34649
-
-
Lamark, T.1
-
70
-
-
0019799551
-
Hippocampal aging in rats: A morphometric study of multiple variables in semithin sections
-
DOI 10.1016/0197-4580(81)90034-8
-
Landfield P et al (1981) Hippocampal aging in rats: a morphometric study of multiple variables in semithin sections. Neurobiol Aging 2(4):265-275 (Pubitemid 12152572)
-
(1981)
Neurobiology of Aging
, vol.2
, Issue.4
, pp. 265-275
-
-
Landfield, P.W.1
Braun, L.D.2
Pitler, T.A.3
-
71
-
-
77953366801
-
A noncanonical mechanism of Nrf2 activation by autophagy deficiency: Direct interaction between Keap1 and p62
-
Lau A et al (2010) A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62. Mol Cell Biol 30(13):3275-3285
-
(2010)
Mol Cell Biol
, vol.30
, Issue.13
, pp. 3275-3285
-
-
Lau, A.1
-
72
-
-
0036094026
-
Recurrent mutation of the gene encoding sequestosome 1 (SQSTM1/p62) in paget disease of bone
-
DOI 10.1086/340731
-
Laurin N et al (2002) Recurrent mutation of the gene encoding sequestosome 1 (SQSTM1/p62) in Paget disease of bone. Am J Hum Genet 70(6):1582-1588 (Pubitemid 34533906)
-
(2002)
American Journal of Human Genetics
, vol.70
, Issue.6
, pp. 1582-1588
-
-
Laurin, N.1
Brown, J.P.2
Morissette, J.3
Raymond, V.4
-
74
-
-
77956631023
-
PKCzeta-regulated inflammation in the nonhematopoietic compartment is critical for obesity-induced glucose intolerance
-
64b8228e-3e87-bfd5-890a-3e48b17b5d2c
-
Lee S et al (2010) PKCzeta-regulated inflammation in the nonhematopoietic compartment is critical for obesity-induced glucose intolerance. Cell Metab 12(64b8228e-3e87-bfd5-890a-3e48b17b5d2c):65-142
-
(2010)
Cell Metab
, vol.12
, pp. 65-142
-
-
Lee, S.1
-
75
-
-
84863078686
-
Autophagy suppresses interleukin-1β (IL-1β) signaling by activation of p62 degradation via lysosomal and proteasomal pathways
-
21aff234-8231-4f10-7d43-1535e01980f9
-
Lee J et al (2012) Autophagy suppresses interleukin-1β (IL-1β) signaling by activation of p62 degradation via lysosomal and proteasomal pathways. J Biol Chem 287(21aff234-8231-4f10-7d43-1535e01980f9):4033-4073
-
(2012)
J Biol Chem
, vol.287
, pp. 4033-4073
-
-
Lee, J.1
-
76
-
-
75149117017
-
Nrf2 signaling, a mechanism for cellular stress resistance in long-lived mice
-
f6928770-a92a-c84b-70bf-3f502d906abb
-
Leiser S, Miller R (2010) Nrf2 signaling, a mechanism for cellular stress resistance in long-lived mice. Mol Cell Biol 30(f6928770-a92a-c84b-70bf- 3f502d906abb):871-955
-
(2010)
Mol Cell Biol
, vol.30
, pp. 871-955
-
-
Leiser, S.1
Miller, R.2
-
77
-
-
84905364102
-
Reduced mTOR activity facilitates mitochondrial retrograde signaling and increases lifespan in normal fibroblasts
-
In press
-
Lerner C et al (2013) Reduced mTOR activity facilitates mitochondrial retrograde signaling and increases lifespan in normal fibroblasts. Aging Cell (In press)
-
(2013)
Aging Cell
-
-
Lerner, C.1
-
78
-
-
84859161154
-
Microautophagy: Lesser-known self-eating
-
Li W-W, Li J, Bao J-K (2012) Microautophagy: lesser-known self-eating. CMLS 69(7):1125-1136
-
(2012)
CMLS
, vol.69
, Issue.7
, pp. 1125-1136
-
-
Li, W.-W.1
Li, J.2
Bao, J.-K.3
-
79
-
-
33750347347
-
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
-
DOI 10.1038/nature05292, PII NATURE05292
-
Lin MT, Beal MF (2006) Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 443(7113):787-795 (Pubitemid 44622683)
-
(2006)
Nature
, vol.443
, Issue.7113
, pp. 787-795
-
-
Lin, M.T.1
Beal, M.F.2
-
80
-
-
0033405860
-
Mutations in signal transduction proteins increase stress resistance and longevity in yeast, nematodes, fruit flies, and mammalian neuronal cells
-
Longo V (1999) Mutations in signal transduction proteins increase stress resistance and longevity in yeast, nematodes, fruit flies, and mammalian neuronal cells. Neurobiol Aging 20(5):479-486
-
(1999)
Neurobiol Aging
, vol.20
, Issue.5
, pp. 479-486
-
-
Longo, V.1
-
81
-
-
0037008693
-
Identification of interleukin 1 receptor-associated kinase as a conserved component in the p75-neurotrophin receptor activation of nuclear factorkappa B
-
48659987-f63a-21a3-c089-152bf7a64ec3
-
Mamidipudi V, Li X, Wooten M (2002) Identification of interleukin 1 receptor-associated kinase as a conserved component in the p75-neurotrophin receptor activation of nuclear factorkappa B. J Biol Chem 277(48659987-f63a- 21a3-c089-152bf7a64ec3):28010-28018
-
(2002)
J Biol Chem
, vol.277
, pp. 28010-28018
-
-
Mamidipudi, V.1
Li, X.2
Wooten, M.3
-
82
-
-
36448940798
-
FoxO3 Controls Autophagy in Skeletal Muscle In Vivo
-
DOI 10.1016/j.cmet.2007.11.001, PII S1550413107003361
-
Mammucari C et al (2007) FoxO3 controls autophagy in skeletal muscle in vivo. Cell Metab 6(6):458-471 (Pubitemid 350163055)
-
(2007)
Cell Metabolism
, vol.6
, Issue.6
, pp. 458-471
-
-
Mammucari, C.1
Milan, G.2
Romanello, V.3
Masiero, E.4
Rudolf, R.5
Del, P.P.6
Burden, S.J.7
Di, L.R.8
Sandri, C.9
Zhao, J.10
Goldberg, A.L.11
Schiaffino, S.12
Sandri, M.13
-
83
-
-
32244448364
-
Alterations in mitochondrial function, hydrogen peroxide release and oxidative damage in mouse hind-limb skeletal muscle during aging
-
DOI 10.1016/j.mad.2005.11.004, PII S0047637405003015
-
Mansouri A et al (2006) Alterations in mitochondrial function, hydrogen peroxide release and oxidative damage in mouse hind-limb skeletal muscle during aging. Mech Ageing Dev 127(3):298-306 (Pubitemid 43214503)
-
(2006)
Mechanisms of Ageing and Development
, vol.127
, Issue.3
, pp. 298-306
-
-
Mansouri, A.1
Muller, F.L.2
Liu, Y.3
Ng, R.4
Faulkner, J.5
Hamilton, M.6
Richardson, A.7
Huang, T.-T.8
Epstein, C.J.9
Van Remmen, H.10
-
84
-
-
0029970868
-
A p56(lck) ligand serves as a coactivator of an orphan nuclear hormone receptor
-
b9b0da87-fccd-43cc-0095-0174c302442e
-
Marcus S et al (1996) A p56(lck) ligand serves as a coactivator of an orphan nuclear hormone receptor. J Biol Chem 271(b9b0da87-fccd-43cc-0095- 0174c302442e):27197-27397
-
(1996)
J Biol Chem
, vol.271
, pp. 27197-27397
-
-
Marcus, S.1
-
85
-
-
82455172117
-
Serine 403 phosphorylation of p62/SQSTM1 regulates selective autophagic clearance of ubiquitinated proteins
-
75e058b6-11c7-0417-c1eb-374a0a09fa5f
-
Matsumoto G et al (2011) Serine 403 phosphorylation of p62/SQSTM1 regulates selective autophagic clearance of ubiquitinated proteins. Mol Cell 44(75e058b6-11c7-0417-c1eb-374a0a09fa5f):279-368
-
(2011)
Mol Cell
, vol.44
, pp. 279-368
-
-
Matsumoto, G.1
-
86
-
-
72149118710
-
Perspective: Does brown fat protect against diseases of aging?
-
Mattson MP (2010) Perspective: does brown fat protect against diseases of aging? Ageing Res Rev 9(1):69-76
-
(2010)
Ageing Res Rev
, vol.9
, Issue.1
, pp. 69-76
-
-
Mattson, M.P.1
-
87
-
-
33749661651
-
Immunoreactivities of p62, an ubiqutin-binding protein, in the spinal anterior horn cells of patients with amyotrophic lateral sclerosis
-
DOI 10.1016/j.jns.2006.05.060, PII S0022510X06002747
-
Mizuno Y et al (2006) Immunoreactivities of p62, an ubiquitinbinding protein, in the spinal anterior horn cells of patients with amyotrophic lateral sclerosis. J Neurol Sci 249(1):13-18 (Pubitemid 44665902)
-
(2006)
Journal of the Neurological Sciences
, vol.249
, Issue.1
, pp. 13-18
-
-
Mizuno, Y.1
Amari, M.2
Takatama, M.3
Aizawa, H.4
Mihara, B.5
Okamoto, K.6
-
88
-
-
0038325675
-
Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate
-
DOI 10.1242/jcs.00381
-
Mizushima N et al (2003) Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate. J Cell Sci 116(Pt 9):1679-1688 (Pubitemid 36582155)
-
(2003)
Journal of Cell Science
, vol.116
, Issue.9
, pp. 1679-1688
-
-
Mizushima, N.1
Kuma, A.2
Kobayashi, Y.3
Yamamoto, A.4
Matsubae, M.5
Takao, T.6
Natsume, T.7
Ohsumi, Y.8
Yoshimori, T.9
-
89
-
-
39849109338
-
Autophagy fights disease through cellular self-digestion
-
DOI 10.1038/nature06639, PII NATURE06639
-
Mizushima N et al (2008) Autophagy fights disease through cellular self-digestion. Nature 451(7182):1069-1075 (Pubitemid 351317450)
-
(2008)
Nature
, vol.451
, Issue.7182
, pp. 1069-1075
-
-
Mizushima, N.1
Levine, B.2
Cuervo, A.M.3
Klionsky, D.J.4
-
90
-
-
81055140893
-
Feedback on fat: P62-mTORC1-autophagy connections
-
7fe468c7-09ee-421a-bbe5-0fa750b8a785
-
Moscat J, Diaz-Meco M (2011) Feedback on fat: p62-mTORC1-autophagy connections. Cell 147(7fe468c7-09ee-421a-bbe5-0fa750b8a785)
-
(2011)
Cell
, vol.147
-
-
Moscat, J.1
Diaz-Meco, M.2
-
91
-
-
58149314211
-
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
-
89cd27ab-ae69-8528-c6f4-1f3f639dc970
-
Narendra D et al (2008) Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol 183(89cd27ab-ae69-8528- c6f4-1f3f639dc970):795-1598
-
(2008)
J Cell Biol
, vol.183
, pp. 795-1598
-
-
Narendra, D.1
-
92
-
-
78649300971
-
p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both
-
Narendra D et al (2010a) p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both. Autophagy 6(8):1090-1106
-
(2010)
Autophagy
, vol.6
, Issue.8
, pp. 1090-1106
-
-
Narendra, D.1
-
93
-
-
75749156257
-
PINK1 is selectively stabilized on impaired mitochondria to activate Parkin
-
Narendra DP et al (2010b) PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. PLoS Biol 8(1):e1000298
-
(2010)
PLoS Biol
, vol.8
, Issue.1
-
-
Narendra, D.P.1
-
94
-
-
84863425313
-
p62 at the interface of autophagy, oxidative stress signaling, and cancer
-
Nezis I, Stenmark H (2012) p62 at the interface of autophagy, oxidative stress signaling, and cancer. Antioxid Redox Signal 17(5):786-793
-
(2012)
Antioxid Redox Signal
, vol.17
, Issue.5
, pp. 786-793
-
-
Nezis, I.1
Stenmark, H.2
-
95
-
-
41549151641
-
Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain
-
DOI 10.1083/jcb.200711108
-
Nezis I et al (2008) Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain. J Cell Biol 180(6):1065-1071 (Pubitemid 351468465)
-
(2008)
Journal of Cell Biology
, vol.180
, Issue.6
, pp. 1065-1071
-
-
Nezis, I.P.1
Simonsen, A.2
Sagona, A.P.3
Finley, K.4
Gaumer, S.5
Contamine, D.6
Rusten, T.E.7
Stenmark, H.8
Brech, A.9
-
96
-
-
68349097450
-
p62/SQSTM1 is overexpressed and prominently accumulated in inclusions of sporadic inclusion-body myositis muscle fibers, and can help differentiating it from polymyositis and dermatomyositis
-
Nogalska A et al (2009) p62/SQSTM1 is overexpressed and prominently accumulated in inclusions of sporadic inclusion-body myositis muscle fibers, and can help differentiating it from polymyositis and dermatomyositis. Acta Neuropathol 118(3):407-413
-
(2009)
Acta Neuropathol
, vol.118
, Issue.3
, pp. 407-413
-
-
Nogalska, A.1
-
97
-
-
78149406278
-
Novel demonstration of amyloid-β oligomers in sporadic inclusion-body myositis muscle fibers
-
Nogalska A et al (2010) Novel demonstration of amyloid-β oligomers in sporadic inclusion-body myositis muscle fibers. Acta Neuropathol 120(5):661-666
-
(2010)
Acta Neuropathol
, vol.120
, Issue.5
, pp. 661-666
-
-
Nogalska, A.1
-
98
-
-
80053247082
-
Novel demonstration of conformationally modified tau in sporadic inclusion-body myositis muscle fibers
-
Nogalska A et al (2011) Novel demonstration of conformationally modified tau in sporadic inclusion-body myositis muscle fibers. Neurosci Lett 503(3):229-233
-
(2011)
Neurosci Lett
, vol.503
, Issue.3
, pp. 229-233
-
-
Nogalska, A.1
-
99
-
-
77954695260
-
p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria
-
Okatsu K et al (2010) p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria. Genes Cells 15(8):887-900
-
(2010)
Genes Cells
, vol.15
, Issue.8
, pp. 887-900
-
-
Okatsu, K.1
-
100
-
-
0032425350
-
Mitochondrial DNA mutations and age
-
Ozawa T (1998) Mitochondrial DNA mutations and age. Ann N Y Acad Sci 854:128-154
-
(1998)
Ann N Y Acad Sci
, vol.854
, pp. 128-154
-
-
Ozawa, T.1
-
101
-
-
34548259958
-
p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy*[S]
-
DOI 10.1074/jbc.M702824200
-
Pankiv S et al (2007) p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem 282(33):24131-24145 (Pubitemid 47328003)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.33
, pp. 24131-24145
-
-
Pankiv, S.1
Clausen, T.H.2
Lamark, T.3
Brech, A.4
Bruun, J.-A.5
Outzen, H.6
Overvatn, A.7
Bjorkoy, G.8
Johansen, T.9
-
102
-
-
77949324195
-
Nucleocytoplasmic shuttling of p62/SQSTM1 and its role in recruitment of nuclear polyubiquitinated proteins to promyelocytic leukemia bodies
-
3c704f44-98ab-1180-47d3-0682c131049e
-
Pankiv S et al (2010) Nucleocytoplasmic shuttling of p62/SQSTM1 and its role in recruitment of nuclear polyubiquitinated proteins to promyelocytic leukemia bodies. J Biol Chem 285(3c704f44-98ab-1180-47d3-0682c131049e):5941-5994
-
(2010)
J Biol Chem
, vol.285
, pp. 5941-5994
-
-
Pankiv, S.1
-
103
-
-
25144457455
-
Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy
-
DOI 10.1016/j.cell.2005.07.002, PII S0092867405006926
-
Pattingre S et al (2005) Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 122(6):927-939 (Pubitemid 41345209)
-
(2005)
Cell
, vol.122
, Issue.6
, pp. 927-939
-
-
Pattingre, S.1
Tassa, A.2
Qu, X.3
Garuti, R.4
Xiao, H.L.5
Mizushima, N.6
Packer, M.7
Schneider, M.D.8
Levine, B.9
-
104
-
-
58149328569
-
Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via Nrf2-mediated transcriptional control of nuclear respiratory factor-1
-
Piantadosi CA et al (2008) Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via Nrf2-mediated transcriptional control of nuclear respiratory factor-1. Circ Res 103(11):1232-1240
-
(2008)
Circ Res
, vol.103
, Issue.11
, pp. 1232-1240
-
-
Piantadosi, C.A.1
-
105
-
-
54849431380
-
Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration
-
84e93330-7322-b853-cd6e-3a6ea7481b27
-
Polak P et al (2008) Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration. Cell Metab 8(84e93330-7322-b853- cd6e-3a6ea7481b27):399-809
-
(2008)
Cell Metab
, vol.8
, pp. 399-809
-
-
Polak, P.1
-
106
-
-
0025862009
-
Advances in age pigment research
-
Porta EA (1991) Advances in age pigment research. Arch Gerontol Geriatr 12(2-3):303-320
-
(1991)
Arch Gerontol Geriatr
, vol.12
, Issue.2-3
, pp. 303-320
-
-
Porta, E.A.1
-
107
-
-
0033603345
-
The p56(lck)-interacting protein p62 stimulates transcription via the SV40 enhancer
-
5ae492ce-035d-a8aa-4ee9-fc2e2b0a2e07
-
Rachubinski R, Marcus S, Capone J (1999) The p56(lck)-interacting protein p62 stimulates transcription via the SV40 enhancer. J Biol Chem 274(5ae492ce-035d-a8aa-4ee9-fc2e2b0a2e07):18278-18362
-
(1999)
J Biol Chem
, vol.274
, pp. 18278-18362
-
-
Rachubinski, R.1
Marcus, S.2
Capone, J.3
-
108
-
-
45249105920
-
Genetic inactivation of p62 leads to accumulation of hyperphosphorylated tau and neurodegeneration
-
27a74d97-a739-d297-646d-16c8da17e322
-
Ramesh Babu J et al (2008) Genetic inactivation of p62 leads to accumulation of hyperphosphorylated tau and neurodegeneration. J Neurochem 106(27a74d97-a739-d297-646d-16c8da17e322):107-127
-
(2008)
J Neurochem
, vol.106
, pp. 107-127
-
-
Ramesh Babu, J.1
-
109
-
-
33846073880
-
Expression of Nrf2 in neurodegenerative diseases
-
6a48f324-2d51-2aa2-8725-1b0928e05358
-
Ramsey C et al (2007) Expression of Nrf2 in neurodegenerative diseases. J Neuropathol Exp Neurol 66(6a48f324-2d51-2aa2-8725-1b0928e05358):75-160
-
(2007)
J Neuropathol Exp Neurol
, vol.66
, pp. 75-160
-
-
Ramsey, C.1
-
110
-
-
2642586352
-
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
-
DOI 10.1038/ng1362
-
Ravikumar B et al (2004) Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mousemodels ofHuntington disease. NatGenet 36(6):585-595 (Pubitemid 38715985)
-
(2004)
Nature Genetics
, vol.36
, Issue.6
, pp. 585-595
-
-
Ravikumar, B.1
Vacher, C.2
Berger, Z.3
Davies, J.E.4
Luo, S.5
Oroz, L.G.6
Scaravilli, F.7
Easton, D.F.8
Duden, R.9
O'Kane, C.J.10
Rubinsztein, D.C.11
-
112
-
-
84860461929
-
TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO
-
Robida-Stubbs S et al (2012) TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO. Cell Metab 15(5):713-724
-
(2012)
Cell Metab
, vol.15
, Issue.5
, pp. 713-724
-
-
Robida-Stubbs, S.1
-
113
-
-
33644629034
-
Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62
-
0a30ac0c-ca9e-5ee9-59ec-24cbc90092cf
-
Rodriguez A et al (2006) Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62. Cell Metab 3(0a30ac0c-ca9e-5ee9- 59ec-24cbc90092cf):211-233
-
(2006)
Cell Metab
, vol.3
, pp. 211-233
-
-
Rodriguez, A.1
-
114
-
-
79959953782
-
Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotype
-
Salminen A et al (2011) Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotype. Eur J Neurosci 34(1):3-11
-
(2011)
Eur J Neurosci
, vol.34
, Issue.1
, pp. 3-11
-
-
Salminen, A.1
-
115
-
-
21044450084
-
Fibroblast cell lines from young adult mice of long-lived mutant strains are resistant to multiple forms of stress
-
Salmon A et al (2005) Fibroblast cell lines from young adult mice of long-lived mutant strains are resistant to multiple forms of stress. Am J Physiol Endocrinol Metab 289(1):9
-
(2005)
Am J Physiol Endocrinol Metab
, vol.289
, Issue.1
, pp. 9
-
-
Salmon, A.1
-
116
-
-
45849105156
-
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
-
56ca5f23-896a-b94e-de3e-0c4be356193c
-
Sancak Y et al (2008) The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Sci (New York, NY) 320(56ca5f23-896a-b94e-de3e- 0c4be356193c):1496-1997
-
(2008)
Sci (New York, NY)
, vol.320
, pp. 1496-1997
-
-
Sancak, Y.1
-
117
-
-
77951768486
-
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
-
01f0f45f-84d6-a5ce-e325-0c4b1f2cde36
-
Sancak Y et al (2010) Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell 141(01f0f45f-84d6-a5ce-e325-0c4b1f2cde36):290-593
-
(2010)
Cell
, vol.141
, pp. 290-593
-
-
Sancak, Y.1
-
118
-
-
0031946369
-
Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62
-
6abf35eb-a291-e542-7256-008f126e35a9
-
Sanchez P et al (1998) Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62. Mol Cell Biol 18(6abf35eb-a291-e542-7256-008f126e35a9):3069-3149
-
(1998)
Mol Cell Biol
, vol.18
, pp. 3069-3149
-
-
Sanchez, P.1
-
119
-
-
0033153320
-
The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation
-
28a44be7-14d0-4c74-cc5a-01ea9df668a3
-
Sanz L et al (1999) The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation. EMBO J 18(28a44be7-14d0-4c74-cc5a-01ea9df668a3): 3044-3097
-
(1999)
EMBO J
, vol.18
, pp. 3044-3097
-
-
Sanz, L.1
-
120
-
-
0034599476
-
The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway
-
dec466e5-a9e0-db20-d2db-01c4befea22f
-
Sanz L et al (2000) The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway. EMBO J 19(dec466e5-a9e0-db20- d2db-01c4befea22f):1576-1662
-
(2000)
EMBO J
, vol.19
, pp. 1576-1662
-
-
Sanz, L.1
-
121
-
-
24644438250
-
Age-related changes in liver structure and function: Implications for disease?
-
Schmucker D (2005) Age-related changes in liver structure and function: implications for disease ? Exp Gerontol 40(8-9):650-659
-
(2005)
Exp Gerontol
, vol.40
, Issue.8-9
, pp. 650-659
-
-
Schmucker, D.1
-
122
-
-
0036123267
-
Quantifying dense bodies and lipofuscin during aging: A morphologist's perspective
-
DOI 10.1016/S0167-4943(01)00218-7, PII S0167494301002187
-
Schmucker D, Sachs H (2002) Quantifying dense bodies and lipofuscin during aging: a morphologist's perspective. Arch Gerontol Geriatr 34(3):249-261 (Pubitemid 34224165)
-
(2002)
Archives of Gerontology and Geriatrics
, vol.34
, Issue.3
, pp. 249-261
-
-
Schmucker, D.L.1
Sachs, H.2
-
124
-
-
77955351652
-
New insights into the role of mitochondria in aging: Mitochondrial dynamics and more
-
Seo A et al (2010) New insights into the role of mitochondria in aging: mitochondrial dynamics and more. J Cell Sci 123(Pt 15):2533-2542
-
(2010)
J Cell Sci
, vol.123
, Issue.PART 15
, pp. 2533-2542
-
-
Seo, A.1
-
125
-
-
0031459980
-
Extrachromosomal rDNA circles - A cause of aging in yeast
-
DOI 10.1016/S0092-8674(00)80493-6
-
Sinclair D, Guarente L (1997) Extrachromosomal rDNA circles - a cause of aging in yeast. Cell 91(7):1033-1042 (Pubitemid 28027835)
-
(1997)
Cell
, vol.91
, Issue.7
, pp. 1033-1042
-
-
Sinclair, D.A.1
Guarente, L.2
-
126
-
-
77956305343
-
Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease
-
Spilman P et al (2010) Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease. PLoS One 5(4):e9979
-
(2010)
PLoS One
, vol.5
, Issue.4
-
-
Spilman, P.1
-
127
-
-
84865108931
-
Activation of genes involved in xenobiotic metabolismis a shared signature ofmousemodels with extended lifespan
-
Steinbaugh M et al (2012) Activation of genes involved in xenobiotic metabolismis a shared signature ofmousemodels with extended lifespan. Am J Physiol Endocrinol Metab 303(4):95
-
(2012)
Am J Physiol Endocrinol Metab
, vol.303
, Issue.4
, pp. 95
-
-
Steinbaugh, M.1
-
128
-
-
79953236274
-
Molecular cross-talk between the NRF2/KEAP1 signaling pathway, autophagy, and apoptosis
-
36577d97-5454-ace8-d631-84b2eb1acb05
-
Stȩpkowski T, Kruszewski M (2011) Molecular cross-talk between the NRF2/KEAP1 signaling pathway, autophagy, and apoptosis. Free Radic Biol Med 50(36577d97-5454-ace8-d631-84b2eb1acb05):1186-1281
-
(2011)
Free Radic Biol Med
, vol.50
, pp. 1186-1281
-
-
Stȩpkowski, T.1
Kruszewski, M.2
-
129
-
-
0141650806
-
Aging, lipofuscin formation, and free radical-mediated inhibition of cellular proteolytic systems
-
DOI 10.1016/S1568-1637(03)00028-X
-
Szweda P et al (2003) Aging, lipofuscin formation, and free radical-mediated inhibition of cellular proteolytic systems. Ageing Res Rev 2(4):383-405 (Pubitemid 37159400)
-
(2003)
Ageing Research Reviews
, vol.2
, Issue.4
, pp. 383-405
-
-
Szweda, P.A.1
Camouse, M.2
Lundberg, K.C.3
Oberley, T.D.4
Szweda, L.I.5
-
130
-
-
38949162988
-
Lysine 63-linked polyubiquitin potentially partners with p62 to promote the clearance of protein inclusions by autophagy
-
Tan J, et al (2008) Lysine 63-linked polyubiquitin potentially partners with p62 to promote the clearance of protein inclusions by autophagy. Autophagy 4:251-253 (Pubitemid 351231194)
-
(2008)
Autophagy
, vol.4
, Issue.2
, pp. 251-253
-
-
Tan, J.M.M.1
Wong, E.S.P.2
Dawson, V.L.3
Dawson, T.M.4
Lim, K.-L.5
-
131
-
-
38349114036
-
Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases
-
Tan JM et al (2008b) Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases. Hum Mol Genet 17(3):431-439
-
(2008)
Hum Mol Genet
, vol.17
, Issue.3
, pp. 431-439
-
-
Tan, J.M.1
-
132
-
-
80052564638
-
RNF185, a novel mitochondrial ubiquitin E3 ligase, regulates autophagy through interaction with BNIP1
-
2caa5a85-183c-3c9d-537c-84b2eb293c9e
-
Tang F et al (2011) RNF185, a novel mitochondrial ubiquitin E3 ligase, regulates autophagy through interaction with BNIP1. PLoS One 6(2caa5a85-183c-3c9d-537c-84b2eb293c9e)
-
(2011)
PLoS One
, vol.6
-
-
Tang, F.1
-
133
-
-
0014254961
-
The origin of lipofuscin age pigments
-
Toth SE (1968) The origin of lipofuscin age pigments. Exp Gerontol 3(1):19-30
-
(1968)
Exp Gerontol
, vol.3
, Issue.1
, pp. 19-30
-
-
Toth, S.E.1
-
134
-
-
41449102024
-
Longevity pathways converge on autophagy genes to regulate life span in Caenorhabditis elegans
-
Tóth M et al (2008) Longevity pathways converge on autophagy genes to regulate life span in Caenorhabditis elegans. Autophagy 4(3):330-338 (Pubitemid 351458094)
-
(2008)
Autophagy
, vol.4
, Issue.3
, pp. 330-338
-
-
Toth, M.L.1
Sigmond, T.2
Borsos, E.3
Barna, J.4
Erdelyi, P.5
Takacs-Vellai, K.6
Orosz, L.7
Kovacs, A.L.8
Csikos, G.9
Sass, M.10
Vellai, T.11
-
135
-
-
4544220704
-
Absence of S6K1 protects against age- and dietinduced obesity while enhancing insulin sensitivity
-
1ae7851e-f1fe-5adc-6b8c-3a5109b98611
-
Um S et al (2004) Absence of S6K1 protects against age- and dietinduced obesity while enhancing insulin sensitivity. Nature 431(1ae7851e-f1fe-5adc-6b8c- 3a5109b98611):200-205
-
(2004)
Nature
, vol.431
, pp. 200-205
-
-
Um, S.1
-
136
-
-
33744505375
-
Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1
-
fb9365a2-b3f2-6ed9-7322-3edcb615be48
-
Um S, D'Alessio D, Thomas G (2006) Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1. Cell Metab 3(fb9365a2-b3f2-6ed9-7322- 3edcb615be48):393-795
-
(2006)
Cell Metab
, vol.3
, pp. 393-795
-
-
Um, S.1
D'Alessio, D.2
Thomas, G.3
-
137
-
-
0032544438
-
Genomic structure and promoter analysis of the p62 gene encoding a non-proteasomal multiubiquitin chain binding protein
-
DOI 10.1016/S0014-5793(98)01021-7, PII S0014579398010217
-
Vadlamudi R, Shin J (1998) Genomic structure and promoter analysis of the p62 gene encoding a non-proteasomal multiubiquitin chain binding protein. FEBS Lett 435(2-3):138-142 (Pubitemid 28434987)
-
(1998)
FEBS Letters
, vol.435
, Issue.2-3
, pp. 138-142
-
-
Vadlamudi, R.K.1
Shin, J.2
-
138
-
-
0029809134
-
p62, a phosphotyrosine-independent ligand of the SH2 domain of p56lck, belongs to a new class of ubiquitin-binding proteins
-
e002a393-07b2-a95e-5354-fc56877148c3
-
Vadlamudi R et al (1996) p62, a phosphotyrosine-independent ligand of the SH2 domain of p56lck, belongs to a new class of ubiquitin-binding proteins. J BiolChem 271(e002a393-07b2-a95e-5354-fc56877148c3):20235-20242
-
(1996)
J BiolChem
, vol.271
, pp. 20235-20242
-
-
Vadlamudi, R.1
-
139
-
-
0016261856
-
Neuroglial cells in the cerebral cortex of rats from young adulthood to old age: An electron microscope study
-
Vaughan D, Peters A (1974) Neuroglial cells in the cerebral cortex of rats from young adulthood to old age: an electron microscope study. J Neurocytol 3(4):405-429
-
(1974)
J Neurocytol
, vol.3
, Issue.4
, pp. 405-429
-
-
Vaughan, D.1
Peters, A.2
-
140
-
-
77951176535
-
Association of Nrf2-encoding NFE2L2 haplotypes with Parkinson's disease
-
ea342ab4-65bd-117a-1b99-1f4bd0e008b2
-
von Otter M et al (2010) Association of Nrf2-encoding NFE2L2 haplotypes with Parkinson's disease. BMC Med Genet 11(ea342ab4-65bd-117a-1b99-1f4bd0e008b2) :36
-
(2010)
BMC Med Genet
, vol.11
, pp. 36
-
-
Von Otter, M.1
-
141
-
-
84864008371
-
Fibroblasts fromlong-livedmutantmice exhibit increased autophagy and lower TOR activity after nutrient deprivation or oxidative stress
-
Wang M, Miller R (2012) Fibroblasts fromlong-livedmutantmice exhibit increased autophagy and lower TOR activity after nutrient deprivation or oxidative stress. Aging Cell 11(4):668-674
-
(2012)
Aging Cell
, vol.11
, Issue.4
, pp. 668-674
-
-
Wang, M.1
Miller, R.2
-
142
-
-
79961142199
-
p62/SQSTM1 in autophagic clearance of a non-ubiquitylated substrate
-
Watanabe Y, Tanaka M (2011) p62/SQSTM1 in autophagic clearance of a non-ubiquitylated substrate. J Cell Sci 124(Pt 16):2692-2701
-
(2011)
J Cell Sci
, vol.124
, Issue.PART 16
, pp. 2692-2701
-
-
Watanabe, Y.1
Tanaka, M.2
-
143
-
-
38949137849
-
Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9
-
Wei M et al (2008) Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9. PLoS Genet 4(1)
-
(2008)
PLoS Genet
, vol.4
, Issue.1
-
-
Wei, M.1
-
144
-
-
0035896518
-
The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor
-
95729bab-6726-13b1-9482-01c430398cd6
-
Wooten M et al (2001) The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor. J Biol Chem 276(95729bab-6726-13b1-9482-01c430398cd6):7709-7721
-
(2001)
J Biol Chem
, vol.276
, pp. 7709-7721
-
-
Wooten, M.1
-
145
-
-
27444433045
-
The p62 scaffold regulates nerve growth factor-induced NF-kappaB activation by influencing TRAF6 polyubiquitination
-
2978358a-d99d-7f3a-c8da-01c23fc80840
-
Wooten M et al (2005) The p62 scaffold regulates nerve growth factor-induced NF-kappaB activation by influencing TRAF6 polyubiquitination. J Biol Chem 280(2978358a-d99d-7f3a-c8da-01c23fc80840):35625-35634
-
(2005)
J Biol Chem
, vol.280
, pp. 35625-35634
-
-
Wooten, M.1
-
146
-
-
47549092694
-
Atg8 controls phagophore expansion during autophagosome formation
-
Xie Z, Nair U, Klionsky D (2008) Atg8 controls phagophore expansion during autophagosome formation. Mol Biol Cell 19(8):3290-3298
-
(2008)
Mol Biol Cell
, vol.19
, Issue.8
, pp. 3290-3298
-
-
Xie, Z.1
Nair, U.2
Klionsky, D.3
-
147
-
-
64349123107
-
Autophagy mediates the mitotic senescence transition
-
Young A et al (2009) Autophagy mediates the mitotic senescence transition. Genes Dev 23(7):798-803
-
(2009)
Genes Dev
, vol.23
, Issue.7
, pp. 798-803
-
-
Young, A.1
-
148
-
-
73949124173
-
Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis
-
f900c956-7e9b-e365-2109-3a67f3160fb4
-
Zhang Y et al (2009) Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis. Proc Natl Acad Sci U S A 106(f900c956-7e9b-e365-2109-3a67f3160fb4):19860-19865
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 19860-19865
-
-
Zhang, Y.1
-
149
-
-
36448968532
-
FoxO3 Coordinately Activates Protein Degradation by the Autophagic/Lysosomal and Proteasomal Pathways in Atrophying Muscle Cells
-
DOI 10.1016/j.cmet.2007.11.004, PII S1550413107003397
-
Zhao J et al (2007) FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells. Cell Metab 6(6):472-483 (Pubitemid 350163056)
-
(2007)
Cell Metabolism
, vol.6
, Issue.6
, pp. 472-483
-
-
Zhao, J.1
Brault, J.J.2
Schild, A.3
Cao, P.4
Sandri, M.5
Schiaffino, S.6
Lecker, S.H.7
Goldberg, A.L.8
-
150
-
-
74049126112
-
The adaptor protein p62/SQSTM1 targets invading bacteria to the autophagy pathway
-
Zheng YT et al (2009) The adaptor protein p62/SQSTM1 targets invading bacteria to the autophagy pathway. J Immunol 183(9):5909-5916
-
(2009)
J Immunol
, vol.183
, Issue.9
, pp. 5909-5916
-
-
Zheng, Y.T.1
|