PKCζ-regulated inflammation in the nonhematopoietic compartment is critical for obesity-induced glucose intolerance

Cell Metabolism

Volumn 12, Issue 1, 2010, Pages 65-77

  Lee, Sang Jun ^a   Kim, Ji Young ^a   Nogueiras, Ruben ^a   Linares, Juan F ^a   Perez Tilve, Diego ^a   Jung, Dae Young ^b   Ko, Hwi Jin ^b   Hofmann, Susanna M ^a   Drew, Angela ^a   Leitges, Michael ^c   Kim, Jason K ^b   Tschöp, Matthias H ^a   Diaz Meco, Maria T ^a   Moscat, Jorge ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF OSLO   (Norway)

Author keywords

HUMDISEASE

Indexed keywords

INTERLEUKIN 6; PROTEIN KINASE C ZETA; PROTEIN KINASE C; PROTEIN KINASE C ZETA, MOUSE;

ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CYTOKINE PRODUCTION; ENZYME DEFICIENCY; ENZYME INACTIVATION; EX VIVO STUDY; GLUCOSE INTOLERANCE; HEMATOPOIETIC SYSTEM; IN VIVO STUDY; INFLAMMATION; INSULIN RESISTANCE; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; REGULATORY MECHANISM; T LYMPHOCYTE; ANIMAL; GENETICS; IMMUNOLOGY; MACROPHAGE; METABOLISM; MOUSE MUTANT;

MUS;

ADIPOSE TISSUE; ANIMALS; GLUCOSE INTOLERANCE; INFLAMMATION; INSULIN RESISTANCE; INTERLEUKIN-6; MACROPHAGES; MICE; MICE, KNOCKOUT; OBESITY; PROTEIN KINASE C;

EID: 77956631023     PISSN: 15504131     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cmet.2010.05.003     Document Type: Article

References (41)

1. G.B. Di Gregorio, L. Hensley, T. Lu, G. Ranganathan, and P.A. Kern Lipid and carbohydrate metabolism in mice with a targeted mutation in the IL-6 gene: absence of development of age-related obesity Am. J. Physiol. Endocrinol. Metab. 287 2004 E182 E187
2. A. Duran, M.T. Diaz-Meco, and J. Moscat Essential role of RelA Ser311 phosphorylation by zetaPKC in NF-kappaB transcriptional activation EMBO J. 22 2003 3910 3918
3. A. Durán, A. Rodriguez, P. Martin, M. Serrano, J.M. Flores, M. Leitges, M.T. Diaz-Meco, and J. Moscat Crosstalk between PKCzeta and the IL4/Stat6 pathway during T-cell-mediated hepatitis EMBO J. 23 2004 4595 4605
4. L. Fajas, R.L. Landsberg, Y. Huss-Garcia, C. Sardet, J.A. Lees, and J. Auwerx E2Fs regulate adipocyte differentiation Dev. Cell 3 2002 39 49
5. R.V. Farese, and M.P. Sajan Metabolic functions of atypical protein kinase C: "good" and "bad" as defined by nutritional status Am. J. Physiol. Endocrinol. Metab. 298 2010 E385 E394
6. R.V. Farese, M.P. Sajan, H. Yang, P. Li, S. Mastorides, W.R. Gower Jr., S. Nimal, C.S. Choi, S. Kim, and G.I. Shulman Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes J. Clin. Invest. 117 2007 2289 2301
7. M. Feuerer, L. Herrero, D. Cipolletta, A. Naaz, J. Wong, A. Nayer, J. Lee, A.B. Goldfine, C. Benoist, S. Shoelson, and D. Mathis Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters Nat. Med. 15 2009 930 939
8. J.S. Flier Obesity wars: molecular progress confronts an expanding epidemic Cell 116 2004 337 350
9. S. Gordon Alternative activation of macrophages Nat. Rev. Immunol. 3 2003 23 35
10. J. Hirosumi, G. Tuncman, L. Chang, C.Z. Görgün, K.T. Uysal, K. Maeda, M. Karin, and G.S. Hotamisligil A central role for JNK in obesity and insulin resistance Nature 420 2002 333 336
11. G.S. Hotamisligil Inflammation and metabolic disorders Nature 444 2006 860 867
12. J. Joshi, P.J. Fernandez-Marcos, A. Galvez, R. Amanchy, J.F. Linares, A. Duran, P. Pathrose, M. Leitges, M. Cañamero, and M. Collado Par-4 inhibits Akt and suppresses Ras-induced lung tumorigenesis EMBO J. 27 2008 2181 2193
13. K. Kang, S.M. Reilly, V. Karabacak, M.R. Gangl, K. Fitzgerald, B. Hatano, and C.H. Lee Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity Cell Metab. 7 2008 485 495
14. H.J. Kim, T. Higashimori, S.Y. Park, H. Choi, J. Dong, Y.J. Kim, H.L. Noh, Y.R. Cho, G. Cline, Y.B. Kim, and J.K. Kim Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivo Diabetes 53 2004 1060 1067
15. J.K. Kim, J.J. Fillmore, M.J. Sunshine, B. Albrecht, T. Higashimori, D.W. Kim, Z.X. Liu, T.J. Soos, G.W. Cline, and W.R. O'Brien PKC-theta knockout mice are protected from fat-induced insulin resistance J. Clin. Invest. 114 2004 823 827
16. M. Leitges, L. Sanz, P. Martin, A. Duran, U. Braun, J.F. García, F. Camacho, M.T. Diaz-Meco, P.D. Rennert, and J. Moscat Targeted disruption of the zetaPKC gene results in the impairment of the NF-kappaB pathway Mol. Cell 8 2001 771 780
17. J. Liu, A. Divoux, J. Sun, J. Zhang, K. Clément, J.N. Glickman, G.K. Sukhova, P.J. Wolters, J. Du, and C.Z. Gorgun Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice Nat. Med. 15 2009 940 945
18. P. Martin, R. Villares, S. Rodriguez-Mascarenhas, A. Zaballos, M. Leitges, J. Kovac, I. Sizing, P. Rennert, G. Márquez, and C. Martínez-A Control of T helper 2 cell function and allergic airway inflammation by PKCzeta Proc. Natl. Acad. Sci. USA 102 2005 9866 9871
19. M. Matsumoto, W. Ogawa, K. Akimoto, H. Inoue, K. Miyake, K. Furukawa, Y. Hayashi, H. Iguchi, Y. Matsuki, and R. Hiramatsu PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity J. Clin. Invest. 112 2003 935 944
20. J.C. Molero, T.E. Jensen, P.C. Withers, M. Couzens, H. Herzog, C.B. Thien, W.Y. Langdon, K. Walder, M.A. Murphy, and D.D. Bowtell c-Cbl-deficient mice have reduced adiposity, higher energy expenditure, and improved peripheral insulin action J. Clin. Invest. 114 2004 1326 1333
21. J. Moscat, M.T. Diaz-Meco, A. Albert, and S. Campuzano Cell signaling and function organized by PB1 domain interactions Mol. Cell 23 2006 631 640
22. J. Moscat, P. Rennert, and M.T. Diaz-Meco PKCzeta at the crossroad of NF-kappaB and Jak1/Stat6 signaling pathways Cell Death Differ. 13 2006 702 711
23. J. Moscat, M.T. Diaz-Meco, and M.W. Wooten Of the atypical PKCs, Par-4 and p62: recent understandings of the biology and pathology of a PB1-dominated complex Cell Death Differ. 16 2009 1426 1437
24. J. Nakae, T. Kitamura, Y. Kitamura, W.H. Biggs 3rd, K.C. Arden, and D. Accili The forkhead transcription factor Foxo1 regulates adipocyte differentiation Dev. Cell 4 2003 119 129
25. S. Nishimura, I. Manabe, M. Nagasaki, K. Eto, H. Yamashita, M. Ohsugi, M. Otsu, K. Hara, K. Ueki, and S. Sugiura CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity Nat. Med. 15 2009 914 920
26. J.I. Odegaard, R.R. Ricardo-Gonzalez, A. Red Eagle, D. Vats, C.R. Morel, M.H. Goforth, V. Subramanian, L. Mukundan, A.W. Ferrante, and A. Chawla Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance Cell Metab. 7 2008 496 507
27. E.J. Park, J.H. Lee, G.Y. Yu, G. He, S.R. Ali, R.G. Holzer, C.H. Osterreicher, H. Takahashi, and M. Karin Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression Cell 140 2010 197 208
28. D. Patsouris, P.P. Li, D. Thapar, J. Chapman, J.M. Olefsky, and J.G. Neels Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals Cell Metab. 8 2008 301 309
29. M. Qatanani, and M.A. Lazar Mechanisms of obesity-associated insulin resistance: many choices on the menu Genes Dev. 21 2007 1443 1455
30. M. Saberi, N.B. Woods, C. de Luca, S. Schenk, J.C. Lu, G. Bandyopadhyay, I.M. Verma, and J.M. Olefsky Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice Cell Metab. 10 2009 419 429
31. G. Sabio, M. Das, A. Mora, Z. Zhang, J.Y. Jun, H.J. Ko, T. Barrett, J.K. Kim, and R.J. Davis A stress signaling pathway in adipose tissue regulates hepatic insulin resistance Science 322 2008 1539 1543
32. S. Schenk, M. Saberi, and J.M. Olefsky Insulin sensitivity: modulation by nutrients and inflammation J. Clin. Invest. 118 2008 2992 3002
33. C.F. Semenkovich Insulin resistance and atherosclerosis J. Clin. Invest. 116 2006 1813 1822
34. H. Shi, M.V. Kokoeva, K. Inouye, I. Tzameli, H. Yin, and J.S. Flier TLR4 links innate immunity and fatty acid-induced insulin resistance J. Clin. Invest. 116 2006 3015 3025
35. S.E. Shoelson, J. Lee, and A.B. Goldfine Inflammation and insulin resistance J. Clin. Invest. 116 2006 1793 1801
36. G. Solinas, C. Vilcu, J.G. Neels, G.K. Bandyopadhyay, J.L. Luo, W. Naugler, S. Grivennikov, A. Wynshaw-Boris, M. Scadeng, J.M. Olefsky, and M. Karin JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity Cell Metab. 6 2007 386 397
37. M. Suzawa, I. Takada, J. Yanagisawa, F. Ohtake, S. Ogawa, T. Yamauchi, T. Kadowaki, Y. Takeuchi, H. Shibuya, and Y. Gotoh Cytokines suppress adipogenesis and PPAR-gamma function through the TAK1/TAB1/NIK cascade Nat. Cell Biol. 5 2003 224 230
38. S.H. Um, F. Frigerio, M. Watanabe, F. Picard, M. Joaquin, M. Sticker, S. Fumagalli, P.R. Allegrini, S.C. Kozma, J. Auwerx, and G. Thomas Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity Nature 431 2004 200 205
39. D. Vats, L. Mukundan, J.I. Odegaard, L. Zhang, K.L. Smith, C.R. Morel, R.A. Wagner, D.R. Greaves, P.J. Murray, and A. Chawla Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation Cell Metab. 4 2006 13 24
40. V. Wallenius, K. Wallenius, B. Ahrén, M. Rudling, H. Carlsten, S.L. Dickson, C. Ohlsson, and J.O. Jansson Interleukin-6-deficient mice develop mature-onset obesity Nat. Med. 8 2002 75 79
41. S. Winer, Y. Chan, G. Paltser, D. Truong, H. Tsui, J. Bahrami, R. Dorfman, Y. Wang, J. Zielenski, and F. Mastronardi Normalization of obesity-associated insulin resistance through immunotherapy Nat. Med. 15 2009 921 929