-
1
-
-
33645116252
-
Genetics of Parkinson disease: Paradigm shifts and future prospects
-
Farrer MJ (2006) Genetics of Parkinson disease: Paradigm shifts and future prospects. Nat Rev Genet 7:306-318.
-
(2006)
Nat Rev Genet
, vol.7
, pp. 306-318
-
-
Farrer, M.J.1
-
3
-
-
77956213267
-
Mitochondrial dysfunction in Parkinson's disease
-
Zhu J, Chu CT (2010) Mitochondrial dysfunction in Parkinson's disease. J Alzheimers Dis 20(Suppl 2):S325-S334.
-
(2010)
J Alzheimers Dis
, vol.20
, Issue.SUPPL. 2
-
-
Zhu, J.1
Chu, C.T.2
-
5
-
-
79952451427
-
Mitophagy: The latest problem for Parkinson's disease
-
Vives-Bauza C, Przedborski S (2011) Mitophagy: The latest problem for Parkinson's disease. Trends Mol Med 17:158-165.
-
(2011)
Trends Mol Med
, vol.17
, pp. 158-165
-
-
Vives-Bauza, C.1
Przedborski, S.2
-
6
-
-
75749156257
-
PINK1 is selectively stabilized on impaired mitochondria to activate Parkin
-
Narendra DP, et al. (2010) PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. PLoS Biol 8:e1000298.
-
(2010)
PLoS Biol
, vol.8
-
-
Narendra, D.P.1
-
7
-
-
77950384477
-
Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin
-
Ziviani E, Tao RN, Whitworth AJ (2010) Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin. Proc Natl Acad Sci USA 107:5018-5023.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 5018-5023
-
-
Ziviani, E.1
Tao, R.N.2
Whitworth, A.J.3
-
8
-
-
75949098487
-
PINK1-dependent recruitment of Parkin to mitochondria in mitophagy
-
Vives-Bauza C, et al. (2010) PINK1-dependent recruitment of Parkin to mitochondria in mitophagy. Proc Natl Acad Sci USA 107:378-383.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 378-383
-
-
Vives-Bauza, C.1
-
9
-
-
77955844260
-
The mitochondrial fusion-promoting factor mitofusin is a substrate of the PINK1/parkin pathway
-
Poole AC, Thomas RE, Yu S, Vincow ES, Pallanck L (2010) The mitochondrial fusion-promoting factor mitofusin is a substrate of the PINK1/parkin pathway. PLoS ONE 5:e10054.
-
(2010)
PLoS ONE
, vol.5
-
-
Poole, A.C.1
Thomas, R.E.2
Yu, S.3
Vincow, E.S.4
Pallanck, L.5
-
10
-
-
78650729600
-
Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin
-
Tanaka A, et al. (2010) Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin. J Cell Biol 191:1367-1380.
-
(2010)
J Cell Biol
, vol.191
, pp. 1367-1380
-
-
Tanaka, A.1
-
11
-
-
79960493052
-
Parkin promotes the ubiquitination and degradation of the mitochondrial fusion factor mitofusin 1
-
Glauser L, Sonnay S, Stafa K, Moore DJ (2011) Parkin promotes the ubiquitination and degradation of the mitochondrial fusion factor mitofusin 1. J Neurochem118:636-645.
-
(2011)
J Neurochem
, vol.118
, pp. 636-645
-
-
Glauser, L.1
Sonnay, S.2
Stafa, K.3
Moore, D.J.4
-
12
-
-
79952369437
-
Mutations in PINK1 and Parkin impair ubiquitination of Mitofusins in human fibroblasts
-
Rakovic A, et al. (2011) Mutations in PINK1 and Parkin impair ubiquitination of Mitofusins in human fibroblasts. PLoS ONE 6:e16746.
-
(2011)
PLoS ONE
, vol.6
-
-
Rakovic, A.1
-
13
-
-
78649463381
-
Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy
-
Gegg ME, et al. (2010) Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy. Hum Mol Genet 19:4861-4870.
-
(2010)
Hum Mol Genet
, vol.19
, pp. 4861-4870
-
-
Gegg, M.E.1
-
14
-
-
79954520907
-
Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy
-
Chan NC, et al. (2011) Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy. Hum Mol Genet 20:1726-1737.
-
(2011)
Hum Mol Genet
, vol.20
, pp. 1726-1737
-
-
Chan, N.C.1
-
15
-
-
77957673363
-
The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations
-
Geisler S, et al. (2010) The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations. Autophagy 6:871-878.
-
(2010)
Autophagy
, vol.6
, pp. 871-878
-
-
Geisler, S.1
-
16
-
-
81055140895
-
PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility
-
Wang X, et al. (2011) PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility. Cell 147:893-906.
-
(2011)
Cell
, vol.147
, pp. 893-906
-
-
Wang, X.1
-
17
-
-
58149314211
-
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
-
Narendra D, Tanaka A, Suen DF, Youle RJ (2008) Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol 183:795-803.
-
(2008)
J Cell Biol
, vol.183
, pp. 795-803
-
-
Narendra, D.1
Tanaka, A.2
Suen, D.F.3
Youle, R.J.4
-
18
-
-
79961239061
-
Impaired mitochondrial transport and Parkin-independent degeneration of respiratory chain-deficient dopamine neurons in vivo
-
Sterky FH, Lee S, Wibom R, Olson L, Larsson NG (2011) Impaired mitochondrial transport and Parkin-independent degeneration of respiratory chain-deficient dopamine neurons in vivo. Proc Natl Acad Sci USA 108:12937-12942.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 12937-12942
-
-
Sterky, F.H.1
Lee, S.2
Wibom, R.3
Olson, L.4
Larsson, N.G.5
-
19
-
-
79551603345
-
Bioenergetics of neurons inhibit the translocation response of Parkin following rapid mitochondrial depolarization
-
Van Laar VS, et al. (2011) Bioenergetics of neurons inhibit the translocation response of Parkin following rapid mitochondrial depolarization. Hum Mol Genet 20:927-940.
-
(2011)
Hum Mol Genet
, vol.20
, pp. 927-940
-
-
Van Laar, V.S.1
-
20
-
-
33745602748
-
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
-
DOI 10.1038/nature04788, PII N04788
-
Park J, et al. (2006) Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin. Nature 441:1157-1161. (Pubitemid 43990737)
-
(2006)
Nature
, vol.441
, Issue.7097
, pp. 1157-1161
-
-
Park, J.1
Lee, S.B.2
Lee, S.3
Kim, Y.4
Song, S.5
Kim, S.6
Bae, E.7
Kim, J.8
Shong, M.9
Kim, J.-M.10
Chung, J.11
-
21
-
-
20344369560
-
Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease
-
DOI 10.1073/pnas.0501078102
-
Whitworth AJ, et al. (2005) Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease. Proc Natl Acad Sci USA 102:8024-8029. (Pubitemid 40781056)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.22
, pp. 8024-8029
-
-
Whitworth, A.J.1
Theodore, D.A.2
Greene, J.C.3
Benes, H.4
Wes, P.D.5
Pallanck, L.J.6
-
22
-
-
0027160708
-
Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
-
Brand AH, Perrimon N (1993) Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118:401-415. (Pubitemid 23214028)
-
(1993)
Development
, vol.118
, Issue.2
, pp. 401-415
-
-
Brand, A.H.1
Perrimon, N.2
-
23
-
-
33846804056
-
A Drosophila model of mutant human parkin-induced toxicity demonstrates selective loss of dopaminergic neurons and dependence on cellular dopamine
-
Sang TK, et al. (2007) A Drosophila model of mutant human parkin-induced toxicity demonstrates selective loss of dopaminergic neurons and dependence on cellular dopamine. J Neurosci 27:981-992.
-
(2007)
J Neurosci
, vol.27
, pp. 981-992
-
-
Sang, T.K.1
-
24
-
-
0032499264
-
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
-
DOI 10.1038/33416
-
Kitada T, et al. (1998) Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature 392:605-608. (Pubitemid 28207717)
-
(1998)
Nature
, vol.392
, Issue.6676
, pp. 605-608
-
-
Kitada, T.1
Asakawa, S.2
Hattori, N.3
Matsumine, H.4
Yamamura, Y.5
Minoshima, S.6
Yokochi, M.7
Mizuno, Y.8
Shimizu, N.9
-
25
-
-
39449088321
-
The PINK1/Parkin pathway regulates mitochondrial morphology
-
DOI 10.1073/pnas.0709336105
-
Poole AC, et al. (2008) The PINK1/Parkin pathway regulates mitochondrial morphology. Proc Natl Acad Sci USA 105:1638-1643. (Pubitemid 351346567)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.5
, pp. 1638-1643
-
-
Poole, A.C.1
Thomas, R.E.2
Andrews, L.A.3
McBride, H.M.4
Whitworth, A.J.5
Pallanck, L.J.6
-
26
-
-
55749090654
-
The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila
-
Deng H, Dodson MW, Huang H, Guo M (2008) The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila. Proc Natl Acad Sci USA 105:14503-14508.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 14503-14508
-
-
Deng, H.1
Dodson, M.W.2
Huang, H.3
Guo, M.4
-
27
-
-
44349195101
-
Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery
-
DOI 10.1073/pnas.0711845105
-
Yang Y, et al. (2008) Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery. Proc Natl Acad Sci USA 105:7070-7075. (Pubitemid 351754531)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.19
, pp. 7070-7075
-
-
Yang, Y.1
Ouyang, Y.2
Yang, L.3
Beal, M.F.4
McQuibban, A.5
Vogel, H.6
Lu, B.7
-
28
-
-
57749194390
-
The PINK1-Parkin pathway is involved in the regulation of mitochondrial remodeling process
-
Park J, Lee G, Chung J (2009) The PINK1-Parkin pathway is involved in the regulation of mitochondrial remodeling process. Biochem Biophys Res Commun 378: 518-523.
-
(2009)
Biochem Biophys Res Commun
, vol.378
, pp. 518-523
-
-
Park, J.1
Lee, G.2
Chung, J.3
-
29
-
-
79954603862
-
To eat or not to eat: Neuronal metabolism, mitophagy, and Parkinson's disease
-
Gusdon AM, Chu CT (2011) To eat or not to eat: Neuronal metabolism, mitophagy, and Parkinson's disease. Antioxid Redox Signal 14:1979-1987.
-
(2011)
Antioxid Redox Signal
, vol.14
, pp. 1979-1987
-
-
Gusdon, A.M.1
Chu, C.T.2
-
30
-
-
77955829612
-
Surprising gene expression patterns within and between PDF-containing circadian neurons in Drosophila
-
Kula-Eversole E, et al. (2010) Surprising gene expression patterns within and between PDF-containing circadian neurons in Drosophila. Proc Natl Acad Sci USA 107: 13497-13502.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 13497-13502
-
-
Kula-Eversole, E.1
-
31
-
-
80055122463
-
Laser microdissection applied to gene expression profiling of subset of cells from the Drosophila wing disc
-
Vicidomini R, Tortoriello G, Furia M, Polese G (2010) Laser microdissection applied to gene expression profiling of subset of cells from the Drosophila wing disc. J Vis Exp, (38): 1895.
-
(2010)
J Vis Exp
, Issue.38
, pp. 1895
-
-
Vicidomini, R.1
Tortoriello, G.2
Furia, M.3
Polese, G.4
-
33
-
-
0037386532
-
Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants
-
DOI 10.1073/pnas.0737556100
-
Greene JC, et al. (2003) Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants. Proc Natl Acad Sci USA 100:4078-4083. (Pubitemid 36418160)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.7
, pp. 4078-4083
-
-
Greene, J.C.1
Whitworth, A.J.2
Kuo, I.3
Andrews, L.A.4
Feany, M.B.5
Pallanck, L.J.6
-
34
-
-
79960826207
-
The PINK1/Parkin pathway regulates mitochondrial dynamics and function in mammalian hippocampal and dopaminergic neurons
-
Yu W, Sun Y, Guo S, Lu B (2011) The PINK1/Parkin pathway regulates mitochondrial dynamics and function in mammalian hippocampal and dopaminergic neurons. Hum Mol Genet 20:3227-3240.
-
(2011)
Hum Mol Genet
, vol.20
, pp. 3227-3240
-
-
Yu, W.1
Sun, Y.2
Guo, S.3
Lu, B.4
-
35
-
-
79955623510
-
During autophagy mitochondria elongate, are spared from degradation and sustain cell viability
-
Gomes LC, Di Benedetto G, Scorrano L (2011) During autophagy mitochondria elongate, are spared from degradation and sustain cell viability. Nat Cell Biol 13:589-598.
-
(2011)
Nat Cell Biol
, vol.13
, pp. 589-598
-
-
Gomes, L.C.1
Di Benedetto, G.2
Scorrano, L.3
-
36
-
-
79959987510
-
Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation
-
Rambold AS, Kostelecky B, Elia N, Lippincott-Schwartz J (2011) Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation. Proc Natl Acad Sci USA 108:10190-10195.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 10190-10195
-
-
Rambold, A.S.1
Kostelecky, B.2
Elia, N.3
Lippincott-Schwartz, J.4
-
37
-
-
38549110110
-
Fission and selective fusion govern mitochondrial segregation and elimination by autophagy
-
DOI 10.1038/sj.emboj.7601963, PII 7601963
-
Twig G, et al. (2008) Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J 27:433-446. (Pubitemid 351161653)
-
(2008)
EMBO Journal
, vol.27
, Issue.2
, pp. 433-446
-
-
Twig, G.1
Elorza, A.2
Molina, A.J.A.3
Mohamed, H.4
Wikstrom, J.D.5
Walzer, G.6
Stiles, L.7
Haigh, S.E.8
Katz, S.9
Las, G.10
Alroy, J.11
Wu, M.12
Py, B.F.13
Yuan, J.14
Deeney, J.T.15
Corkey, B.E.16
Shirihai, O.S.17
-
38
-
-
50949115617
-
High levels of Fis1, a pro-fission mitochondrial protein, trigger autophagy
-
Gomes LC, Scorrano L (2008) High levels of Fis1, a pro-fission mitochondrial protein, trigger autophagy. Biochim Biophys Acta 1777:860-866.
-
(2008)
Biochim Biophys Acta
, vol.1777
, pp. 860-866
-
-
Gomes, L.C.1
Scorrano, L.2
-
39
-
-
0037361388
-
Molecular mechanisms of selective dopaminergic neuronal death in Parkinson's disease
-
DOI 10.1016/S1471-4914(03)00020-0
-
Barzilai A, Melamed E (2003) Molecular mechanisms of selective dopaminergic neuronal death in Parkinson's disease. Trends Mol Med 9:126-132. (Pubitemid 36433894)
-
(2003)
Trends in Molecular Medicine
, vol.9
, Issue.3
, pp. 126-132
-
-
Barzilai, A.1
Melamed, E.2
-
40
-
-
38349014710
-
Induction of the phase II detoxification pathway suppresses neuron loss in Drosophila models of Parkinson's disease
-
Trinh K, et al. (2008) Induction of the phase II detoxification pathway suppresses neuron loss in Drosophila models of Parkinson's disease. J Neurosci 28:465-472.
-
(2008)
J Neurosci
, vol.28
, pp. 465-472
-
-
Trinh, K.1
|