Mitochondrial DNA mutations and age

Annals of the New York Academy of Sciences

Volumn 854, Issue , 1998, Pages 128-154

  Ozawa, Takayuki ^a  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS DNA; DNA FRAGMENT; HYDROXYL RADICAL; MITOCHONDRIAL DNA;

ADULT; AGED; AGING; APOPTOSIS; BIOENERGY; CARDIOMYOPATHY; CASE REPORT; CELL CULTURE; CELL LINE; CELL NUCLEUS; CHILD; CONFERENCE PAPER; CYTOSOL; ENERGY TRANSFER; FEMALE; GENE DELETION; HEART MUSCLE CELL; HUMAN; HUMAN CELL; HYPERBARISM; MALE; MEMBRANE POTENTIAL; NORMAL HUMAN; PHYSIOLOGY; POINT MUTATION; SENESCENCE;

EID: 0032425350     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1998.tb09898.x     Document Type: Conference Paper

References (164)

1. EPHRUSSI, B., H. HOTTINGUER & A.M. CHIMENES. 1949. Action de l'acriflavine sur les levures. I. La mutation "petite colonie". Ann. Inst. Pasteur 76: 351-367.
2. TZAGOLOFF, A. 1982. Mitochondrial Genetics. In Mitochondria: 267-322. Plenum Press. New York and London.
3. SCHATZ, G., E. HALSBRUNNER & H. TUPPY. 1954.Deoxyribonucleic acid associated with yeast mitochondria. Biochem. Biophys. Res. Commun. 15: 127-132.
4. MOLLOY, P.L., A.W. LINNANE & H.B. LUKINS. 1975. Biogenesis of mitochondria: Analysis of deletion of mitochondrial antibiotic resistance markers in petite mutants of Saccharomyces cerevisiae. J. Bacteriol. 122: 7-18.
5. ANDERSOM, S. et al. 1981. Sequence and organization of the human mitochondrial genome. Nature 290: 457-465.
6. WALLACE, D.C. et al. 1988. Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy. Science 242: 1427-1430.
7. YONEDA, M., Y. TANNO, S. HORAI, T. OZAWA, T. MIYATAKE & S. TSUJI. 1990. A common mitochondrial DNA mutation in the t-RNA(Lys) of patients with myoclonus epilepsy associated with ragged-red fibers. Biochem. Int. 21: 789-796.
8. TANAKA, M., M. NISHIKIMI, H. SUZUKI, T. OZAWA, E. OKINO & H. TAKAHASHI. 1986. Multiple cytochrome deficiency and deteriorated mitochondrial polypeptide composition in fatal infantile mitochondrial myopathy and renal dysfunction. Biochem. Biophys. Res. Commun. 137: 911-916.
9. TANAKA, M., M. NISHIKIMI, T. OZAWA, S. MIYABAYASHI & K. TADA. 1987. Lack of subunit II of cytochrome c oxidase in a patient with mitochondrial myopathy. Ann. N.Y. Acad. Sci. 488: 503-504.
10. DIMAURO, S., E. BONILLA, M. ZEVIANI, M. NAKAGAWA & D.C. DEVIVO. 1985. Mitochondrial myopathies. Ann. Neurol. 17: 521-538.
11. OZAWA, T. et al. 1988. Maternal inheritance of deleted mitochondrial DNA in a family with mitochondrial myopathy. Biochem. & Biophys. Res. Commun. 154: 1240-1247.
12. HOLT, I.J., A.E. HARDING & J.A. MORGAN-HUCHES. 1988. Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies. Nature 331: 717-719.
13. ROTIG, A. et al. 1989. Mitochondrial DNA deletion in Peason's marrow/pancreas syndrome. Lancet i: 902-903.
14. TAUCHI, H. & T. Sato. 1968. Age changes in size and numbers of mitochondria of human hepatic cells. J. Gerontol. 23: 454-461.
15. MULLER-HOCKER, J. 1992. Mitochondria and ageing [Review]. Brain Pathology 2: 149-158.
16. LINNANE, A.W., S. MARZUKI, T. OZAWA & M. TANAKA. 1989. Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases. Lancet i: 642-645.
17. IKEBE, S. et al. 1990. Increase of deleted mitochondrial DNA in the striatum in Parkinson's disease and senescence. Biochem. Biophys. Res. Commun. 170: 1044-1048.
18. LINNANE, A.W., A. BAUMER, R.J. MAXWELL, H. PRESTON, C.F. ZHANG & S. MARZUKI. 1990. Mitochondrial gene mutation: The ageing process and degenerative diseases. Biochem. Int. 22: 1067-1076.
19. CORTOPASSI, G.A. & N. ARNHEIM. 1990. Detection of a specific mitochondrial DNA deletion in tissues of older humans. Nucleic Acids Res. 18: 6927-6933.
20. HATTORI, K. et al. 1991. Age-dependent increase in deleted mitochondrial DNA in the human heart: Possible contributing factor to "presbycardia." Am. Heart J. 121: 1735-1742.
21. CORRAL-DEBRINSKI, M., J.M. SHOFFNER, M.T. LOTT & D.C. WALLACE. 1992. Association of mitochondrial DNA damage with aging and coronary atherosclerotic heart disease. Mutat. Res. 275: 169-180.
22. HAYAKAWA, M., K. HATTORI, S. SUGIYAMA & T. OZAWA. 1992. Age-associated oxygen damage and mutations in mitochondrial DNA in human hearts. Biochem. Biophys. Res. Commun. 189: 979-985.
23. TANAKA, M., M. HAYAKAWA & T. OZAWA. 1996. Automated sequencing of mitochondrial DNA. In Methods in Enzymology, 264, Mitochondrial genetics and biogenesis. G.M. Attardi & A. Chomyn, Eds.: 407-421. Academic Press. Orlando, FL.
24. HAYAKAWA, M., K. KATSUMATA, M. YONEDA, M. TANAKA, S. SUGIYAMA & T. OZAWA. 1995. Mitochondrial DNA minicircles, lacking replication origins, exist in the cardiac muscle of a young normal subject. Biochem. Biophys. Res. Commun. 215: 952-960.
25. RICHTER, C., J.-W. PARK & B.N. AMES. 1988. Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proc. Natl. Acad. Sci. USA 85: 6465-6467.
26. HAYAKAWA, M., K. TORII, S. SUGIYAMA, M. TANAKA & T. OZAWA. 1991. Age-associated accumulation of 8-hydroxydeoxyguanosine in mitochondrial DNA of human diaphragm. Biochem. Biophys. Res. Commun. 179: 1023-1029.
27. OZAWA, T. 1994. Mitochondrial cardiomyopathy [Review]. Herz 19: 105-118.
28. HARMAN, D. 1960. The free radical theory of aging: The effect of age on serum mercaptan levels. J. Gerontol. 15: 38-40.
29. OZAWA, T. 1995. Mechanism of somatic mitochondrial DNA mutations associated with age and diseases. [Review]. Biochim. Biophys. Acta 1271: 177-189.
30. OZAWA, T. 1997. Genetic and functional changes in mitochondria associated with aging. Physiol. Rev. 77: 425-464.
31. OZAWA, T., M. HAYAKAWA, K. KATSUMATA, M. YONEDA, S. IKEBE & Y. MIZUNO. 1997. Fragile mitochondrial DNA: The missing link in the apoptotic neuronal cell death in Parkinson's disease. Biochem. Biophys. Res. Commun. 235: 158-161.
32. SUGIYAMA, S., K. YAMADA & T. OZAWA. 1995. Preservation of mitochondrial respiratory function by coenzyme Q10 in aged rat skeletal muscle. Biochem. Mol. Biol. Int. 37: 1111-1120.
33. OZAWA, T., K. SAHASHI, Y. NAKASE & B. CHANCE. 1995. Extensive tissue oxygenation associated with mitochondrial DNA mutations. Biochem. Biophys. Res. Commun. 213: 432-438.
34. HAYAKAWA, M., K. KATSUMATA, M. YONEDA, M. TANAKA, S. SUGIYAMA & T. OZAWA. 1996. Age-related extensive fragmentation of mitochondrial DNA into minicircles. Biochem. Biophys. Res. Commun. 226: 369-377.
35. KATSUMATA, K., M. HAYAKAWA, M. TANAKA, S. SUGIYAMA & T. OZAWA. 1994. Fragmentation of human heart mitochondrial DNA associated with premature aging. Biochem. Biophys. Res. Commun. 202: 102-110.
36. OZAWA, T. et al. 1995. Genotype and phenotype of severe mitochondrial cardiomyopathy: A recipient of heart transplantation and the genetic control. Biochem. Biophys. Res. Commun. 207: 613-620.
37. YONEDA, M., K. KATSUMATA, M. HAYAKAWA, M. TANAKA & T. OZAWA. 1995. Oxygen stress induces an apoptotic cell death associated with fragmentation of mitochondrial genome. Biochem. Biophys. Res. Commun. 209: 723-729.
38. WYLLIE, A.H., J.F.R. KERR & A.R. CURRIE. 1980. Cell death: The significance of apoptosis. Int. Rev. Cytol. 68: 251-305.
39. JACOBSON, M.D., J.F. BURNE & M.C. RAFF. 1994. Programmed cell death and Bcl-2 protection in the absence of a nucleus. EMBO J. 13: 1899-1910.
40. SCHULZE-OSTHOFF, K., H. WALCZAK, W. DROGE & P.H. KRAMMER. 1994. Cell nucleus and DNA fragmentation are not required for apoptosis. J. Cell Biol. 127: 15-20.
41. NAKAJIMA, H., P. GOLSTEIN & P.A. HENKART. 1995. The target cell nucleus is not required for cell-mediated granzyme- or fas-based cytotoxicily. J. Exp. Med. 181: 1905-1909.
42. SHIMIZU, S., Y. EGUCHI, W. KAMIIKE, H. MATSUDA & Y. TSUJIMOTO. 1996. Bcl-2 expression prevents activation of the ICE protease cascade. Oncogene 12: 2251-2257.
43. ZAMZAMI, N. et al. 1996. Mitochondrial control of nuclear apoptosis. J. Exp. Med. 183: 1553-1544.
44. LIU, X., C.N. KIM, J. YANG, R. JEMMERSON & X. WANG. 1996. Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c. Cell 86: 147-157.
45. MITCHELL, P. 1979. David Keilin's respiratory chain concept and its chemiosmotic consequences. In Les Prix Nobel en 1978. The Nobel Foundation. Stockholm.
46. SKULACHEV, V.P. 1996. Role of uncoupled and non-coupled oxidations in maintenance of safely low level of oxygen and its one-electron reductants [Review]. Q. Rev. Biophys. 29: 169-202.
47. JACOBSON, M.D. & M.C. RAFF. 1995. Programmed cell death and Bcl-2 protection in very low oxygen. Nature 374: 814-816.
48. SHIMIZU, S., Y. EGUCHI, H. KOSAKA, W. KAMIIKE, H. MATSUDA & Y. TSUJIMOTO. 1995. Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL. Nature 374: 811-813.
49. OZAWA, T. 1997. Oxidative damage and fragmentation of mitochondrial DNA in cellular apoptosis. Biosci. Rep. 17: 237-250.
50. WALKER, J.E. 1995. Determination of the structures of respiratory enzyme complexes from mammalian mitochondria [Review]. Biochim. Biophys. Acta 1271: 221-227.
51. ZORATTI, M. & I. SZABO. 1995. The mitochondrial permeability transition. Biochim. Biophys. Acta - Rev. Biomembranes 1241: 139-176.
52. WALLACE, D.C. 1992. Diseases of the mitochondrial DNA [Review]. Annu. Rev. Biochem. 61: 1175-1212.
53. WALLACE, D.C. et al. 1988. Familial mitochondrial encephalomyopathy (MERRF): Genetic, pathophysiological, and biochemical characterization of a mitochondrial DNA disease. Cell 66: 601-610.
54. KOVALENKO, S.A., M. TANAKA, M. YONEDA, A.F. IAKOVLEV & T. OZAWA. 1996. Accumulation of somatic nucleotide substitutions in mitochondrial DNA associated with the 3243 A-to-G tRNA(leu)(UUR) mutation in encephalomyopathy and cardiomyopathy. Biochem. Biophys. Res. Commun. 222: 201-207.
55. OZAWA, T. 1995. Mitochondrial DNA mutations associated with aging and degenerative diseases [Review]. Exp. Gerontol. 30: 269-290.
56. YONEDA, M. et al. 1989. Mitochondrial DNA mutation in family with Leber's hereditary optic neuropathy [letter]. Lancet i: 1076-1077.
57. Leu(UUR) gene associated with the MELAS subgroup of mitochondrial encephalomyopathy. Nature 348: 651-653.
58. INO, H. et al. 1991. Mitochondrial leucine tRNA mutation in a mitochondrial encephalomyopathy [letter; comment). Lancet 337: 234-235.
59. MITA, S. et al. 1990. Recombination via flanking direct repeats is a major cause of large-scale deletions of human mitochondrial DNA. Nucleic Acids Res. 18: 561-567.
60. IKEBE, S., M. TANAKA & T. OZAWA. 1995. Point mutations of mitochondrial genome in Parkinson's disease. Am. Heart J. 28: 281-295.
61. OZAWA, T. et al. 1990. Multiple mitochondrial DNA deletions exist in cardiomyocytes of patients with hypertrophie or dilated cardiomyopathy. Biochem. Biophys. Res. Commun. 170: 830-836.
62. OBAYASHI, T. et al. 1992. Point mutations in mitochondrial DNA in patients with hypertrophic cardiomyopathy. Am. Heart J. 124: 1263-1269.
63. CHEN, X., E. BONILLA, M. SCIACCO & E.A. SCHON. 1995. Paucity of deleted mitochondrial DNAs in brain regions of Huntington's disease patients. Biochim. Biophys. Acta 1271: 229-233.
64. van den OUWELAND, J.M.W. et al. 1992. Mutation in mitochondrial tRNAleu(UUR) gene in a large pedigree with maternally transmitted type II diabetes mellitus and deafness. Nat. Genet. 1: 368-371.
65. OZAWA, T. et al. 1991. Patients with idiopathic cardiomyopathy belong to the same mitochondrial DNA gene family of Parkinson's disease and mitochondrial encephalomyopathy. Biochem. Biophys. Res. Commun. 177: 518-525.
66. KADOWAKI, H. et al. 1993. Mitochondrial gene mutation and insulin-deficient type of diabetes mellitus [letter]. Lancet 341: 893-894.
67. CANN, R.L., M. STONEKING & A.C. WILSON. 1987. Mitochondrial DNA and human evolution. Nature 325: 31-36.
68. SATO, W. et al. 1992. Genetic analysis of three pedigrees of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS). Am. J. Hum. Genet. 50: 655-657.
69. UPHOLT, W.B. & I.B. DAWID. 1977. Mapping of mitochondrial DNA of individual sheep and goats: Rapid evolution in the D loop region. Cell 11: 571-583.
70. HAUSWIRTH, W.W. & P. LAIPIS. 1982. Mitochondrial DNA polymorphism in a maternal lineage of Holstein cows. Proc. Natl. Acad. Sci. USA 79: 4686-4690.
71. PIKO, L. & L. MATSUMOTO. 1976. Number of mitochondria and some properties of mitochondrial DNA in the mouse egg. Dev. Biol. 19: 1-10.
72. ZHANG, C., A. LINNANE & P. NAGLEY. 1993. Occurrence of a particular base substitution (3243 A to G) in mitochondrial DNA of tissues of ageing humans. Biochem. Biophys. Res. Commun. 195: 1104-1110.
73. KAPLAN, E.L. & P. MEIER. 1958. Nonparametric estimation for incomplete observations. J. Am. Stat. Assoc. 52: 457-481.
74. OZAWA, T., K. KATSUMATA, M. HAYAKAWA, M. YONEDA, M. TANAKA & S. SUGIYAMA. 1995. Mitochondrial DNA mutations and survival rate. Lancet 355: 189.
75. KATZ, A.M. 1995. Cell death in the failing heart: Role of an unnatural growth response to overload [Review]. Clin. Cardiol. 18: IV36-44.
76. TEIGER, E. et al. 1996. Apoptosis in pressure overload-induced heart hypertrophy in the rat. J. Clin. Invest. 97: 2891-2897.
77. JAMES, T.N., E. ST. MARTIN, P.W.r. WILLIS & T.O. Lohr. 1996. Apoptosis as a possible cause of gradual development of complete heart block and fatal arrhythmias associated with absence of the AV node, sinus node, and internodal pathways. Circulation 93: 1424-1438.
78. WILLIAMS, G.H. & E. BRAUNWALD. 1988. Endocrine and nutritional disorders and heart disease. In Heart Disease. E. Braunwald, Ed.: 1800-1827. W.B. Saunders. Philadelphia, London, Toronto, Montreal, Sidney, Tokyo.
79. GRIVELL, L.A. 1989. Mitochondrial DNA: Small, beautiful and essential. Nature 341: 569-571.
80. SATO, W., M. TANAKA, K. OHNO, T. YAMAMOTO, G. TAKADA & T. OZAWA. 1989. Multiple populations of deleted mitochondrial DNA detected by a novel gene amplification method. Biochem. Biophys. Res. Commun. 162: 664-672.
81. OZAWA, T., M. TANAKA, W. SATO, K. OHNO, M. YONEDA & T. YAMAMOTO. 1991. Types and mechanism of mitochondrial DNA mutations in mitochondrial myopathy and related diseases. In Molecular Basis of Neurological Disorders and their Treatment. J.W. Gorrod, O. Albano, E. Ferrari & S. Papa, Eds.: 171-190. Chapman & Hall. London, New York, Tokyo, Melbourne, Madras.
82. SUGIYAMA, S., K. HATTORI, M. HAYAKAWA & T. OZAWA. 1991. Quantitative analysis of age-associated accumulation of mitochondrial DNA with deletion in human hearts. Biochem. Biophys. Res. Commun. 180: 894-899.
83. SIMONETTI, S., X. CHEN, S. DIMAURO & E.A. SCHON. 1992. Accumulation of deletions in human mitochondrial DNA during normal aging: Analysis by quantitative PCR. Biochim. Biophys. Acta 1180: 113-122.
84. OZAWA, T., M. TANAKA, S. IKEBE, K. OHNO, T. KONDO & Y. MIZUNO. 1990. Quantitative determination of deleted mitochondrial DNA relative to normal DNA in parkinsonian striatum by a kinetic PCR analysis. Biochem. Biophys. Res. Commun. 172: 483-489.
85. COOPER, J.M., V.M. MANN & A.H. SCHAPIRA. 1992. Analyses of mitochondrial respiratory chain function and mitochondrial DNA deletion in human skeletal muscle: Effect of ageing. J. Neurol. Sci. 113: 91-98.
86. REMES, A.M., I.E. HASSINEN, M.J. IKAHEIMO, R. HERVA, J. HIRVONEN & K.J. PEUHKURINEN. 1994. Mitochondrial DNA deletions in dilated cardiomyopathy: a clinical study employing endomyocardial sampling. J. Am. Coll. Cardiol. 23: 935-942.
87. ZHANG, C., A. BAUMER, R.J. MAXWELL, A.W. LINNANE & P. NAGLEY. 1992. Multiple mitochondrial DNA deletions in an elderly human individual. FEBS Lett. 297: 34-38.
88. SOONG, N.W., D.R. HINTON, G. CORTOPASSI & N. ARNHEIM. 1992. Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain. Nat. Genet. 2: 318-323.
89. POULTON, J., M.E. DEADMAN, L. BINDOFF, K. MORTEN, J. LAND & G. BROWN. 1993. Families of mtDNA rearrangements can be detected in patients with mtDNA deletions: Duplications may be a transient intermediate form. Hum. Mol. Genet. 2: 23-30.
90. KOVALENKO, S.A., J.M. KOPSIDAS, J.M. KELSO & A.W. LINNANE. 1997. Deltoid human muscle mtDNA is extensively rearranged in old age subjects. Biochem. Biophys. Res. Commun. 232: 147-152.
91. PRIESTLEY, J. 1775. Experiments and observations on different kinds of air. Vol. 3. 101-102. J. Johnson at St. Paul's Churchyard. London.
92. HARMAN, D. 1956. Aging: A theory based on free radical and radiation chemistry. J. Gerontrol. 11: 298-300.
93. WARBURG, O. 1924. Über Eisen, den sauerstoff Übertragenden Bestandteil des Atmungsferments. Biochem. Z. 152: 479-494.
94. MICHAELIS, L. 1946. Fundamentals of oxidation and reduction. In Currents in Biochemical Research. D.E. Green, Ed.: 207-227. Interscience. New York.
95. BOVERIS, A. & B. CHANCE. 1973. The mitochondrial generation of hydrogen peroxide: General properties and effect of hyperbaric oxygen. Biochem. J. 134: 707-716.
96. 2 release by lung mitochondria and microsomes. Arch. Biochem. Biophys. 217: 411-421.
97. KSENZENKO, M., A.A. KONSTANTINOV, G.B. KHOMUTOV, A.N. TIKHONOV & E.K. RUUGE. 1983. Effect of electron transfer inhibitors on superoxide generation in the cytochrome bc1 site of the mitochondrial respiratory chain. FEBS Lett. 155: 19-24.
98. MASSEY, V. 1994. Activation of molecular oxygen by flavins and flavoproteins [Review]. J. Biol. Chem. 269: 22459-22462.
99. CROSS, A.R. & O.T. JONES. 1991. Enzymic mechanisms of superoxide production [Review]. Biochim. Biophys. Acta 1057: 281-298.
100. HAYAKAWA, M., T. OGAWA, S. SUGIYAMA & T. OZAWA. 1989. Hydroxyl radical and leukotoxin biosynthesis in neutrophil plasma membrane. Biochem. Biophys. Res. Commun. 161: 1077-1085.
101. HOGG, N., V.M. DARLEY-USMAR, M.T. WILSON & S. MONCADA. 1992. Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide. Biochem. J. 281: 419-424.
102. GENG, Y.J., Q. WU, M. MUSZYNSKI, G.K. HANSSON & P. LIBBY. 1996. Apoptosis of vascular smooth muscle cells induced by in vitro stimulation with interferon-gamma, tumor necrosis factor-alpha, and interleukin-1 beta. Arterioscler. Thromb. Vasc. Biol. 16: 19-27.
103. DONG, H.D., Y. KIMOTO, S. TAKAI & T. TAGUCHI. 1996. Apoptosis as a mechanism of lectin-dependent monocyte-mediated cytotoxicity. Immunol. Invest. 25: 65-78.
104. ANKARCRONA, M., J.M. DYPBUKT, B. BRUNE & P. NICOTERA. 1994. Interleukin-1 beta-induced nitric oxide production activates apoptosis in pancreatic RINm5F cells. Exp. Cell Res. 213: 172-177.
105. DUNGER, A., P. AUGSTEIN, S. SCHMIDT & U. FISCHER. 1996. Identification of interleukin 1-induced apoptosis in rat islets using in situ specific labelling of fragmented DNA. J. Autoimmunity 9: 309-313.
106. CHANCE, B., H. SIES & A. BOVFERIES. 1979. Hydroperoxide metabolism in mammalian organs. Physiol. Rev. 59: 527-605.
107. YU, B.P. 1994. Cellular defenses against damage from reactive oxygen species. Physiol. Rev. 74: 139-162.
108. DENG, R.Y. & I. FRIDOVICH. 1989. Formation of endonuclease III sensitive sites as a consequence of oxygen radical attack on DNA. Free Radical Biol. Med. 6: 123-129.
109. FRAGA, C.G., M.K. SHIGENAGA, J.W. PARK, P. DEGAN & B.N. AMES. 1990. Oxidative damage to DNA during aging: 8-hydroxy-2′-deoxyguanosine in rat organ DNA and urine. Proc. Natl. Acad. Sci. USA 87: 4533-1537.
110. MECOCCI, P. et al. 1993. Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain. Ann. Neurol. 34: 609-616.
111. BELGUISE-VALLADIER, P. & R.P.P. FUCHS. 1991. Strong sequence-dependent polymorphism in adduct-induced DNA structure: Analysis of single N-2-acetyl-aminofluorene residues bound within the NarI mutation hot spot. Biochemistry 30: 10091-10100.
112. KAMIYA, H., K. MIURA, H. ISHIKAWA, H. INDUE, S. NISHIMURA & E. OHTSUKA. 1992. c-Ha-ras containing 8-hydroxyguanine at codon 12 induces point mutations at the modified and adjacent positions. Cancer Res. 52: 3483-3485.
113. HAYAKAWA, M., T. OGAWA, S. SUGIYAMA, M. TANAKA & T. OZAWA. 1991. Massive conversion of guanosine to 8-hydroxy-guanosine in mouse liver mitochondrial DNA by administration of azidothymidine. Biochem. Biophys. Res. Commun. 176: 87-93.
114. HAYAKAWA, M., S. SUGIYAMA, K. HATTORI, M. TAKASAWA & T. OZAWA. 1993. Age-associated damage in mitochondrial DNA in human hearts. Mol. Cell. Biochem. 119: 95-103.
115. TAKASAWA, M., M. HAYAKAWA, S. SUGIYAMA, K. HATTORI, T. ITO & T. OZAWA. 1993. Age-associated damage in mitochondrial function in rat hearts. Exp. Gerontol. 28: 269-280.
116. HOYER, S. 1986. Senile dementia and Alzheimer's disease. Brain blood flow and metabolism. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 10: 447-478.
117. KERR, J.F.R., A.H. WYLLIE & A.R. CURRIE. 1972. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 26: 239-257.
118. KATZ, A.M. 1995. The cardiomyopathy of overload: An unnatural growth response [Review]. Eur. Heart J. 16: 110-114.
119. SHAROV, V.G., H.N. SABBAH, H. SHIMOYAMA, A.V. GOUSSEV, M. LESCH & S. GOLDSTEIN. 1996. Evidence of cardiocyte apoptosis in myocardium of dogs with chronic heart failure. Amer. J. Pathol. 148: 141-149.
120. YAO, M., A. KEOGH, P. SPRATT, C.G. dos REMEDIOS & P.C. KIESSLING. 1996. Elevated DNase I levels in human idiopathic dilated cardiomyopathy: An indicator of apoptosis? J. Mol. Cell. Cardiol. 28: 95-101.
121. WELSH, N. et al. 1995. Differences in the expression of heat-shock proteins and antioxidant enzymes between human and rodent pancreatic islets: Implications for the pathogenesis of insulin-dependent diabetes mellitus. Mol. Med. 1: 806-820.
122. O'BRIEN, B.A., B.V. HARMON, D.P. CAMERON & D.J. ALLAN. 1996. Beta-cell apoptosis is responsible for the development of IDDM in the multiple low-dose streptozotocin model. J. Pathol. 178: 176-181.
123. SIMONIAN, N.A. & J.T. COYLE. 1996. Oxidative stress in neurodegenerative diseases [Review]. Annu. Rev. Pharmacol. Toxicol. 36: 83-106.
124. WYLLIE, A.H. 1980. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 284: 555-556.
125. TSUJIMOTO, Y. & C.M. CROCE. 1986. Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma. Proc Natl Acad Sci. USA 83: 5214-5218.
126. HENGARTNER, M.O. & R.H. HORVITZ. 1994. The ins and cuts of programmed cell death during C. elegans development. Philos. Trans. R. Soc. Lond B 345: 243-246.
127. HENGARTNER, M.O. & R.H. HORVITZ. 1994. C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian protooncogene bcl-2. Cell 76: 665-676.
128. YUAN, J.-Y., S. SHAHAM, S. LEDOUX, M.H. ELLIS & R.H. HORVITZ. 1993. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β converting enzyme. Cell 75: 641-652.
129. LAZEBNIK, Y.A., S.H. KAUFMANN, S. DESNOYERS, G.G. POIRIER & W.C. EAMSHAW. 1994. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature 371: 346-347.
130. NICHOLSON, D.W. et al. 1995. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis [see comments]. Nature 376: 37-43.
131. SCHLEGEL, J. et al. 1996. CPP32/Apopain is a key interleukin 1β converting enzyme-like protease involved in Fas-mediated apoptosis. J. Biol. Chem. 271: 1841-1844.
132. WANG, X., N.G. ZELENSKI, J. YANG, J. SAKAI, M.S. BROWN & J.L. GOLDSTEIN. 1996. Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis. EMBO J. 15: 1012-1020.
133. XUE, D. & H.R. HORVITZ. 1995. Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein. Nature 377: 248-251.
134. WANG, X. et al. 1995. Purification of an interleukin-1β converting enzyme-related cysteine protease that cleaves sterol regulatory element-binding proteins between the leucine zipper and transmembrane domains. J. Biol. Chem. 270: 18044-18050.
135. TEWARI, M. et al. 1995. Yama/CPP32β, a mammalian homolog of ced-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell 81: 801-809.
136. LAZEBNIK, Y.A., S. COLE, C.A. COOKE, W.G. NELSON & W.C. EAMSHAW. 1993. Nuclear events of apoptosis in vitro in cell-free mitotic extracts: A model system for analysis of the active phase of apoptosis. J. Cell Biol. 123: 7-22.
137. GAIDO, M.L. & J.A. CIDLOWSKI. 1991. Identification, purification, and characterization of a calcium-dependent endonuclease (NUC18) from apoptotic rat thymocytes. NUC18 is not histone H2B. J. Biol. Chem. 266: 18580-18585.
138. PEITSCH, M.C. et al. 1993. Characterization of the endogenous deoxyribonuclease involved in nuclear DNA degradation during apoptosis (programmed cell death). EMBO J. 12: 371-377.
139. BERNARDI, P., S. VASSANELLI, P. VERONESE, R. COLONNA, I. SZABO & M. ZORATTI. 1992. Modulation of the mitochondrial permeability transition pore: Effect of protons and divalent cations. J. Biol. Chem. 267: 2934-2939.
140. SZABO, I., P. BERNARDI & M. ZORATTI. 1992. Modulation of the mitochondrial megachannel by divalent cations and protons. J. Biol. Chem. 267: 2940-2946.
141. REED, D.J. & M.K. SAVAGE. 1995. Influence of metabolic inhibitors on mitochondrial permeability transition and glutathione status. Biochim. Biophys. Acta 1271: 43-50.
142. SKULACHEV, V.P. 1996. Why are mitochondria involved in apoptosis? Permeability transition pores and apoptosis as selective mechanisms to eliminate superoxide-producing mitochondria and cell. FEBS Lett. 397: 7-10.
143. THIERS, R.E. & B.L. VALLEE. 1957. Distribution of metals in subcellular fractions of rat. J. Biol. Chem. 226: 911-920.
144. DALNZANI, M.U. & I. VITI. 1955. The content and distribution of cytochrome c in the fatty liver of rats. Biochem. J. 59: 141-145.
145. MAYER, A., W. NEUPERT & R. LILL. 1995. Translocation of apocytochrome c across the outer membrane of mitochondria. J. Biol. Chem. 270: 12390-12397.
146. GONZALES, D.H. & W. NEUPERT. 1990. Biogenesis of mitochondrial c-type cytochromes. J. Bioenerg. Biomembr. 22: 753-768.
147. BEINERT, H. 1951. The extent of artificial redistribution of cytochrome c in rat liver homogenate. J. Biol. Chem. 190: 287-292.
148. SHIMIZU, S. et al. 1996. Bcl-2 blocks loss of mitochondrial membrane potential while ICE inhibitors act at a different step during inhibition of death induced by respiratory chain inhibitors. Oncogene 13: 21-29.
149. SHIMIZU, S. et al. 1996. Retardation of chemical hypoxia-induced necrotic cell death by Bcl-2 and ICE inhibitors: Possible involvement of common mediators in apoptotic and necrotic signal transductions. Oncogene 12: 2045-2050.
150. KORSMEYER, S.J., X.-M. YIN, Z.N. OLTVAI, D.J. VEIS-NOVACK & G.P. LINETTE. 1995. Reactive oxygen species and the regulation of cell death by the Bcl-2 gene family. Biochim. Biophys. Acta 1271: 63-66.
151. OLTVAI, Z.N., C.L. MILLLMAN & S.J. KORSMEYER. 1993. Bcl-2 heterodimerizes in vivo with a conserved homologue, Bax, that accelerates programmed cell death. Cell 74: 609-619.
152. BOISE, L.H. et al. 1993. bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 74: 597-608.
153. OFFEN, D., I. ZIV, S. GORODIN, A. BARZILAI, Z. MALIK & E. MELAMED. 1995. Dopamine-induced programmed cell death in mouse thymocytes. Biochim. Biophys. Acta 1268: 171-177.
154. KANE, D. et al. 1993. Bcl-2 inhibition of neural death: Decreased generation of reactive oxygen species. Science 262: 1274-1277.
155. HOCKENBERG, D.M., Z.N. OLTVAI, X.-M. YIN, C.L. MILLLMAN & S.J. KORSMEYER. 1993. Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 75: 241-251.
156. ZAMZAMI, N. et al. 1995. Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death. J. Exp. Med. 182: 367-377.
157. ALBLNA, J.E., B.A. MARTIN, W. HENRY, Jr., C.A. Louis & J.S. REICHNER. 1996. B cell lymphoma-2 transfected P815 cells resist reactive nitrogen intermediate-mediated macrophage-dependent cytotoxicity. J. Immunol. 157: 279-283.
158. MESSMER, U.K., U.K. REED & B. BRUNE. 1996. Bcl-2 protects macrophages from nitric oxide-induced apoptosis. J. Biol. Chem. 271: 20192-20197.
159. JONES, D.E. 1995. Mitochondrial dysfunction during anoxia and acute cell injury. Biochim. Biophys. Acta 1271: 29-33.
160. MEISTER, A. 1995. Mitochondrial changes associated with glutathione deficiency. Biochim. Biophys. Acta 1271: 35-42.
161. SUGIYAMA, S., M. TAKASAWA, M. HAYAKAWA & T. OZAWA. 1993. Changes in skeletal muscle, heart and liver mitochondrial electron transport activities in rats and dogs of various ages. Biochem. Mol. Biol. Int. 30: 937-944.
162. SAKAI, T. et al. 1996. Role of nitric oxide and superoxide anion in leukotoxin, 9,10-epoxy-12-octadecanoate-induced mitochondrial dysfunction. Free Radical Biol. Med. 20: 607-612.
163. PETIT, P.X., H. LECOEUR, E. ZORN, C. DAUGUET, B. MIGNOTTE & M.L. GOUGEON. 1995. Alterations in mitochondrial structure and function are early events of dexamethasone-induced thymocyte apoptosis. J. Cell Biol. 130: 157-167.
164. LAZEBNIK, Y.A. et al. 1995. Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution. Proc. Natl. Acad. Sci. USA 92: 9042-9046.