p62/SQSTM1 is overexpressed and prominently accumulated in inclusions of sporadic inclusion-body myositis muscle fibers, and can help differentiating it from polymyositis and dermatomyositis

Acta Neuropathologica

Volumn 118, Issue 3, 2009, Pages 407-413

  Nogalska, Anna ^a   Terracciano, Chiara ^a   D'Agostino, Carla ^a   King Engel, W ^a   Askanas, Valerie ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Cultured human muscle fibers; Inclusions; Lysosome inhibition; P62 sequestosome1 (p62 SQSTM1); Phosphorylated tau; Proteasome inhibition; Sporadic inclusion body myositis

Indexed keywords

MESSENGER RNA; PROTEIN P62; TAU PROTEIN;

ADULT; AGED; ARTICLE; CELL CULTURE; CELL INCLUSION; CLINICAL ARTICLE; CONTROLLED STUDY; DERMATOMYOSITIS; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; IMMUNOGOLD ELECTRON MICROSCOPY; IMMUNOREACTIVITY; MICROSCOPY; MUSCLE BIOPSY; MUSCLE CELL; MYOSITIS; POLYMYOSITIS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SPORADIC INCLUSION BODY MYOSITIS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; BLOTTING, WESTERN; CELLS, CULTURED; DERMATOMYOSITIS; DIAGNOSIS, DIFFERENTIAL; GENE EXPRESSION PROFILING; HUMANS; IMMUNOHISTOCHEMISTRY; LYSOSOMES; MICROSCOPY, FLUORESCENCE; MICROSCOPY, IMMUNOELECTRON; MIDDLE AGED; MUSCLE FIBERS, SKELETAL; MYOSITIS, INCLUSION BODY; PHOSPHORYLATION; POLYMYOSITIS; PROTEASOME ENDOPEPTIDASE COMPLEX; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TAU PROTEINS;

EID: 68349097450     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00401-009-0564-6     Document Type: Article

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