Long-term IGF-I exposure decreases autophagy and cell viability

PLoS ONE

Volumn 5, Issue 9, 2010, Pages 1-10

  Bitto, Alessandro ^a   Lerner, Chad ^a   Torres, Claudio ^a   Roell, Michaela ^b   Malaguti, Marco ^b   Perez, Viviana ^c   Lorenzini, Antonello ^a,b   Hrelia, Silvana ^c   Ikeno, Yuji ^c   Matzko, Michelle Elizabeth ^d   McCarter, Roger ^c   Sell, Christian ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^d PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SOMATOMEDIN C;

ANIMAL CELL; ARTICLE; AUTOPHAGY; CELL AGING; CELL CULTURE; CELL DAMAGE; CELL MEMBRANE DEPOLARIZATION; CELL PROTECTION; CELL STIMULATION; CELL SURVIVAL; CELL TYPE; CELL VIABILITY; COLONY FORMATION; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; EMBRYO; FIBROBLAST; HUMAN; HUMAN CELL; LIFESPAN; MITOCHONDRION; MOUSE; NONHUMAN; SIGNAL TRANSDUCTION;

ANIMALIA; MUS;

EID: 77958611244     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0012592     Document Type: Article

References (46)

1. O'Kusky JR, Ye P, D'Ercole AJ (2000) Insulin-like growth factor-I promotes neurogenesis and synaptogenesis in the hippocampal dentate gyrus during postnatal development. J Neurosci 20: 8435-8442.
2. Smith PJ, Wise LS, Berkowitz R, Wan C, Rubin CS (1988) Insulin-like growth factor-I is an essential regulator of the differentiation of 3T3-L1 adipocytes. J Biol Chem 263: 9402-9408.
3. Tollefsen SE, Lajara R, McCusker RH, Clemmons DR, Rotwein P (1989) Insulin-like growth factors (IGF) in muscle development. Expression of IGF-I, the IGF-I receptor, and an IGF binding protein during myoblast differentiation. J Biol Chem 264: 13810-13817.
4. Baker J, Liu JP, Robertson EJ, Efstratiadis A (1993) Role of insulin-like growth factors in embryonic and postnatal growth. Cell 75: 73-82.
5. Florini JR, Ewton DZ, Coolican SA (1996) Growth hormone and the insulin-like growth factor system in myogenesis. Endocr Rev 17: 481-517.
6. Liu JP, Baker J, Perkins AS, Robertson EJ, Efstratiadis A (1993) Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell 75: 59-72.
7. Galvin CD, Hardiman O, Nolan CM (2003) IGF-1 receptor mediates differentiation of primary cultures of mouse skeletal myoblasts. Mol Cell Endocrinol 200: 19-29.
8. Bluher S, Kratzsch J, Kiess W (2005) Insulin-like growth factor I, growth hormone and insulin in white adipose tissue. Best Pract Res Clin Endocrinol Metab 19: 577-587.
9. Torres-Aleman I, Naftolin F, Robbins RJ (1989) Growth promoting effects of IGF-I on fetal hypothalamic cell lines under serum-free culture conditions. Int J Dev Neurosci 7: 195-202.
10. Sell C, Baserga R, Rubin R (1995) Insulin-like growth factor I (IGF-I) and the IGF-I receptor prevent etoposide-induced apoptosis. Cancer Res 55: 303-306.
11. Kulik G, Klippel A, Weber MJ (1997) Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt. Mol Cell Biol 17: 1595-1606.
12. Martin MJ, Melnyk N, Pollard M, Bowden M, Leong H, et al. (2006) The insulin-like growth factor I receptor is required for Akt activation and suppression of anoikis in cells transformed by the ETV6-NTRK3 chimeric tyrosine kinase. Mol Cell Biol 26: 1754-1769.
13. Valentinis B, Morrione A, Peruzzi F, Prisco M, Reiss K, et al. (1999) Antiapoptotic signaling of the IGF-I receptor in fibroblasts following loss of matrix adhesion. Oncogene 18: 1827-1836.
14. Valentinis B, Reiss K, Baserga R (1998) Insulin-like growth factor-I-mediated survival from anoikis: role of cell aggregation and focal adhesion kinase. J Cell Physiol 176: 648-657.
15. Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R (1993) A C. elegans mutant that lives twice as long as wild type. Nature 366: 461-464.
16. Kimura KD, Tissenbaum HA, Liu Y, Ruvkun G (1997) daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science 277: 942-946.
17. Tatar M, Kopelman A, Epstein D, Tu MP, Yin CM, et al. (2001) A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. Science 292: 107-110.
18. Brown-Borg HM, Borg KE, Meliska CJ, Bartke A (1996) Dwarf mice and the ageing process. Nature 384: 33.
19. Flurkey K, Papaconstantinou J, Miller RA, Harrison DE (2001) Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production. Proc Natl Acad Sci U S A 98: 6736-6741.
20. Coschigano KT, Clemmons D, Bellush LL, Kopchick JJ (2000) Assessment of growth parameters and life span of GHR/BP gene-disrupted mice. Endocrinology 141: 2608-2613.
21. Holzenberger M, Dupont J, Ducos B, Leneuve P, Geloen A, et al. (2003) IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature 421: 182-187.
22. McKeehan WL, Ham RG (1976) Methods for reducing the serum requirement for growth in vitro of nontransformed diploid fibroblasts. Dev Biol Stand 37: 97-98.
23. Dell'Orco RT (1975) The use of arrested populations of human diploid fibroblasts for the study of senescence in vitro. Adv Exp Med Biol 53: 41-49.
24. Sarbassov DD, Guertin DA, Ali SM, Sabatini DM (2005) Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307: 1098-1101.
25. Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, et al. (2008) Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 4: 151-175.
26. Komatsu M, Waguri S, Koike M, Sou YS, Ueno T, et al. (2007) Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagydeficient mice. Cell 131: 1149-1163.
27. Kuma A, Hatano M, Matsui M, Yamamoto A, Nakaya H, et al. (2004) The role of autophagy during the early neonatal starvation period. Nature 432: 1032-1036.
28. Lembo G, Rockman HA, Hunter JJ, Steinmetz H, Koch WJ, et al. (1996) Elevated blood pressure and enhanced myocardial contractility in mice with severe IGF-1 deficiency. J Clin Invest 98: 2648-2655.
29. Mizushima N The role of the Atg1/ULK1 complex in autophagy regulation. Curr Opin Cell Biol 22: 132-139.
30. Geng J, Klionsky DJ (2008) The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. 'Protein modifications: beyond the usual suspects' review series. EMBO Rep 9: 859-864.
31. Mizushima N, Levine B, Cuervo AM, Klionsky DJ (2008) Autophagy fights disease through cellular self-digestion. Nature 451: 1069-1075.
32. Zhang C, Cuervo AM (2008) Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function. Nat Med 14: 959-965.
33. Nakai A, Yamaguchi O, Takeda T, Higuchi Y, Hikoso S, et al. (2007) The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress. Nat Med 13: 619-624.
34. Cuervo AM, Dice JF (2000) Age-related decline in chaperone-mediated autophagy. J Biol Chem 275: 31505-31513.
35. Cuervo AM (2008) Autophagy and aging: keeping that old broom working. Trends Genet 24: 604-612.
36. Cavallini G, Donati A, Gori Z, Pollera M, Bergamini E (2001) The protection of rat liver autophagic proteolysis from the age-related decline co-varies with the duration of anti-ageing food restriction. Exp Gerontol 36: 497-506.
37. Hansen M, Chandra A, Mitic LL, Onken B, Driscoll M, et al. (2008) A role for autophagy in the extension of lifespan by dietary restriction in C. elegans. PLoS Genet 4: e24.
38. Melendez A, Talloczy Z, Seaman M, Eskelinen EL, Hall DH, et al. (2003) Autophagy genes are essential for dauer development and life-span extension in C. elegans. Science 301: 1387-1391.
39. Hashimoto Y, Ookuma S, Nishida E (2009) Lifespan extension by suppression of autophagy genes in Caenorhabditis elegans. Genes Cells.
40. Farre JC, Krick R, Subramani S, Thumm M (2009) Turnover of organelles by autophagy in yeast. Curr Opin Cell Biol 21: 522-530.
41. Gu Y, Wang C, Cohen A (2004) Effect of IGF-1 on the balance between autophagy of dysfunctional mitochondria and apoptosis. FEBS Lett 577: 357-360.
42. Hagen TM, Yowe DL, Bartholomew JC, Wehr CM, Do KL, et al. (1997) Mitochondrial decay in hepatocytes from old rats: membrane potential declines, heterogeneity and oxidants increase. Proc Natl Acad Sci U S A 94: 3064-3069.
43. Hiona A, Leeuwenburgh C (2008) The role of mitochondrial DNA mutations in aging and sarcopenia: implications for the mitochondrial vicious cycle theory of aging. Exp Gerontol 43: 24-33.
44. Cristofalo VJ, Charpentier R (1980) A standard procedure for cultivating human diploid fibroblastlike cells to study cellular aging. Journal of Tissue Culture Methods 6: 117-121.
45. Guo W, Jiang L, Bhasin S, Khan SM, Swerdlow RH (2009) DNA extraction procedures meaningfully influence qPCR-based mtDNA copy number determination. Mitochondrion 9: 261-265.
46. Trinei M, Berniakovich I, Pelicci PG, Giorgio M (2006) Mitochondrial DNA copy number is regulated by cellular proliferation: a role for Ras and p66(Shc). Biochim Biophys Acta 1757: 624-630.