-
1
-
-
79952232216
-
Global cancer statistics
-
Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin 2011; 61: 69-90
-
(2011)
CA Cancer J Clin
, vol.61
, pp. 69-90
-
-
Jemal, A.1
Bray, F.2
Center, M.M.3
Ferlay, J.4
Ward, E.5
Forman, D.6
-
2
-
-
18444412609
-
Global trends in breast cancer incidence and mortality 1973-1997
-
Althuis MD, Dozier JM, Anderson WF, Devesa SS, Brinton LA. Global trends in breast cancer incidence and mortality 1973-1997. Int J Epidemiol 2005; 34: 405-412
-
(2005)
Int J Epidemiol
, vol.34
, pp. 405-412
-
-
Althuis, M.D.1
Dozier, J.M.2
Anderson, W.F.3
Devesa, S.S.4
Brinton, L.A.5
-
3
-
-
81555216077
-
Gene expression profiling in breast cancer: Classification, prognostication, and prediction
-
Reis-Filho JS, Pusztai L. Gene expression profiling in breast cancer: classification, prognostication, and prediction. Lancet 2011; 378: 1812-1823
-
(2011)
Lancet
, vol.378
, pp. 1812-1823
-
-
Reis-Filho, J.S.1
Pusztai, L.2
-
4
-
-
79959605900
-
Inherited mutations in breast cancer genes-risk and response
-
Shuen AY, Foulkes WD. Inherited mutations in breast cancer genes-risk and response. J Mammary Gland Biol Neoplasia 2011; 16: 3-15
-
(2011)
J Mammary Gland Biol Neoplasia
, vol.16
, pp. 3-15
-
-
Shuen, A.Y.1
Foulkes, W.D.2
-
5
-
-
79959587205
-
Clinical management of hereditary breast cancer syndromes
-
Clark AS, Domchek SM. Clinical management of hereditary breast cancer syndromes. J Mammary Gland Biol Neoplasia 2011; 16: 17-25
-
(2011)
J Mammary Gland Biol Neoplasia
, vol.16
, pp. 17-25
-
-
Clark, A.S.1
Domchek, S.M.2
-
6
-
-
34447303102
-
Clinical outcomes of breast cancer in carriers of BRCA1 and BRCA2 mutations
-
Rennert G, Bisland-Naggan S, Barnett-Griness O, Bar-Joseph N, Zhang S, Rennert HS.et al.. Clinical outcomes of breast cancer in carriers of BRCA1 and BRCA2 mutations. N Engl J Med 2007; 357: 115-123
-
(2007)
N Engl J Med
, vol.357
, pp. 115-123
-
-
Rennert, G.1
Bisland-Naggan, S.2
Barnett-Griness, O.3
Bar-Joseph, N.4
Zhang, S.5
Rennert, H.S.6
-
7
-
-
72449148140
-
Prognosis of BRCA-Associated breast cancer: A summary of evidence
-
Bordeleau L, Panchal S, Goodwin P. Prognosis of BRCA-Associated breast cancer: a summary of evidence. Breast Cancer Res Treat 2010; 119: 13-24
-
(2010)
Breast Cancer Res Treat
, vol.119
, pp. 13-24
-
-
Bordeleau, L.1
Panchal, S.2
Goodwin, P.3
-
8
-
-
84555196106
-
BRCA1 and BRCA2: Different roles in a common pathway of genome protection
-
Roy R, Chun J, Powell SN. BRCA1 and BRCA2: different roles in a common pathway of genome protection. Nat Rev Cancer 2011; 12: 68-78
-
(2011)
Nat Rev Cancer
, vol.12
, pp. 68-78
-
-
Roy, R.1
Chun, J.2
Powell, S.N.3
-
9
-
-
0032441791
-
The genetics of breast cancer susceptibility
-
Rahman N, Stratton MR. The genetics of breast cancer susceptibility. Annu Rev Genet 1998; 32: 95-121
-
(1998)
Annu Rev Genet
, vol.32
, pp. 95-121
-
-
Rahman, N.1
Stratton, M.R.2
-
10
-
-
0037130887
-
Cancer Incidence in BRCA1 mutation carriers
-
Thompson D, Easton DF. Cancer Incidence in BRCA1 mutation carriers. J Natl Cancer Inst 2002; 94: 1358-1365
-
(2002)
J Natl Cancer Inst
, vol.94
, pp. 1358-1365
-
-
Thompson, D.1
Easton, D.F.2
-
11
-
-
0033523268
-
Cancer risks in BRCA2 mutation carriers the breast cancer linkage consortium
-
Cancer risks in BRCA2 mutation carriers. The Breast Cancer Linkage Consortium. J Natl Cancer Inst 1999; 91: 1310-1316
-
(1999)
J Natl Cancer Inst
, vol.91
, pp. 1310-1316
-
-
-
12
-
-
0028148889
-
Mutations in the BRCA1 gene in families with early-onset breast and ovarian cancer
-
Castilla LH, Couch FJ, Erdos MR, Hoskins KF, Calzone K, Garber JE.et al.. Mutations in the BRCA1 gene in families with early-onset breast and ovarian cancer. Nat Genet 1994; 8: 387-391
-
(1994)
Nat Genet
, vol.8
, pp. 387-391
-
-
Castilla, L.H.1
Couch, F.J.2
Erdos, M.R.3
Hoskins, K.F.4
Calzone, K.5
Garber, J.E.6
-
13
-
-
0028034348
-
Confirmation of BRCA1 by analysis of germline mutations linked to breast and ovarian cancer in ten families
-
Friedman LS, Ostermeyer EA, Szabo CI, Dowd P, Lynch ED, Rowell SE.et al.. Confirmation of BRCA1 by analysis of germline mutations linked to breast and ovarian cancer in ten families. Nat Genet 1994; 8: 399-404
-
(1994)
Nat Genet
, vol.8
, pp. 399-404
-
-
Friedman, L.S.1
Ostermeyer, E.A.2
Szabo, C.I.3
Dowd, P.4
Lynch, E.D.5
Rowell, S.E.6
-
14
-
-
0031025322
-
Prevalence and contribution of BRCA1 mutations in breast cancer and ovarian cancer: Results from three US population-based case-control studies of ovarian cancer
-
Whittemore AS, Gong G, Itnyre J. Prevalence and contribution of BRCA1 mutations in breast cancer and ovarian cancer: results from three U.S. population-based case-control studies of ovarian cancer. Am J Hum Genet 1997; 60: 496-504
-
(1997)
Am J Hum Genet
, vol.60
, pp. 496-504
-
-
Whittemore, A.S.1
Gong, G.2
Itnyre, J.3
-
15
-
-
33845654907
-
Population BRCA1 and BRCA2 mutation frequencies and cancer penetrances: A kin-cohort study in Ontario, Canada
-
Risch HA, McLaughlin JR, Cole DEC, Rosen B, Bradley L, Fan I.et al.. Population BRCA1 and BRCA2 mutation frequencies and cancer penetrances: a kin-cohort study in Ontario, Canada. J Natl Cancer Inst 2006; 98: 1694-1706
-
(2006)
J Natl Cancer Inst
, vol.98
, pp. 1694-1706
-
-
Risch, H.A.1
McLaughlin, J.R.2
Dec, C.3
Rosen, B.4
Bradley, L.5
Fan, I.6
-
16
-
-
75749096049
-
Screening for founder mutations in BRCA1 and BRCA2 in unselected Jewish women
-
Metcalfe KA, Poll A, Royer R, Llacuachaqui M, Tulman A, Sun P.et al.. Screening for founder mutations in BRCA1 and BRCA2 in unselected Jewish women. J Clin Oncol 2010; 28: 387-391
-
(2010)
J Clin Oncol
, vol.28
, pp. 387-391
-
-
Metcalfe, K.A.1
Poll, A.2
Royer, R.3
Llacuachaqui, M.4
Tulman, A.5
Sun, P.6
-
17
-
-
0029794992
-
Ashkenazi Jewish population frequencies for common mutations in BRCA1 and BRCA2
-
Roa BB, Boyd AA, Volcik K, Richards CS. Ashkenazi Jewish population frequencies for common mutations in BRCA1 and BRCA2. Nat Genet 1996; 14: 185-187
-
(1996)
Nat Genet
, vol.14
, pp. 185-187
-
-
Roa, B.B.1
Boyd, A.A.2
Volcik, K.3
Richards, C.S.4
-
19
-
-
37248999372
-
Triple negative tumours: A critical review
-
Reis-Filho JS, Tutt ANJ. Triple negative tumours: a critical review. Histopathology 2008; 52: 108-118
-
(2008)
Histopathology
, vol.52
, pp. 108-118
-
-
Reis-Filho, J.S.1
Anj, T.2
-
20
-
-
0030860404
-
P53 mutations in BRCA1-Associated familial breast cancer
-
Crook T, Crossland S, Crompton MR, Osin P, Gusterson BA. p53 mutations in BRCA1-Associated familial breast cancer. Lancet 1997; 350: 638-639
-
(1997)
Lancet
, vol.350
, pp. 638-639
-
-
Crook, T.1
Crossland, S.2
Crompton, M.R.3
Osin, P.4
Gusterson, B.A.5
-
21
-
-
65949105079
-
High incidence of protein-truncating TP53 mutations in BRCA1-related breast cancer
-
Holstege H, Joosse SA, van Oostrom CTM, Nederlof PM, de Vries A, Jonkers J. High incidence of protein-truncating TP53 mutations in BRCA1-related breast cancer. Cancer Res 2009; 69: 3625-3633
-
(2009)
Cancer Res
, vol.69
, pp. 3625-3633
-
-
Holstege, H.1
Joosse, S.A.2
Van Oostrom Ctm3
Nederlof, P.M.4
De Vries, A.5
Jonkers, J.6
-
22
-
-
37549020704
-
Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair
-
Saal LH, Gruvberger-Saal SK, Persson C, Lövgren K, Jumppanen M, Staaf J.et al.. Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair. Nat Genet 2008; 40: 102-107
-
(2008)
Nat Genet
, vol.40
, pp. 102-107
-
-
Saal, L.H.1
Gruvberger-Saal, S.K.2
Persson, C.3
Lövgren, K.4
Jumppanen, K.M.5
Staaf, J.6
-
23
-
-
0036389638
-
BRCA1 methylation: A significant role in tumour development?
-
Catteau A, Morris JR. BRCA1 methylation: a significant role in tumour development? Semin Cancer Biol 2002; 12: 359-371
-
(2002)
Semin Cancer Biol
, vol.12
, pp. 359-371
-
-
Catteau, A.1
Morris, J.R.2
-
24
-
-
79959838081
-
Cancer genome atlas research network integrated genomic analyses of ovarian carcinoma
-
Cancer Genome Atlas Research Network. Integrated genomic analyses of ovarian carcinoma. Nature 2011; 474: 609-615
-
(2011)
Nature
, vol.474
, pp. 609-615
-
-
-
25
-
-
84882958819
-
Cancer genome atlas network comprehensive molecular portraits of human breast tumours
-
Cancer Genome Atlas Network. Comprehensive molecular portraits of human breast tumours. Nature 2012; 490: 61-70
-
(2012)
Nature
, vol.490
, pp. 61-70
-
-
-
26
-
-
4944229642
-
Hallmarks of BRCAness in sporadic cancers
-
Turner N, Tutt A, Ashworth A. Hallmarks of BRCAness in sporadic cancers. Nat Rev Cancer 2004; 4: 814-819
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 814-819
-
-
Turner, N.1
Tutt, A.2
Ashworth, A.3
-
27
-
-
0028950999
-
Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression
-
Thompson ME, Jensen RA, Obermiller PS, Page DL, Holt JT. Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression. Nat Genet 1995; 9: 444-450
-
(1995)
Nat Genet
, vol.9
, pp. 444-450
-
-
Thompson, M.E.1
Jensen, R.A.2
Obermiller, P.S.3
Page, D.L.4
Holt, J.T.5
-
28
-
-
0032542339
-
Down-regulation of BRCA1 in human sporadic breast cancer; Analysis of DNA methylation patterns of the putative promoter region
-
Magdinier F, Ribieras S, Lenoir GM, Frappart L, Dante R. Down-regulation of BRCA1 in human sporadic breast cancer; analysis of DNA methylation patterns of the putative promoter region. Oncogene 1998; 17: 3169-3176
-
(1998)
Oncogene
, vol.17
, pp. 3169-3176
-
-
Magdinier, F.1
Ribieras, S.2
Lenoir, G.M.3
Frappart, L.4
Dante, R.5
-
29
-
-
0034256069
-
Frequent loss of BRCA1 mRNA and protein expression in sporadic ovarian cancers
-
Russell PA, Pharoah PD, De Foy K, Ramus SJ, Symmonds I, Wilson A.et al.. Frequent loss of BRCA1 mRNA and protein expression in sporadic ovarian cancers. Int J Cancer 2000; 87: 317-321
-
(2000)
Int J Cancer
, vol.87
, pp. 317-321
-
-
Russell, P.A.1
Pharoah, P.D.2
De Foy, K.3
Ramus, S.J.4
Symmonds, I.5
Wilson, A.6
-
30
-
-
77951129391
-
BRCA1 expression in triple negative sporadic breast cancers
-
Galizia E, Giorgetti G, Piccinini G, Santinelli A, Loretelli C, Bianchi F.et al.. BRCA1 expression in triple negative sporadic breast cancers. Anal Quant Cytol Histol 2010; 32: 24-29
-
(2010)
Anal Quant Cytol Histol
, vol.32
, pp. 24-29
-
-
Galizia, E.1
Giorgetti, G.2
Piccinini, G.3
Santinelli, A.4
Loretelli, C.5
Bianchi, F.6
-
31
-
-
33847022042
-
BRCA1 dysfunction in sporadic basal-like breast cancer
-
Turner NC, Reis-Filho JS, Russell AM, Springall RJ, Ryder K, Steele D.et al.. BRCA1 dysfunction in sporadic basal-like breast cancer. Oncogene 2007; 26: 2126-2132
-
(2007)
Oncogene
, vol.26
, pp. 2126-2132
-
-
Turner, N.C.1
Reis-Filho, J.S.2
Russell, A.M.3
Springall, R.J.4
Ryder, K.5
Steele, D.6
-
32
-
-
0037377764
-
Negative regulation of BRCA1 gene expression by HMGA1 proteins accounts for the reduced BRCA1 protein levels in sporadic breast carcinoma
-
Baldassarre G, Battista S, Belletti B, Thakur S, Pentimalli F, Trapasso F.et al.. Negative regulation of BRCA1 gene expression by HMGA1 proteins accounts for the reduced BRCA1 protein levels in sporadic breast carcinoma. Mol Cell Biol 2003; 23: 2225-2238
-
(2003)
Mol Cell Biol
, vol.23
, pp. 2225-2238
-
-
Baldassarre, G.1
Battista, S.2
Belletti, B.3
Thakur, S.4
Pentimalli, F.5
Trapasso, F.6
-
33
-
-
0030843274
-
Methylation of the BRCA1 gene in sporadic breast cancer
-
Dobrovic A, Simpfendorfer D. Methylation of the BRCA1 gene in sporadic breast cancer. Cancer Res 1997; 57: 3347-3350
-
(1997)
Cancer Res
, vol.57
, pp. 3347-3350
-
-
Dobrovic, A.1
Simpfendorfer, D.2
-
34
-
-
0034607234
-
Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors
-
Esteller M, Silva JM, Dominguez G, Bonilla F, Matias-Guiu X, Lerma E.et al.. Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors. J Natl Cancer Inst 2000; 92: 564-569
-
(2000)
J Natl Cancer Inst
, vol.92
, pp. 564-569
-
-
Esteller, M.1
Silva, J.M.2
Dominguez, G.3
Bonilla, F.4
Matias-Guiu, X.5
Lerma, E.6
-
35
-
-
0034307160
-
BRCA1 promoter region hypermethylation in ovarian carcinoma: A population-based study
-
Baldwin RL, Nemeth E, Tran H, Shvartsman H, Cass I, Narod S.et al.. BRCA1 promoter region hypermethylation in ovarian carcinoma: a population-based study. Cancer Res 2000; 60: 5329-5333
-
(2000)
Cancer Res
, vol.60
, pp. 5329-5333
-
-
Baldwin, R.L.1
Nemeth, E.2
Tran, H.3
Shvartsman, H.4
Cass, I.5
Narod, S.6
-
36
-
-
0033857349
-
Methylation of the BRCA1 promoter is associated with decreased BRCA1 mRNA levels in clinical breast cancer specimens
-
Rice JC, Ozcelik H, Maxeiner P, Andrulis I, Futscher BW. Methylation of the BRCA1 promoter is associated with decreased BRCA1 mRNA levels in clinical breast cancer specimens. Carcinogenesis 2000; 21: 1761-1765
-
(2000)
Carcinogenesis
, vol.21
, pp. 1761-1765
-
-
Rice, J.C.1
Ozcelik, H.2
Maxeiner, P.3
Andrulis, I.4
Futscher, B.W.5
-
37
-
-
0028113345
-
A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1
-
Miki Y, Swensen J, Shattuck-Eidens D, Futreal PA, Harshman K, Tavtigian S.et al.. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 1994; 266: 66-71
-
(1994)
Science
, vol.266
, pp. 66-71
-
-
Miki, Y.1
Swensen, J.2
Shattuck-Eidens, D.3
Futreal, P.A.4
Harshman, K.5
Tavtigian, S.6
-
38
-
-
1842364973
-
Localization of BRCA1 and a splice variant identifies the nuclear localization signal
-
Thakur S, Zhang HB, Peng Y, Le H, Carroll B, Ward T.et al.. Localization of BRCA1 and a splice variant identifies the nuclear localization signal. Mol Cell Biol 1997; 17: 444-452
-
(1997)
Mol Cell Biol
, vol.17
, pp. 444-452
-
-
Thakur, S.1
Zhang, H.B.2
Peng, Y.3
Le Carroll, H.B.4
Ward, T.5
-
39
-
-
0347320584
-
Cytoplasmic mislocalization of BRCA1 caused by cancer-Associated mutations in the BRCT domain
-
Rodriguez JA, Au WWY, Henderson BR. Cytoplasmic mislocalization of BRCA1 caused by cancer-Associated mutations in the BRCT domain. Exp Cell Res 2004; 293: 14-21
-
(2004)
Exp Cell Res
, vol.293
, pp. 14-21
-
-
Rodriguez, J.A.1
Wwy, A.2
Henderson, B.R.3
-
40
-
-
20444462760
-
An amino-terminal motif functions as a second nuclear export sequence in BRCA1
-
Thompson ME, Robinson-Benion CL, Holt JT. An amino-terminal motif functions as a second nuclear export sequence in BRCA1. J Biol Chem 2005; 280: 21854-21857
-
(2005)
J Biol Chem
, vol.280
, pp. 21854-21857
-
-
Thompson, M.E.1
Robinson-Benion, C.L.2
Holt, J.T.3
-
41
-
-
75149189204
-
BRCA1 and its toolbox for the maintenance of genome integrity
-
Huen MSY, Sy SMH, Chen J. BRCA1 and its toolbox for the maintenance of genome integrity. Nat Rev Mol Cell Biol 2010; 11: 138-148
-
(2010)
Nat Rev Mol Cell Biol
, vol.11
, pp. 138-148
-
-
Msy, H.1
Smh, S.2
Chen, J.3
-
42
-
-
77649131406
-
Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis
-
Moynahan ME, Jasin M. Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis. Nat Rev Mol Cell Biol 2010; 11: 196-207
-
(2010)
Nat Rev Mol Cell Biol
, vol.11
, pp. 196-207
-
-
Moynahan, M.E.1
Jasin, M.2
-
43
-
-
10544231876
-
Identification of a RING protein that can interact in vivo with the BRCA1 gene product
-
Wu LC, Wang ZW, Tsan JT, Spillman MA, Phung A, Xu XL.et al.. Identification of a RING protein that can interact in vivo with the BRCA1 gene product. Nat Genet 1996; 14: 430-440
-
(1996)
Nat Genet
, vol.14
, pp. 430-440
-
-
Wu, L.C.1
Wang, Z.W.2
Tsan, J.T.3
Spillman, M.A.4
Phung, A.5
Xu, X.L.6
-
44
-
-
0035805582
-
The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancerderived mutation
-
Hashizume R, Fukuda M, Maeda I, Nishikawa H, Oyake D, Yabuki Y.et al.. The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancerderived mutation. J Biol Chem 2001; 276: 14537-14540
-
(2001)
J Biol Chem
, vol.276
, pp. 14537-14540
-
-
Hashizume, R.1
Fukuda, M.2
Maeda, I.3
Nishikawa, H.4
Oyake, D.5
Yabuki, Y.6
-
45
-
-
33644850903
-
A UbcH5/ubiquitin noncovalent complex is required for processive BRCA1-directed ubiquitination
-
Brzovic PS, Lissounov A, Christensen DE, Hoyt DW, Klevit RE. A UbcH5/ubiquitin noncovalent complex is required for processive BRCA1-directed ubiquitination. Mol Cell 2006; 21: 873-880
-
(2006)
Mol Cell
, vol.21
, pp. 873-880
-
-
Brzovic, P.S.1
Lissounov, A.2
Christensen, D.E.3
Hoyt, D.W.4
Klevit, R.E.5
-
46
-
-
34948848684
-
E2-BRCA1 RING interactions dictate synthesis of mono-or specific polyubiquitin chain linkages
-
Christensen DE, Brzovic PS, Klevit RE. E2-BRCA1 RING interactions dictate synthesis of mono-or specific polyubiquitin chain linkages. Nat Struct Mol Biol 2007; 14: 941-948
-
(2007)
Nat Struct Mol Biol
, vol.14
, pp. 941-948
-
-
Christensen, D.E.1
Brzovic, P.S.2
Klevit, R.E.3
-
47
-
-
84886089987
-
BRCA1 targets G2/M cell cycle proteins for ubiquitination and proteasomal degradation
-
Shabbeer S, Omer D, Berneman D, Weitzman O, Alpaugh A, Pietraszkiewicz A.et al.. BRCA1 targets G2/M cell cycle proteins for ubiquitination and proteasomal degradation. Oncogene 2013; 32: 5005-5016
-
(2013)
Oncogene
, vol.32
, pp. 5005-5016
-
-
Shabbeer, S.1
Omer, D.2
Berneman, D.3
Weitzman, O.4
Alpaugh, A.5
Pietraszkiewicz, A.6
-
48
-
-
33750434275
-
The BRCA1/BARD1 heterodimer modulates ran-dependent mitotic spindle assembly
-
Joukov V, Groen AC, Prokhorova T, Gerson R, White E, Rodriguez A.et al.. The BRCA1/BARD1 heterodimer modulates ran-dependent mitotic spindle assembly. Cell 2006; 127: 539-552
-
(2006)
Cell
, vol.127
, pp. 539-552
-
-
Joukov, V.1
Groen, A.C.2
Prokhorova, T.3
Gerson, R.4
White, E.5
Rodriguez, A.6
-
49
-
-
4544240599
-
BRCA1-dependent ubiquitination of gamma-tubulin regulates centrosome number
-
Starita LM, Machida Y, Sankaran S, Elias JE, Griffin K, Schlegel BP.et al.. BRCA1-dependent ubiquitination of gamma-tubulin regulates centrosome number. Mol Cell Biol 2004; 24: 8457-8466
-
(2004)
Mol Cell Biol
, vol.24
, pp. 8457-8466
-
-
Starita, L.M.1
Machida, Y.2
Sankaran, S.3
Elias, J.E.4
Griffin, K.5
Schlegel, B.P.6
-
50
-
-
80052416177
-
The BRCA1 ubiquitin ligase and homologous recombination repair
-
Ohta T, Sato K, Wu W. The BRCA1 ubiquitin ligase and homologous recombination repair. FEBS Lett 2011; 585: 2836-2844
-
(2011)
FEBS Lett
, vol.585
, pp. 2836-2844
-
-
Ohta, T.1
Sato, K.2
Wu, W.3
-
51
-
-
0033527717
-
Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks
-
Cortez D, Wang Y, Qin J, Elledge SJ. Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks. Science 1999; 286: 1162-1166
-
(1999)
Science
, vol.286
, pp. 1162-1166
-
-
Cortez, D.1
Wang, Y.2
Qin, J.3
Elledge, S.J.4
-
52
-
-
0037102275
-
Phosphorylation of serine 1387 in Brca1 is specifically required for the Atm-mediated S-phase checkpoint after ionizing irradiation
-
Xu B, ODonnell AH, Kim S-T, Kastan MB. Phosphorylation of serine 1387 in Brca1 is specifically required for the Atm-mediated S-phase checkpoint after ionizing irradiation. Cancer Res 2002; 62: 4588-4591
-
(2002)
Cancer Res
, vol.62
, pp. 4588-4591
-
-
Xu, B.1
Odonnell, A.H.2
Kim, S.-T.3
Kastan, M.B.4
-
53
-
-
84875872895
-
Double-strand break repair by homologous recombination in primary mouse somatic cells requires BRCA1 but not the ATM kinase
-
Kass EM, Helgadottir HR, Chen C-C, Barbera M, Wang R, Westermark UK.et al.. Double-strand break repair by homologous recombination in primary mouse somatic cells requires BRCA1 but not the ATM kinase. Proc Natl Acad Sci USA 2013; 110: 5564-5569
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. 5564-5569
-
-
Kass, E.M.1
Helgadottir, H.R.2
Chen, C.-C.3
Barbera, M.4
Wang, R.5
Westermark, U.K.6
-
54
-
-
67651166786
-
PALB2 functionally connects the breast cancer susceptibility proteins BRCA1 and BRCA2
-
Zhang F, Fan Q, Ren K, Andreassen PR. PALB2 functionally connects the breast cancer susceptibility proteins BRCA1 and BRCA2. Mol Cancer Res 2009; 7: 1110-1118
-
(2009)
Mol Cancer Res
, vol.7
, pp. 1110-1118
-
-
Zhang, F.1
Fan, Q.2
Ren, K.3
Andreassen, P.R.4
-
55
-
-
62549115236
-
PALB2 links BRCA1 and BRCA2 in the DNA-damage response
-
Zhang F, Ma J, Wu J, Ye L, Cai H, Xia B.et al.. PALB2 links BRCA1 and BRCA2 in the DNA-damage response. Curr Biol 2009; 19: 524-529
-
(2009)
Curr Biol
, vol.19
, pp. 524-529
-
-
Zhang, F.1
Ma, J.2
Wu, J.3
Ye, L.4
Cai, H.5
Xia, B.6
-
56
-
-
66349096607
-
PALB2 is an integral component of the BRCA complex required for homologous recombination repair
-
Sy SMH, Huen MSY, Chen J. PALB2 is an integral component of the BRCA complex required for homologous recombination repair. Proc Natl Acad Sci USA 2009; 106: 7155-7160
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 7155-7160
-
-
Smh, S.1
Msy, H.2
Chen, J.3
-
57
-
-
33745200945
-
Control of BRCA2 cellular and clinical functions by a nuclear partner
-
Xia B, Sheng Q, Nakanishi K, Ohashi A, Wu J, Christ N.et al.. Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2. Mol Cell 2006; 22: 719-729
-
(2006)
PALB2. Mol Cell
, vol.22
, pp. 719-729
-
-
Xia, B.1
Sheng, Q.2
Nakanishi, K.3
Ohashi, A.4
Wu, J.5
Christ, N.6
-
58
-
-
0031472370
-
Association of BRCA1 with Rad51 in mitotic and meiotic cells
-
Scully R, Chen J, Plug A, Xiao Y, Weaver D, Feunteun J.et al.. Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell 1997; 88: 265-275
-
(1997)
Cell
, vol.88
, pp. 265-275
-
-
Scully, R.1
Chen, J.2
Plug, A.3
Xiao, Y.4
Weaver, D.5
Feunteun, J.6
-
59
-
-
0032159062
-
Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells
-
Chen J, Silver DP, Walpita D, Cantor SB, Gazdar AF, Tomlinson G.et al.. Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. Mol Cell 1998; 2: 317-328
-
(1998)
Mol Cell
, vol.2
, pp. 317-328
-
-
Chen, J.1
Silver, D.P.2
Walpita, D.3
Cantor, S.B.4
Gazdar, A.F.5
Tomlinson, G.6
-
60
-
-
79960066235
-
Unraveling the mechanism of BRCA2 in homologous recombination
-
Holloman WK. Unraveling the mechanism of BRCA2 in homologous recombination. Nat Struct Mol Biol 2011; 18: 748-754
-
(2011)
Nat Struct Mol Biol
, vol.18
, pp. 748-754
-
-
Holloman, W.K.1
-
61
-
-
77957975815
-
Purified human BRCA2 stimulates RAD51-mediated recombination
-
Jensen RB, Carreira A, Kowalczykowski SC. Purified human BRCA2 stimulates RAD51-mediated recombination. Nature 2010; 467: 678-683
-
(2010)
Nature
, vol.467
, pp. 678-683
-
-
Jensen, R.B.1
Carreira, A.2
Kowalczykowski, S.C.3
-
62
-
-
77957804215
-
Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA
-
Liu J, Doty T, Gibson B, Heyer W-D. Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA. Nat Struct Mol Biol 2010; 17: 1260-1262
-
(2010)
Nat Struct Mol Biol
, vol.17
, pp. 1260-1262
-
-
Liu, J.1
Doty, T.2
Gibson, B.3
Heyer, W.-D.4
-
63
-
-
77957804604
-
The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA
-
Thorslund T, McIlwraith MJ, Compton SA, Lekomtsev S, Petronczki M Griffith JD.et al.. The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA. Nat Struct Mol Biol 2010; 17: 1263-1265
-
(2010)
Nat Struct Mol Biol
, vol.17
, pp. 1263-1265
-
-
Thorslund, T.1
McIlwraith, M.J.2
Compton, S.A.3
Lekomtsev, S.4
Petronczki, M.5
Griffith, J.D.6
-
64
-
-
84866608818
-
Links between genome integrity and BRCA1 tumor suppression
-
Li ML, Greenberg RA. Links between genome integrity and BRCA1 tumor suppression. Trends Biochem Sci 2012; 37: 418-424
-
(2012)
Trends Biochem Sci
, vol.37
, pp. 418-424
-
-
Li, M.L.1
Greenberg, R.A.2
-
65
-
-
34249946686
-
Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response
-
Wang B, Matsuoka S, Ballif BA, Zhang D, Smogorzewska A, Gygi SP.et al.. Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response. Science 2007; 316: 1194-1198
-
(2007)
Science
, vol.316
, pp. 1194-1198
-
-
Wang, B.1
Matsuoka, S.2
Ballif, B.A.3
Zhang, D.4
Smogorzewska, A.5
Gygi, S.P.6
-
66
-
-
20644461718
-
BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function
-
Cantor SB, Bell DW, Ganesan S, Kass EM, Drapkin R, Grossman S.et al.. BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function. Cell 2001; 105: 149-160
-
(2001)
Cell
, vol.105
, pp. 149-160
-
-
Cantor, S.B.1
Bell, D.W.2
Ganesan, S.3
Kass, E.M.4
Drapkin, R.5
Grossman, S.6
-
67
-
-
0032566753
-
The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression
-
Yu X, Wu LC, Bowcock AM, Aronheim A, Baer R. The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression. J Biol Chem 1998; 273: 25388-25392
-
(1998)
J Biol Chem
, vol.273
, pp. 25388-25392
-
-
Yu, X.1
Wu, L.C.2
Bowcock, A.M.3
Aronheim, A.4
Baer, R.5
-
68
-
-
43149118369
-
Cell cycle-dependent complex formation of BRCA1CtIPMRN is important for DNA double-strand break repair
-
Chen L, Nievera CJ, Lee AY-L, Wu X. Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair. J Biol Chem 2008; 283: 7713-7720
-
(2008)
J Biol Chem
, vol.283
, pp. 7713-7720
-
-
Chen, L.1
Nievera, C.J.2
Ay-L, L.3
Wu, X.4
-
69
-
-
0030833568
-
BRCA1 is a cell cycle-regulated nuclear phosphoprotein
-
Ruffner H, Verma IM. BRCA1 is a cell cycle-regulated nuclear phosphoprotein. Proc Natl Acad Sci USA 1997; 94: 7138-7143
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 7138-7143
-
-
Ruffner, H.1
Verma, I.M.2
-
70
-
-
33645003172
-
BRCA1: Cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution
-
Deng C-X. BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution. Nucleic Acids Res 2006; 34: 1416-1426
-
(2006)
Nucleic Acids Res
, vol.34
, pp. 1416-1426
-
-
Deng, C.-X.1
-
71
-
-
0037169354
-
Cancer susceptibility and the functions of BRCA1 and BRCA2
-
Venkitaraman AR. Cancer susceptibility and the functions of BRCA1 and BRCA2. Cell 2002; 108: 171-182
-
(2002)
Cell
, vol.108
, pp. 171-182
-
-
Venkitaraman, A.R.1
-
72
-
-
0035032649
-
Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation
-
Xu B, Kim St, Kastan MB. Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation. Mol Cell Biol 2001; 21: 3445-3450
-
(2001)
Mol Cell Biol
, vol.21
, pp. 3445-3450
-
-
Xu, B.1
St, K.2
Kastan, M.B.3
-
73
-
-
0036510163
-
BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage
-
Yarden RI, Pardo-Reoyo S, Sgagias M, Cowan KH, Brody LC. BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage. Nat Genet 2002; 30: 285-289
-
(2002)
Nat Genet
, vol.30
, pp. 285-289
-
-
Yarden, R.I.1
Pardo-Reoyo, S.2
Sgagias, M.3
Cowan, K.H.4
Brody, L.C.5
-
74
-
-
0032573068
-
BRCA1 is associated with the centrosome during mitosis
-
Hsu LC, White RL. BRCA1 is associated with the centrosome during mitosis. Proc Natl Acad Sci USA 1998; 95: 12983-12988
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 12983-12988
-
-
Hsu, L.C.1
White, R.L.2
-
75
-
-
0037048290
-
Roles of BRCA1 in centrosome duplication
-
Deng C-X. Roles of BRCA1 in centrosome duplication. Oncogene 2002; 21: 6222-6227
-
(2002)
Oncogene
, vol.21
, pp. 6222-6227
-
-
Deng, C.-X.1
-
76
-
-
0032999336
-
BRCA1 is phosphorylated at serine 1497 in vivo at a cyclin-dependent kinase 2 phosphorylation site
-
Ruffner H, Jiang W, Craig AG, Hunter T, Verma IM. BRCA1 is phosphorylated at serine 1497 in vivo at a cyclin-dependent kinase 2 phosphorylation site. Mol Cell Biol 1999; 19: 4843-4854
-
(1999)
Mol Cell Biol
, vol.19
, pp. 4843-4854
-
-
Ruffner, H.1
Jiang, W.2
Craig, A.G.3
Hunter, T.4
Verma, I.M.5
-
77
-
-
0033106326
-
Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells
-
Xu X, Weaver Z, Linke SP, Li C, Gotay J, Wang XW.et al.. Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells. Mol Cell 1999; 3: 389-395
-
(1999)
Mol Cell
, vol.3
, pp. 389-395
-
-
Xu, X.1
Weaver, Z.2
Linke, S.P.3
Li, C.4
Gotay, J.5
Wang, X.W.6
-
78
-
-
0036675318
-
Mammary tumors in mice conditionally mutant for Brca1 exhibit gross genomic instability and centrosome amplification yet display a recurring distribution of genomic imbalances that is similar to human breast cancer
-
Weaver Z, Montagna C, Xu X, Howard T, Gadina M, Brodie SG.et al.. Mammary tumors in mice conditionally mutant for Brca1 exhibit gross genomic instability and centrosome amplification yet display a recurring distribution of genomic imbalances that is similar to human breast cancer. Oncogene 2002; 21: 5097-5107
-
(2002)
Oncogene
, vol.21
, pp. 5097-5107
-
-
Weaver, Z.1
Montagna, C.2
Xu, X.3
Howard, T.4
Gadina, M.5
Brodie, S.G.6
-
79
-
-
0029830051
-
Transcriptional activation by BRCA1
-
Chapman MS, Verma IM. Transcriptional activation by BRCA1. Nature 1996; 382: 678-679
-
(1996)
Nature
, vol.382
, pp. 678-679
-
-
Chapman, M.S.1
Verma, I.M.2
-
80
-
-
0030474170
-
Evidence for a transcriptional activation function of BRCA1 C-terminal region
-
Monteiro AN, August A, Hanafusa H. Evidence for a transcriptional activation function of BRCA1 C-terminal region. Proc Natl Acad Sci USA 1996; 93: 13595-13599
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 13595-13599
-
-
Monteiro, A.N.1
August, A.2
Hanafusa, H.3
-
81
-
-
0036724986
-
BRCA1 induces DNA damage recognition factors and enhances nucleotide excision repair
-
Hartman A-R, Ford JM. BRCA1 induces DNA damage recognition factors and enhances nucleotide excision repair. Nat Genet 2002; 32: 180-184
-
(2002)
Nat Genet
, vol.32
, pp. 180-184
-
-
Hartman, A.-R.1
Ford, J.M.2
-
82
-
-
80052567822
-
BRCA1 tumour suppression occurs via heterochromatin-mediated silencing
-
Zhu Q, Pao GM, Huynh AM, Suh H, Tonnu N, Nederlof PM.et al.. BRCA1 tumour suppression occurs via heterochromatin-mediated silencing. Nature 2011; 477: 179-184
-
(2011)
Nature
, vol.477
, pp. 179-184
-
-
Zhu, Q.1
Pao, G.M.2
Huynh, A.M.3
Suh, H.4
Tonnu, N.5
Nederlof, P.M.6
-
83
-
-
80055092789
-
BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not its E3 ligase activity
-
Shakya R, Reid LJ, Reczek CR, Cole F, Egli D, Lin C-S.et al.. BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not its E3 ligase activity. Science 2011; 334: 525-528
-
(2011)
Science
, vol.334
, pp. 525-528
-
-
Shakya, R.1
Reid, L.J.2
Reczek, C.R.3
Cole, F.4
Egli, D.5
Lin, C.-S.6
-
84
-
-
0037610801
-
Binding and recognition in the assembly of an active BRCA1/BARD1 ubiquitin-ligase complex
-
Brzovic PS, Keeffe JR, Nishikawa H, Miyamoto K, Fox D, Fukuda M.et al.. Binding and recognition in the assembly of an active BRCA1/BARD1 ubiquitin-ligase complexProc Natl Acad Sci USA 2003; 100: 5646-5651
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 5646-5651
-
-
Brzovic, P.S.1
Keeffe, J.R.2
Nishikawa, H.3
Miyamoto, K.4
Fox, D.5
Fukuda, M.6
-
85
-
-
83455229693
-
BRCA1 RING function is essential for tumor suppression but dispensable for therapy resistance
-
Drost R, Bouwman P, Rottenberg S, Boon U, Schut E, Klarenbeek S.et al.. BRCA1 RING function is essential for tumor suppression but dispensable for therapy resistance. Cancer Cell 2011; 20: 797-809
-
(2011)
Cancer Cell
, vol.20
, pp. 797-809
-
-
Drost, R.1
Bouwman, P.2
Rottenberg, S.3
Boon, U.4
Schut, E.5
Klarenbeek, S.6
-
86
-
-
0035942190
-
Cancer-predisposing mutations within the RING domain of BRCA1: Loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity
-
Ruffner H, Joazeiro CA, Hemmati D, Hunter T, Verma IM. Cancer-predisposing mutations within the RING domain of BRCA1: loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity. Proc Natl Acad Sci USA 2001; 98: 5134-5139
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 5134-5139
-
-
Ruffner, H.1
Joazeiro, C.A.2
Hemmati, D.3
Hunter, T.4
Verma, I.M.5
-
87
-
-
0037122004
-
Activation of the E3 ligase function of the BRCA1/BARD1 complex by polyubiquitin chains
-
Mallery DL, Vandenberg CJ, Hiom K. Activation of the E3 ligase function of the BRCA1/BARD1 complex by polyubiquitin chains. EMBO J 2002; 21: 6755-6762
-
(2002)
EMBO J
, vol.21
, pp. 6755-6762
-
-
Mallery, D.L.1
Vandenberg, C.J.2
Hiom, K.3
-
88
-
-
44349095084
-
The basallike mammary carcinomas induced by Brca1 or Bard1 inactivation implicate the BRCA1/BARD1 heterodimer in tumor suppression
-
Shakya R, Szabolcs M, McCarthy E, Ospina E, Basso K, Nandula S.et al.. The basallike mammary carcinomas induced by Brca1 or Bard1 inactivation implicate the BRCA1/BARD1 heterodimer in tumor suppression. Proc Natl Acad Sci USA 2008; 105: 7040-7045
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 7040-7045
-
-
Shakya, R.1
Szabolcs, M.2
McCarthy, E.3
Ospina, E.4
Basso, K.5
Nandula, S.6
-
89
-
-
0030850047
-
Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage
-
Scully R, Chen J, Ochs RL, Keegan K, Hoekstra M, Feunteun J.et al.. Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage. Cell 1997; 90: 425-435
-
(1997)
Cell
, vol.90
, pp. 425-435
-
-
Scully, R.1
Chen, J.2
Ochs, R.L.3
Keegan, K.4
Hoekstra, M.5
Feunteun, J.6
-
90
-
-
82455218968
-
BRCA1 is required for postreplication repair after UV-induced DNA damage
-
Pathania S, Nguyen J, Hill SJ, Scully R, Adelmant GO, Marto JA.et al.. BRCA1 is required for postreplication repair after UV-induced DNA damage. Mol Cell 2011; 44: 235-251
-
(2011)
Mol Cell
, vol.44
, pp. 235-251
-
-
Pathania, S.1
Nguyen, J.2
Hill, S.J.3
Scully, R.4
Adelmant, G.O.5
Marto, J.A.6
-
91
-
-
84866261844
-
Telomeric allelic imbalance indicates defective DNA repair and sensitivity to DNA-damaging agents
-
Birkbak NJ, Wang ZC, Kim J-Y, Eklund AC, Li Q, Tian R.et al.. Telomeric allelic imbalance indicates defective DNA repair and sensitivity to DNA-damaging agents. Cancer Discov 2012; 2: 366-375
-
(2012)
Cancer Discov
, vol.2
, pp. 366-375
-
-
Birkbak, N.J.1
Wang, Z.C.2
Kim, J.-Y.3
Eklund, A.C.4
Li, Q.5
Tian, R.6
-
92
-
-
9744263911
-
The role of BRCA1 in the cellular response to chemotherapy
-
Kennedy RD, Quinn JE, Mullan PB, Johnston PG, Harkin DP. The role of BRCA1 in the cellular response to chemotherapy. J Natl Cancer Inst 2004; 96: 1659-1668
-
(2004)
J Natl Cancer Inst
, vol.96
, pp. 1659-1668
-
-
Kennedy, R.D.1
Quinn, J.E.2
Mullan, P.B.3
Johnston, P.G.4
Harkin, D.P.5
-
93
-
-
0035807219
-
Inhibition of BRCA1 leads to increased chemoresistance to microtubule-interfering agents, an effect that involves the JNK pathway
-
Lafarge S, Sylvain V, Ferrara M, Bignon YJ. Inhibition of BRCA1 leads to increased chemoresistance to microtubule-interfering agents, an effect that involves the JNK pathway. Oncogene 2001; 20: 6597-6606
-
(2001)
Oncogene
, vol.20
, pp. 6597-6606
-
-
Lafarge, S.1
Sylvain, V.2
Ferrara, M.3
Bignon, Y.J.4
-
94
-
-
0141954010
-
BRCA1 functions as a differential modulator of chemotherapy-induced apoptosis
-
Quinn JE, Kennedy RD, Mullan PB, Gilmore PM, Carty M, Johnston PG.et al.. BRCA1 functions as a differential modulator of chemotherapy-induced apoptosis. Cancer Res 2003; 63: 6221-6228
-
(2003)
Cancer Res
, vol.63
, pp. 6221-6228
-
-
Quinn, J.E.1
Kennedy, R.D.2
Mullan, P.B.3
Gilmore, P.M.4
Carty, M.5
Johnston, P.G.6
-
95
-
-
0038147067
-
BRCA1 expression modulates chemosensitivity of BRCA1-defective HCC1937 human breast cancer cells
-
Tassone P, Tagliaferri P, Perricelli A, Blotta S, Quaresima B, Martelli ML.et al.. BRCA1 expression modulates chemosensitivity of BRCA1-defective HCC1937 human breast cancer cells. Br J Cancer 2003; 88: 1285-1291
-
(2003)
Br J Cancer
, vol.88
, pp. 1285-1291
-
-
Tassone, P.1
Tagliaferri, P.2
Perricelli, A.3
Blotta, S.4
Quaresima, B.5
Martelli, M.L.6
-
96
-
-
33646409883
-
BRCA1 downregulation leads to premature inactivation of spindle checkpoint and confers paclitaxel resistance
-
Chabalier C, Lamare C, Racca C, Privat M, Valette A, Larminat F. BRCA1 downregulation leads to premature inactivation of spindle checkpoint and confers paclitaxel resistance. Cell Cycle 2006; 5: 1001-1007
-
(2006)
Cell Cycle
, vol.5
, pp. 1001-1007
-
-
Chabalier, C.1
Lamare, C.2
Racca, C.3
Privat, M.4
Valette, A.5
Larminat, F.6
-
97
-
-
39749119151
-
Response to neo-Adjuvant chemotherapy in women with BRCA1-positive breast cancers
-
Byrski T, Gronwald J, Huzarski T, Grzybowska E, Budryk M, Stawicka M.et al.. Response to neo-Adjuvant chemotherapy in women with BRCA1-positive breast cancers. Breast Cancer Res Treat 2008; 108: 289-296
-
(2008)
Breast Cancer Res Treat
, vol.108
, pp. 289-296
-
-
Byrski, T.1
Gronwald, J.2
Huzarski, T.3
Grzybowska, E.4
Budryk, M.5
Stawicka, M.6
-
98
-
-
48349109492
-
Primary resistance to docetaxel-based chemotherapy in metastatic breast cancer patients correlates with a high frequency of BRCA1 mutations
-
Wysocki PJ, Korski K, Lamperska K, Zaluski J, Mackiewicz A. Primary resistance to docetaxel-based chemotherapy in metastatic breast cancer patients correlates with a high frequency of BRCA1 mutations. Med Sci Monit 2008; 14: SC7-10
-
(2008)
Med Sci Monit
, vol.14
-
-
Wysocki, P.J.1
Korski, K.2
Lamperska, K.3
Zaluski, J.4
Mackiewicz, A.5
-
99
-
-
83755168231
-
The efficacy of taxane chemotherapy for metastatic breast cancer in BRCA1 and BRCA2 mutation carriers
-
Kriege M, Jager A, Hooning MJ, Huijskens E, Blom J, van Deurzen CHM.et al.. The efficacy of taxane chemotherapy for metastatic breast cancer in BRCA1 and BRCA2 mutation carriers. Cancer 2012; 118: 899-907
-
(2012)
Cancer
, vol.118
, pp. 899-907
-
-
Kriege, M.1
Jager, A.2
Hooning, M.J.3
Huijskens, E.4
Blom, J.5
Van Deurzen, C.H.M.6
-
100
-
-
84860528208
-
Impact of intertumoral heterogeneity on predicting chemotherapy response of BRCA1-deficient mammary tumors
-
Rottenberg S, Vollebergh MA, de Hoon B, de Ronde J, Schouten PC, Kersbergen A.et al.. Impact of intertumoral heterogeneity on predicting chemotherapy response of BRCA1-deficient mammary tumors. Cancer Res 2012; 72: 2350-2361
-
(2012)
Cancer Res
, vol.72
, pp. 2350-2361
-
-
Rottenberg, S.1
Vollebergh, M.A.2
De Hoon, B.3
De Ronde, J.4
Schouten, P.C.5
Kersbergen, A.6
-
101
-
-
0034600109
-
Clinicopathologic features of BRCA-linked and sporadic ovarian cancer
-
Boyd J, Sonoda Y, Federici MG, Bogomolniy F, Rhei E, Maresco DL.et al.. Clinicopathologic features of BRCA-linked and sporadic ovarian cancer. JAMA 2000; 283: 2260-2265
-
(2000)
JAMA
, vol.283
, pp. 2260-2265
-
-
Boyd, J.1
Sonoda, Y.2
Federici, M.G.3
Bogomolniy, F.4
Rhei, E.5
Maresco, D.L.6
-
102
-
-
0037080115
-
Effect of BRCA mutations on the length of survival in epithelial ovarian tumors
-
Ben David Y, Chetrit A, Hirsh-Yechezkel G, Friedman E, Beck BD, Beller U.et al.. Effect of BRCA mutations on the length of survival in epithelial ovarian tumors. J Clin Oncol 2002; 20: 463-466
-
(2002)
J Clin Oncol
, vol.20
, pp. 463-466
-
-
Ben David, Y.1
Chetrit, A.2
Hirsh-Yechezkel, G.3
Friedman, E.4
Beck, B.D.5
Beller, U.6
-
103
-
-
0037403380
-
Improved survival in women with BRCA-Associated ovarian carcinoma
-
Cass I, Baldwin RL, Varkey T, Moslehi R, Narod SA, Karlan BY. Improved survival in women with BRCA-Associated ovarian carcinoma. Cancer 2003; 97: 2187-2195
-
(2003)
Cancer
, vol.97
, pp. 2187-2195
-
-
Cass, I.1
Baldwin, R.L.2
Varkey, T.3
Moslehi, R.4
Narod, S.A.5
Karlan, B.Y.6
-
104
-
-
37849030476
-
Effect of BRCA1/2 mutations on long-term survival of patients with invasive ovarian cancer: The national Israeli study of ovarian cancer
-
Chetrit A, Hirsh-Yechezkel G, Ben-David Y, Lubin F, Friedman E, Sadetzki S. Effect of BRCA1/2 mutations on long-term survival of patients with invasive ovarian cancer: the national Israeli study of ovarian cancer. J Clin Oncol 2008; 26: 20-25
-
(2008)
J Clin Oncol
, vol.26
, pp. 20-25
-
-
Chetrit, A.1
Hirsh-Yechezkel, G.2
Ben-David, Y.3
Lubin, F.4
Friedman, E.5
Sadetzki, S.6
-
105
-
-
79959635260
-
DNA interstrand crosslink repair and cancer
-
Deans AJ, West SC. DNA interstrand crosslink repair and cancer. Nat Rev Cancer 2011; 11: 467-480
-
(2011)
Nat Rev Cancer
, vol.11
, pp. 467-480
-
-
Deans, A.J.1
West, S.C.2
-
106
-
-
0034777823
-
Current and future potential roles of the platinum drugs in the treatment of ovarian cancer
-
Piccart MJ, Lamb H, Vermorken JB. Current and future potential roles of the platinum drugs in the treatment of ovarian cancer. Ann Oncol 2001; 12: 1195-1203
-
(2001)
Ann Oncol
, vol.12
, pp. 1195-1203
-
-
Piccart, M.J.1
Lamb, H.2
Vermorken, J.B.3
-
107
-
-
34547504504
-
Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer
-
Rottenberg S, Nygren AOH, Pajic M, van Leeuwen FWB, van der Heijden I, van de Wetering K.et al.. Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer. Proc Natl Acad Sci USA 2007; 104: 12117-12122
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 12117-12122
-
-
Rottenberg, S.1
Aoh, N.2
Pajic, M.3
Van Leeuwen Fwb4
Van Der Heijden, I.5
Van De Wetering, K.6
-
108
-
-
85046914617
-
Loss of BRCA1 function increases the antitumor activity of cisplatin against human breast cancer xenografts in vivo
-
Tassone P, Di Martino MT, Ventura M, Pietragalla A, Cucinotto I, Calimeri T.et al.. Loss of BRCA1 function increases the antitumor activity of cisplatin against human breast cancer xenografts in vivo. Cancer Biol Ther 2009; 8: 648-653
-
(2009)
Cancer Biol Ther
, vol.8
, pp. 648-653
-
-
Tassone, P.1
Di Martino, M.T.2
Ventura, M.3
Pietragalla, A.4
Cucinotto, I.5
Calimeri, T.6
-
109
-
-
75749143502
-
Pathologic complete response rates in young women with BRCA1-positive breast cancers after neoadjuvant chemotherapy
-
Byrski T, Gronwald J, Huzarski T, Grzybowska E, Budryk M, Stawicka M.et al.. Pathologic complete response rates in young women with BRCA1-positive breast cancers after neoadjuvant chemotherapy. J Clin Oncol 2010; 28: 375-379
-
(2010)
J Clin Oncol
, vol.28
, pp. 375-379
-
-
Byrski, T.1
Gronwald, J.2
Huzarski, T.3
Grzybowska, E.4
Budryk, M.5
Stawicka, M.6
-
110
-
-
67349284098
-
Response to neoadjuvant therapy with cisplatin in BRCA1-positive breast cancer patients
-
Byrski T, Huzarski T, Dent R, Gronwald J, Zuziak D, Cybulski C.et al.. Response to neoadjuvant therapy with cisplatin in BRCA1-positive breast cancer patients. Breast Cancer Res Treat 2009; 115: 359-363
-
(2009)
Breast Cancer Res Treat
, vol.115
, pp. 359-363
-
-
Byrski, T.1
Huzarski, T.2
Dent, R.3
Gronwald, J.4
Zuziak, D.5
Cybulski, C.6
-
111
-
-
84866165483
-
Results of a phase II open-label, non-randomized trial of cisplatin chemotherapy in patients with BRCA1-positive metastatic breast cancer
-
Byrski T, Dent R, Blecharz P, Foszczynska-Kloda M, Gronwald J, Huzarski T.et al.. Results of a phase II open-label, non-randomized trial of cisplatin chemotherapy in patients with BRCA1-positive metastatic breast cancer. Breast Cancer Res 2012; 14: R110
-
(2012)
Breast Cancer Res
, vol.14
-
-
Byrski, T.1
Dent, R.2
Blecharz, P.3
Foszczynska-Kloda, M.4
Gronwald, J.5
Huzarski, T.6
-
112
-
-
77949908546
-
Efficacy of neoadjuvant Cisplatin in triple-negative breast cancer
-
Silver DP, Richardson AL, Eklund AC, Wang ZC, Szallasi Z, Li Q.et al.. Efficacy of neoadjuvant Cisplatin in triple-negative breast cancer. J Clin Oncol 2010; 28: 1145-1153
-
(2010)
J Clin Oncol
, vol.28
, pp. 1145-1153
-
-
Silver, D.P.1
Richardson, A.L.2
Eklund, A.C.3
Wang, Z.C.4
Szallasi, Z.5
Li, Q.6
-
113
-
-
0028117527
-
HMG-domain proteins specifically inhibit the repair of the major DNA adduct of the anticancer drug cisplatin by human excision nuclease
-
Huang JC, Zamble DB, Reardon JT, Lippard SJ, Sancar A. HMG-domain proteins specifically inhibit the repair of the major DNA adduct of the anticancer drug cisplatin by human excision nuclease. Proc Natl Acad Sci USA 1994; 91: 10394-10398
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 10394-10398
-
-
Huang, J.C.1
Zamble, D.B.2
Reardon, J.T.3
Lippard, S.J.4
Sancar, A.5
-
114
-
-
0029783348
-
Repair of cisplatin-DNA adducts by the mammalian excision nuclease
-
Zamble DB, Mu D, Reardon JT, Sancar A, Lippard SJ. Repair of cisplatin-DNA adducts by the mammalian excision nuclease. Biochemistry 1996; 35: 10004-10013
-
(1996)
Biochemistry
, vol.35
, pp. 10004-10013
-
-
Zamble, D.B.1
Mu, D.2
Reardon, J.T.3
Sancar, A.4
Lippard, S.J.5
-
115
-
-
84862776819
-
BRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair
-
Bunting SF, Callen E, Kozak ML, Kim JM, Wong N, López-Contreras AJ.et al.. BRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair. Mol Cell 2012; 46: 125-135
-
(2012)
Mol Cell
, vol.46
, pp. 125-135
-
-
Bunting, S.F.1
Callen, E.2
Kozak, M.L.3
Kim, J.M.4
Wong, N.5
López-Contreras, A.J.6
-
116
-
-
74949093142
-
A high-throughput pharmaceutical screen identifies compounds with specific toxicity against BRCA2-deficient tumors
-
Evers B, Schut E, van der Burg E, Braumuller TM, Egan DA, Holstege H.et al.. A high-throughput pharmaceutical screen identifies compounds with specific toxicity against BRCA2-deficient tumors. Clin Cancer Res 2010; 16: 99-108
-
(2010)
Clin Cancer Res
, vol.16
, pp. 99-108
-
-
Evers, B.1
Schut, E.2
Van Der Burg, E.3
Braumuller, T.M.4
Egan, D.A.5
Holstege, H.6
-
117
-
-
80053209565
-
Melphalan as a treatment for BRCA-related ovarian carcinoma can you teach an old drug new tricks?
-
Osher DJ, Kushner YB, Arseneau J, Foulkes WD. Melphalan as a treatment for BRCA-related ovarian carcinoma: can you teach an old drug new tricks? J Clin Pathol 2011; 64: 924-926
-
(2011)
J Clin Pathol
, vol.64
, pp. 924-926
-
-
Osher, D.J.1
Kushner, Y.B.2
Arseneau, J.3
Foulkes, W.D.4
-
118
-
-
79959733228
-
An aCGH classifier derived from BRCA1-mutated breast cancer and benefit of high-dose platinum-based chemotherapy in HER2-negative breast cancer patients
-
Vollebergh MA, Lips EH, Nederlof PM, Wessels LFA, Schmidt MK, van Beers EH.et al.. An aCGH classifier derived from BRCA1-mutated breast cancer and benefit of high-dose platinum-based chemotherapy in HER2-negative breast cancer patients. Ann Oncol 2011; 22: 1561-1570
-
(2011)
Ann Oncol
, vol.22
, pp. 1561-1570
-
-
Vollebergh, M.A.1
Lips, E.H.2
Nederlof, P.M.3
Lfa, W.4
Schmidt, M.K.5
Van Beers, E.H.6
-
119
-
-
25444497278
-
The concept of synthetic lethality in the context of anticancer therapy
-
Kaelin Jr. WG. The concept of synthetic lethality in the context of anticancer therapy. Nat Rev Cancer 2005; 5: 689-698
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 689-698
-
-
Kaelin Jr., W.G.1
-
120
-
-
84868221110
-
Trapping of PARP1 and PARP2 by clinical PARP inhibitors
-
Murai J, Huang SN, Das BB, Renaud A, Zhang Y, Doroshow JH.et al.. Trapping of PARP1 and PARP2 by clinical PARP inhibitors. Cancer Res 2012; 72: 5588-5599
-
(2012)
Cancer Res
, vol.72
, pp. 5588-5599
-
-
Murai, J.1
Huang, S.N.2
Das, B.B.3
Renaud, A.4
Zhang, Y.5
Doroshow, J.H.6
-
121
-
-
17244375049
-
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
-
Bryant HE, Schultz N, Thomas HD, Parker KM, Flower D, Lopez E.et al.. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature 2005; 434: 913-917
-
(2005)
Nature
, vol.434
, pp. 913-917
-
-
Bryant, H.E.1
Schultz, N.2
Thomas, H.D.3
Parker, K.M.4
Flower, D.5
Lopez, E.6
-
122
-
-
17244373777
-
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
-
Farmer H, McCabe N, Lord CJ, Tutt AN, Johnson DA, Richardson TB.et al.. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 2005; 434: 917-921
-
(2005)
Nature
, vol.434
, pp. 917-921
-
-
Farmer, H.1
McCabe, N.2
Lord, C.J.3
Tutt, A.N.4
Johnson, D.A.5
Richardson, T.B.6
-
123
-
-
52449111109
-
Selective inhibition of BRCA2-deficient mammary tumor cell growth by AZD2281 and cisplatin
-
Evers B, Drost R, Schut E, de Bruin M, van der Burg E, Derksen PWB.et al.. Selective inhibition of BRCA2-deficient mammary tumor cell growth by AZD2281 and cisplatin. Clin Cancer Res 2008; 14: 3916-3925
-
(2008)
Clin Cancer Res
, vol.14
, pp. 3916-3925
-
-
Evers, B.1
Drost, R.2
Schut, E.3
De Bruin, M.4
Van Der Burg, E.5
Derksen, P.W.B.6
-
124
-
-
55949092708
-
High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs
-
Rottenberg S, Jaspers JE, Kersbergen A, van der Burg E, Nygren AOH, Zander SAL.et al.. High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs. Proc Natl Acad Sci USA 2008; 105: 17079-17084
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 17079-17084
-
-
Rottenberg, S.1
Jaspers, J.E.2
Kersbergen, A.3
Van Der Burg, E.4
Aoh, N.5
Zander, S.A.L.6
-
125
-
-
67650471685
-
Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers
-
Fong PC, Boss DS, Yap TA, Tutt A, Wu P, Mergui-Roelvink M.et al.. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med 2009; 361: 123-134
-
(2009)
N Engl J Med
, vol.361
, pp. 123-134
-
-
Fong, P.C.1
Boss, D.S.2
Yap, T.A.3
Tutt, A.4
Wu, P.5
Mergui-Roelvink, M.6
-
126
-
-
34249006299
-
ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models
-
Donawho CK, Luo Y, Luo Y, Penning TD, Bauch JL, Bouska JJ.et al.. ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models. Clin Cancer Res 2007; 13: 2728-2737
-
(2007)
Clin Cancer Res
, vol.13
, pp. 2728-2737
-
-
Donawho, C.K.1
Luo, Y.2
Luo, Y.3
Penning, T.D.4
Bauch, J.L.5
Bouska, J.J.6
-
127
-
-
60549117554
-
Discovery of the Poly(ADP-ribose) polymerase (PARP) inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1Hbenzimidazole-4-carboxamide (ABT-888) for the treatment of cancer
-
Penning TD, Zhu G-D, Gandhi VB, Gong J, Liu X, Shi Y.et al.. Discovery of the Poly(ADP-ribose) polymerase (PARP) inhibitor 2-[(R)-2-methylpyrrolidin-2- yl]-1Hbenzimidazole-4-carboxamide (ABT-888) for the treatment of cancer. J Med Chem 2009; 52: 514-523
-
(2009)
J Med Chem
, vol.52
, pp. 514-523
-
-
Penning, T.D.1
Zhu, G.-D.2
Gandhi, V.B.3
Gong, J.4
Liu, X.5
Shi, Y.6
-
128
-
-
59449085305
-
Phase i study of the poly(ADP-ribose) polymerase inhibitor, AG014699, in combination with temozolomide in patients with advanced solid tumors
-
Plummer R, Jones C, Middleton M, Wilson R, Evans J, Olsen A.et al.. Phase I study of the poly(ADP-ribose) polymerase inhibitor, AG014699, in combination with temozolomide in patients with advanced solid tumors. Clin Cancer Res 2008; 14: 7917-7923
-
(2008)
Clin Cancer Res
, vol.14
, pp. 7917-7923
-
-
Plummer, R.1
Jones, C.2
Middleton, M.3
Wilson, R.4
Evans, J.5
Olsen, A.6
-
129
-
-
70949086814
-
Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): A novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and-2 mutant tumors
-
Jones P, Altamura S, Boueres J, Ferrigno F, Fonsi M, Giomini C.et al.. Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and-2 mutant tumors. J Med Chem 2009; 52: 7170-7185
-
(2009)
J Med Chem
, vol.52
, pp. 7170-7185
-
-
Jones, P.1
Altamura, S.2
Boueres, J.3
Ferrigno, F.4
Fonsi, M.5
Giomini, C.6
-
130
-
-
77955019276
-
Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: A proof-of-concept trial
-
Tutt A, Robson M, Garber JE, Domchek SM, Audeh MW, Weitzel JN.et al.. Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial. Lancet 2010; 376: 235-244
-
(2010)
Lancet
, vol.376
, pp. 235-244
-
-
Tutt, A.1
Robson, M.2
Garber, J.E.3
Domchek, S.M.4
Audeh, M.W.5
Weitzel, J.N.6
-
131
-
-
77955039099
-
Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: A proof-of-concept trial
-
Audeh MW, Carmichael J, Penson RT, Friedlander M, Powell B, Bell-McGuinn KM.et al.. Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial. Lancet 2010; 376: 245-251
-
(2010)
Lancet
, vol.376
, pp. 245-251
-
-
Audeh, M.W.1
Carmichael, J.2
Penson, R.T.3
Friedlander, M.4
Powell, B.5
Bell-Mcguinn, K.M.6
-
132
-
-
78751610848
-
Iniparib plus chemotherapy in metastatic triple-negative breast cancer
-
OShaughnessy J, Osborne C, Pippen JE, Yoffe M, Patt D, Rocha C.et al.. Iniparib plus chemotherapy in metastatic triple-negative breast cancer. N Engl J Med 2011; 364: 205-214
-
(2011)
N Engl J Med
, vol.364
, pp. 205-214
-
-
Oshaughnessy, J.1
Osborne, C.2
Pippen, J.E.3
Yoffe, M.4
Patt, D.5
Rocha, C.6
-
133
-
-
80052535308
-
PARP inhibitors stumble in breast cancer
-
Guha M. PARP inhibitors stumble in breast cancer. Nat Biotechnol 2011; 29: 373-374
-
(2011)
Nat Biotechnol
, vol.29
, pp. 373-374
-
-
Guha, M.1
-
134
-
-
84862907868
-
Iniparib nonselectively modifies cysteine-containing proteins in tumor cells and is not a bona fide PARP inhibitor
-
Liu X, Shi Y, Maag DX, Palma JP, Patterson MJ, Ellis PA.et al.. Iniparib nonselectively modifies cysteine-containing proteins in tumor cells and is not a bona fide PARP inhibitor. Clin Cancer Res 2012; 18: 510-523
-
(2012)
Clin Cancer Res
, vol.18
, pp. 510-523
-
-
Liu, X.1
Shi, Y.2
Maag, D.X.3
Palma, J.P.4
Patterson, M.J.5
Ellis, P.A.6
-
135
-
-
84858198901
-
Failure of iniparib to inhibit poly(ADP-Ribose) polymerase in vitro
-
Patel AG, De Lorenzo SB, Flatten KS, Poirier GG, Kaufmann SH. Failure of iniparib to inhibit poly(ADP-Ribose) polymerase in vitro. Clin Cancer Res 2012; 18: 1655-1662
-
(2012)
Clin Cancer Res
, vol.18
, pp. 1655-1662
-
-
Patel, A.G.1
De Lorenzo, S.B.2
Flatten, K.S.3
Poirier, G.G.4
Kaufmann, S.H.5
-
136
-
-
0034604716
-
The breast cancer susceptibility gene BRCA1 is required for subnuclear assembly of Rad51 and survival following treatment with the DNA cross-linking agent cisplatin
-
Bhattacharyya A, Ear US, Koller BH, Weichselbaum RR, Bishop DK. The breast cancer susceptibility gene BRCA1 is required for subnuclear assembly of Rad51 and survival following treatment with the DNA cross-linking agent cisplatin. J Biol Chem 2000; 275: 23899-23903
-
(2000)
J Biol Chem
, vol.275
, pp. 23899-23903
-
-
Bhattacharyya, A.1
Ear, U.S.2
Koller, B.H.3
Weichselbaum, R.R.4
Bishop, D.K.5
-
137
-
-
77953270903
-
Enhancing tumor-specific uptake of the anticancer drug cisplatin with a copper chelator
-
Ishida S, McCormick F, Smith-McCune K, Hanahan D. Enhancing tumor-specific uptake of the anticancer drug cisplatin with a copper chelator. Cancer Cell 2010; 17: 574-583
-
(2010)
Cancer Cell
, vol.17
, pp. 574-583
-
-
Ishida, S.1
McCormick, F.2
Smith-Mccune, K.3
Hanahan, D.4
-
138
-
-
33846404174
-
Molecular mechanisms of resistance and toxicity associated with platinating agents
-
Rabik CA, Dolan ME. Molecular mechanisms of resistance and toxicity associated with platinating agents. Cancer Treat Rev 2007; 33: 9-23
-
(2007)
Cancer Treat Rev
, vol.33
, pp. 9-23
-
-
Rabik, C.A.1
Dolan, M.E.2
-
139
-
-
77954032829
-
Poly(ADP)-ribose polymerase inhibition: Frequent durable responses in BRCA carrier ovarian cancer correlating with platinum-free interval
-
Fong PC, Yap TA, Boss DS, Carden CP, Mergui-Roelvink M, Gourley C.et al.. Poly(ADP)-ribose polymerase inhibition: frequent durable responses in BRCA carrier ovarian cancer correlating with platinum-free interval. J Clin Oncol 2010; 28: 2512-2519
-
(2010)
J Clin Oncol
, vol.28
, pp. 2512-2519
-
-
Fong, P.C.1
Yap, T.A.2
Boss, D.S.3
Carden, C.P.4
Mergui-Roelvink, M.5
Gourley, C.6
-
140
-
-
84866358168
-
The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance
-
Bouwman P, Jonkers J. The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance. Nat Rev Cancer 2012; 12: 587-598
-
(2012)
Nat Rev Cancer
, vol.12
, pp. 587-598
-
-
Bouwman, P.1
Jonkers, J.2
-
141
-
-
39849097680
-
Resistance to therapy caused by intragenic deletion in BRCA2
-
Edwards SL, Brough R, Lord CJ, Natrajan R, Vatcheva R, Levine DA.et al.. Resistance to therapy caused by intragenic deletion in BRCA2. Nature 2008; 451: 1111-1115
-
(2008)
Nature
, vol.451
, pp. 1111-1115
-
-
Edwards, S.L.1
Brough, R.2
Lord, C.J.3
Natrajan, R.4
Vatcheva, R.5
Levine, D.A.6
-
142
-
-
69249100461
-
Functional restoration of BRCA2 protein by secondary BRCA2 mutations in BRCA2-mutated ovarian carcinoma
-
Sakai W, Swisher EM, Jacquemont C, Chandramohan KV, Couch FJ, Langdon SP.et al.. Functional restoration of BRCA2 protein by secondary BRCA2 mutations in BRCA2-mutated ovarian carcinoma. Cancer Res 2009; 69: 6381-6386
-
(2009)
Cancer Res
, vol.69
, pp. 6381-6386
-
-
Sakai, W.1
Swisher, E.M.2
Jacquemont, C.3
Chandramohan, K.V.4
Couch, F.J.5
Langdon, S.P.6
-
143
-
-
39849106300
-
Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers
-
Sakai W, Swisher EM, Karlan BY, Agarwal MK, Higgins J, Friedman C.et al.. Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers. Nature 2008; 451: 1116-1120
-
(2008)
Nature
, vol.451
, pp. 1116-1120
-
-
Sakai, W.1
Swisher, E.M.2
Karlan, B.Y.3
Agarwal, M.K.4
Higgins, J.5
Friedman, C.6
-
144
-
-
42349096328
-
Secondary BRCA1 mutations in BRCA1-mutated ovarian carcinomas with platinum resistance
-
Swisher EM, Sakai W, Karlan BY, Wurz K, Urban N, Taniguchi T. Secondary BRCA1 mutations in BRCA1-mutated ovarian carcinomas with platinum resistance. Cancer Res 2008; 68: 2581-2586
-
(2008)
Cancer Res
, vol.68
, pp. 2581-2586
-
-
Swisher, E.M.1
Sakai, W.2
Karlan, B.Y.3
Wurz, K.4
Urban, N.5
Taniguchi, T.6
-
145
-
-
80051642095
-
Secondary somatic mutations restoring BRCA1/2 predict chemotherapy resistance in hereditary ovarian carcinomas
-
Norquist B, Wurz KA, Pennil CC, Garcia R, Gross J, Sakai W.et al.. Secondary somatic mutations restoring BRCA1/2 predict chemotherapy resistance in hereditary ovarian carcinomas. J Clin Oncol 2011; 29: 3008-3015
-
(2011)
J Clin Oncol
, vol.29
, pp. 3008-3015
-
-
Norquist, B.1
Wurz, K.A.2
Pennil, C.C.3
Garcia, R.4
Gross, J.5
Sakai, W.6
-
146
-
-
47949114668
-
Detection of mutations in EGFR in circulating lung-cancer cells
-
Maheswaran S, Sequist LV, Nagrath S, Ulkus L, Brannigan B, Collura CV.et al.. Detection of mutations in EGFR in circulating lung-cancer cells. N Engl J Med 2008; 359: 366-377
-
(2008)
N Engl J Med
, vol.359
, pp. 366-377
-
-
Maheswaran, S.1
Sequist, L.V.2
Nagrath, S.3
Ulkus, L.4
Brannigan, B.5
Collura, C.V.6
-
147
-
-
33644879468
-
Insights into the molecular basis of human hereditary breast cancer from studies of the BRCA1 BRCT domain
-
Glover JNM. Insights into the molecular basis of human hereditary breast cancer from studies of the BRCA1 BRCT domain. Fam Cancer 2006; 5: 89-93
-
(2006)
Fam Cancer
, vol.5
, pp. 89-93
-
-
Jnm, G.1
-
148
-
-
84862875408
-
BRCA1 tumor suppressor network: Focusing on its tail
-
Wang B. BRCA1 tumor suppressor network: focusing on its tail. Cell &Bioscience 2012; 2: 6
-
(2012)
Cell &Bioscience
, vol.2
, pp. 6
-
-
Wang, B.1
-
149
-
-
77953291328
-
53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers
-
Bouwman P, Aly A, Escandell JM, Pieterse M, Bartkova J, van der Gulden H.et al.. 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers. Nat Struct Mol Biol 2010; 17: 688-695
-
(2010)
Nat Struct Mol Biol
, vol.17
, pp. 688-695
-
-
Bouwman, P.1
Aly, A.2
Escandell, J.M.3
Pieterse, M.4
Bartkova, J.5
Van Der Gulden, H.6
-
150
-
-
77950958141
-
53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks
-
Bunting SF, Callen E, Wong N, Chen H-T, Polato F, Gunn A.et al.. 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks. Cell 2010; 141: 243-254
-
(2010)
Cell
, vol.141
, pp. 243-254
-
-
Bunting, S.F.1
Callen, E.2
Wong, N.3
Chen, H.-T.4
Polato, F.5
Gunn, A.6
-
151
-
-
84872837247
-
Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors
-
Jaspers JE, Kersbergen A, Boon U, Sol W, van Deemter L, Zander SA.et al.. Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors. Cancer Discov 2013; 3: 68-81
-
(2013)
Cancer Discov
, vol.3
, pp. 68-81
-
-
Jaspers, J.E.1
Kersbergen, A.2
Boon, U.3
Sol, W.4
Van Deemter, L.5
Zander, S.A.6
-
152
-
-
77956985875
-
Tumorinitiating cells are not enriched in cisplatin-surviving BRCA1;p53-deficient mammary tumor cells in vivo
-
Pajic M, Kersbergen A, van Diepen F, Pfauth A, Jonkers J, Borst P.et al.. Tumorinitiating cells are not enriched in cisplatin-surviving BRCA1;p53-deficient mammary tumor cells in vivo. Cell Cycle 2010; 9: 3780-3791
-
(2010)
Cell Cycle
, vol.9
, pp. 3780-3791
-
-
Pajic, M.1
Kersbergen, A.2
Van Diepen, F.3
Pfauth, A.4
Jonkers, J.5
Borst, P.6
-
153
-
-
44849143103
-
Cancer stem cells contribute to cisplatin resistance in Brca1/p53-mediated mouse mammary tumors
-
Shafee N, Smith CR, Wei S, Kim Y, Mills GB, Hortobagyi GN.et al.. Cancer stem cells contribute to cisplatin resistance in Brca1/p53-mediated mouse mammary tumors. Cancer Res 2008; 68: 3243-3250
-
(2008)
Cancer Res
, vol.68
, pp. 3243-3250
-
-
Shafee, N.1
Smith, C.R.2
Wei, S.3
Kim, Y.4
Mills, G.B.5
Hortobagyi, G.N.6
-
154
-
-
84866071912
-
Enhancement of synthetic lethality via combinations of ABT-888, a PARP inhibitor, and carboplatin in vitro and in vivo using BRCA1 and BRCA2 isogenic models
-
Clark CC, Weitzel JN, OConnor TR. Enhancement of synthetic lethality via combinations of ABT-888, a PARP inhibitor, and carboplatin in vitro and in vivo using BRCA1 and BRCA2 isogenic models. Mol Cancer Ther 2012; 11: 1948-1958
-
(2012)
Mol Cancer Ther
, vol.11
, pp. 1948-1958
-
-
Clark, C.C.1
Weitzel, J.N.2
Oconnor, T.R.3
-
155
-
-
76749114340
-
Sensitivity and acquired resistance of BRCA1;p53-deficient mouse mammary tumors to the topoisomerase i inhibitor topotecan
-
Zander SAL, Kersbergen A, van der Burg E, de Water N, van Tellingen O, Gunnarsdottir S.et al.. Sensitivity and acquired resistance of BRCA1;p53-deficient mouse mammary tumors to the topoisomerase I inhibitor topotecan. Cancer Res 2010; 70: 1700-1710
-
(2010)
Cancer Res
, vol.70
, pp. 1700-1710
-
-
Sal, Z.1
Kersbergen, A.2
Van Der Burg, E.3
De Water, N.4
Van Tellingen, O.5
Gunnarsdottir, S.6
-
156
-
-
69549145898
-
The potential role and application of PARP inhibitors in cancer treatment
-
Chalmers AJ. The potential role and application of PARP inhibitors in cancer treatment. Br Med Bull 2009; 89: 23-40
-
(2009)
Br Med Bull
, vol.89
, pp. 23-40
-
-
Chalmers, A.J.1
-
157
-
-
0033527577
-
Heregulin induces phosphorylation of BRCA1 through phosphatidylinositol 3-Kinase/AKT in breast cancer cells
-
Altiok S, Batt D, Altiok N, Papautsky A, Downward J, Roberts TM.et al.. Heregulin induces phosphorylation of BRCA1 through phosphatidylinositol 3-Kinase/AKT in breast cancer cells. J Biol Chem 1999; 274: 32274-32278
-
(1999)
J Biol Chem
, vol.274
, pp. 32274-32278
-
-
Altiok, S.1
Batt, D.2
Altiok, N.3
Papautsky, A.4
Downward, J.5
Roberts, T.M.6
-
158
-
-
33646869228
-
BRCA1 phosphorylation: Biological consequences
-
Ouchi T. BRCA1 phosphorylation: biological consequences. Cancer Biol Ther 2006; 5: 470-475
-
(2006)
Cancer Biol Ther
, vol.5
, pp. 470-475
-
-
Ouchi, T.1
-
159
-
-
57749115897
-
Negative regulation of AKT activation by BRCA1
-
Xiang T, Ohashi A, Huang Y, Pandita TK, Ludwig T, Powell SN.et al.. Negative regulation of AKT activation by BRCA1. Cancer Res 2008; 68: 10040-10044
-
(2008)
Cancer Res
, vol.68
, pp. 10040-10044
-
-
Xiang, T.1
Ohashi, A.2
Huang, Y.3
Pandita, T.K.4
Ludwig, T.5
Powell, S.N.6
-
160
-
-
79957585507
-
Targeting the Akt/mTOR pathway in Brca1-deficient cancers
-
Xiang T, Jia Y, Sherris D, Li S, Wang H, Lu D.et al.. Targeting the Akt/mTOR pathway in Brca1-deficient cancers. Oncogene 2011; 30: 2443-2450
-
(2011)
Oncogene
, vol.30
, pp. 2443-2450
-
-
Xiang, T.1
Jia, Y.2
Sherris, D.3
Li, S.4
Wang, H.5
Lu, D.6
-
161
-
-
84859481137
-
Co-targeting of the PI3K pathway improves the response of BRCA1 deficient breast cancer cells to PARP1 inhibition
-
Kimbung S, Biskup E, Johansson I, Aaltonen K, Ottosson-Wadlund A, Gruvberger-Saal S.et al.. Co-targeting of the PI3K pathway improves the response of BRCA1 deficient breast cancer cells to PARP1 inhibition. Cancer Letters [Internet] 2012; 319: 232-241
-
(2012)
Cancer Letters [Internet]
, vol.319
, pp. 232-241
-
-
Kimbung, S.1
Biskup, E.2
Johansson, I.3
Aaltonen, K.4
Ottosson-Wadlund, A.5
Gruvberger-Saal, S.6
-
162
-
-
84866709651
-
Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast Cancer
-
Juvekar A, Burga LN, Hu H, Lunsford EP, Ibrahim YH, Balmañá J.et al.. Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast Cancer. Cancer Discov 2012; 2: 1048-1063
-
(2012)
Cancer Discov
, vol.2
, pp. 1048-1063
-
-
Juvekar, A.1
Burga, L.N.2
Hu, H.3
Lunsford, E.P.4
Ibrahim, Y.H.5
Balmañá, J.6
-
163
-
-
84866681744
-
PI3K inhibition impairs BRCA1/2 expression and sensitizes BRCA-proficient triplenegative breast cancer to PARP inhibition
-
Ibrahim YH, García-García C, Serra V, He L, Torres-Lockhart K, Prat A.et al.. PI3K inhibition impairs BRCA1/2 expression and sensitizes BRCA-proficient triplenegative breast cancer to PARP inhibition. Cancer Discov 2012; 2: 1036-1047
-
(2012)
Cancer Discov
, vol.2
, pp. 1036-1047
-
-
Ibrahim, Y.H.1
García-García, C.2
Serra, V.3
He, L.4
Torres-Lockhart, K.5
Prat, A.6
-
164
-
-
33748069123
-
Cyclindependent kinase 2 functions in normal DNA repair and is a therapeutic target in BRCA1-deficient cancers
-
Deans AJ, Khanna KK, McNees CJ, Mercurio C, Heierhorst J, McArthur GA. Cyclindependent kinase 2 functions in normal DNA repair and is a therapeutic target in BRCA1-deficient cancers. Cancer Res 2006; 66: 8219-8226
-
(2006)
Cancer Res
, vol.66
, pp. 8219-8226
-
-
Deans, A.J.1
Khanna, K.K.2
McNees, C.J.3
Mercurio, C.4
Heierhorst, J.5
McArthur, G.A.6
-
165
-
-
34547628200
-
Proteasome function is required for DNA damage response and fanconi anemia pathway activation
-
Jacquemont C, Taniguchi T. Proteasome function is required for DNA damage response and fanconi anemia pathway activation. Cancer Res 2007; 67: 7395-7405
-
(2007)
Cancer Res
, vol.67
, pp. 7395-7405
-
-
Jacquemont, C.1
Taniguchi, T.2
-
166
-
-
68849126662
-
Enhanced radiosensitization of human glioma cells by combining inhibition of poly(ADP-ribose) polymerase with inhibition of heat shock protein 90
-
Dungey FA, Caldecott KW, Chalmers AJ. Enhanced radiosensitization of human glioma cells by combining inhibition of poly(ADP-ribose) polymerase with inhibition of heat shock protein 90. Mol Cancer Ther 2009; 8: 2243-2254
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 2243-2254
-
-
Dungey, F.A.1
Caldecott, K.W.2
Chalmers, A.J.3
-
167
-
-
79960003299
-
Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition
-
Krawczyk PM, Eppink B, Essers J, Stap J, Rodermond H, Odijk H.et al.. Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition. Proc Natl Acad Sci USA 2011; 108: 9851-9856
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 9851-9856
-
-
Krawczyk, P.M.1
Eppink, B.2
Essers, J.3
Stap, J.4
Rodermond, H.5
Odijk, H.6
-
168
-
-
77954702308
-
BRCA1 16 years later: DNA damage-induced BRCA1 shuttling
-
Yang ES, Xia F. BRCA1 16 years later: DNA damage-induced BRCA1 shuttling. FEBS J 2010; 277: 3079-3085
-
(2010)
FEBS J
, vol.277
, pp. 3079-3085
-
-
Yang, E.S.1
Xia, F.2
-
169
-
-
56449098784
-
Erlotinib attenuates homologous recombinational repair of chromosomal breaks in human breast cancer cells
-
Li L, Wang H, Yang ES, Arteaga CL, Xia F. Erlotinib attenuates homologous recombinational repair of chromosomal breaks in human breast cancer cells. Cancer Res 2008; 68: 9141-9146
-
(2008)
Cancer Res
, vol.68
, pp. 9141-9146
-
-
Li, L.1
Wang, H.2
Yang, E.S.3
Arteaga, C.L.4
Xia, F.5
-
170
-
-
84868237277
-
Targeting BRCA1 localization to augment breast tumor sensitivity to poly(ADP-Ribose) polymerase inhibition
-
Yang ES, Nowsheen S, Rahman MA, Cook RS, Xia F. Targeting BRCA1 localization to augment breast tumor sensitivity to poly(ADP-Ribose) polymerase inhibition. Cancer Res 2012; 72: 5547-5555
-
(2012)
Cancer Res
, vol.72
, pp. 5547-5555
-
-
Yang, E.S.1
Nowsheen, S.2
Rahman, M.A.3
Cook, R.S.4
Xia, F.5
-
171
-
-
80052389761
-
Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: A phase 2, multicentre, openlabel, non-randomised study
-
Gelmon KA, Tischkowitz M, Mackay H, Swenerton K, Robidoux A, Tonkin K.et al.. Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, openlabel, non-randomised study. Lancet Oncol 2011; 12: 852-861.
-
(2011)
Lancet Oncol
, vol.12
, pp. 852-861
-
-
Gelmon, K.A.1
Tischkowitz, M.2
Mackay, H.3
Swenerton, K.4
Robidoux, A.5
Tonkin, K.6
-
172
-
-
84863236347
-
A phase i study of veliparib in combination with metronomic cyclophosphamide in adults with refractory solid tumors and lymphomas
-
Kummar S, Ji J, Morgan R, Lenz H-J, Puhalla SL, Belani CP.et al.. A phase I study of veliparib in combination with metronomic cyclophosphamide in adults with refractory solid tumors and lymphomas. Clin Cancer Res 2012; 18: 1726-1734.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 1726-1734
-
-
Kummar, S.1
Ji, J.2
Morgan, R.3
Lenz, H.-J.4
Puhalla, S.L.5
Belani, C.P.6
|