BRCA1 tumour suppression occurs via heterochromatin-mediated silencing

Nature

Volumn 477, Issue 7363, 2011, Pages 179-184

  Zhu, Quan ^a   Pao, Gerald M ^a   Huynh, Alexis M ^a,c   Suh, Hoonkyo ^a,d   Tonnu, Nina ^a   Nederlof, Petra M ^b   Gage, Fred H ^a   Verma, Inder M ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b NETHERLANDS CANCER INSTITUTE   (Netherlands)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; HISTONE H2A; SATELLITE DNA;

BIOCHEMISTRY; CANCER; DNA; FUNCTIONAL ROLE; GENE EXPRESSION; GENETIC MARKER; GENOME; HOMINID; MUTATION; PROTEIN; RODENT; TUMOR; WOMENS HEALTH;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BREAST CANCER; CANCER INHIBITION; CELL CYCLE; CENTROSOME; CONTROLLED STUDY; DNA DAMAGE; FEMALE; GENE EXPRESSION; GENE MUTATION; GENE REPRESSION; GENE SILENCING; GENETIC TRANSCRIPTION; GENOME; GENOMIC INSTABILITY; HETEROCHROMATIN; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE; UBIQUITINATION;

ANIMALS; BRCA1 PROTEIN; BREAST; BREAST NEOPLASMS; CELL LINE, TUMOR; CELLS, CULTURED; DNA, SATELLITE; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; GENES, BRCA1; GENOMIC INSTABILITY; HELA CELLS; HETEROCHROMATIN; HISTONES; HUMANS; MICE; OVARIAN NEOPLASMS; RNA, MESSENGER; TRANSCRIPTION, GENETIC; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATED PROTEINS; UBIQUITINATION;

MUS;

EID: 80052567822     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature10371     Document Type: Article

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