Prevalence and contribution of BRCA1 mutations in breast cancer and ovarian cancer: Results from three U.S. population-based case-control studies of ovarian cancer

American Journal of Human Genetics

Volumn 60, Issue 3, 1997, Pages 496-504

  Whittemore, Alice S ^a   Gong, Gail ^a   Itnyre, Jacqueline ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; BREAST CANCER; CANCER RISK; ETHNOLOGY; FEMALE; GENE MUTATION; HETEROZYGOTE; HUMAN; MAJOR CLINICAL STUDY; OVARY CANCER; PREVALENCE; PRIORITY JOURNAL; RISK ASSESSMENT;

ADULT; AGED; AGED, 80 AND OVER; BRCA1 PROTEIN; BREAST NEOPLASMS; CASE-CONTROL STUDIES; FEMALE; GENE FREQUENCY; GERM-LINE MUTATION; HETEROZYGOTE; HUMANS; MIDDLE AGED; MODELS, GENETIC; OVARIAN NEOPLASMS; PEDIGREE; PREVALENCE; REGISTRIES; RISK FACTORS; UNITED STATES;

EID: 0031025322     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Auranen A, Gienman S, Makinen E, Sankila R, Salmi T (1996) Borderline ovarian tumors in Einhard: epidemiology and familial occurrence. Am J Epidemiol 144:548-553
2. Cancer and Steroid Hormone (CASH) Study of the Centers for Disease Control and the National Institute of Child Health and Human Development, The (1987) The reduction in risk of ovarian cancer associated with oral-contraceptive use. N Engl J Med 316:650-655
3. Casagrande JT, Louie EW, Pike MC, Roy S, Ross RK, Henderson BE (1979) Incessant ovulation and ovarian cancer. Lancet 2:170-173
4. Claus EB, Risch N, Thompson WD (1991) Genetic analysis of breast cancer in the Cancer and Steroid Hormone Study. Am J Hum Genet 48:232-242
5. Easton DF, Ford D, Bishop DT, Breast Cancer Linkage Consortium (1995) Breast and ovarian cancer incidence in BRCA1-mutation carriers. Am J Hum Genet 56:265-271
6. Ford D, Easton DF, Peto J (1995) Estimates of the gene frequency of BRCA1 and its contribution to breast and ovarian cancer incidence. Am J Hum Genet 57:1457-1462
7. Kelsey J, Whittemore AS, Even A, Thompson WD (1996) Observational epidemiology, 2d ed. Oxford University Press, Oxford
8. Krontiris TG, Devlin B, Karp DD, Robert NJ, Risch N (1993) An association between the risk of cancer and mutations in the HRAS1 minisatellite locus. N Engl J Med 329:517-523
9. Langston AA, Malone KE, Thompson JD, Daling JR, Ostrander EA (1996) BRCA1 mutations in a population-based sample of young women with breast cancer. N Engl J Med 334:137-142
10. Narod SA, Ford D, Devilee P, Barkardottir RB, Lynch HT, Smith SA, Ponder BAJ, et al (1995) An evaluation of genetic heterogeneity in 145 breast-ovarian cancer families. Am J Hum Genet 56:254-264
11. Phelan CM, Lancaster JM, Tonin P, Gumbs C, Cochran C, Carter R, Ghadirian P, et al (1996) Mutation analysis of the BRCA2 gene in 49 site-specific breast cancer families. Nat Genet 13:120-122
12. Schildkraut JM, Thompson WD (1988) Familial ovarian cancer: a population-based case control study. Am J Epidemiol 128:456-466
13. Whittemore AS, Harris R, Itnyre J, Halpern J, Collaborative Ovarian Cancer Group (1992) Characteristics relating to ovarian cancer risk: collaborative analysis of 12 US case-control studies. I. Methods. Am J Epidemiol 136:1175-1183
14. Whittemore AS, Wu ML, Paffenbarger RS Jr, Sarles DL, Kampert JB, Grosser S, Jung DL, et al (1988) Personal and environmental characteristics related to epithelial ovarian cancer. II. Exposures to talcum powder, tobacco, alcohol, and coffee. Am J Epidemiol 128:1228-1240