Discovery of the Poly(ADP-ribose) polymerase (PARP) inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the treatment of cancer.

Journal of medicinal chemistry

Volumn 52, Issue 2, 2009, Pages 514-523

  Penning, Thomas D ^a   Zhu, Gui Dong ^a   Gandhi, Viraj B ^a   Gong, Jianchun ^a   Liu, Xuesong ^a   Shi, Yan ^a   Klinghofer, Vered ^a   Johnson, Eric F ^a   Donawho, Cherrie K ^a   Frost, David J ^a   Bontcheva Diaz, Velitchka ^a   Bouska, Jennifer J ^a   Osterling, Donald J ^a   Olson, Amanda M ^a   Marsh, Kennan C ^a   Luo, Yan ^a   Giranda, Vincent L ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 ((R) 2 METHYLPYRROLIDIN 2 YL) 1H BENZIMIDAZOLE 4 CARBOXAMIDE; 2-((R)-2-METHYLPYRROLIDIN-2-YL)-1H-BENZIMIDAZOLE-4-CARBOXAMIDE; ANTINEOPLASTIC AGENT; BENZIMIDAZOLE DERIVATIVE; CARBOPLATIN; CYCLOPHOSPHAMIDE; DACARBAZINE; DRUG DERIVATIVE; ENZYME INHIBITOR; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; TEMOZOLOMIDE;

ANIMAL; AREA UNDER THE CURVE; ARTICLE; BIOAVAILABILITY; DOG; DRUG ANTAGONISM; EXPERIMENTAL MELANOMA; FEMALE; HAPLORHINI; HUMAN; MOUSE; MOUSE MUTANT; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PATHOLOGY; RAT;

ANIMALS; ANTINEOPLASTIC AGENTS; AREA UNDER CURVE; BENZIMIDAZOLES; BIOLOGICAL AVAILABILITY; CARBOPLATIN; CYCLOPHOSPHAMIDE; DACARBAZINE; DOGS; ENZYME INHIBITORS; FEMALE; HAPLORHINI; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MELANOMA, EXPERIMENTAL; MICE; MICE, SCID; POLY(ADP-RIBOSE) POLYMERASES; RATS;

EID: 60549117554     PISSN: None     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm801171j     Document Type: Article

References (0)