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Volumn 21, Issue 33, 2002, Pages 5097-5107

Mammary tumors in mice conditionally mutant for Brca1 exhibit gross genomic instability and centrosome amplification yet display a recurring distribution of genomic imbalances that is similar to human breast cancer

(8) Weaver, Zoë a,e Montagna, Cristina a Xu, Xiaoling b Howard, Tamara c Gadina, Massimo d Brodie, Steven G b Deng, Chu Xia b Ried, Thomas a

a NATIONAL CANCER INSTITUTE (United States)

b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES (United States)

c Simons Center for Quantitative Biology (United States)

d NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES (United States)

e Avalon Pharmaceuticals (United States)

Author keywords

Brca1; Centrosome; Genomic imbalances; Mouse models; SKY

Indexed keywords

ANEUPLOIDY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; CARCINOGENESIS; CENTROSOME; CHROMOSOME 11; CHROMOSOME 14; CHROMOSOME 15; CHROMOSOME 17Q; CHROMOSOME LOSS; CHROMOSOME MAP; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; FIBROBLAST; GENE AMPLIFICATION; GENE MUTATION; GENETIC CONSERVATION; GENETIC SUSCEPTIBILITY; GENOME; HUMAN; HUMAN CELL; KARYOTYPING; MICROSATELLITE INSTABILITY; MITOSIS; MOUSE; MOUSE MUTANT; NONHUMAN; ONCOGENE; ONCOGENE C MYC; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

ANEUPLOIDY; ANIMALS; BLOTTING, WESTERN; BRCA1 PROTEIN; BREAST NEOPLASMS; CENTROSOME; CHROMOSOME ABERRATIONS; CHROMOSOME PAINTING; CHROMOSOMES, HUMAN, PAIR 11; GENES, BRCA1; HUMANS; KARYOTYPING; MAMMARY NEOPLASMS, ANIMAL; MICE; MITOSIS; MUTATION; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA; MAMMALIA;

EID: 0036675318 PISSN: 09509232 EISSN: None Source Type: Journal
DOI: 10.1038/sj.onc.1205636 Document Type: Article

Times cited : (126)

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