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Volumn 28, Issue 7, 2014, Pages 961-975

Puerarin: A review of pharmacological effects

Author keywords

pharmacology; Pueraria lobata; puerarin

Indexed keywords

ADENYLATE KINASE; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PUERARIN; PURINERGIC P2X3 RECEPTOR; THROMBOSPONDIN 1;

EID: 84904262184     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.5083     Document Type: Review
Times cited : (549)

References (174)
  • 1
    • 77953376745 scopus 로고    scopus 로고
    • Puerarin antagonizes activation effect of LPS on N9 microglia cells
    • Bai QH, Li WM, Liu HT, et al,. 2010. Puerarin antagonizes activation effect of LPS on N9 microglia cells. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 26: 227-230.
    • (2010) Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi , vol.26 , pp. 227-230
    • Bai, Q.H.1    Li, W.M.2    Liu, H.T.3
  • 2
    • 24044443879 scopus 로고    scopus 로고
    • Protection by puerarin against MPP+-induced neurotoxicity in PC12 cells mediated by inhibiting mitochondrial dysfunction and caspase-3-like activation
    • DOI 10.1016/j.neures.2005.06.014, PII S0168010205001847
    • +-induced neurotoxicity in PC12 cells mediated by inhibiting mitochondrial dysfunction and caspase-3-like activation. Neurosci Res 53: 183-188. (Pubitemid 41219535)
    • (2005) Neuroscience Research , vol.53 , Issue.2 , pp. 183-188
    • Bo, J.1    Bao, Y.M.2    Li, Z.G.3    Lei, C.4    An, L.J.5
  • 3
    • 0034687171 scopus 로고    scopus 로고
    • Vasoregulation by the β1 subunit of the calcium-activated potassium channel
    • Brenner R, Perez GJ, Bonev AD, et al,. 2000. Vasoregulation by the β1 subunit of the calcium-activated potassium channel. Nature 407: 870-876.
    • (2000) Nature , vol.407 , pp. 870-876
    • Brenner, R.1    Perez, G.J.2    Bonev, A.D.3
  • 4
    • 79959471923 scopus 로고    scopus 로고
    • Effects of puerarin on proliferation and differentiation of umbilical cord mesenchymal stem cells into osteoblasts in vitro
    • Cai H, Wu LL, Sun XC, et al,. 2011. Effects of puerarin on proliferation and differentiation of umbilical cord mesenchymal stem cells into osteoblasts in vitro. Yao Xue Xue Bao 46: 738-741.
    • (2011) Yao Xue Xue Bao , vol.46 , pp. 738-741
    • Cai, H.1    Wu, L.L.2    Sun, X.C.3
  • 5
    • 63449119215 scopus 로고    scopus 로고
    • Neuroprotective mechanisms of puerarin in middle cerebral artery occlusion-induced brain infarction in rats
    • Chang Y, Hsieh CY, Peng ZA, et al,. 2009. Neuroprotective mechanisms of puerarin in middle cerebral artery occlusion-induced brain infarction in rats. J Biomed Sci 16: 19.
    • (2009) J Biomed Sci , vol.16 , pp. 19
    • Chang, Y.1    Hsieh, C.Y.2    Peng, Z.A.3
  • 6
    • 84863392435 scopus 로고    scopus 로고
    • Puerarin induces mitochondria-dependent apoptosis in hypoxic human pulmonary arterial smooth muscle cells
    • Chen C, Chen C, Wang Z, et al,. 2012a. Puerarin induces mitochondria-dependent apoptosis in hypoxic human pulmonary arterial smooth muscle cells. PLoS One 7: e34181.
    • (2012) PLoS One , vol.7
    • Chen, C.1    Chen, C.2    Wang, Z.3
  • 7
    • 84872043922 scopus 로고    scopus 로고
    • Effects of puerarin on proliferation, apoptosis and Kv1.5 gene expression of pulmonary artery smooth muscle cells induced by hypoxia
    • Chen C, Wang ZY, Wang LX, et al,. 2011a. Effects of puerarin on proliferation, apoptosis and Kv1.5 gene expression of pulmonary artery smooth muscle cells induced by hypoxia. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 29: 731-734.
    • (2011) Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi , vol.29 , pp. 731-734
    • Chen, C.1    Wang, Z.Y.2    Wang, L.X.3
  • 8
    • 70350243047 scopus 로고    scopus 로고
    • Impact effects of puerarin on mouse embryonic development
    • Chen CC, Chan WH,. 2009. Impact effects of puerarin on mouse embryonic development. Reprod Toxicol 28: 530-535.
    • (2009) Reprod Toxicol , vol.28 , pp. 530-535
    • Chen, C.C.1    Chan, W.H.2
  • 9
    • 84869066558 scopus 로고    scopus 로고
    • Puerarin enhances superoxide dismutase activity and inhibits RAGE and VEGF expression in retinas of STZ-induced early diabetic rats
    • Chen F, Zhang HQ, Zhu J, et al,. 2012b. Puerarin enhances superoxide dismutase activity and inhibits RAGE and VEGF expression in retinas of STZ-induced early diabetic rats. Asian Pac J Trop Med 5: 891-896.
    • (2012) Asian Pac J Trop Med , vol.5 , pp. 891-896
    • Chen, F.1    Zhang, H.Q.2    Zhu, J.3
  • 10
    • 42149186404 scopus 로고    scopus 로고
    • Molecular mechanism of reversing multi-drug resistance of K562/AO2 by puerarin
    • Chen JW, Tao S, Luo R, et al,. 2008. Molecular mechanism of reversing multi-drug resistance of K562/AO2 by puerarin. Zhong Nan Da Xue Xue Bao Yi Xue Ban 33: 216-221.
    • (2008) Zhong Nan da Xue Xue Bao Yi Xue Ban , vol.33 , pp. 216-221
    • Chen, J.W.1    Tao, S.2    Luo, R.3
  • 11
    • 84865063532 scopus 로고    scopus 로고
    • Puerarin prevents isoprenaline-induced myocardial fibrosis in mice by reduction of myocardial TGF-β1 expression
    • Chen R, Xue J, Xie M,. 2012c. Puerarin prevents isoprenaline-induced myocardial fibrosis in mice by reduction of myocardial TGF-β1 expression. J Nutr Biochem 23: 1080-1085.
    • (2012) J Nutr Biochem , vol.23 , pp. 1080-1085
    • Chen, R.1    Xue, J.2    Xie, M.3
  • 12
    • 80052003622 scopus 로고    scopus 로고
    • Endometriotic implants regress in rat models treated with puerarin by decreasing estradiol level
    • Chen Y, Chen C, Shi S, et al,. 2011b. Endometriotic implants regress in rat models treated with puerarin by decreasing estradiol level. Reprod Sci 18: 886-891.
    • (2011) Reprod Sci , vol.18 , pp. 886-891
    • Chen, Y.1    Chen, C.2    Shi, S.3
  • 13
    • 84860242273 scopus 로고    scopus 로고
    • Puerarin protects human umbilical vein endothelial cells against high glucose-induced apoptosis by upregulating heme oxygenase-1 and inhibiting calpain activation
    • Chen YY, Chen J, Zhou XM, et al,. 2012d. Puerarin protects human umbilical vein endothelial cells against high glucose-induced apoptosis by upregulating heme oxygenase-1 and inhibiting calpain activation. Fundam Clin Pharmacol 26: 322-331.
    • (2012) Fundam Clin Pharmacol , vol.26 , pp. 322-331
    • Chen, Y.Y.1    Chen, J.2    Zhou, X.M.3
  • 14
    • 84866546246 scopus 로고    scopus 로고
    • Puerarin suppresses proliferation of endometriotic stromal cells partly via the MAPK signaling pathway induced by 17β-estradiol-BSA
    • Cheng W, Chen L, Yang S, et al,. 2012. Puerarin suppresses proliferation of endometriotic stromal cells partly via the MAPK signaling pathway induced by 17β-estradiol-BSA. PLoS One 7: e45529.
    • (2012) PLoS One , vol.7
    • Cheng, W.1    Chen, L.2    Yang, S.3
  • 15
    • 80051524339 scopus 로고    scopus 로고
    • Protective effects of puerarin against 1-methyl-4-phenylpyridinium- induced mitochondrial apoptotic death in differentiated SH-SY5Y cells
    • Cheng Y, Zhu G, Guan Y, et al,. 2011. Protective effects of puerarin against 1-methyl-4-phenylpyridinium-induced mitochondrial apoptotic death in differentiated SH-SY5Y cells. Zhongguo Zhong Yao Za Zhi 36: 1222-1226.
    • (2011) Zhongguo Zhong Yao Za Zhi , vol.36 , pp. 1222-1226
    • Cheng, Y.1    Zhu, G.2    Guan, Y.3
  • 16
    • 57649142972 scopus 로고    scopus 로고
    • Involvement of ubiquitin proteasome system in protective mechanisms of Puerarin to MPP(+)-elicited apoptosis
    • Cheng YF, Zhu GQ, Wang M, et al,. 2009. Involvement of ubiquitin proteasome system in protective mechanisms of Puerarin to MPP(+)-elicited apoptosis. Neurosci Res 63: 52-58.
    • (2009) Neurosci Res , vol.63 , pp. 52-58
    • Cheng, Y.F.1    Zhu, G.Q.2    Wang, M.3
  • 17
    • 77952425134 scopus 로고    scopus 로고
    • Effects of the isoflavone puerarin and its glycosides on melanogenesis in B16 melanocytes
    • Choi YM, Jun HJ, Dawson K, et al,. 2010. Effects of the isoflavone puerarin and its glycosides on melanogenesis in B16 melanocytes. Eur Food Res Technol 231: 75-83.
    • (2010) Eur Food Res Technol , vol.231 , pp. 75-83
    • Choi, Y.M.1    Jun, H.J.2    Dawson, K.3
  • 19
    • 84877139221 scopus 로고    scopus 로고
    • Effect of puerarin in myocardial protection in rats with acute and chronic alcoholism
    • Cui SQ,. 2011. Effect of puerarin in myocardial protection in rats with acute and chronic alcoholism. Nan Fang Yi Ke Da Xue Xue Bao 31: 2035-2038.
    • (2011) Nan Fang Yi Ke da Xue Xue Bao , vol.31 , pp. 2035-2038
    • Cui, S.Q.1
  • 20
    • 83555165215 scopus 로고    scopus 로고
    • Mechanisms of the cerebral vasodilator actions of isoflavonoids of Gegen on rat isolated basilar artery
    • Deng Y, Ng ES, Yeung JH, et al,. 2012. Mechanisms of the cerebral vasodilator actions of isoflavonoids of Gegen on rat isolated basilar artery. J Ethnopharmacol 139: 294-304.
    • (2012) J Ethnopharmacol , vol.139 , pp. 294-304
    • Deng, Y.1    Ng, E.S.2    Yeung, J.H.3
  • 21
    • 38549120211 scopus 로고    scopus 로고
    • Effects of puerarin on expression of nuclear factor kappaB after cerebral ischemia/reperfusion in rats
    • Ding MP, Feng F, Hu HT,. 2007. Effects of puerarin on expression of nuclear factor kappaB after cerebral ischemia/reperfusion in rats. Zhongguo Zhong Yao Za Zhi 32: 2515-2518.
    • (2007) Zhongguo Zhong Yao Za Zhi , vol.32 , pp. 2515-2518
    • Ding, M.P.1    Feng, F.2    Hu, H.T.3
  • 22
    • 67149102151 scopus 로고    scopus 로고
    • Puerarin protects against ischemic brain injury in a rat model of transient focal ischemia
    • Gao L, Ji X, Song J, et al,. 2009a. Puerarin protects against ischemic brain injury in a rat model of transient focal ischemia. Neurol Res 31: 402-406.
    • (2009) Neurol Res , vol.31 , pp. 402-406
    • Gao, L.1    Ji, X.2    Song, J.3
  • 23
    • 84864322341 scopus 로고    scopus 로고
    • Of berberine and puerarin on dexamethesone-induced insulin resistance in porcine ovarian thecal cells
    • Gao L, Li W, Kuang HY,. 2009b. Of berberine and puerarin on dexamethesone-induced insulin resistance in porcine ovarian thecal cells. Zhongguo Zhong Xi Yi Jie He Za Zhi 29: 623-627.
    • (2009) Zhongguo Zhong Xi Yi Jie He Za Zhi , vol.29 , pp. 623-627
    • Gao, L.1    Li, W.2    Kuang, H.Y.3
  • 24
    • 33646890644 scopus 로고    scopus 로고
    • Atractyloside and 5-hydroxydecanoate block the protective effect of puerarin in isolated rat heart
    • DOI 10.1016/j.lfs.2005.12.040, PII S0024320506000142
    • Gao Q, Pan HY, Qiu S, et al,. 2006. Atractyloside and 5-hydroxydecanoate block the protective effect of puerarin in isolated rat. Life Sci 79: 217-224. (Pubitemid 43782549)
    • (2006) Life Sciences , vol.79 , Issue.3 , pp. 217-224
    • Gao, Q.1    Pan, H.-Y.2    Qiu, S.3    Lu, Y.4    Bruce, I.C.5    Luo, J.-H.6    Xia, Q.7
  • 25
    • 35348870371 scopus 로고    scopus 로고
    • Opening the calcium-activated potassium channel participates in the cardioprotective effect of puerarin
    • DOI 10.1016/j.ejphar.2007.07.018, PII S0014299907007972
    • Gao Q, Yang B, Ye ZG, et al,. 2007. Opening the calcium-activated potassium channel participates in the cardioprotective effect of puerarin. Eur J Pharmacol 574: 179-184. (Pubitemid 47575526)
    • (2007) European Journal of Pharmacology , vol.574 , Issue.2-3 , pp. 179-184
    • Gao, Q.1    Yang, B.2    Ye, Z.-g.3    Wang, J.4    Bruce, I.C.5    Xia, Q.6
  • 26
    • 77951058366 scopus 로고    scopus 로고
    • Puerarin inhibits acid-sensing ion channels and protects against neuron death induced by acidosis
    • Gu L, Yang Y, Sun Y, Zheng X,. 2010. Puerarin inhibits acid-sensing ion channels and protects against neuron death induced by acidosis. Planta Med 76: 583-588.
    • (2010) Planta Med , vol.76 , pp. 583-588
    • Gu, L.1    Yang, Y.2    Sun, Y.3    Zheng, X.4
  • 27
    • 84875768328 scopus 로고    scopus 로고
    • Anti-fibrotic effects of puerarin on CCl4-induced hepatic fibrosis in rats possibly through the regulation of PPAR-γ expression and inhibition of PI3K/Akt pathway
    • Guo C, Xu L, He Q, et al,. 2013. Anti-fibrotic effects of puerarin on CCl4-induced hepatic fibrosis in rats possibly through the regulation of PPAR-γ expression and inhibition of PI3K/Akt pathway. Food Chem Toxicol 56C: 436-442.
    • (2013) Food Chem Toxicol , vol.56 C , pp. 436-442
    • Guo, C.1    Xu, L.2    He, Q.3
  • 28
    • 23244456299 scopus 로고    scopus 로고
    • Effect of puerarin on l -type calcium channel in isolated rat ventricular myocytes
    • Guo XG, Chen JZ, Zhang X, Xia Q,. 2004. Effect of puerarin on l -type calcium channel in isolated rat ventricular myocytes. Zhongguo Zhong Yao Za Zhi 29: 248-251.
    • (2004) Zhongguo Zhong Yao Za Zhi , vol.29 , pp. 248-251
    • Guo, X.G.1    Chen, J.Z.2    Zhang, X.3    Xia, Q.4
  • 29
    • 84864306824 scopus 로고    scopus 로고
    • Inhibitory effects of puerarin on invasion and metastasis of oophoroma cells HO-8910
    • Han J, Yu CQ, Shen W,. 2009. Inhibitory effects of puerarin on invasion and metastasis of oophoroma cells HO-8910. Zhongguo Zhong Xi Yi Jie He Za Zhi 29: 632-635.
    • (2009) Zhongguo Zhong Xi Yi Jie He Za Zhi , vol.29 , pp. 632-635
    • Han, J.1    Yu, C.Q.2    Shen, W.3
  • 30
    • 84880211278 scopus 로고    scopus 로고
    • Effects of puerarin on the neurocyte apoptosis and p-Akt (Ser473) expressions in rats with cerebral ischemia/reperfusion injury
    • Han JQ, Yu KY, He M,. 2012. Effects of puerarin on the neurocyte apoptosis and p-Akt (Ser473) expressions in rats with cerebral ischemia/reperfusion injury. Zhongguo Zhong Xi Yi Jie He Za Zhi 32: 1069-1072.
    • (2012) Zhongguo Zhong Xi Yi Jie He Za Zhi , vol.32 , pp. 1069-1072
    • Han, J.Q.1    Yu, K.Y.2    He, M.3
  • 31
    • 57949115419 scopus 로고    scopus 로고
    • The effect of puerarin on prevention of oxidative damage of cultured lens capsule epithelial cells
    • Hao LN, He SZ, Luo XM, et al,. 2008. The effect of puerarin on prevention of oxidative damage of cultured lens capsule epithelial cells. Zhonghua Yan Ke Za Zhi 44: 163-169.
    • (2008) Zhonghua Yan Ke Za Zhi , vol.44 , pp. 163-169
    • Hao, L.N.1    He, S.Z.2    Luo, X.M.3
  • 32
    • 84860813183 scopus 로고    scopus 로고
    • Protective effects of puerarin on lens epithelial cells in rat diabetic cataract
    • Hao LN, He SZ, Shen YH, et al,. 2011a. Protective effects of puerarin on lens epithelial cells in rat diabetic cataract. Zhonghua Yan Ke Za Zhi 47: 320-326.
    • (2011) Zhonghua Yan Ke Za Zhi , vol.47 , pp. 320-326
    • Hao, L.N.1    He, S.Z.2    Shen, Y.H.3
  • 33
    • 84878090328 scopus 로고    scopus 로고
    • Puerarin decreases apoptosis of retinal pigment epithelial cells in diabetic rats by reducing peroxynitrite level and iNOS expression
    • Hao LN, Wang M, Ma JL, Yang T,. 2012. Puerarin decreases apoptosis of retinal pigment epithelial cells in diabetic rats by reducing peroxynitrite level and iNOS expression. Sheng Li Xue Bao 64: 199-206.
    • (2012) Sheng Li Xue Bao , vol.64 , pp. 199-206
    • Hao, L.N.1    Wang, M.2    Ma, J.L.3    Yang, T.4
  • 34
    • 80053099098 scopus 로고    scopus 로고
    • Effect of puerarin on retinal pigment epithelial cells in diabetic rats by reducing peroxynitrite level and iNOS expression
    • Hao LN, Zhang YQ, Shen YH, et al,. 2010. Effect of puerarin on retinal pigment epithelial cells in diabetic rats by reducing peroxynitrite level and iNOS expression. Int J Ophthalmol 3: 283-287.
    • (2010) Int J Ophthalmol , vol.3 , pp. 283-287
    • Hao, L.N.1    Zhang, Y.Q.2    Shen, Y.H.3
  • 35
    • 80051965446 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase and Fas/FasL with C3 expression of mouse retinal pigment epithelial cells in response to stimulation by peroxynitrite and antagonism of puerarin
    • Hao LN, Zhang YQ, Shen YH, et al,. 2011b. Inducible nitric oxide synthase and Fas/FasL with C3 expression of mouse retinal pigment epithelial cells in response to stimulation by peroxynitrite and antagonism of puerarin. Chin Med J (Engl) 124: 2522-2529.
    • (2011) Chin Med J (Engl) , vol.124 , pp. 2522-2529
    • Hao, L.N.1    Zhang, Y.Q.2    Shen, Y.H.3
  • 36
    • 69849112974 scopus 로고    scopus 로고
    • Protective effect of puerarin on the secondary spinal cord injury in rats
    • Heng LS, Lan BS, Jia Z, et al,. 2009. Protective effect of puerarin on the secondary spinal cord injury in rats. Zhong Yao Cai 32: 395-397.
    • (2009) Zhong Yao Cai , vol.32 , pp. 395-397
    • Heng, L.S.1    Lan, B.S.2    Jia, Z.3
  • 37
    • 77954633764 scopus 로고    scopus 로고
    • Molecular mechanism of suppression of MDR1 by puerarin from Pueraria lobata via NF-κB pathway and cAMP-responsive element transcriptional activity-dependent up-regulation of AMP-activated protein kinase in breast cancer MCF-7/adr cells
    • Hien TT, Kim HG, Han EH, et al,. 2010. Molecular mechanism of suppression of MDR1 by puerarin from Pueraria lobata via NF-κB pathway and cAMP-responsive element transcriptional activity-dependent up-regulation of AMP-activated protein kinase in breast cancer MCF-7/adr cells. Mol Nutr Food Res 54: 918-928.
    • (2010) Mol Nutr Food Res , vol.54 , pp. 918-928
    • Hien, T.T.1    Kim, H.G.2    Han, E.H.3
  • 38
    • 79957651266 scopus 로고    scopus 로고
    • Role of the interaction between puerarin and the erythrocyte membrane in puerarin-induced hemolysis
    • Hou SZ, Su ZR, Chen SX, et al,. 2011. Role of the interaction between puerarin and the erythrocyte membrane in puerarin-induced hemolysis. Chem Biol Interact 192: 184-192.
    • (2011) Chem Biol Interact , vol.192 , pp. 184-192
    • Hou, S.Z.1    Su, Z.R.2    Chen, S.X.3
  • 39
    • 81155139247 scopus 로고    scopus 로고
    • Puerarin accelerates peripheral nerve regeneration
    • Hsiang SW, Lee HC, Tsai FJ, et al,. 2011. Puerarin accelerates peripheral nerve regeneration. Am J Chin Med 39: 1207-1217.
    • (2011) Am J Chin Med , vol.39 , pp. 1207-1217
    • Hsiang, S.W.1    Lee, H.C.2    Tsai, F.J.3
  • 40
    • 0038204299 scopus 로고    scopus 로고
    • Antihyperglycemic effect of puerarin in streptozotocin-induced diabetic rats
    • Hsu FL, Liu IM, Kuo DH, et al,. 2003. Antihyperglycemic effect of puerarin in streptozotocin-induced diabetic rats. J Nat Prod 66: 788-792.
    • (2003) J Nat Prod , vol.66 , pp. 788-792
    • Hsu, F.L.1    Liu, I.M.2    Kuo, D.H.3
  • 41
    • 57849109804 scopus 로고    scopus 로고
    • Puerariae radix isoflavones and their metabolites inhibit growth and induce apoptosis in breast cancer cells
    • Hsu YA, Sheu JJ, Lai CH, et al,. 2009. Puerariae radix isoflavones and their metabolites inhibit growth and induce apoptosis in breast cancer cells. Biochem Biophys Res Commun 378: 683-688.
    • (2009) Biochem Biophys Res Commun , vol.378 , pp. 683-688
    • Hsu, Y.A.1    Sheu, J.J.2    Lai, C.H.3
  • 42
    • 84873426066 scopus 로고    scopus 로고
    • Effect of pretreatment with puerarin on activation of LPS-induced RAW264. 7 cells
    • Hu JJ, Zhang DD, Chen JJ, et al,. 2012. Effect of pretreatment with puerarin on activation of LPS-induced RAW264. 7 cells. Zhongguo Zhong Yao Za Zhi 37: 3112-3116.
    • (2012) Zhongguo Zhong Yao Za Zhi , vol.37 , pp. 3112-3116
    • Hu, J.J.1    Zhang, D.D.2    Chen, J.J.3
  • 43
    • 80051526767 scopus 로고    scopus 로고
    • Puerarin inhibits iNOS, COX-2 and CRP expression via suppression of NF-κB activation in LPS-induced RAW264.7 macrophage cells
    • Hu W, Yang X, Zhe C, et al,. 2011. Puerarin inhibits iNOS, COX-2 and CRP expression via suppression of NF-κB activation in LPS-induced RAW264.7 macrophage cells. Pharmacol Rep 63: 781-789.
    • (2011) Pharmacol Rep , vol.63 , pp. 781-789
    • Hu, W.1    Yang, X.2    Zhe, C.3
  • 44
    • 72049109482 scopus 로고    scopus 로고
    • Puerarin inhibits adhesion molecule expression in tnf-alpha-stimulated human endothelial cells via modulation of the nuclear factor kappaB pathway
    • Hu W, Zhang Q, Yang X, et al,. 2010. Puerarin inhibits adhesion molecule expression in tnf-alpha-stimulated human endothelial cells via modulation of the nuclear factor kappaB pathway. Pharmacology 85: 27-35.
    • (2010) Pharmacology , vol.85 , pp. 27-35
    • Hu, W.1    Zhang, Q.2    Yang, X.3
  • 45
    • 84862819019 scopus 로고    scopus 로고
    • Puerarin attenuates endothelial insulin resistance through inhibition of inflammatory response in an IKKβ/IRS-1-dependent manner
    • Huang F, Liu K, Du H, et al,. 2012a. Puerarin attenuates endothelial insulin resistance through inhibition of inflammatory response in an IKKβ/IRS-1-dependent manner. Biochimie 94: 1143-50.
    • (2012) Biochimie , vol.94 , pp. 1143-1150
    • Huang, F.1    Liu, K.2    Du, H.3
  • 46
    • 84863678341 scopus 로고    scopus 로고
    • Puerarin inhibits DNA damage of HaCaT cells induced by UVB via ceramide pathway
    • Huang MQ, Yang ZX, Yao MZ, et al,. 2012b. Puerarin inhibits DNA damage of HaCaT cells induced by UVB via ceramide pathway. Yao Xue Xue Bao 47: 609-613.
    • (2012) Yao Xue Xue Bao , vol.47 , pp. 609-613
    • Huang, M.Q.1    Yang, Z.X.2    Yao, M.Z.3
  • 47
    • 33846133772 scopus 로고
    • Effect d Puerarin on bovine arterial endothelial cells
    • Huang ZH, He GX, Zhang ZJ, et al,. 1992. Effect d Puerarin on bovine arterial endothelial cells. J Gerontol 12: 350-351.
    • (1992) J Gerontol , vol.12 , pp. 350-351
    • Huang, Z.H.1    He, G.X.2    Zhang, Z.J.3
  • 48
    • 35649020801 scopus 로고    scopus 로고
    • Protective effects of puerarin on carbon tetrachloride-induced hepatotoxicity
    • Hwang YP, Choi CY, Chung YC, et al,. 2007. Protective effects of puerarin on carbon tetrachloride-induced hepatotoxicity. Arch Pharm Res 30: 1309-1317.
    • (2007) Arch Pharm Res , vol.30 , pp. 1309-1317
    • Hwang, Y.P.1    Choi, C.Y.2    Chung, Y.C.3
  • 49
    • 56549083649 scopus 로고    scopus 로고
    • Mechanism of phytoestrogen puerarin-mediated cytoprotection following oxidative injury: Estrogen receptor-dependent up-regulation of PI3K/Akt and HO-1
    • Hwang YP, Jeong HG,. 2008. Mechanism of phytoestrogen puerarin-mediated cytoprotection following oxidative injury: estrogen receptor-dependent up-regulation of PI3K/Akt and HO-1. Toxicol Appl Pharmacol 233: 371-381.
    • (2008) Toxicol Appl Pharmacol , vol.233 , pp. 371-381
    • Hwang, Y.P.1    Jeong, H.G.2
  • 50
    • 81255176611 scopus 로고    scopus 로고
    • Puerarin activates endothelial nitric oxide synthase through estrogen receptor-dependent PI3-kinase and calcium-dependent AMP-activated protein kinase
    • Hwang YP, Kim HG, Hien TT, et al,. 2011. Puerarin activates endothelial nitric oxide synthase through estrogen receptor-dependent PI3-kinase and calcium-dependent AMP-activated protein kinase. Toxicol Appl Pharmacol 257: 48-58.
    • (2011) Toxicol Appl Pharmacol , vol.257 , pp. 48-58
    • Hwang, Y.P.1    Kim, H.G.2    Hien, T.T.3
  • 51
    • 77749314687 scopus 로고    scopus 로고
    • Effects of puerarin on expression of apelin and its receptor of 2K1C renal hypertension rats
    • Jin G, Yang P, Gong Y, et al,. 2009. Effects of puerarin on expression of apelin and its receptor of 2K1C renal hypertension rats. Zhongguo Zhong Yao Za Zhi 34: 3263-3267.
    • (2009) Zhongguo Zhong Yao Za Zhi , vol.34 , pp. 3263-3267
    • Jin, G.1    Yang, P.2    Gong, Y.3
  • 52
    • 77955422033 scopus 로고    scopus 로고
    • Glucose uptake enhancing activity of puerarin and the role of C-glucoside suggested from activity of related compounds
    • Kato E, Kawabata J,. 2010. Glucose uptake enhancing activity of puerarin and the role of C-glucoside suggested from activity of related compounds. Bioorg Med Chem Lett 20: 4333-4336.
    • (2010) Bioorg Med Chem Lett , vol.20 , pp. 4333-4336
    • Kato, E.1    Kawabata, J.2
  • 53
    • 84862282700 scopus 로고    scopus 로고
    • Puerarin inhibits the retinal pericyte apoptosis induced by advanced glycation end products in vitro and in vivo by inhibiting NADPH oxidase-related oxidative stress
    • Kim J, Kim KM, Kim CS, et al,. 2012. Puerarin inhibits the retinal pericyte apoptosis induced by advanced glycation end products in vitro and in vivo by inhibiting NADPH oxidase-related oxidative stress. Free Radic Biol Med 53: 357-365.
    • (2012) Free Radic Biol Med , vol.53 , pp. 357-365
    • Kim, J.1    Kim, K.M.2    Kim, C.S.3
  • 54
    • 77950033149 scopus 로고    scopus 로고
    • Puerarin suppresses AGEs-induced inflammation in mouse mesangial cells: A possible pathway through the induction of heme oxygenase-1 expression
    • Kim KM, Jung DH, Jang DS, et al,. 2010. Puerarin suppresses AGEs-induced inflammation in mouse mesangial cells: a possible pathway through the induction of heme oxygenase-1 expression. Toxicol Appl Pharmacol 244: 106-113.
    • (2010) Toxicol Appl Pharmacol , vol.244 , pp. 106-113
    • Kim, K.M.1    Jung, D.H.2    Jang, D.S.3
  • 55
    • 78650098818 scopus 로고    scopus 로고
    • Puerarin enhances adipocyte differentiation, adiponectin expression, and antioxidant response in 3T3-L1 cells
    • Lee OH, Seo DH, Park CS, Kim YC,. 2010. Puerarin enhances adipocyte differentiation, adiponectin expression, and antioxidant response in 3T3-L1 cells. Biofactors 36: 459-467.
    • (2010) Biofactors , vol.36 , pp. 459-467
    • Lee, O.H.1    Seo, D.H.2    Park, C.S.3    Kim, Y.C.4
  • 56
    • 0028212936 scopus 로고
    • Antiinflammatory activity of isoflavonoids from Pueraria radix and biochanin A derivatives
    • Lee SJ, Baek HJ, Lee CH, Kim HP,. 1994. Antiinflammatory activity of isoflavonoids from Pueraria radix and biochanin A derivatives. Arch Pharm Res pp. 31-35. (Pubitemid 24125176)
    • (1994) Archives of Pharmacal Research , vol.17 , Issue.1 , pp. 31-35
    • Lee, S.J.1    Baek, H.J.2    Lee, C.H.3    Kim, H.P.4
  • 57
    • 78049296008 scopus 로고    scopus 로고
    • Puerarin attenuates amyloid-beta-induced cognitive impairment through suppression of apoptosis in rat hippocampus in vivo
    • Li J, Wang G, Liu J, et al,. 2010. Puerarin attenuates amyloid-beta-induced cognitive impairment through suppression of apoptosis in rat hippocampus in vivo. Eur J Pharmacol 649: 195-201.
    • (2010) Eur J Pharmacol , vol.649 , pp. 195-201
    • Li, J.1    Wang, G.2    Liu, J.3
  • 58
    • 67650854594 scopus 로고    scopus 로고
    • Effect of puerarin on the expression of extracellular matrix in rats with streptozotocin-induced diabetic nephropathy
    • Li Q, Xiao Y, Gong H, et al,. 2009. Effect of puerarin on the expression of extracellular matrix in rats with streptozotocin-induced diabetic nephropathy. Natl Med J India 22: 9-12.
    • (2009) Natl Med J India , vol.22 , pp. 9-12
    • Li, Q.1    Xiao, Y.2    Gong, H.3
  • 59
    • 77956088595 scopus 로고    scopus 로고
    • Study of regulation of Puerarin on blood P-selectin and the expression of aorta VCAM mRNA in diabetes
    • Li Q, Zhang X, Zhu F, Zhang Z,. 2007. Study of regulation of Puerarin on blood P-selectin and the expression of aorta VCAM mRNA in diabetes. Wei Sheng Yan Jiu 36: 581-3, 595.
    • (2007) Wei Sheng Yan Jiu , vol.36 , Issue.581-583 , pp. 595
    • Li, Q.1    Zhang, X.2    Zhu, F.3    Zhang, Z.4
  • 60
    • 79954424232 scopus 로고    scopus 로고
    • Effect of compound Puerarin on the collage IV in streptozotocin-induced diabetic nephropathy rats
    • Li QX, Zhong HJ, Gong HR, et al,. 2008a. Effect of compound Puerarin on the collage IV in streptozotocin-induced diabetic nephropathy rats. Zhonghua Yu Fang Yi Xue Za Zhi 42: 254-259.
    • (2008) Zhonghua Yu Fang Yi Xue Za Zhi , vol.42 , pp. 254-259
    • Li, Q.X.1    Zhong, H.J.2    Gong, H.R.3
  • 61
    • 84869864308 scopus 로고    scopus 로고
    • Puerarin mediates hepatoprotection against CCl4-induced hepatic fibrosis rats through attenuation of inflammation response and amelioration of metabolic function
    • Li R, Xu L, Liang T, et al,. 2013. Puerarin mediates hepatoprotection against CCl4-induced hepatic fibrosis rats through attenuation of inflammation response and amelioration of metabolic function. Food Chem Toxicol 52: 69-75.
    • (2013) Food Chem Toxicol , vol.52 , pp. 69-75
    • Li, R.1    Xu, L.2    Liang, T.3
  • 63
    • 81955160817 scopus 로고    scopus 로고
    • Puerarin alleviates burn-related procedural pain mediated by P2X3 receptors
    • Li X, Zhang J, Gao Y, et al,. 2011. Puerarin alleviates burn-related procedural pain mediated by P2X3 receptors. Purinergic Signal 7: 489-497.
    • (2011) Purinergic Signal , vol.7 , pp. 489-497
    • Li, X.1    Zhang, J.2    Gao, Y.3
  • 64
    • 55049094548 scopus 로고    scopus 로고
    • Regulation of aromatase P450 expression by puerarin in endometrial cell line RL95-2
    • Li YW, Cai ZL, Shen W, et al,. 2008b. Regulation of aromatase P450 expression by puerarin in endometrial cell line RL95-2. Zhong Xi Yi Jie He Xue Bao 6: 1017-1023.
    • (2008) Zhong Xi Yi Jie He Xue Bao , vol.6 , pp. 1017-1023
    • Li, Y.W.1    Cai, Z.L.2    Shen, W.3
  • 65
    • 84860739072 scopus 로고    scopus 로고
    • Puerarin inhibits caspase-3 expression in osteoblasts of diabetic rats
    • Liang J, Chen H, Pan W, Xu C,. 2012. Puerarin inhibits caspase-3 expression in osteoblasts of diabetic rats. Mol Med Rep 5: 1419-1422.
    • (2012) Mol Med Rep , vol.5 , pp. 1419-1422
    • Liang, J.1    Chen, H.2    Pan, W.3    Xu, C.4
  • 66
    • 77958112584 scopus 로고    scopus 로고
    • P2X receptors and modulation of pain transmission: Focus on effects of drugs and compounds used in traditional Chinese medicine
    • Liang S, Xu C, Li G, Gao Y,. 2010. P2X receptors and modulation of pain transmission: focus on effects of drugs and compounds used in traditional Chinese medicine. Neurochem Int 57: 705-712.
    • (2010) Neurochem Int , vol.57 , pp. 705-712
    • Liang, S.1    Xu, C.2    Li, G.3    Gao, Y.4
  • 67
    • 84861687097 scopus 로고    scopus 로고
    • Protective effect of Puerarin on β-amyloid-induced neurotoxicity in rat hippocampal neurons
    • Lin F, Xie B, Cai F, Wu G,. 2012. Protective effect of Puerarin on β-amyloid-induced neurotoxicity in rat hippocampal neurons. Arzneimittelforschung 62: 187-193.
    • (2012) Arzneimittelforschung , vol.62 , pp. 187-193
    • Lin, F.1    Xie, B.2    Cai, F.3    Wu, G.4
  • 68
    • 57849109804 scopus 로고    scopus 로고
    • Puerariae radix isoflavones and their metabolites inhibit growth and induce apoptosis in breast cancer cells
    • Lin YJ, Hou YC, Lin CH, et al,. 2009. Puerariae radix isoflavones and their metabolites inhibit growth and induce apoptosis in breast cancer cells. Biochem Biophys Res Commun 378: 683-688.
    • (2009) Biochem Biophys Res Commun , vol.378 , pp. 683-688
    • Lin, Y.J.1    Hou, Y.C.2    Lin, C.H.3
  • 69
    • 80054862903 scopus 로고    scopus 로고
    • Protective role of puerarin on lead-induced alterations of the hepatic glutathione antioxidant system and hyperlipidemia in rats
    • Liu CM, Ma JQ, Sun YZ,. 2011. Protective role of puerarin on lead-induced alterations of the hepatic glutathione antioxidant system and hyperlipidemia in rats. Food Chem Toxicol 49: 3119-3127.
    • (2011) Food Chem Toxicol , vol.49 , pp. 3119-3127
    • Liu, C.M.1    Ma, J.Q.2    Sun, Y.Z.3
  • 70
    • 84855911161 scopus 로고    scopus 로고
    • Puerarin protects rat kidney from lead-induced apoptosis by modulating the PI3K/Akt/eNOS pathway
    • Liu CM, Ma JQ, Sun YZ,. 2012a. Puerarin protects rat kidney from lead-induced apoptosis by modulating the PI3K/Akt/eNOS pathway. Toxicol Appl Pharmacol 258: 330-342.
    • (2012) Toxicol Appl Pharmacol , vol.258 , pp. 330-342
    • Liu, C.M.1    Ma, J.Q.2    Sun, Y.Z.3
  • 71
    • 84864513400 scopus 로고    scopus 로고
    • Puerarin protects the rat liver against oxidative stress-mediated DNA damage and apoptosis induced by lead
    • Liu CM, Ma JQ, Sun YZ,. 2012b. Puerarin protects the rat liver against oxidative stress-mediated DNA damage and apoptosis induced by lead. Exp Toxicol Pathol 64: 575-582.
    • (2012) Exp Toxicol Pathol , vol.64 , pp. 575-582
    • Liu, C.M.1    Ma, J.Q.2    Sun, Y.Z.3
  • 72
    • 84875266579 scopus 로고    scopus 로고
    • Protective effect of puerarin on lead-induced mouse cognitive impairment via altering activities of acetyl cholinesterase, monoamine oxidase and nitric oxide synthase
    • Liu CM, Zheng GH, Ming QL, et al,. 2013. Protective effect of puerarin on lead-induced mouse cognitive impairment via altering activities of acetyl cholinesterase, monoamine oxidase and nitric oxide synthase. Environ Toxicol Pharmacol 35: 502-510.
    • (2013) Environ Toxicol Pharmacol , vol.35 , pp. 502-510
    • Liu, C.M.1    Zheng, G.H.2    Ming, Q.L.3
  • 73
    • 0642305219 scopus 로고    scopus 로고
    • Restrictive Effect of Puerarin on Myocardial Infarct Area in Dogs and Its Possible Mechanism
    • Liu Q, Lu Z, Wang L,. 2000. Restrictive effect of puerarin on myocardial infarct area in dogs and its possible mechanism. J Tongji Med Univ 20: 43-45. (Pubitemid 33210417)
    • (2000) Journal- Tongji Medical University , vol.20 , Issue.1 , pp. 43-45
    • Liu, Q.1    Lu, Z.2    Wang, L.3
  • 75
    • 76149111123 scopus 로고    scopus 로고
    • The effects of genistein and puerarin on the activation of nuclear actor-kappaB and the production of tumor necrosis factor-alpha in asthma patients
    • Liu XJ, Zhao J, Gu XY,. 2010. The effects of genistein and puerarin on the activation of nuclear actor-kappaB and the production of tumor necrosis factor-alpha in asthma patients. Pharmazie 65: 127-131.
    • (2010) Pharmazie , vol.65 , pp. 127-131
    • Liu, X.J.1    Zhao, J.2    Gu, X.Y.3
  • 76
    • 67349110498 scopus 로고    scopus 로고
    • Nitrite-glucose-glucose oxidase system directly induces rat heart homogenate oxidation and tyrosine nitration: Effects of some flavonoids
    • Lu N, Zhang Y, Gao Z,. 2009. Nitrite-glucose-glucose oxidase system directly induces rat heart homogenate oxidation and tyrosine nitration: effects of some flavonoids. Toxicol In Vitro 23: 627-633.
    • (2009) Toxicol in Vitro , vol.23 , pp. 627-633
    • Lu, N.1    Zhang, Y.2    Gao, Z.3
  • 77
    • 0038385330 scopus 로고    scopus 로고
    • Effects of Puerarin on experimental hyperlipidemia in rabbits
    • Lu XR, Zhu QL,. 1998. Effects of Puerarin on experimental hyperlipidemia in rabbits. Naunyn Schnfiedebergss Arch Phannacol 358 (suppl 2): R486.
    • (1998) Naunyn Schnfiedebergss Arch Phannacol , vol.358 , Issue.SUPPL. 2
    • Lu, X.R.1    Zhu, Q.L.2
  • 78
    • 77955716038 scopus 로고    scopus 로고
    • Puerarin exhibits weak estrogenic activity in female rats
    • Malaivijitnond S, Tungmunnithum D, Gittarasanee S, et al,. 2010. Puerarin exhibits weak estrogenic activity in female rats. Fitoterapia 81: 569-576.
    • (2010) Fitoterapia , vol.81 , pp. 569-576
    • Malaivijitnond, S.1    Tungmunnithum, D.2    Gittarasanee, S.3
  • 79
    • 23844529555 scopus 로고    scopus 로고
    • Puerarin reduces increased c-fos, c-jun, and type IV collagen expression caused by high glucose in glomerular mesangial cells
    • Mao CP, Gu ZL,. 2005. Puerarin reduces increased c-fos, c-jun, and type IV collagen expression caused by high glucose in glomerular mesangial cells. Acta Pharmacol Sin 26: 982-986.
    • (2005) Acta Pharmacol Sin , vol.26 , pp. 982-986
    • Mao, C.P.1    Gu, Z.L.2
  • 80
    • 0033232275 scopus 로고    scopus 로고
    • Clinical observation on the treatment of infantile viral myocarditis with puerarin
    • Meng P, Zhou D, Hu X,. 1999. Clinical observation on the treatment of infantile viral myocarditis with puerarin. Zhongguo Zhong Xi Yi Jie He Za Zhi 19: 647-648.
    • (1999) Zhongguo Zhong Xi Yi Jie He Za Zhi , vol.19 , pp. 647-648
    • Meng, P.1    Zhou, D.2    Hu, X.3
  • 81
    • 58549095630 scopus 로고    scopus 로고
    • Puerarin protects against high glucose-induced acute vascular dysfunction: Role of heme oxygenase-1 in rat thoracic aorta
    • Meng XH, Ni C, Zhu L, et al,. 2009. Puerarin protects against high glucose-induced acute vascular dysfunction: role of heme oxygenase-1 in rat thoracic aorta. Vascul Pharmacol 50: 110-115.
    • (2009) Vascul Pharmacol , vol.50 , pp. 110-115
    • Meng, X.H.1    Ni, C.2    Zhu, L.3
  • 82
    • 84930481252 scopus 로고    scopus 로고
    • Puerarin exerted anti-osteoporotic action independent of estrogen receptor-mediated pathway
    • Michihara S, Tanaka T, Uzawa Y, et al,. 2012. Puerarin exerted anti-osteoporotic action independent of estrogen receptor-mediated pathway. J Nutr Sci Vitaminol (Tokyo) 58: 202-209.
    • (2012) J Nutr Sci Vitaminol (Tokyo) , vol.58 , pp. 202-209
    • Michihara, S.1    Tanaka, T.2    Uzawa, Y.3
  • 83
    • 80054836991 scopus 로고    scopus 로고
    • Restoration of autophagy by puerarin in ethanol-treated hepatocytes via the activation of AMP-activated protein kinase
    • Noh BK, Lee JK, Jun HJ, et al,. 2011. Restoration of autophagy by puerarin in ethanol-treated hepatocytes via the activation of AMP-activated protein kinase. Biochem Biophys Res Commun 414: 361-366.
    • (2011) Biochem Biophys Res Commun , vol.414 , pp. 361-366
    • Noh, B.K.1    Lee, J.K.2    Jun, H.J.3
  • 84
    • 0041853717 scopus 로고    scopus 로고
    • 2C agonists
    • DOI 10.1016/S0091-3057(03)00114-X
    • Overstreet DH, Kralic JE, Morrow AL, et al,. 2003. NPI-031G (puerarin) reduces anxiogenic effects of alcohol withdrawal or benzodiazepine inverse or 5-HT2C agonists. Pharmacol Biochem Behav 75: 619-625. (Pubitemid 36939172)
    • (2003) Pharmacology Biochemistry and Behavior , vol.75 , Issue.3 , pp. 619-625
    • Overstreet, D.H.1    Kralic, J.E.2    Morrow, A.L.3
  • 85
    • 34547715603 scopus 로고    scopus 로고
    • The isoflavone puerarin reduces anxiety symptoms induced by acute 5-HT2C or inverse benzodiazepine agonists or alcohol withdrawal
    • Overstreet DH, Ma ZZ, Lee DYW,. 2002. The isoflavone puerarin reduces anxiety symptoms induced by acute 5-HT2C or inverse benzodiazepine agonists or alcohol withdrawal. Eur Neuropsychopharmacol 12: 361-365.
    • (2002) Eur Neuropsychopharmacol , vol.12 , pp. 361-365
    • Overstreet, D.H.1    Ma, Z.Z.2    Lee, D.Y.W.3
  • 86
    • 56049090343 scopus 로고    scopus 로고
    • Protecting mechanism of puerarin on the brain neurocyte of rat in acute local ischemia brain injury and local cerebral ischemia-reperfusion injury
    • Pan HP, Li G,. 2008. Protecting mechanism of puerarin on the brain neurocyte of rat in acute local ischemia brain injury and local cerebral ischemia-reperfusion injury. Yakugaku Zasshi 128: 1689-1698.
    • (2008) Yakugaku Zasshi , vol.128 , pp. 1689-1698
    • Pan, H.P.1    Li, G.2
  • 87
    • 67651146484 scopus 로고    scopus 로고
    • The myocardial protective effects of puerarin on STZ-induced diabetic rats
    • Pan ZY, Bao ZS, Wu ZM, et al,. 2009. The myocardial protective effects of puerarin on STZ-induced diabetic rats. Fen Zi Xi Bao Sheng Wu Xue Bao 42: 137-144.
    • (2009) Fen Zi Xi Bao Sheng Wu Xue Bao , vol.42 , pp. 137-144
    • Pan, Z.Y.1    Bao, Z.S.2    Wu, Z.M.3
  • 88
    • 84862726782 scopus 로고    scopus 로고
    • Effect of puerarin on the release of interleukin-8 in co-culture of human bronchial epithelial cells and neutrophils
    • Pang W, Lan XM, Wang CB,. 2012. Effect of puerarin on the release of interleukin-8 in co-culture of human bronchial epithelial cells and neutrophils. Chin J Integr Med 18: 283-287.
    • (2012) Chin J Integr Med , vol.18 , pp. 283-287
    • Pang, W.1    Lan, X.M.2    Wang, C.B.3
  • 89
    • 1842584266 scopus 로고    scopus 로고
    • Chemopreventive potential of epigallocatechin gallate and genistein: Evidence from epidemiological and laboratory studies
    • DOI 10.1016/j.toxlet.2003.06.001, PII S0378427404000384
    • Park OJ, Surh YJ,. 2004. Chemopreventive potential of epigallocatechin gallate and genistein: evidence from epidemiological and laboratory studies. Toxicol Lett 150: 43-56 (Pubitemid 38447236)
    • (2004) Toxicology Letters , vol.150 , Issue.1 , pp. 43-56
    • Park, O.J.1    Surh, Y.-J.2
  • 90
    • 84867849150 scopus 로고    scopus 로고
    • The isoflavone puerarin reduces alcohol intake in heavy drinkers: A pilot study
    • Penetar DM, Toto LH, Farmer SL, et al,. 2012. The isoflavone puerarin reduces alcohol intake in heavy drinkers: a pilot study. Drug Alcohol Depend 126: 251-256.
    • (2012) Drug Alcohol Depend , vol.126 , pp. 251-256
    • Penetar, D.M.1    Toto, L.H.2    Farmer, S.L.3
  • 91
    • 84874439498 scopus 로고    scopus 로고
    • Puerarin ameliorates experimental alcoholic liver injury by inhibition of endotoxin gut leakage, Kupffer cell activation, and endotoxin receptors expression
    • Peng JH, Cui T, Huang F, et al,. 2013. Puerarin ameliorates experimental alcoholic liver injury by inhibition of endotoxin gut leakage, Kupffer cell activation, and endotoxin receptors expression. J Pharmacol Exp Ther 344: 646-654.
    • (2013) J Pharmacol Exp Ther , vol.344 , pp. 646-654
    • Peng, J.H.1    Cui, T.2    Huang, F.3
  • 92
    • 0037817324 scopus 로고    scopus 로고
    • Profiling and quantification of isoflavonoids in kudzu dietary supplements by high-performance liquid chromatography and electrospray ionization tandem mass spectrometry
    • Prasain JK, Jones K, Kirk M, et al,. 2003. Profiling and quantification of isoflavonoids in kudzu dietary supplements by high-performance liquid chromatography and electrospray ionization tandem mass spectrometry. J Agric Food Chem 51: 4213-4218.
    • (2003) J Agric Food Chem , vol.51 , pp. 4213-4218
    • Prasain, J.K.1    Jones, K.2    Kirk, M.3
  • 93
    • 84870443436 scopus 로고    scopus 로고
    • The Chinese Pueraria root extract (Pueraria lobata) ameliorates impaired glucose and lipid metabolism in obese mice
    • Prasain JK, Peng N, Rajbhandari R, Wyss JM,. 2012. The Chinese Pueraria root extract (Pueraria lobata) ameliorates impaired glucose and lipid metabolism in obese mice. Phytomedicine 20: 17-23.
    • (2012) Phytomedicine , vol.20 , pp. 17-23
    • Prasain, J.K.1    Peng, N.2    Rajbhandari, R.3    Wyss, J.M.4
  • 94
    • 34248652109 scopus 로고    scopus 로고
    • Dietary daidzein and puerarin do not affect pituitary LH expression but exert uterotropic effects in ovariectomized rats
    • DOI 10.1016/j.maturitas.2006.12.003, PII S0378512206004014
    • Rachoń D, Vortherms T, Seidlova-Wuttke D, Wuttke W,. 2007. Dietary daidzein and puerarin do not affect pituitary LH expression but exert uterotropic effects in ovariectomized rats. Maturitas 57: 161-170. (Pubitemid 46771028)
    • (2007) Maturitas , vol.57 , Issue.2 , pp. 161-170
    • Rachon, D.1    Vortherms, T.2    Seidlova-Wuttke, D.3    Wuttke, W.4
  • 96
    • 79954421831 scopus 로고    scopus 로고
    • Chapter 5: Chemical constituents of Pueraria plants: Identification and methods of analysis
    • Keung, W.M. (Ed.), CRC Press, USA.
    • Rong H, Keukeleire DD, Cooman LD,. 2002. Chapter 5: chemical constituents of Pueraria plants: identification and methods of analysis. In:, Keung, W.M., (Ed.), Pueraria: The Genus Pueraria. CRC Press, USA, 23-25.
    • (2002) Pueraria: The Genus Pueraria , pp. 23-25
    • Rong, H.1    Keukeleire, D.D.2    Cooman, L.D.3
  • 97
    • 0242496947 scopus 로고    scopus 로고
    • Soy Isoflavones and Cancer Prevention
    • DOI 10.1081/CNV-120023773
    • Sarkar FH, Li Y,. 2003. Soy isoflavones and cancer prevention. Cancer Invest 21: 744-757. (Pubitemid 37377330)
    • (2003) Cancer Investigation , vol.21 , Issue.5 , pp. 744-757
    • Sarkar, F.H.1    Li, Y.2
  • 98
    • 80053298358 scopus 로고    scopus 로고
    • Inhibitory effect of flavonoids of puerarin on proliferation of different human acutemyeloid leukemia cell lines in vitro
    • Shao HM, Tang YH, Jiang PJ, et al,. 2010. Inhibitory effect of flavonoids of puerarin on proliferation of different human acutemyeloid leukemia cell lines in vitro. Zhongguo Shi Yan Xue Ye Xue Za Zhi 18: 296-299.
    • (2010) Zhongguo Shi Yan Xue Ye Xue Za Zhi , vol.18 , pp. 296-299
    • Shao, H.M.1    Tang, Y.H.2    Jiang, P.J.3
  • 99
    • 70350348348 scopus 로고    scopus 로고
    • Effects of puerarin on receptor for advanced glycation end products in nephridial tissue of streptozotocin-induced diabetic rats
    • Shen JG, Yao MF, Chen XC, et al,. 2009. Effects of puerarin on receptor for advanced glycation end products in nephridial tissue of streptozotocin- induced diabetic rats. Mol Biol Rep 36: 2229-2233.
    • (2009) Mol Biol Rep , vol.36 , pp. 2229-2233
    • Shen, J.G.1    Yao, M.F.2    Chen, X.C.3
  • 100
    • 84867908758 scopus 로고    scopus 로고
    • Stimulatory effect of puerarin on bone formation through co-activation of nitric oxide and bone morphogenetic protein-2/mitogen-activated protein kinases pathways in mice
    • Sheu SY, Tsai CC, Sun JS, et al,. 2012. Stimulatory effect of puerarin on bone formation through co-activation of nitric oxide and bone morphogenetic protein-2/mitogen-activated protein kinases pathways in mice. Chin Med J (Engl) 125: 3646-5363.
    • (2012) Chin Med J (Engl) , vol.125 , pp. 3646-5363
    • Sheu, S.Y.1    Tsai, C.C.2    Sun, J.S.3
  • 101
    • 52649120928 scopus 로고    scopus 로고
    • Effects of puerarin on ADRP gene expression in fatty tissue of type 2 diabetes mellitus rats
    • 2060.
    • Sun W, Zheng XZ, Xu QL, et al,. 2008. Effects of puerarin on ADRP gene expression in fatty tissue of type 2 diabetes mellitus rats. Zhongguo Zhong Yao Za Zhi 33: 2026-2028, 2060.
    • (2008) Zhongguo Zhong Yao Za Zhi , vol.33 , pp. 2026-2028
    • Sun, W.1    Zheng, X.Z.2    Xu, Q.L.3
  • 102
    • 34548842533 scopus 로고    scopus 로고
    • Activation of large-conductance calcium-activated potassium channels by puerarin: The underlying mechanism of puerarin-mediated vasodilation
    • DOI 10.1124/jpet.107.125567
    • Sun XH, Ding JP, Li H, et al,. 2007. Activation of large-conductance calcium-activated potassium channels by puerarin: the underlying mechanism of puerarin-mediated vasodilation. J Pharmacol Exp Ther 323: 391-397. (Pubitemid 47443248)
    • (2007) Journal of Pharmacology and Experimental Therapeutics , vol.323 , Issue.1 , pp. 391-397
    • Sun, X.-H.1    Ding, J.-P.2    Li, H.3    Pan, N.4    Gan, L.5    Yang, X.-L.6    Xu, H.-B.7
  • 103
    • 65449172057 scopus 로고    scopus 로고
    • Phytoestrogens induce differential estrogen receptor β-mediated responses in transfected MG-63 cells
    • Tang X, Zhu X, Liu S, et al,. 2008. Phytoestrogens induce differential estrogen receptor β-mediated responses in transfected MG-63 cells. Endocrine 34: 29-35.
    • (2008) Endocrine , vol.34 , pp. 29-35
    • Tang, X.1    Zhu, X.2    Liu, S.3
  • 104
    • 84864009043 scopus 로고    scopus 로고
    • Dynamic oxidative stress and DNA damage induced by oestrogen deficiency and protective effects of puerarinand 17β-oestradiol in ovariectomized rats
    • Tang XL, Liu XJ, Tian Q, Zhang W,. 2012. Dynamic oxidative stress and DNA damage induced by oestrogen deficiency and protective effects of puerarinand 17β-oestradiol in ovariectomized rats. Basic Clin Pharmacol Toxicol 111: 87-91.
    • (2012) Basic Clin Pharmacol Toxicol , vol.111 , pp. 87-91
    • Tang, X.L.1    Liu, X.J.2    Tian, Q.3    Zhang, W.4
  • 105
    • 80053314845 scopus 로고    scopus 로고
    • Apoptosis of NB4 cells induced by flavonoids of puerarin in vitro
    • Tang YH, Zhu HQ, Zhang YC, et al,. 2010. Apoptosis of NB4 cells induced by flavonoids of puerarin in vitro. Zhongguo Shi Yan Xue Ye Xue Za Zhi 18: 326-329.
    • (2010) Zhongguo Shi Yan Xue Ye Xue Za Zhi , vol.18 , pp. 326-329
    • Tang, Y.H.1    Zhu, H.Q.2    Zhang, Y.C.3
  • 106
    • 63949083987 scopus 로고    scopus 로고
    • Protective effect of puerarin on diabetic retinopathy in rat
    • Teng Y, Cui H, Yang M, et al,. 2009. Protective effect of puerarin on diabetic retinopathy in rat. Mol Biol Rep 36: 1129-1133.
    • (2009) Mol Biol Rep , vol.36 , pp. 1129-1133
    • Teng, Y.1    Cui, H.2    Yang, M.3
  • 107
    • 74649086714 scopus 로고    scopus 로고
    • Comparison of urodynamic effects of phytoestrogens equol, puerarin and genistein with these of estradiol 17 b in ovariectomized rats
    • Thielemann A, Wuttke W, Wuttke M, Seidlova-Wuttke D,. 2010. Comparison of urodynamic effects of phytoestrogens equol, puerarin and genistein with these of estradiol 17 b in ovariectomized rats. Exp Gerontol 45: 129-137.
    • (2010) Exp Gerontol , vol.45 , pp. 129-137
    • Thielemann, A.1    Wuttke, W.2    Wuttke, M.3    Seidlova-Wuttke, D.4
  • 108
    • 79954420564 scopus 로고    scopus 로고
    • The optimal therapeutic timing and mechanism of puerarin treatment of spinal cord ischemia-reperfusion injury in rats
    • Tian F, Xu LH, Zhao W, et al,. 2011. The optimal therapeutic timing and mechanism of puerarin treatment of spinal cord ischemia-reperfusion injury in rats. J Ethnopharmacol 134: 892-896.
    • (2011) J Ethnopharmacol , vol.134 , pp. 892-896
    • Tian, F.1    Xu, L.H.2    Zhao, W.3
  • 109
    • 84866741445 scopus 로고    scopus 로고
    • Upregulation of osteoblastic differentiation marker mRNA expression in osteoblast-like UMR106 cells by puerarin and phytoestrogens from Pueraria mirifica
    • Tiyasatkulkovit W, Charoenphandhu N, Wongdee K, et al,. 2012. Upregulation of osteoblastic differentiation marker mRNA expression in osteoblast-like UMR106 cells by puerarin and phytoestrogens from Pueraria mirifica. Phytomedicine 19: 1147-1155.
    • (2012) Phytomedicine , vol.19 , pp. 1147-1155
    • Tiyasatkulkovit, W.1    Charoenphandhu, N.2    Wongdee, K.3
  • 110
    • 80052860607 scopus 로고    scopus 로고
    • Puerarin suppresses invasion and vascularization of endometriosis tissue stimulated by 17β-estradiol
    • Wang D, Liu Y, Han J, et al,. 2011a. Puerarin suppresses invasion and vascularization of endometriosis tissue stimulated by 17β-estradiol. PLoS One 6: e25011.
    • (2011) PLoS One , vol.6
    • Wang, D.1    Liu, Y.2    Han, J.3
  • 111
    • 78650212384 scopus 로고    scopus 로고
    • Implication of the c-Jun-NH2-terminal kinase pathway in the neuroprotective effect of puerarin against 1-methyl-4-phenylpyridinium (MPP+)-induced apoptosis in PC-12 cells
    • Wang G, Zhou L, Zhang Y, et al,. 2011b. Implication of the c-Jun-NH2-terminal kinase pathway in the neuroprotective effect of puerarin against 1-methyl-4-phenylpyridinium (MPP+)-induced apoptosis in PC-12 cells. Neurosci Lett 487: 88-93.
    • (2011) Neurosci Lett , vol.487 , pp. 88-93
    • Wang, G.1    Zhou, L.2    Zhang, Y.3
  • 112
    • 84890119945 scopus 로고    scopus 로고
    • Effects of puerarin on the vascular active factor related to cerebral vasospasm after aneurysm subarachnoid hemorrhage
    • Wang JW, Gao JM, Huang YJ,. 2012a. Effects of puerarin on the vascular active factor related to cerebral vasospasm after aneurysm subarachnoid hemorrhage. Zhongguo Zhong Xi Yi Jie He Za Zhi 32: 164-167.
    • (2012) Zhongguo Zhong Xi Yi Jie He Za Zhi , vol.32 , pp. 164-167
    • Wang, J.W.1    Gao, J.M.2    Huang, Y.J.3
  • 113
    • 84872299083 scopus 로고    scopus 로고
    • Protective effects of puerarin on experimental chronic lead nephrotoxicity in immature female rats
    • Wang L, Lin S, Li Z, et al,. 2013. Protective effects of puerarin on experimental chronic lead nephrotoxicity in immature female rats. Hum Exp Toxicol 32: 172-185.
    • (2013) Hum Exp Toxicol , vol.32 , pp. 172-185
    • Wang, L.1    Lin, S.2    Li, Z.3
  • 114
    • 84866697815 scopus 로고    scopus 로고
    • Puerarin stimulates osteoblasts differentiation and bone formation through estrogen receptor, p38 MAPK, and Wnt/β-catenin pathways
    • Wang PP, Zhu XF, Yang L, et al,. 2012b. Puerarin stimulates osteoblasts differentiation and bone formation through estrogen receptor, p38 MAPK, and Wnt/β-catenin pathways. J Asian Nat Prod Res 14: 897-905.
    • (2012) J Asian Nat Prod Res , vol.14 , pp. 897-905
    • Wang, P.P.1    Zhu, X.F.2    Yang, L.3
  • 115
    • 33750095175 scopus 로고    scopus 로고
    • Puerarin injection for unstable angina pectoris
    • doi: 10.1002/14651858.CD004196.pub2.
    • Wang Q, Wu T, Chen X, et al,. 2006. Puerarin injection for unstable angina pectoris. Cochrane Database Syst Rev 3, doi: 10.1002/14651858.CD004196. pub2.
    • (2006) Cochrane Database Syst Rev , vol.3
    • Wang, Q.1    Wu, T.2    Chen, X.3
  • 116
    • 84891588707 scopus 로고    scopus 로고
    • Protective effects of puerarin on 60Co-gamma-induced acute injury of sertoli cells of testis in mice
    • Wang R, Wang L, Zhang WX,. et al. 2012c. Protective effects of puerarin on 60Co-gamma-induced acute injury of sertoli cells of testis in mice. Zhongguo Zhong Xi Yi Jie He Za Zhi 32: 385-389.
    • (2012) Zhongguo Zhong Xi Yi Jie He Za Zhi , vol.32 , pp. 385-389
    • Wang, R.1    Wang, L.2    Zhang, W.X.3
  • 117
    • 44649155045 scopus 로고    scopus 로고
    • Preventive effects of puerarin on alcohol-induced osteonecrosis
    • Wang Y, Yin L, Li Y, et al,. 2008. Preventive effects of puerarin on alcohol-induced osteonecrosis. Clin Orthop Relat Res 466: 1059-1067.
    • (2008) Clin Orthop Relat Res , vol.466 , pp. 1059-1067
    • Wang, Y.1    Yin, L.2    Li, Y.3
  • 118
    • 79954422522 scopus 로고    scopus 로고
    • Kudzu root: Traditional uses and potential medicinal benefits in diabetes and cardiovascular diseases
    • Wong KH, Li GQ, Li KM, et al,. 2011. Kudzu root: traditional uses and potential medicinal benefits in diabetes and cardiovascular diseases. J Ethnopharmacol 134: 584-607.
    • (2011) J Ethnopharmacol , vol.134 , pp. 584-607
    • Wong, K.H.1    Li, G.Q.2    Li, K.M.3
  • 119
    • 84904246573 scopus 로고    scopus 로고
    • Effect of puerarin on bone formation
    • Wong R, Rabie B,. 2003. Effect of puerarin on bone formation. Beijing Da Xue Xue Bao 35: 74-77.
    • (2003) Beijing da Xue Xue Bao , vol.35 , pp. 74-77
    • Wong, R.1    Rabie, B.2
  • 120
    • 56749131600 scopus 로고    scopus 로고
    • Effect of puerarin on levels of TGF-beta1 and alpha-SMA in rats with alcoholic injury liver
    • Wu GL, Chen J, Yu GY, et al,. 2008. Effect of puerarin on levels of TGF-beta1 and alpha-SMA in rats with alcoholic injury liver. Zhongguo Zhong Yao Za Zhi 33: 2245-2249.
    • (2008) Zhongguo Zhong Yao Za Zhi , vol.33 , pp. 2245-2249
    • Wu, G.L.1    Chen, J.2    Yu, G.Y.3
  • 121
    • 60849084558 scopus 로고    scopus 로고
    • Protective effects and mechanism of puerarin on learning-memory disorder after global cerebral ischemia-reperfusion injury in rats
    • Wu HQ, Guo HN, Wang HQ, et al,. 2009. Protective effects and mechanism of puerarin on learning-memory disorder after global cerebral ischemia-reperfusion injury in rats. Chin J Integr Med 15: 54-59.
    • (2009) Chin J Integr Med , vol.15 , pp. 54-59
    • Wu, H.Q.1    Guo, H.N.2    Wang, H.Q.3
  • 122
    • 79951931336 scopus 로고    scopus 로고
    • Diabetes is an inflammatory disease: Evidence from traditional Chinese medicines
    • Xie W, Du L,. 2011. Diabetes is an inflammatory disease: evidence from traditional Chinese medicines. Diabetes Obes Metab 13: 289-301.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 289-301
    • Xie, W.1    Du, L.2
  • 123
    • 79957873239 scopus 로고    scopus 로고
    • Neuroprotective effects of puerarin against beta-amyloid-induced neurotoxicity in PC12 cells via a PI3K-dependent signaling pathway
    • Xing G, Dong M, Li X, et al,. 2011. Neuroprotective effects of puerarin against beta-amyloid-induced neurotoxicity in PC12 cells via a PI3K-dependent signaling pathway. Brain Res Bull 85: 212-218.
    • (2011) Brain Res Bull , vol.85 , pp. 212-218
    • Xing, G.1    Dong, M.2    Li, X.3
  • 124
    • 29344444326 scopus 로고    scopus 로고
    • Puerarin protects rat pancreatic islets from damage by hydrogen peroxide
    • Xiong FL, Sun XH, Gan L, et al,. 2006. Puerarin protects rat pancreatic islets from damage by hydrogen peroxide. Eur J Pharmacol 529: 1-7.
    • (2006) Eur J Pharmacol , vol.529 , pp. 1-7
    • Xiong, F.L.1    Sun, X.H.2    Gan, L.3
  • 125
    • 70349952173 scopus 로고    scopus 로고
    • Effect of puerarin on P2X3 receptor involved in hyperalgesia after burn injury in the rat
    • Xu C, Li G, Gao Y, et al,. 2009. Effect of puerarin on P2X3 receptor involved in hyperalgesia after burn injury in the rat. Brain Res Bull 80: 341-346.
    • (2009) Brain Res Bull , vol.80 , pp. 341-346
    • Xu, C.1    Li, G.2    Gao, Y.3
  • 126
    • 84155172059 scopus 로고    scopus 로고
    • Role of puerarin in the signalling of neuropathic pain mediated by P2X3 receptor of dorsal root ganglion neurons
    • Xu C, Xu W, Xu H, et al,. 2012. Role of puerarin in the signalling of neuropathic pain mediated by P2X3 receptor of dorsal root ganglion neurons. Brain Res Bull 87: 37-43.
    • (2012) Brain Res Bull , vol.87 , pp. 37-43
    • Xu, C.1    Xu, W.2    Xu, H.3
  • 127
    • 84904253965 scopus 로고    scopus 로고
    • Mechanism of advanced glycation end-products in the inducement of apoptosis of human gingival fibroblast and related effect of puerarin in the process
    • Xu HX, Fu Y, Li HJ,. 2011. Mechanism of advanced glycation end-products in the inducement of apoptosis of human gingival fibroblast and related effect of puerarin in the process. Zhonghua Kou Qiang Yi Xue Za Zhi 46: 31-34.
    • (2011) Zhonghua Kou Qiang Yi Xue Za Zhi , vol.46 , pp. 31-34
    • Xu, H.X.1    Fu, Y.2    Li, H.J.3
  • 128
    • 34548397110 scopus 로고    scopus 로고
    • Potential involvement of calcium and nitric oxide in protective effects of puerarin on oxygen-glucose deprivation in cultured hippocampal neurons
    • DOI 10.1016/j.jep.2007.06.012, PII S0378874107003091
    • Xu X, Zheng X,. 2007. Potential involvement of calcium and nitric oxide in protective effects of puerarin on oxygen-glucose deprivation in cultured hippocampal neurons. J Ethnopharmacol 113: 421-426. (Pubitemid 47361557)
    • (2007) Journal of Ethnopharmacology , vol.113 , Issue.3 , pp. 421-426
    • Xu, X.1    Zheng, X.2
  • 129
    • 0042413373 scopus 로고    scopus 로고
    • Effect of puerarin on learning-memory behavior and synaptic structure of hippocampus in the aging mice induced by d -galactose
    • Xu XH, Zhang ZG,. 2002. Effect of puerarin on learning-memory behavior and synaptic structure of hippocampus in the aging mice induced by d -galactose. Acta Pharmaceutica Sinica (Chin) 37: 1-4.
    • (2002) Acta Pharmaceutica Sinica (Chin) , vol.37 , pp. 1-4
    • Xu, X.H.1    Zhang, Z.G.2
  • 130
    • 34548815007 scopus 로고    scopus 로고
    • Inhibition of excitatory amino acid efflux contributes to protective effects of puerarin against cerebral ischemia in rats
    • Xu XH, Zheng XX, Zhou Q, Li H,. 2007. Inhibition of excitatory amino acid efflux contributes to protective effects of puerarin against cerebral ischemia in rats. Biomed Environ Sci 20: 336-342. (Pubitemid 47441814)
    • (2007) Biomedical and Environmental Sciences , vol.20 , Issue.4 , pp. 336-342
    • Xu, X.-H.1    Zheng, X.-X.2    Zhou, Q.3    Li, H.4
  • 131
    • 64749108685 scopus 로고    scopus 로고
    • Analysis of the mechanisms underlying the endothelium-dependent antivasoconstriction of puerarin in rat aorta
    • Yan LP, Zhuang YL, Chan SW, et al,. 2009. Analysis of the mechanisms underlying the endothelium-dependent antivasoconstriction of puerarin in rat aorta. Naunyn Schmiedebergs Arch Pharmacol 379: 587-597.
    • (2009) Naunyn Schmiedebergs Arch Pharmacol , vol.379 , pp. 587-597
    • Yan, L.P.1    Zhuang, Y.L.2    Chan, S.W.3
  • 132
    • 79960335547 scopus 로고    scopus 로고
    • Mitochondrial mechanism of cardioprotective effect of puerarin against H2O2-stress in rats
    • Yang B, Gao Q, Yao H, Xia Q,. 2008. Mitochondrial mechanism of cardioprotective effect of puerarin against H2O2-stress in rats. Zhongguo Ying Yong Sheng Li Xue Za Zhi 24: 399-404.
    • (2008) Zhongguo Ying Yong Sheng Li Xue Za Zhi , vol.24 , pp. 399-404
    • Yang, B.1    Gao, Q.2    Yao, H.3    Xia, Q.4
  • 133
    • 84862812464 scopus 로고    scopus 로고
    • Osteoblast response to puerarin-loaded porous titanium surfaces: An in vitro study
    • Yang F, Zhang R, He F, et al,. 2012. Osteoblast response to puerarin-loaded porous titanium surfaces: an in vitro study. J Biomed Mater Res A 100: 1419-1426.
    • (2012) J Biomed Mater Res A , vol.100 , pp. 1419-1426
    • Yang, F.1    Zhang, R.2    He, F.3
  • 134
    • 85059108593 scopus 로고
    • Effects of Puerarin against angina pectoris and on TXA2 and PGI2 in patients with coronary heart disease
    • Yang GJ, Zhang IS, Fan LL,. 1990. Effects of Puerarin against angina pectoris and on TXA2 and PGI2 in patients with coronary heart disease. J Integr Tradit and West Med 10: 82-84.
    • (1990) J Integr Tradit and West Med , vol.10 , pp. 82-84
    • Yang, G.J.1    Zhang, I.S.2    Fan, L.L.3
  • 135
    • 84864057402 scopus 로고    scopus 로고
    • Effect of puerarin on liver injury in KKAy mice with type 2 diabetes mellitus
    • Yang S, Lou JL, Wang Q,. 2009. Effect of puerarin on liver injury in KKAy mice with type 2 diabetes mellitus. Zhongguo Zhong Xi Yi Jie He Za Zhi 29: 707-710.
    • (2009) Zhongguo Zhong Xi Yi Jie He Za Zhi , vol.29 , pp. 707-710
    • Yang, S.1    Lou, J.L.2    Wang, Q.3
  • 136
    • 77954754224 scopus 로고    scopus 로고
    • Puerarin inhibits C-reactive protein expression via suppression of nuclear factor kappaB activation in lipopolysaccharide-induced peripheral blood mononuclear cells of patients with stable angina pectoris
    • Yang X, Hu W, Zhang Q, et al,. 2010. Puerarin inhibits C-reactive protein expression via suppression of nuclear factor kappaB activation in lipopolysaccharide-induced peripheral blood mononuclear cells of patients with stable angina pectoris. Basic Clin Pharmacol Toxicol 107: 637-642.
    • (2010) Basic Clin Pharmacol Toxicol , vol.107 , pp. 637-642
    • Yang, X.1    Hu, W.2    Zhang, Q.3
  • 137
    • 84859740569 scopus 로고    scopus 로고
    • Puerarin exerts antipyretic effect on LPS-induced fever in rats involving inhibition of pyrogen production from macrophages
    • Yao XJ, Yin JA, Xia YF, et al,. 2012. Puerarin exerts antipyretic effect on LPS-induced fever in rats involving inhibition of pyrogen production from macrophages. J Ethnopharmacol 141: 322-330.
    • (2012) J Ethnopharmacol , vol.141 , pp. 322-330
    • Yao, X.J.1    Yin, J.A.2    Xia, Y.F.3
  • 138
    • 33750480231 scopus 로고    scopus 로고
    • Puerarin, an isoflavonoid derived from Radix puerariae, potentiates endothelium-independent relaxation via the cyclic AMP pathway in porcine coronary artery
    • DOI 10.1016/j.ejphar.2006.08.078, PII S0014299906009642
    • Yeung DK, Leung SW, Xu YC, et al,. 2006. Puerarin, an isoflavonoid derived from Radix puerariae, potentiates endothelium-independent relaxation via the cyclic AMP pathway in porcine coronary artery. Eur J Pharmacol 552: 105-111. (Pubitemid 44649298)
    • (2006) European Journal of Pharmacology , vol.552 , Issue.1-3 , pp. 105-111
    • Yeung, D.K.Y.1    Leung, S.W.S.2    Xu, Y.C.3    Vanhoutte, P.M.4    Man, R.Y.K.5
  • 139
    • 55949098220 scopus 로고    scopus 로고
    • Decreased expression of aromatase in the Ishikawa and RL95-2 cells by the isoflavone, puerarin, is associated with inhibition of c-jun expression and AP-1 activity
    • Yu C, Li Y, Chen H, et al,. 2008. Decreased expression of aromatase in the Ishikawa and RL95-2 cells by the isoflavone, puerarin, is associated with inhibition of c-jun expression and AP-1 activity. Food Chem Toxicol 46: 3671-3676.
    • (2008) Food Chem Toxicol , vol.46 , pp. 3671-3676
    • Yu, C.1    Li, Y.2    Chen, H.3
  • 140
    • 65349193880 scopus 로고    scopus 로고
    • Regulatory mechanism of malignant behavior of endometriosis mediated by puerarin
    • Yu CQ, Yu J, Han J, et al,. 2009. Regulatory mechanism of malignant behavior of endometriosis mediated by puerarin. Zhong Xi Yi Jie He Xue Bao 7: 41-47.
    • (2009) Zhong Xi Yi Jie He Xue Bao , vol.7 , pp. 41-47
    • Yu, C.Q.1    Yu, J.2    Han, J.3
  • 141
    • 33744936020 scopus 로고    scopus 로고
    • Induction of apoptosis by puerarin in colon cancer HT-29 cells
    • DOI 10.1016/j.canlet.2005.06.022, PII S0304383505005884
    • Yu Z, Li W,. 2006. Induction of apoptosis by puerarin in colon cancer HT-29 cells. Cancer Lett 238: 53-60. (Pubitemid 43851146)
    • (2006) Cancer Letters , vol.238 , Issue.1 , pp. 53-60
    • Yu, Z.1    Li, W.2
  • 142
    • 37849046449 scopus 로고    scopus 로고
    • The study to reduce the hemolysis side effect of puerarin by a submicron emulsion delivery system
    • Yue PF, Hai-Long Yuan HL, Zhu WF, et al,. 2008. The study to reduce the hemolysis side effect of puerarin by a submicron emulsion delivery system. Biol Pharm Bull 31: 45-50.
    • (2008) Biol Pharm Bull , vol.31 , pp. 45-50
    • Yue, P.F.1    Hai-Long Yuan, H.L.2    Zhu, W.F.3
  • 144
    • 78649812471 scopus 로고    scopus 로고
    • Puerarin protects Alzheimer's disease neuronal cybrids from oxidant-stress induced apoptosis by inhibiting pro-death signaling pathways
    • Zhang H, Liu Y, Lao M, et al,. 2011a. Puerarin protects Alzheimer's disease neuronal cybrids from oxidant-stress induced apoptosis by inhibiting pro-death signaling pathways. Exp Gerontol 46: 30-37.
    • (2011) Exp Gerontol , vol.46 , pp. 30-37
    • Zhang, H.1    Liu, Y.2    Lao, M.3
  • 145
    • 79959233968 scopus 로고    scopus 로고
    • Puerarin a novel antagonist to inward rectifier potassium channel (IK1)
    • Zhang H, Zhang L, Zhang Q, et al,. 2011b. Puerarin a novel antagonist to inward rectifier potassium channel (IK1). Mol Cell Biochem 352: 117-123.
    • (2011) Mol Cell Biochem , vol.352 , pp. 117-123
    • Zhang, H.1    Zhang, L.2    Zhang, Q.3
  • 146
    • 79959335349 scopus 로고    scopus 로고
    • Effect of puerarin on PC12 cells apoptosis induced by Abeta25-35 in vitro
    • Zhang HY, Hu HT, Liu YH, et al,. 2008a. Effect of puerarin on PC12 cells apoptosis induced by Abeta25-35 in vitro. Zhong Yao Cai 31: 543-546.
    • (2008) Zhong Yao Cai , vol.31 , pp. 543-546
    • Zhang, H.Y.1    Hu, H.T.2    Liu, Y.H.3
  • 147
    • 52949146386 scopus 로고    scopus 로고
    • Puerarin protects PC12 cells against beta-amyloid-induced cell injury
    • Zhang HY, Liu YH, Wang HQ, et al,. 2008b. Puerarin protects PC12 cells against beta-amyloid-induced cell injury. Cell Biol Int 32: 1230-1237.
    • (2008) Cell Biol Int , vol.32 , pp. 1230-1237
    • Zhang, H.Y.1    Liu, Y.H.2    Wang, H.Q.3
  • 148
    • 84904262573 scopus 로고    scopus 로고
    • Effects of puerarin on the inflammatory role of burn-related procedural pain mediated by P2X(7) receptors
    • pii:S0305-4179(12)00262-8.
    • Zhang J, Li X, Gao Y, et al,. 2012a. Effects of puerarin on the inflammatory role of burn-related procedural pain mediated by P2X(7) receptors. Burns pii:S0305-4179(12)00262-8.
    • (2012) Burns
    • Zhang, J.1    Li, X.2    Gao, Y.3
  • 149
    • 84862726583 scopus 로고    scopus 로고
    • In vitro and in vivo effects of puerarin on promotion of osteoblast bone formation
    • Zhang MY, Qiang H, Yang HQ, et al,. 2012b. In vitro and in vivo effects of puerarin on promotion of osteoblast bone formation. Chin J Integr Med 18: 276-282.
    • (2012) Chin J Integr Med , vol.18 , pp. 276-282
    • Zhang, M.Y.1    Qiang, H.2    Yang, H.Q.3
  • 150
    • 52949135150 scopus 로고    scopus 로고
    • Effects of different doses of puerarin on vascular endothelial cell proliferation in vitro
    • Zhang MY, Shi ZB, Yang HQ, et al,. 2008c. Effects of different doses of puerarin on vascular endothelial cell proliferation in vitro. Zhong Xi Yi Jie He Xue Bao 6: 942-945.
    • (2008) Zhong Xi Yi Jie He Xue Bao , vol.6 , pp. 942-945
    • Zhang, M.Y.1    Shi, Z.B.2    Yang, H.Q.3
  • 151
    • 82455164223 scopus 로고    scopus 로고
    • Effects of puerarin on expression of cardiac Smad3 and Smad7 mRNA in spontaneously hypertensive rat
    • Zhang NB, Huang ZG, Cui WD, Ding BP,. 2011c. Effects of puerarin on expression of cardiac Smad3 and Smad7 mRNA in spontaneously hypertensive rat. J Ethnopharmacol 138: 737-740.
    • (2011) J Ethnopharmacol , vol.138 , pp. 737-740
    • Zhang, N.B.1    Huang, Z.G.2    Cui, W.D.3    Ding, B.P.4
  • 153
    • 79751516920 scopus 로고    scopus 로고
    • Effect of puerarin on the expression of NMDA receptor in the hippocampus CA1 region after focal cerebral ischemia in rats
    • Zhang R, Guo HN, Wu HQ, et al,. 2011d. Effect of puerarin on the expression of NMDA receptor in the hippocampus CA1 region after focal cerebral ischemia in rats. Sichuan Da Xue Xue Bao Yi Xue Ban 42: 52-55.
    • (2011) Sichuan da Xue Xue Bao Yi Xue Ban , vol.42 , pp. 52-55
    • Zhang, R.1    Guo, H.N.2    Wu, H.Q.3
  • 154
    • 33744988997 scopus 로고    scopus 로고
    • Reversal of chemical-induced liver fibrosis in Wistar rats by puerarin
    • DOI 10.1016/j.jnutbio.2005.09.002, PII S0955286305002391
    • Zhang S, Ji G, Liu J,. 2006. Reversal of chemical-induced liver fibrosis in Wistar rats by puerarin. J Nutr Biochem 17: 485-491. (Pubitemid 43867250)
    • (2006) Journal of Nutritional Biochemistry , vol.17 , Issue.7 , pp. 485-491
    • Zhang, S.1    Ji, G.2    Liu, J.3
  • 155
    • 40949119894 scopus 로고    scopus 로고
    • The effect of puerarin on serum nitric oxide concentration and myocardial eNOS expression in rats with myocardial infarction
    • Zhang SY, Chen G, Wei PF, et al,. 2008d. The effect of puerarin on serum nitric oxide concentration and myocardial eNOS expression in rats with myocardial infarction. J Asian Nat Prod Res 10: 373-381.
    • (2008) J Asian Nat Prod Res , vol.10 , pp. 373-381
    • Zhang, S.Y.1    Chen, G.2    Wei, P.F.3
  • 156
    • 78049259598 scopus 로고    scopus 로고
    • Puerarin improves insulin resistance and modulates adipokine expression in rats fed a high-fat diet
    • Zhang W, Liu CQ, Wang PW, et al,. 2010a. Puerarin improves insulin resistance and modulates adipokine expression in rats fed a high-fat diet. Eur J Pharmacol 649: 398-402.
    • (2010) Eur J Pharmacol , vol.649 , pp. 398-402
    • Zhang, W.1    Liu, C.Q.2    Wang, P.W.3
  • 157
    • 80052845774 scopus 로고    scopus 로고
    • Puerarin induced apoptosis of pulmonary artery smooth muscle cell by mitochondrial pathway
    • Zhang X, Zhao F, Zhang X, Sheng J,. 2011e. Puerarin induced apoptosis of pulmonary artery smooth muscle cell by mitochondrial pathway. Zhongguo Zhong Yao Za Zhi 36: 2255-2258.
    • (2011) Zhongguo Zhong Yao Za Zhi , vol.36 , pp. 2255-2258
    • Zhang, X.1    Zhao, F.2    Zhang, X.3    Sheng, J.4
  • 158
    • 34250348437 scopus 로고    scopus 로고
    • Stimulatory effect of puerarin on bone formation through activation of PI3K/Akt pathway in rat calvaria osteoblasts
    • DOI 10.1055/s-2007-967168
    • Zhang Y, Zeng X, Zhang L, Zheng X,. 2007. Stimulatory effect of puerarin on bone formation through activation of PI3K/Akt pathway in rat calvaria osteoblasts. Planta Med 73: 341-347. (Pubitemid 46910416)
    • (2007) Planta Medica , vol.73 , Issue.4 , pp. 341-347
    • Zhang, Y.1    Zeng, X.2    Zhang, L.3    Zheng, X.4
  • 159
    • 77958138748 scopus 로고    scopus 로고
    • Preventive effects of Flos Perariae (Gehua) water extract and its active ingredient puerarin in rodent alcoholism models
    • Zhang Z, Li S, Jiang J, et al,. 2010b. Preventive effects of Flos Perariae (Gehua) water extract and its active ingredient puerarin in rodent alcoholism models. Chin Med 5: 36.
    • (2010) Chin Med , vol.5 , pp. 36
    • Zhang, Z.1    Li, S.2    Jiang, J.3
  • 160
    • 77951668368 scopus 로고    scopus 로고
    • Protective effect of puerarin on acute alcoholic liver injury
    • Zhao M, Du YQ, Yuan L, Wang NN,. 2010. Protective effect of puerarin on acute alcoholic liver injury. Am J Chin Med 38: 241-249.
    • (2010) Am J Chin Med , vol.38 , pp. 241-249
    • Zhao, M.1    Du, Y.Q.2    Yuan, L.3    Wang, N.N.4
  • 161
    • 84862726907 scopus 로고    scopus 로고
    • Puerarin improve insulin resistance of adipocyte through activating Cb1 binding protein path
    • Zhao Y, Zhou Y,. 2012. Puerarin improve insulin resistance of adipocyte through activating Cb1 binding protein path. Chin J Integr Med 18: 293-298.
    • (2012) Chin J Integr Med , vol.18 , pp. 293-298
    • Zhao, Y.1    Zhou, Y.2
  • 162
    • 65449162655 scopus 로고    scopus 로고
    • Therapeutic effect of puerarin on non-alcoholic rat fatty liver by improving leptin signal transduction through JAK2/STAT3 pathways
    • Zheng P, Ji G, Ma Z, et al,. 2009. Therapeutic effect of puerarin on non-alcoholic rat fatty liver by improving leptin signal transduction through JAK2/STAT3 pathways. Am J Chin Med 37: 69-83.
    • (2009) Am J Chin Med , vol.37 , pp. 69-83
    • Zheng, P.1    Ji, G.2    Ma, Z.3
  • 163
    • 52949102165 scopus 로고    scopus 로고
    • Effects of puerarin on expressions of leptin receptor mRNA, phosphorylated Janus kinase 2/phosphorylated signal transducers and activators of transcription 3 proteins in the liver of rats with non-alcoholic fatty liver
    • Zheng PY, Ma ZS, Hua YQ, et al,. 2008. Effects of puerarin on expressions of leptin receptor mRNA, phosphorylated Janus kinase 2/phosphorylated signal transducers and activators of transcription 3 proteins in the liver of rats with non-alcoholic fatty liver. Zhong Xi Yi Jie He Xue Bao 6: 921-927.
    • (2008) Zhong Xi Yi Jie He Xue Bao , vol.6 , pp. 921-927
    • Zheng, P.Y.1    Ma, Z.S.2    Hua, Y.Q.3
  • 164
    • 77957807199 scopus 로고    scopus 로고
    • Puerarin attenuates glutamate-induced neurofilament axonal transport impairment
    • Zhou J, Wang H, Xiong Y, et al,. 2010. Puerarin attenuates glutamate-induced neurofilament axonal transport impairment. J Ethnopharmacol 132: 150-156.
    • (2010) J Ethnopharmacol , vol.132 , pp. 150-156
    • Zhou, J.1    Wang, H.2    Xiong, Y.3
  • 165
    • 33746547990 scopus 로고    scopus 로고
    • Clinical observation of puerarin in treating patients with vertebral artery insufficiency due to cervical spondylosis: A report of 123 cases
    • Zhou PQ, Shen L, Yang YP, Xie J,. 2006. Clinical observation of puerarin in treating patients with vertebral artery insufficiency due to cervical spondylosis: a report of 123 cases. Zhong Xi Yi Jie He Xue Bao 4: 80-81.
    • (2006) Zhong Xi Yi Jie He Xue Bao , vol.4 , pp. 80-81
    • Zhou, P.Q.1    Shen, L.2    Yang, Y.P.3    Xie, J.4
  • 166
    • 78349270212 scopus 로고    scopus 로고
    • Puerarin protects dopaminergic neurons against 6-hydroxydopamine neurotoxicity via inhibiting apoptosis and upregulating glial cell line-derived neurotrophic factor in a rat model of Parkinson's disease
    • Zhu G, Wang X, Chen Y, et al,. 2010a. Puerarin protects dopaminergic neurons against 6-hydroxydopamine neurotoxicity via inhibiting apoptosis and upregulating glial cell line-derived neurotrophic factor in a rat model of Parkinson's disease. Planta Med 76: 1820-1826.
    • (2010) Planta Med , vol.76 , pp. 1820-1826
    • Zhu, G.1    Wang, X.2    Chen, Y.3
  • 167
    • 84893748975 scopus 로고    scopus 로고
    • Neuroprotective effects of puerarin on 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine induced Parkinson's disease model in mice
    • Mar 20. doi: 10.1002/ptr.4975
    • Zhu G, Wang X, Wu S, et al,. 2013. Neuroprotective effects of puerarin on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induced Parkinson's disease model in mice. Phytother Res Mar 20. doi: 10.1002/ptr.4975.
    • (2013) Phytother Res
    • Zhu, G.1    Wang, X.2    Wu, S.3
  • 168
    • 84862785124 scopus 로고    scopus 로고
    • +-induced human neuroblastoma SH-SY5Y cell death
    • +-induced human neuroblastoma SH-SY5Y cell death. Neurochem Int 60: 400-408.
    • (2012) Neurochem Int , vol.60 , pp. 400-408
    • Zhu, G.1    Wang, X.2    Wu, S.3    Li, Q.4
  • 169
    • 50849101649 scopus 로고    scopus 로고
    • Puerarin reduces endothelial progenitor cells senescence through augmentation of telomerase activity
    • Zhu J, Wang X, Shang Y, et al,. 2008a. Puerarin reduces endothelial progenitor cells senescence through augmentation of telomerase activity. Vascul Pharmacol 49: 106-110.
    • (2008) Vascul Pharmacol , vol.49 , pp. 106-110
    • Zhu, J.1    Wang, X.2    Shang, Y.3
  • 170
    • 74149093839 scopus 로고    scopus 로고
    • Puerarin attenuates high-glucose-and diabetes-induced vascular smooth muscle cell proliferation by blocking PKCbeta2/Rac1-dependent signaling
    • Zhu LH, Wang L, Wang D, et al,. 2010b. Puerarin attenuates
    • (2010) Free Radic Biol Med , vol.48 , pp. 471-482
    • Zhu, L.H.1    Wang, L.2    Wang, D.3
  • 171
    • 84904255391 scopus 로고    scopus 로고
    • The potential effect of puerarin in preventing atherosclerosis
    • Zhu QL, He AX, Han HR, et al,. 2002. The potential effect of puerarin in preventing atherosclerosis. CJIM 8: 290-294.
    • (2002) CJIM , vol.8 , pp. 290-294
    • Zhu, Q.L.1    He, A.X.2    Han, H.R.3
  • 172
    • 84874160734 scopus 로고    scopus 로고
    • Effect and mechanism of puerarin on high glucose-induced hypo-responses in vascular contraction
    • Zhu YM, Ni C, Zhu L, et al,. 2011. Effect and mechanism of puerarin on high glucose-induced hypo-responses in vascular contraction. Zhongguo Ying Yong Sheng Li Xue Za Zhi 27: 62-65.
    • (2011) Zhongguo Ying Yong Sheng Li Xue Za Zhi , vol.27 , pp. 62-65
    • Zhu, Y.M.1    Ni, C.2    Zhu, L.3
  • 173
    • 39349101276 scopus 로고    scopus 로고
    • Effects of puerarin on pulmonary vascular remodeling and protein kinase C-alpha in chronic cigarette smoke exposure smoke-exposed rats
    • Zhu Z, Xu Y, Zou H, et al,. 2008b. Effects of puerarin on pulmonary vascular remodeling and protein kinase C-alpha in chronic cigarette smoke exposure smoke-exposed rats. J Huazhong Univ Sci Technolog Med Sci 28: 27-32.
    • (2008) J Huazhong Univ Sci Technolog Med Sci , vol.28 , pp. 27-32
    • Zhu, Z.1    Xu, Y.2    Zou, H.3
  • 174
    • 84870798936 scopus 로고    scopus 로고
    • Protective effect of puerarin against beta-amyloid-induced oxidative stress in neuronal cultures from rat hippocampus: Involvement of the GSK-3β/Nrf2 signaling pathway
    • Zou Y, Hong B, Fan L, et al,. 2013. Protective effect of puerarin against beta-amyloid-induced oxidative stress in neuronal cultures from rat hippocampus: involvement of the GSK-3β/Nrf2 signaling pathway. Free Radic Res 47: 55-63.
    • (2013) Free Radic Res , vol.47 , pp. 55-63
    • Zou, Y.1    Hong, B.2    Fan, L.3


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