Puerarin protects against ischemic brain injury in a rat model of transient focal ischemia

Neurological Research

Volumn 31, Issue 4, 2009, Pages 402-406

  Gao, Li ^a   Ji, Xunming ^a   Song, Juexian ^a   Liu, Ping ^a   Yan, Feng ^a   Gong, Wei ^a   Dang, Sha ^a   Luo, Yumin ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Erythropoietin; Functional neurological outcome; Ischemia and reperfusion injury; Puerarin

Indexed keywords

ERYTHROPOIETIN; PUERARIN; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN INFARCTION SIZE; BRAIN INJURY; BRAIN ISCHEMIA; CELL DAMAGE; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG EFFICACY; ENZYME LINKED IMMUNOSORBENT ASSAY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NICK END LABELING; NONHUMAN; PROTEIN EXPRESSION; RAT; REPERFUSION;

ANALYSIS OF VARIANCE; ANIMALS; APOPTOSIS; BEHAVIOR, ANIMAL; BRAIN INJURIES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; ERYTHROPOIETIN; GENE EXPRESSION REGULATION; IN SITU NICK-END LABELING; ISCHEMIC ATTACK, TRANSIENT; ISOFLAVONES; MALE; NEUROLOGIC EXAMINATION; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; VASODILATOR AGENTS;

EID: 67149102151     PISSN: 01616412     EISSN: None     Source Type: Journal    
DOI: 10.1179/174313209X444017     Document Type: Article

References (29)

1. Centers for Disease Control and Prevention (CDC). Prevalence of stroke - United States, 2005. MMWR Morb Mortal Wkly Rep 2007; 56: 469-474
2. Luo Y, Qin Z, Hong Z,et al. Astragaloside IV protects against ischemic brain injury in a murine model of transient focal ischemia. Neurosci Lett 2004; 363: 218-223
3. Hsieh CL, Cheng CY, Tsai TH, et al. Paeonol reduced cerebral infarction involving the superoxide anion and microglia activation in ischemia-reperfusion injured rats. J Ethnopharmacol 2006; 106: 208-215 (Pubitemid 43766198)
4. Lin Z, Yan Y, Zhu D, et al. Protective effects of FBD - an experimental Chinese traditional medicinal formula on memory dysfunction in mice induced by cerebral ischemia-reperfusion. J Ethnopharmacol 2005; 97: 477-483 (Pubitemid 40312322)
5. Zhang SY, Chen G, Wei PF, et al.The effect of puerarin on serum nitric oxide concentration and myocardial eNOS expression in rats with myocardial infarction. J Asian Nat Prod Res 2008; 10: 373-381
6. Wu L, Qiao H, Li Y, et al.Cardioprotective effects of the combined use of puerarin and Danshensu on acute ischemic myocardial injury in rats. Phytother Res 2007; 21: 751-756 (Pubitemid 47217775)
7. Wu L, Qiao H, Li Y, et al. Protective roles of puerarin and Danshensu on acute ischemic myocardial injury in rats. Phytomedicine 2007; 14: 652-658 (Pubitemid 47419302)
8. Gao Q, Yang B, Ye ZG, et al. Opening the calcium-activated potassium channel participates in the cardioprotective effect of puerarin. Eur J Pharmacol 2007; 574: 179-184 (Pubitemid 47575526)
9. Gao Q, Pan HY, Bruce IC, et al. Improvement of ventricular mechanical properties by puerarin involves mitochondrial permeability transition in isolated rat heart during ischemia and reperfusion. Conf Proc IEEE Eng Med Biol Soc 2005; 6: 5591-5594 (Pubitemid 46230225)
10. Fan LL, Sun LH, Li J, et al.Protective effect of puerarin against myocardial reperfusion injury. Myocardial metabolism and ultrastructure. Chin Med J (Engl) 1992; 105: 451-456
11. Fan LL, Sun LH, Li J, et al. The protective effect of puerarin against myocardial reperfusion injury. Study on cardiac function. Chin Med J (Engl) 1992; 105: 11-17
12. Xu X, Zhang S, Zhang L, et al.The neuroprotection of puerarin against cerebral ischemia is associated with the prevention of apoptosis in rats. Planta Med 2005; 71: 585-591 (Pubitemid 41133065)
13. Xu XH, Zheng XX, Zhou Q, et al. Inhibition of excitatory amino acid efflux contributes to protective effects of puerarin against cerebral ischemia in rats. Biomed Environ Sci 2007; 20: 336-342 (Pubitemid 47441814)
14. Sang HF, Mei QB, Xu LX,et al. Effect of puerarin on neural function and histopathological damages after transient spinal cord ischemia in rabbits. Chin J Traumatol 2004; 7: 143-147 (Pubitemid 38786901)
15. Bernaudin M, Marti HH, Roussel S, et al. A potential role for erythropoietin in focal permanent cerebral ischemia in mice. J Cereb Blood Flow Metab 1999; 19: 643-651 (Pubitemid 30161216)
16. Brines ML, Ghezzi P, Keenan S, et al. Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury. Proc Natl Acad Sci USA 2000; 97: 10526-10531 (Pubitemid 30707300)
17. Erbayraktar S, Grasso G, Sfacteria A, et al. Asialoerythropoietin is a nonerythropoietic cytokine with broad neuroprotective activity in vivo. Proc Natl Acad Sci USA 2003; 100: 6741-6746 (Pubitemid 36666650)
18. Sakanaka M, Wen TC, Matsuda S, et al. In vivo evidence that erythropoietin protects neurons from ischemic damage. Proc Natl Acad Sci USA 1998; 95: 4635-4640
19. Siren AL, Fratelli M, Brines M, et al. Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress. Proc Natl Acad Sci USA 2001; 98: 4044-4049 (Pubitemid 32249895)
20. Masuda S, Nagao M, Takahata K, et al. Functional erythropoietin receptor of the cells with neural characteristics. Comparison with receptor properties of erythroid cells. J Biol Chem 1993; 268: 11208-11216 (Pubitemid 23162313)
21. Ehrenreich H, Hasselblatt M, Dembowski C, et al. Erythropoietin therapy for acute stroke is both safe and beneficial. Mol Med 2002; 8: 495-505 (Pubitemid 36337492)
22. Chen J, Graham SH, Zhu RL, et al. Stress proteins and tolerance to focal cerebral ischemia. J Cereb Blood Flow Metab 1996; 16: 566-577 (Pubitemid 26227065)
23. Bederson JB, Pitts LH, Tsuji M, et al. Rat middle cerebral artery occlusion: Evaluation of the model and development of a neurologic examination. Stroke 1986; 17: 472-476 (Pubitemid 16085691)
24. de Ryck M, Reempts JV, Borgers M, et al. Photochemical stroke model: Flunarizine prevents sensorimotor deficits after neocortical infarcts in rats. Stroke 1989; 20: 1383-1390 (Pubitemid 19254555)
25. Chen J, Graham SH, Nakayama M, et al. Apoptosis repressor genes Bcl-2 and Bcl-x-long are expressed in the rat brain following global ischemia. J Cereb Blood Flow Metab 1997; 17: 2-10 (Pubitemid 27014902)
26. Ichikawa H, Konishi T. In vitro antioxidant potentials of traditional Chinese medicine, Shengmai San and their relation to in vivo protective effect on cerebral oxidative damage in rats. Biol Pharm Bull 2002; 25: 898-903
27. Brian AK, Ronald JM, Sandra E. A comparison of high-dose recombinant erythropoietin treatment regimens in brain-injured neonatal rats. Pediatr Res 2007; 61: 451-455 (Pubitemid 46569299)
28. McPherson RJ, Juul SE. Recent trends in erythropoietin-mediated neuroprotection. Int J Dev Neurosci 2008; 26: 103-111 (Pubitemid 351192267)
29. Kilic E, Kilic U, Soliz J, et al. Brain-derived erythropoietin protects from focal cerebral ischemia by dual activation of ERK-1/-2 and pathways. FASEB J 2005; 19: 2026-2028 (Pubitemid 41759753)