Protective effects of Puerarin on carbon tetrachloride-induced hepatotoxicity

Archives of Pharmacal Research

Volumn 30, Issue 10, 2007, Pages 1309-1317

  Hwang, Yong Pil ^a   Choi, Chul Yung ^b   Chung, Young Chul ^b   Jeon, Seong Sik ^b   Jeong, Hye Gwang ^a  

^a Chosun University   (South Korea)

^b Jinju International University   (South Korea)

Author keywords

Carbon tetrachloride; Cytochrome P450 2E1; Hepatoprotective effects; Puerarin

Indexed keywords

ALANINE AMINOTRANSFERASE; ANILINE; ANILINE DERIVATIVE; ASPARTATE AMINOTRANSFERASE; CARBON TETRACHLORIDE; CYTOCHROME P450 2E1; ENZYME INHIBITOR; FREE RADICAL; GLUTATHIONE; GLUTATHIONE TRANSFERASE; ISOFLAVONE DERIVATIVE; MALONALDEHYDE; PUERARIN; SCAVENGER;

ANIMAL; ARTICLE; BIOTRANSFORMATION; BLOOD; CHEMICALLY INDUCED DISORDER; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; HYDROXYLATION; INSTITUTE FOR CANCER RESEARCH MOUSE; LIPID PEROXIDATION; LIVER; LIVER DISEASE; MALE; METABOLISM; MOUSE; PATHOLOGY; UPREGULATION;

ALANINE TRANSAMINASE; ANILINE COMPOUNDS; ANIMALS; ASPARTATE AMINOTRANSFERASES; BIOTRANSFORMATION; CARBON TETRACHLORIDE; CYTOCHROME P-450 CYP2E1; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FREE RADICAL SCAVENGERS; FREE RADICALS; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HYDROXYLATION; ISOFLAVONES; LIPID PEROXIDATION; LIVER; LIVER DISEASES; MALE; MALONDIALDEHYDE; MICE; MICE, INBRED ICR; UP-REGULATION;

EID: 35649020801     PISSN: 02536269     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02980272     Document Type: Article

References (43)

1. Allis, J. W., Brown, B. L., Simmons, J. E., Hatch, G. E., McDonald, A., and House, D. E., Methanol potentiation of carbon tetrachloride hepatotoxicity: the central role of cytochrome P450. Toxicology, 112, 131-140 (1996).
2. Bae, H. S., Kim, Y. S., Cho, K. H., Lee, K. S., Kim, J. J., Lee, H. U., and Kim, D. H., Hepatoprotective activity of reduohanxiaotang (yuldahanso-tang) Is related to the inhibition of betaglucuronidase. Am. J. Chin. Med., 31, 111-117 (2003).
3. Boyer, T. D., Vessey, D. A., Holcomb, C., and Saley, N., Studies of the relationship between the catalytic activity and binding of non-substrate ligands by the glutathione S-transferases. Biochem. J., 217, 179-185 (1984).
4. Bradford, M. M., A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72, 248-254 (1976).
5. Brattin, W. J., Glende Jr, E. A., and Recknagel, R. O., Pathological mechanisms in carbon tetrachloride hepatotoxicity. Free Radical Biol. Med., 1, 27-38 (1985).
6. Brautbar, N. and Williams 2nd, J., Industrial solvents and liver toxicity: risk assessment, risk factors and mechanisms. J. Hyg., 205, 479-491 (2002).
7. Brent, J. A. and Rumack, B. H., Role of free radicals in toxic hepatic injury 11. Clin. Toxcol., 31, 173-196 (1993).
8. Campo, G. M., Squadrito, F., Ceccarelli, S., Calo, M., Avenoso, A., Campo, S., Squadrito, G., and Altavilla, D., Reduction of carbon tetrachloride-induced rat liver injury by IRFI 042, a novel dual vitamin E-like antioxidant. Free Free Radical Res., 34, 379-393 (2001).
9. Cervellati, R., Renzulli, C., Guerra, M. C., and Speroni, E., Evaluation of antioxidant activity of some natural polyphenols compounds using the Briggs-Rauscher reaction method. J. Agr. Food Chem., 50, 7504-7509 (2002).
10. Dicker, E., McHugh, T., and Cederbaum, A. I., Increased oxidation of p-nitrophenol and aniline by intact hepatocytes isolated from pyrazole-treated rats. Biochim. Biophys. Acta., 1035, 249-256 (1990).
11. Eaton, D. L., Gallagher, E. P., Bammler, T. K., and Kunze, K. L., Role of cytochrome P4501A2 in chemical carcinogenesis: Implications for human variability in expression and enzyme activity. Pharmacogenetics, 5, 259-274 (1995).
12. Fairhurst, S., Barber, D. J., Clark, B., and Horton, A. A., Studies on paracetamol-induced lipid peroxidation. Toxicology, 23, 249-259 (1982).
13. Fan, L. L., Sun, L. H., and Li, J., The protective effect of puerarin against myocardial reperfusion injury: study on cardiac function. Chin. Med. J., 105, 11-17 (1992).
14. Fang, Q., Some current study and research approaches relating to the use of plants in the traditional Chinese medicine. J. Ethnopharmacol., 2, 57-63 (1980).
15. Gonzalez, F. J., The molecular biology of cytochrome P450s. Pharmacol. Rev., 40, 243-288 (1988).
16. Guengerich, F. P., Kim, D-H., and Iwasaki, M., Role of human cytochrome P-450 HE 1 in the oxidation of many low molecular weight cancer suspects. Chem. Res. Toxicol., 4, 168-179 (1991).
17. Guerra, M. C., Speroni, E., Broccoli, M., Cangini, M., Pasini, P., Minghett, A., Crespi-Perellino, N., Mirasoli, M., Cantelli-Forti, G., and Paolini, M., Comparison between Chinese medical herb Pueraria lobata crude extract and its main isoflavone puerarin antioxidant properties and effects on rat liver CYPcatalysed drug metabolism. Life Sci., 67, 2997-3006 (2000).
18. Guo, Y., Zhou, C. W., and Xu, J., The effects of pueraria on the inhibition of nonenzymatic glycation and oxidation in kidneys of streptozocin-induced diabetic rats. Jiangsu Med. J., 29, 669-671 (2003).
19. Habig, W. H., Pablst, M. J., and Jakoby, W. B., Glutathione Stransferases. The first enzymatic step in mercapturic acid formation. J. Biol. Chem., 49, 7130-7139 (1974).
20. Hsu, F. I., Liu, I. M., Kuo, D. H., Chen, W. C., Su, H. C., and Cheng, J. T., Antihyperglycemic effect of puerarin in streptozotocin-induced diabetic rats. J. Nat. Prod., 66, 788-792 (2003).
21. Jeong, H. G., Inhibition of cytochrome P450 2E1 expression by oleanolic acid: Hepatoprotective effects against carbontetrachloride-induced hepatic injury. Toxbol. Lett., 105, 215-222 (1999).
22. Jeong, H. G. and Yun, C. H., Induction of rat hepatic cytochrome enzymes by myristicin. Biochem. Biophys. Res. Commun., 217, 966-971 (1995).
23. Jin, L. H., Liu, C. F., and Zeng, Y., Protective effects of puerarin on radiation injury of experimental rats. Zhong Xi Yi Jie He Xue Bao., 3, 43-45 (2005).
24. Kim, N. D., Kwak, M. K., and Kim, S. G., Inhibition of cytochrome P450 2E1 expression by 2-(allylthio)pyrazine, a potential chemoprotective agent: hepatoprotective effects. Biochem. Pharmacol., 53, 261-269 (1997).
25. Kim, S. G. and Novak, R. F., Induction of rat hepatic P450IIE1 (CYP 2E1) by pyridine: evidence for a role of protein synthesis in the absence of transcriptional activation. Biochem. Biophys. Res. Commun., 166, 1072-1079 (1990).
26. Koop, D. R., Oxidative and reductive metabolism by cytochrome P450 2E1. FASEB J., 6, 724-730 (1992).
27. Lee, K. J., Woo, E. R., Choi, C. Y., Shin, D. W., Lee, D. G., You. H. J., and Jeong, H. G., Protective effect of acteoside on carbon tetrachloride- induced hepatotoxicity. Life Sci., 74, 1051-1064 (2004).
28. Lee, S. S. T., Buters, J. T. M., and Pineau, T., Fernandez-Salguero, P., Gonzalez, F. J., Role of CYP2E1 in the hepatotoxicity of acetaminophen. J. Bio. Chem., 271, 12063-12067 (1996).
29. Recknagel, R. O., Glende Jr., E. A., and Britton, R. S., Free radical damage and lipid peroxidation. In: Meeks, R.G. (Eds), Hepatotoxicology. CRC Press, Florida, pp. 401-436 (1991).
30. Recknagel, R. O., Glende Jr., E. A., Dolak, J. A., and Waller, R. L., Mechanisms of carbon tetrachloride toxicity. Pharmacol. Ther., 43, 139-154 (1989).
31. Ren, P., Hu, H., and Zhang, R., Observation on efficacy of puerarin in treation diabetic retinopathy. Zhongguo Zhong Xi Yi Jie He Za Zhi., 20, 574-576 (2000).
32. Sedlak, J. and Lindsay, R. H., Estimation of total protein with bound and non-protein sulthydryl groups in tissues with Ellman's reagent. Anal. Biochem. 25, 192-205 (1968).
33. Shi.W. G., Qu, L., and Wang, J. W., Study on interventing effect of puerarin on insulin resistance in patients with coronary heart disease. Zhongguo Zhong Xi Yi Jie He Za Zhi., 22, 21-24 (2002).
34. Ursini, F., Maiorino, M., Morazzoni, P., Roveri, A., and Pifferi, G, A novel antioxidant flavonoid affecting molecular mechanisms of cellular activation. Free Radical Biol. Med., 16, 547-553 (1994).
35. Wang, J., Chen, M., Chao, Y., Lu, Y., and Zhu, Q., Effect of kakonein and gingko flavone on protein nonenzymatic glycosylation. Zhong Yao Yao Li Yu Lin Chuang., 16, 13-14 (2000).
36. Williams, A. T. and Burk, R. F., Carbon tetrachloride hepatotoxicity: an example of free radical-mediated injury. Semin. Liver Dis., 10, 279-284 (1990).
37. Wolf, P. L., Biochemical diagnosis of liver diseases. Clin. Biochem. 14, 59-90 (1999).
38. Xu, X. H., Effects of puerarin on fatty superoxide in aged mice induced by D-galactose. Chin. J. Chin. Mater. Med., 28, 6669 (2003).
39. Xuan, B., Zhou, Y. H., and Yang, R. L., Improvement of ocular blood flow and retinal functions with puerarin analogs. J. Ocular Pharmacol. Ther., 15, 207-216 (1999).
40. Yang, C. S., Yoo, J. S. H., Ishizaki, H., and Hong, J.-Y., Cytochrome P450 IIE1: Roles in nitrosamine metabolism and mechanism of regulation. Drug Metab. Rev., 22, 147-159 (1990).
41. Zangar, R. C., Benson, J. M., Burnett, V. L., and Springer, D. L., Cytochrome P450 2E1 is the primary enzyme responsible for low-dose carbon tetrachloride metabolism in human liver microsomes. Chem-Biol Interact., 125, 233-243 (2000).
42. Zhang, B., Wei, X. B., Liu, H.Q., Wang, L. X., Sun, R., and Zhang, X. M., Protective effects of hydroxyethylpuerarin against brain astrocytes injury induced by hydrogen peroxide. Yao Xue Xue Bao., 41, 171-174 (2006).
43. Zhu, Q. L., He, A. X., and Lu, X. R., Effects of puerarin on the scavenge of oxygen free radicals and the antagonism against oxidative injury. Pharm. J. Clin. PLA., 17, 1-4 (2001).