Protective effects and mechanism of puerarin on learning-memory disorder after global cerebral ischemia-reperfusion injury in rats

Chinese Journal of Integrative Medicine

Volumn 15, Issue 1, 2009, Pages 54-59

  Wu, Hai Qin ^a   Guo, He Na ^a   Wang, Hu Qing ^a   Chang, Ming Ze ^a   Zhang, Gui Lian ^a   Zhao, Ying Xian ^a  

^a MEDICAL SCHOOL OF XI AN JIAOTONG UNIVERSITY   (China)

Author keywords

Cerebral ischemia reperfusion injury; Learning memory disorder; Puerarin

Indexed keywords

PROTEIN BCL 2; PUERARIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN ISCHEMIA; CELL COUNT; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; FEMALE; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; LEARNING DISORDER; MALE; MEMORY DISORDER; NERVE CELL; NEUROPROTECTION; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; UPREGULATION;

ANIMALS; APOPTOSIS; BRAIN ISCHEMIA; HIPPOCAMPUS; ISOFLAVONES; LEARNING; MEMORY DISORDERS; MODELS, BIOLOGICAL; PROTECTIVE AGENTS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; REACTION TIME; REPERFUSION INJURY;

EID: 60849084558     PISSN: 16720415     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11655-009-0054-4     Document Type: Article

References (11)

1. Xu XH, Zhang ZG. Effect of puerarin on learning-memory behavior and synaptic structure of hippocampus in the aging mice induced by D-galactose. Acta Pharmaceutica Sinica (Chin) 2002;37:1-4.
2. Pulsinelli WA, Brierley JB. A new model of bilateral hemisphere ischemia in the unanesthetized rat. Stroke 1979;10: 267-272.
3. He XC, Cai WQ, LI ZG, Yang Z. Experimental study on the effect of Naogongfude on the aging of the rat brain. Acta Academiae Med Milit Tertiae (Chin) 2001; 23:448-450.
4. Kondo T, Reaume AG, Huang TT, Carlson E, Murakami K, Chen SF, et al. Reduction of CuZn-superoxide dismutase activity exacerbates neuronal cell injury and edema formation after transient focal cerebral ischemia. J Neurosci 1997;17:4180-4189.
5. Charriaut-Marlangue C, Margaill I, Represa A, Popovici T, Plotkine M, Ben-Ari Y. Apoptosis and necrosis after reversible focal ischemia: an in situ DNA fragmentation analysis. J Cereb Flow Metab 1996;16:186-194.
6. Li Y, Chopp M, Jiang N, Yao F, Zaloga C. Temporal profile of in situ DNA fragmentation after transient middle cerebral artery occlusion in the rat. J Cereb Flow Metab 1995;15: 389-397.
7. Zhu QL, He AX, Lu XR. Effects of puerarin on the scavenge of oxygen free radicals and the antagonism against oxidative injury. Pharmac J Chin People's Liberation Army (Chin) 2001;17:1-13.
8. Dong LP, Wang TY. Effect of puerarin against glutamate excitotoxicity on cultured mouse cerebral cortical neurons. Acta Pharm Sinica 1998;19:339-342.
9. Sun W, Xu QL, Zheng XZ. Effects of puerarin on lipid metabolism of type 2 diabetes mellitus rats. China Healthcare Innov (Chin) 2007;2:16-17.
10. Gao P, Xia CQ, Wang PY, Liu YG, Mei X. Observation of the puerarin's effect on cerebral inducible nitric oxide synthase during global cerebral ischemia and reperfusion. J Emerg Med (Chin) 2001;10:85-86.
11. Wu HQ, Zhang B, Zhang GL, Zhan SQ, Zhang R, Zhao YX. Effects of puerarin on the expression ot hypoxia inducible factor-1 α and erythropoietin in the hippocampus of vascular dementia rats. J Xi'an Jiaotong Univ (Med Sci, Chin) 2006; 27:132-136.