Effects of puerarin on pulmonary vascular remodeling and protein kinase C-α in chronic cigarette smoke exposure smoke-exposed rats

Journal of Huazhong University of Science and Technology - Medical Science

Volumn 28, Issue 1, 2008, Pages 27-32

  Zhu, Zhaoxia ^a   Xu, Yongjian ^a   Zou, Hui ^a   Zhang, Zhenxiang ^a   Ni, Wang ^a   Chen, Shixin ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Apoptosis; Cigarette smoke; Proliferation; Protein kinase C; Puerarin; Vessel remodeling

Indexed keywords

ISOFLAVONE DERIVATIVE; PROTEIN KINASE C ALPHA; PUERARIN; VASODILATOR AGENT;

ANIMAL; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CYTOLOGY; DRUG EFFECT; LUNG; MALE; METABOLISM; PASSIVE SMOKING; PULMONARY ARTERY; RAT; SMOKING; SMOOTH MUSCLE FIBER; VASCULAR ENDOTHELIUM; WISTAR RAT;

ANIMALS; APOPTOSIS; CELL PROLIFERATION; ENDOTHELIUM, VASCULAR; ISOFLAVONES; LUNG; MALE; MYOCYTES, SMOOTH MUSCLE; PROTEIN KINASE C-ALPHA; PULMONARY ARTERY; RATS; RATS, WISTAR; SMOKING; TOBACCO SMOKE POLLUTION; VASODILATOR AGENTS;

EID: 39349101276     PISSN: 16720733     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11596-008-0107-8     Document Type: Article

References (9)

1. Churg A, Tai H, Coulthard T et al. Cigarette smoke drives small airway remodeling by induction of growth factors in the airway wall. Am J Respir Crit Care Med, 2006,174(12):1327-1334
2. Wright J L, Tai H, Wang R et al. Cigarette smoke upregulates pulmonary vascular matrix metalloproteinases via TNF-alpha signaling. Am J Physiol Lung Cell Mol Physiol, 2007,292(1):L125-L133
3. Santos S, Peinado V I, Ramirez J et al. Characterization of pulmonary vascular remodeling in smokers and patients with mild COPD. Eur Respir J, 2002,19(4):632-638
4. Wright J L, Postma D S, Kerstjens H A et al. Airway remodeling in the smoke exposed guinea pig model. Inhal Toxicol, 2007,19(11):915-923
5. Kang T, Lu S, Wang L et al. Experimental study of vascular smooth muscle cell apoptosis induced by puerarin. Chin J Integrative Med Cardio-/ Cerebrovascular Dis (Chinese), 2003,1(12):703-705
6. Nadziejko C, Fang K, Bravo A, et al. Susceptibility to pulmonary hypertension in inbred strains of mice exposed to cigarette smoke. J Appl Physiol. 2007 May;102(5):1780-1785
7. Xu Y, Stenmark K R, Das M et al. Pulmonary artery smooth muscle cells from chronically hypoxic neonatal calves retain fetal-like and acquire new growth properties. Am J Physiol, 1997,273(17):L234-L235
8. Itoh H, Yamamura S, Ware J A et al. Differential effects of protein kinase C on human vascular smooth muscle cell proliferation and migration. Am J Physiol Heart Circ Physiol, 2001,281(1):H359-H370
9. Lee S D, Lee D S, Chun Y G et al. Cigarette smoke extract induces endothelin-1 via protein kinase C in pulmonary artery endothelial cells. Am J Physiol Lung Cell Mol Physiol, 2001,281:L403-L411