Puerarin attenuates high-glucose-and diabetes-induced vascular smooth muscle cell proliferation by blocking PKCβ2/Rac1-dependent signaling

Free Radical Biology and Medicine

Volumn 48, Issue 4, 2010, Pages 471-482

  Zhu, Li Hua ^a,b   Wang, Lang ^a,b   Wang, Dong ^c   Jiang, Hong ^a,b   Tang, Qi Zhu ^a,b   Yan, Ling ^a,b   Bian, Zhou Yan ^a,b   Wang, Xin An ^a,b   Li, Hongliang ^a,b  

^a RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

^b WUHAN UNIVERSITY   (China)

^c UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

Diabetes; Free radicals; NADPH oxidase; Neointimal formation; Puerarin; Reactive oxygen species

Indexed keywords

GLUCOSE; PLACEBO; PROTEIN KINASE C BETA; PROTEIN P47; PROTEIN P67; PUERARIN; RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTERY INTIMA PROLIFERATION; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DIABETES MELLITUS; DRUG MECHANISM; ENZYME INHIBITION; HYPERGLYCEMIA; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; VASCULAR SMOOTH MUSCLE;

ANIMALS; APOPTOSIS; CELL PROLIFERATION; CELL SURVIVAL; DIABETES MELLITUS; GLUCOSE; ISOFLAVONES; MALE; MODELS, BIOLOGICAL; MYOCYTES, SMOOTH MUSCLE; OXIDATIVE STRESS; PHOSPHORYLATION; PROTEIN KINASE C; RAC1 GTP-BINDING PROTEIN; RATS; RATS, SPRAGUE-DAWLEY; RATS, ZUCKER; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

RATTUS;

EID: 74149093839     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2009.10.040     Document Type: Article

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