Protective role of puerarin on lead-induced alterations of the hepatic glutathione antioxidant system and hyperlipidemia in rats

Food and Chemical Toxicology

Volumn 49, Issue 12, 2011, Pages 3119-3127

  Liu, Chan Min ^a   Ma, Jie Qiong ^b   Sun, Yun Zhi ^a  

^a JIANGSU NORMAL UNIVERSITY   (China)

^b CHINA UNIVERSITY OF MINING AND TECHNOLOGY   (China)

Author keywords

Glutathione antioxidant system; Hyperlipidemia; Lead; Lipid metabolism; Puerarin; Rat liver

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CHOLESTEROL 7ALPHA MONOOXYGENASE; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; HIGH DENSITY LIPOPROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; PUERARIN; REACTIVE OXYGEN METABOLITE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRIACYLGLYCEROL;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; HISTOPATHOLOGY; HYPERLIPIDEMIA; LIPID PEROXIDATION; LIPOPROTEIN BLOOD LEVEL; LIVER INJURY; LIVER PROTECTION; LIVER TOXICITY; MALE; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; TRIACYLGLYCEROL BLOOD LEVEL; WESTERN BLOTTING;

ANIMALS; ANTIOXIDANTS; CHOLESTEROL; CHOLESTEROL 7-ALPHA-HYDROXYLASE; GLUTATHIONE; HYDROXYMETHYLGLUTARYL COA REDUCTASES; HYPERLIPIDEMIAS; ISOFLAVONES; LEAD; LIPID PEROXIDATION; LIPOPROTEINS, HDL; LIPOPROTEINS, LDL; LIVER; LIVER DISEASES; MALE; OXIDATIVE STRESS; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; TRIGLYCERIDES;

RATTUS;

EID: 80054862903     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2011.09.007     Document Type: Article

References (81)

1. Ahamed M., Siddiqui M.K.J. Low levels lead exposure and oxidative stress: current opinions. Clin. Chim. Acta 2007, 383:57-64.
2. Amudha K., Pari L. Beneficial role of naringin, a flavanoid on nickel induced nephrotoxicity in rats. Chem. Biol. Interact. 2011, 193:57-64.
3. Aykin-Burns N., Laegeler A., Kellogg G., Ercal N. Oxidative effects of lead in young and adult Fisher 344 rats. Arch. Environ. Contam. Toxicol. 2003, 44:417-420.
4. Benlhabib E., Baker J.I., Keyler D.E., Singh A.K. Effects of purified puerarin on voluntary alcohol intake and alcohol withdrawal symptoms in P rats receiving free access to water and alcohol. J. Med. Food 2004, 7:180-186.
5. Bo J., Ming B.Y., Gang L.Z., Lei C., Jia A.L. Protection by puerarin against MPP+-induced neurotoxicity in PC12 cells mediated by inhibiting mitochondrial dysfunction and caspase-3-like activation. Neurosci. Res. 2005, 53:183-188.
6. Carlberg I., Mannervik B. Glutathione reductase. Methods Enzymol. 1985, 113:484.
7. Chajet-Shaul T., Friedman G., Stein O., Shiloni F., Etienne J., Stein Y. Mechanism of the hyper triglyceridemia induced by tumor necrosis factor administration to rats. Biochem. Biophys. Acta 1989, 1001:316-324.
8. Chen Y., Ji L., Wang H., Wang Z. Intracellular glutathione plays important roles in pyrrolizidine alkaloids-induced growth inhibition on hepatocytes. Environ. Toxicol. Pharmacol. 2009, 28:357-362.
9. Cheng Y.F., Zhu G.Q., Wang M., Cheng H., Zhou A., Wang N., Fang N., Wang X.C., Xiao X.Q., Chen Z.W., Li Q.L. Involvement of ubiquitin proteasome system in protective mechanisms of puerarin to MPP+-elicited apoptosis. Neurosci. Res. 2009, 63:52-58.
10. Chiba M., Shinohara A., Matsushita K., Watanabe H., Inaba Y. Indices of lead-exposure in blood and urine of lead-exposed workers and concentrations of major and trace elements and activities of SOD, GSH-Px and catalase in their blood. Tohoku J. Exp. Med. 1996, 178:49-62.
11. Chung M.J., Sung N.J., Park C.S., Kweon D.K., Mantovani A., Moon T.W., Lee S.J., Park K.H. Antioxidative and hypocholesterolemic activities of water-soluble puerarin glycosides in HepG2 cells and in C57 BL/6J mice. Eur. J. Pharmacol. 2008, 578:159-170.
12. Columbano A., Ledda G.M., Sirigu P., Perra T., Coni P.P., Pani P. Liver cell proliferation induced by a single dose of lead nitrate. Am. J. Pathol. 1983, 110:83-88.
13. Courtois E., Marques M., Barrientos A. Lead-induced downregulation of soluble guanylate cyclase in isolated rat aortic segments mediated by reactive oxygen species and cyclooxygenase-2. J. Am. Soc. Nephrol. 2003, 14:1464-1470.
14. DeLeve L.D., Kaplowitz N. Glutathione metabolism and its role in hepatotoxicity. Pharmacol. Ther. 1991, 52:287-305.
15. Dessi S., Batetta B., Laconi E., Ennas C., Pani P. Hepatic cholesterol in lead nitrate induced liver hyperplasia. Chem. Biol. Interact. 1984, 48:271-279.
16. Ellman G.L. Tissue sulfhydryl groups. Arch. Biochem. Biophys. 1959, 82:70-77.
17. Flora S.J., Saxena G., Mehta A. Reversal of lead-induced neuronal apoptosis by chelation treatment in rats: role of reactive oxygen species and intracellular Ca(2+). J. Pharmacol. Exp. Ther. 2007, 322:108-116.
18. Fraga C.G., Galleano M., Verstraeten S., Oteiza P.I. Basic biochemical mechanisms behind the health benefits of polyphenols. Mol. Aspects Med. 2010, 31:435-445.
19. Franco R., Sánchez-Olea R., Reyes-Reyes E.M., Panayiotidis M.I. Environmental toxicity, oxidative stress and apoptosis: Ménage à Trois. Mutat. Res. 2009, 674:3-22.
20. Gao L., Ji X., Song J., Liu P., Yan F., Gong W., Dang S., Luo Y. Puerarin protects against ischemic brain injury in a rat model of transient focal ischemia. Neurol. Res. 2009, 31:402-406.
21. Gelman B.B., Michaelson I.A., Bus J.S. The effect of lead on oxidative hemolysis and erythrocyte defense mechanisms in the rat. Toxicol. Appl. Pharmacol. 1978, 45:119-129.
22. Goldstein J.L., Brown M.S. Regulation of mevalonate pathway. Nature 1990, 343:425-430.
23. Griffith O.W. Biologic and pharmacologic regulation of mammalian glutathione synthesis. Free Radic. Biol. Med. 1999, 27:922-935.
24. Guerra M.C., Speroni E., Broccoli M., Cangini M., Pasini P., Minghetti A., Crespi-Perellino N., Mirasoli M., Cantelli-Forti G., Paolini M. Comparison between Chinese medical herb Pueraria lobata crude extract and its main isoflavone puerarin antioxidant properties and effects on rat liver CYP-catalysed drug metabolism. Life Sci. 2000, 67:2997-3006.
25. Gurer-Orhan H., Sabir H.U., Ozgunes H. Correlation between clinical indicator of lead poisoning and oxidative stress parameters in controls and lead exposed workers. Toxicology 2004, 195:147-154.
26. Habig W.H., Pabst M.J., Jakoby W.B. Glutathione S-transferases: the first enzymatic step in mercapturic acid formation. J. Biol. Chem. 1974, 249:7130-7139.
27. Han R.M., Tian Y.X., Becker E.M., Andersen M.L., Zhang J.P., Skibsted L.H. Puerarin and conjugate bases as radical scavengers and antioxidants: molecular mechanism and synergism with β-carotene. J. Agric. Food Chem. 2007, 55:2384-2391.
28. Hsu J.M. Lead toxicity related to glutathione metabolism. J. Nutr. 1981, 111:26-33.
29. Hsu P.C., Guo Y.L. Antioxidant nutrients and lead toxicity. Toxicology 2002, 180:33-44.
30. Hu P., Wang M., Chen W.H., Liu J., Chen L., Yin S.T., Yong W., Chen J.T., Wang H.L., Ruan D.Y. Quercetin relieves chronic lead exposure-induced impairment of synaptic plasticity in rat dentate gyrus in vivo. Naunyn Schmiedebergs Arch. Pharmacol. 2008, 378:43-51.
31. Hwang Y.P., Choi C.Y., Chung Y.C., Jeon S.S., Jeong H.G. Protective effects of puerarin on carbon tetrachloride-induced hepatotoxicity. Arch. Pharm. Res. 2007, 30:1309-1317.
32. Jurczuk M., Moniuszko-Jakoniuk J., Brzóska M.M. Hepatic and renal concentrations of vitamins E and C in lead- and ethanol-exposed rats. An assessment of their involvement in the mechanisms of peroxidative damage. Food Chem. Toxicol. 2007, 45:1478-1486.
33. Kim K.M., Jung D.H., Jang D.S., Kim Y.S., Kim J.M., Kim H.N., Surh Y.J., Kim J.S. Puerarin suppresses AGEs-induced inflammation in mouse mesangial cells: a possible pathway through the induction of heme oxygenase-1 expression. Toxicol. Appl. Pharmacol. 2010, 244:106-113.
34. Knowles S.O., Donaldson W.E. Dietary modification of lead toxicity: effects on fatty acid and eicosanoid metabolism in chicks. Comp. Biochem. Physiol. 1990, 95:99-104.
35. Kojima M., Nemoto K., Murai U., Yoshimura N., Ayabe Y., Degawa M. Altered gene expression of hepatic lanosterol 14a-demethylase (CYP51) in lead nitrate-treated rats. Arch. Toxicol. 2002, 76:398-403.
36. Kojima M., Masui T., Nemoto K., Degawa M. Lead nitrate-induced development of hypercholesterolemia in rats: sterol-independent gene regulation of hepatic enzymes responsible for cholesterol homeostasis. Toxicol. Lett. 2004, 154:35-44.
37. Kojima M., Sekikawa K., Nemoto K., Degawa M. Tumor necrosis factor-a-independent downregulation of hepatic cholesterol 7a-hydroxylase gene in mice treated with lead nitrate. Toxicol. Sci. 2005, 87:537-542.
38. Lawton L., Donaldson W.E. Lead-induced tissue fatty acid alterations and lipid peroxidation. Biol. Trace Elem. Res. 1991, 28:83-97.
39. Li Q., Xiao Y., Gong H., Shen D., Zhu F., Wu Q., Chen H., Zhong H. Effect of puerarin on the expression of extracellular matrix in rats with streptozotocin-induced diabetic nephropathy. Natl. Med. J. India 2009, 22:9-12.
40. Liu C.M., Ma J.Q., Lou Y. Chronic administration of troxerutin protects mouse kidney against d-galactose-induced oxidative DNA damage. Food Chem. Toxicol. 2010, 48:2809-2817.
41. Liu C.M., Zheng Y.L., Lu J., Zhang Z.F., Fan S.H., Wu D.M., Ma J.Q. Quercetin protects rat liver against lead-induced oxidative stress and apoptosis. Environ. Toxicol. Pharmacol. 2010, 29:158-166.
42. Mak D.H., Ip S.P., Lip C., Poon M.K., Ko K.M. Effects of schisandrin B and alpha-tocopherol on lipid peroxidation, in vitro and in vivo. Mol. Cell. Biochem. 1996, 165:161-165.
43. McConnachie L.A., Mohar I., Hudson F.N., Ware C.B., Ladiges W.C., Fernandez C., Chatterton-Kirchmeier S., White C.C., Pierce R.H., Kavanagh T.J. Glutamate cysteine ligasemodifier subunit deficiency and gender as determinants of acetaminophen-induced hepatotoxicity in mice. Toxicol. Sci. 2007, 99:628-636.
44. McGowan C., Donaldson W.E. Changes in organ nonprotein sulfhydryl and glutathione concentrations during acute and chronic administration of inorganic lead to chicks. Biol. Trace Elem. Res. 1986, 10:37-46.
45. Mercer L.D., Kelly B.L., Horne M.K., Beart P.M. Dietary polyphenols protect dopamine neurons from oxidative insults and apoptosis: investigations in primary rat mesencephalic cultures. Biochem. Pharmacol. 2005, 69:339-345.
46. Mizuno Y., Ohta K. Regional distributions of thiobarbituric acid reactive products, activities of enzymes regulating the metabolism of oxygen free radicals, and some of the related enzymes in adult and aged rat brain. J. Neurochem. 1986, 46:1344-1352.
47. Moniuszko-Jakoniuk J., Jurczuk M., Gałaźyn-Sidorczuk M., Brzóska M.M. Lead turnover and changes in the body status of chosen micro- and macroelements in rats exposed to lead and ethanol. Pol. J. Environ. Stud. 2003, 12:335-344.
48. Morgan A., Holmes A., Evans J.C. Retention, distribution, and excretion of lead by the rat after intravenous injection. Br. J. Ind. Med. 1977, 34:39-42.
49. Mudipalli A. Lead hepatotoxicity & potential health effects. Indian J. Med. Res. 2007, 126:518-527.
50. Newairy A.S.A., Abdou H.M. Protective role of flax lignans against lead acetate induced oxidative damage and hyperlipidemia in rats. Food Chem. Toxicol. 2009, 47:813-818.
51. Onkawa H., Ohishi N., Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 1979, 95:351-358.
52. Pande M., Flora S.J.S. Lead induced oxidative damage and its response to combined administration of α-lipoic acid and succimers in rats. Toxicology 2002, 177:187-196.
53. Pari L., Amudha K. Hepatoprotective role of naringin on nickel-induced toxicity in male Wistar rats. Eur. J. Pharmacol. 2011, 650:364-370.
54. Pulido M.D., Parrish A.R. Metal-induced apoptosis: mechanisms. Mutat. Res. 2003, 533:227-241.
55. Rai S.K., Sharma M., Tiwari M. Inhibitory effect of novel diallyldisulfide analogs on HMG-CoA reductase expression in hypercholesterolemic rats: CREB as a potential upstream target. Life Sci. 2009, 85:211-219.
56. Reitman S., Frankel S. A colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminases. Am. J. Clin. Pathol. 1957, 28:56-63.
57. Rotruck J., Pope A., Ganther H., Swanson A., Hafeman D., Hoekstra W. Selenium: biochemical role as a component of glutathione peroxidase. Science 1973, 179:588-590.
58. Russell D.W., Setchell K.D. Bile acid biosynthesis. Biochemistry 1992, 31:4737-4749.
59. Saxena G., Pathak U., Flora S.J.S. Beneficial role of monoesters of meso-2,3-dimercaptosuccinic acid in the mobilization of lead and recovery of tissue oxidative injury in rats. Toxicology 2005, 214:39-56.
60. Shi W.G., Qu L., Wang J.W. Study on interventing effect of puerarin on insulin resistance in patients with coronary heart disease. Zhongguo Zhong Xi Yi Jie He Za Zhi 2002, 22:21-24.
61. Shinomol G.K., Muralidhara Differential induction of oxidative impairments in brain regions of male mice following subchronic consumption of Khesari dhal (Lathyrus sativus) and detoxified Khesari dhal. Neurotoxicology 2007, 28:798-806.
62. Singh A.K., Jiang Y., Benlhabib E., Gupta S. Herbal mixtures consisting of puerarin and either polyenylphosphatidylcholine or curcumin provide comprehensive protection against alcohol-related disorders in P rats receiving free choice water and 15% ethanol in pure water. J. Med. Food 2007, 10:526-542.
63. Sivaprasad R., Nagaraj M., Varalakshmi P. Combined efficacies of lipoic acid and 2,3-dimercaptosuccinic acid against lead-induced lipid peroxidation in rat liver. J. Nutr. Biochem. 2004, 15:18-23.
64. Tanwar Y.S., Goyal S., Ramawat K.G. Hypolipidemic effects of tubers of indian kudzu. J. Herb. Med. Toxicol. 2008, 2:21-25.
65. Tarugl P., Calandra S., Borella P., Vivoli G.F. Effect of lead intoxication on rabbit plasma lipoproteins. Atherosclerosis 1982, 45:221-234.
66. Tokara E.J., Diwanc B.A., Waalkes M.P. Early life inorganic lead exposure induces testicular teratoma and renal and urinary bladder preneoplasia in adult metallothionein-knockout mice but not in wild type mice. Toxicology 2010, 276:5-10.
67. Villarreal-Trevino C.M., Villegas-Navarro A. Differential accumulation of lead by soft tissues of rabbit. Environ. Contam. Toxicol. 1987, 39:334-342.
68. Wang Y., Yin L., Li Y., Liu P., Cui Q. Preventive effects of puerarin on alcohol-induced osteonecrosis. Clin. Orthop. Relat. Res. 2008, 466:1059-1067.
69. Xia D., Yu X., Liao S., Shao Q., Mou H., Ma W. Protective effect of Smilax glabra extract against lead-induced oxidative stress in rats. J. Ethnopharmacol. 2010, 130:414-420.
70. Xiang J.J., Zhai Y.F., Tang Y., Wang H., Liu B., Guo C.W. A competitive indirect enzyme-linked immunoassay for lead ion measurement using mAbs against the lead-DTPA complex. Environ. Pollut. 2010, 158:1376-1380.
71. Xiong F.L., Sun X.H., Gan L., Yang X.L., Xu H.B. Puerarin protects rat pancreatic islets from damage by hydrogen peroxide. Eur. J. Pharmacol. 2006, 529:1-7.
72. Yan L.P., Chan S.W., Chan A.S., Chen S.L., Ma X.J., Xu H.X. Puerarin decreases serum total cholesterol and enhances thoracic aorta endothelial nitric oxide synthase expression in diet-induced hypercholesterolemic rats. Life Sci. 2006, 79:324-330.
73. Yang X., Hu W., Zhang Q., Wang Y., Sun L. Puerarin inhibits C-reactive protein expression via suppression of nuclear factor kappaB activation in lipopolysaccharide-induced peripheral blood mononuclear cells of patients with stable angina pectoris. Basic Clin. Pharmacol. Toxicol. 2010, 107:637-642.
74. Yeung D.K., Leung S.W., Xu Y.C., Vanhoutte P.M., Man R.Y. Puerarin, an isoflavonoid derived from Radix puerariae, potentiates endothelium-independent relaxation via the cyclic AMP pathway in porcine coronary artery. Eur. J. Pharmacol. 2006, 552:105-111.
75. Yumei F., Zhou Y., Zheng S., Chen A. The antifibrogenic effect of (-)-epigallocatechin gallate results from the induction of de novo synthesis of glutathione in passaged rat hepatic stellate cells. Lab. Invest. 2006, 86:697-709.
76. Zhang S.H., Ji G., Liu J.W. Reversal of chemical-induced liver fibrosis in Wistar rats by puerarin. J. Nutr. Biochem. 2006, 17:485-491.
77. Zhang W., Liu C.Q., Wang P.W., Sun S.Y., Su W.J., Zhang H.J., Li X.J., Yang S.Y. Puerarin improves insulin resistance and modulates adipokine expression in rats fed a high-fat diet. Eur. J. Pharmacol. 2010, 649:398-402.
78. Zhao M., Du Y.Q., Yuan L., Wang N.N. Protective effect of puerarin on acute alcoholic liver injury. Am. J. Chin. Med. 2010, 38:241-249.
79. Zheng X., Xu X. Potential involvement of calcium and nitric oxidein protective effects of puerarin on oxygen-glucose deprivation in cultured hippocampal neurons. J. Ethnopharmacol. 2007, 113:421-426.
80. Zheng S., Yumei F., Chen A. De novo synthesis of glutathione is a prerequisite for curcumin to inhibit hepatic stellate cell HSC activation. Free Radic. Biol. Med. 2007, 43:444-453.
81. Zheng P., Ji G., Ma Z., Liu T., Xin L., Wu H., Liang X., Liu J. Therapeutic effect of puerarin on non-alcoholic rat fatty liver by improving leptin signal transduction through JAK2/STAT3 pathways. Am. J. Chin. Med. 2009, 37:69-83.