Puerarin reduces increased c-fos, c-jun, and type IV collagen expression caused by high glucose in glomerular mesangial cells

Acta Pharmacologica Sinica

Volumn 26, Issue 8, 2005, Pages 982-986

  Mao, Cai Ping ^a   Gu, Zhen Lun ^a  

^a MEDICAL COLLEGE OF SOOCHOW UNIVERSITY   (China)

Author keywords

Diabetic nephropathy; Extracellular matrix; Glomerular mesangial cells; Puerarin

Indexed keywords

COLLAGEN TYPE 4; GLUCOSE; PROTEIN C FOS; PROTEIN C JUN; PROTEIN KINASE C; PUERARIN;

ANIMAL CELL; ARTICLE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DIABETIC NEPHROPATHY; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; LIQUID SCINTILLATION COUNTING; MESANGIUM CELL; NONHUMAN; PROTEIN EXPRESSION; RADIOIMMUNOASSAY; RAT;

ANIMALS; CELL LINE; COLLAGEN TYPE IV; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; GLOMERULAR MESANGIUM; GLUCOSE; ISOFLAVONES; PROTEIN KINASE C; PROTO-ONCOGENE PROTEINS C-FOS; PROTO-ONCOGENE PROTEINS C-JUN; RADIOIMMUNOASSAY; RATS; TIME FACTORS;

EID: 23844529555     PISSN: 16714083     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2005.00133.x     Document Type: Article

References (11)

1. Gao YJ, Yue ZJ, Yan LJ, Nan CH, Li DM. Effects of high glucose condition on expression of extracellular matrix of glomerular mesangial cells in rats. Sect Clin Biochem & Lab Med Foreign Med Sci 2004; 25: 99-101.
2. Kikkawa R, Koya D, Haneda M. Progression of diabetic nephropathy. Am J Kidney Dis 2003; 41: S19-21.
3. Haneda M, Koya D, Kikkawa R. Cellular mechanisms in the development and progression of diabetic nephropathy: activation of the DAG-PKC-ERK pathway. Am J Kidney Dis 2001; 38: 178-81.
4. Zhang L, Zhang L, Zhao GS. The regulation of AP-1 on mitosin activating protein kinase signaling pathway. Pathophysiol Clin Med 2002; 20: 32-5.
5. Mao CP, Gu ZL. Researches of puerarin on pharmacological effect and clinical application. Chin J Hemorh 2004; 14: 138-42.
6. Mei CL, Zhang LM, Chen L. Establish and identify rat mesangial cells. J Nephro Dial Transplant 1996; 5: 90-2.
7. Mao CP, Gu ZL, Cao L. Experimental studies on the effects and mechanisms of puerarin in diabetic uninephrectomized rats. Jiangsu Med J 2005; 31: 223-5.
8. Shankland SJ, Scholey JW. Expression of growth-related protooncogenes during diabetic renal hypertrophy. Kidney Int 1995; 47: 782-8.
9. Murphy M, McGinty A, Godson C. Protein kinase C: potential targets for intervention in diabetic nephropathy. Curr Opin Nephrol Hypertens 1998; 7: 563-70.
10. Koya D, King GL. Protein kinase C activation and the development of diabetic complications. Diabetes 1998; 47: 859-66.
11. Pariat M, Salvat C, Bebien M, Brockly F, Altieri E, Carillo S, et al. The sensitivity of c-Jun and c-Fos proteins to calpains depends on conformational determinants of the monomers and not on formation of dimers. Biochem J 2000; 345: 129-38.