Effects of puerarin on expressions of leptin receptor mRNA, phosphorylated Janus kinase 2/phosphorylated signal transducers and activators of transcription 3 proteins in the liver of rats with non-alcoholic fatty liver

Journal of Chinese Integrative Medicine

Volumn 6, Issue 9, 2008, Pages 921-927

  Zheng, Pei Yong ^a   Ma, Zan Song ^a   Hua, Yong Qiang ^a,b   Liu, Tao ^a   Xing, Lian Jun ^a   Ji, Guang ^a  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b FUDAN UNIVERSITY SHANGHAI CANCER CENTER   (China)

Author keywords

Activating transcription factor 3; Fatty liver; Janus kinase 2; Leptin; Puerarin; Rats

Indexed keywords

CHOLESTEROL; JANUS KINASE 2; LEPTIN; LEPTIN RECEPTOR; MESSENGER RNA; PUERARIN; SIMVASTATIN; STAT3 PROTEIN; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; HISTOPATHOLOGY; LIPID DIET; LIVER PROTECTION; MICROSCOPY; NONALCOHOLIC FATTY LIVER; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRIACYLGLYCEROL BLOOD LEVEL; UPREGULATION; WESTERN BLOTTING;

ANIMALS; DIETARY FATS; FATTY LIVER; ISOFLAVONES; JANUS KINASE 2; MALE; PHOSPHORYLATION; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, LEPTIN; RNA, MESSENGER; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR;

EID: 52949102165     PISSN: 16721977     EISSN: None     Source Type: Journal    
DOI: 10.3736/jcim20080909     Document Type: Article

References (26)

1. Zeng MD. Fatty liver. Zhonghua Xiao Hua Za Zhi. 1999; 19(2): 120-122.
2. Qing F, Pan JQ, Xiao LY, et al. Effect of puerarin on insulin sensitivity and blood glucose and lipids levels in insulin-resisting hypertension rats. Zhong Yi Yan Jiu. 2006; 19(3): 14-17.
3. Zhong L, Fan JG, Wang GL, et al. The establishment of nonalcohlic steatohepatitis (NASH) animal model. Shi Yan Dong Wu Ke Xue Yu Guan Li. 2000; 17(2): 16-20.
4. Yan LP, Chen SH, Chen WM, et al. Regulatory effect of puerarin on lipid profile in hypercholesterolemic rats. Zhongguo Lin Chuang Yao Li Xue Yu Zhi Liao Xue. 2006; 11 (5): 574-577.
5. Diehl AM, Goodman Z, Ishak KG. Alcohollike liver disease in nonalcoholics. A clinical and histologic comparison with alcohol-induced liver injury. Gastroenterology. 1988; 95(4): 1056-1062.
6. Knodell RG, Ishak KG, Black WC, et al. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology. 1981; 1(5): 431-435
7. Wang TL, Liu X, Zhou YP, et al. A semiquantitative scoring system or assessment of hepatic inflammation and fibrosis in chronic hepatitis. Zhonghua Gan Zang Bing Za Zhi. 1998; 6 (4): 195-197.
8. Chitturi S, Abeygunasekera S, Farrell GC, et al. NASH and insulin resistance: Insulin hypersecretion and specific association with the insulin resistance syndrome. Hepatology. 2002; 35(2): 373-379.
9. He SL, Li JC, Qin XQ. Clinical physiology. Beijing: Science Press. 2001: 9.
10. Saxena NK, Ikeda K, Rockey DC, et al. Leptin in hepatic fibrosis: evidence for increased collagen production in stellate cells and lean littermates of ob/ob mice. Hepatology. 2002; 35(4): 762-771.
11. Rizk NM, Stammsen D, Preibisch G, et al. Leptin and tumor necrosis factor-alpha induce the tyrosine phosphorylation of signal transducer and activator of transcription proteins in the hypothalamus of normal rats in vivo. Endocrinology. 2001; 142(7): 3027-3032.
12. Larsson H, Elmståhl S, Berglund C, et al. Evidence for leptin regulation of food intake in humans. J Clin Endocrinol Metab. 1998; 83(12): 4382-4385.
13. Flynn MC, Plata-Salamán CR. Leptin (OB protein) and meal size. Nutrition. 1999; 15(6): 508-509.
14. Cohen P, Miyazaki M, Socci ND, et al. Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss. Science. 2002; 297(5579): 240-243.
15. Petersen KF, Oral EA, Dufour S, et al. Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy. J Clin Invest. 2002; 109(10): 1345-1350.
16. Tobe K, Suzuki R, Aoyama M, et al. Increased expression of the sterol regulatory element-binding protein-1 gene in insulin receptor substrate-2/mouse liver. Biol Chem. 2001; 276(42): 38337-38340.
17. Tobe K, Ogura J, Tsuka M, et al. Relationship between serum leptin and fatty liver in Japnese male adolescent university students. Am J Gastroenterol. 1999; 94(11): 3328-3335.
18. Chitturi S, Farrell G, Frost L, et al. Serum leptin in NASH correlates with hepatic steatosis but not fibrosis: a manifestation of lipotoxicity. Hepatology. 2002; 36 (2): 403-409.
19. Campillo B, Sherman E, Richardet JP, et al. Serum leptin levels in alcoholic liver cirrhosis: relationship with gender, nutritional status, liver function and energy metabolism. Eur J Clin Nutr. 2001; 55(1): 980-988.
20. Bartek J, Bartos J, Galuska J, et al. Expression of ob gene coding the production of the hormone leptin in hepatocytes of liver with steatosis. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2001; 145(1): 15-20.
21. Koteish A, Diem AM. Animal models of steatosis. Semin Liver Dis. 2001; 21(1): 89-104.
22. Carpenter LR, Farruggella TJ, Symes A, et al. Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with ob receptor. Proc Natl Acad Sci U S A. 1998; 95(11): 6061-6066.
23. Crouse JA, Elliott GE, Burgess TL, et al. Altered cell surface expression and signaling of leptin receptors containing the fatty mutation. J Biol Chem. 1998; 273(29): 18365-18373.
24. Guo QY, Gao Y, Cong L, et al. Effects of free fatty acids on gene and protein expression and tyrosine phosphorylation of leptin-receptor in rat hepatic cells. Yi Xue Yan Jiu Sheng Xue Bao. 2003; 16(9): 659-662.
25. Zhao CY, Li L, Li JM, et al. Change in the expression of leptin receptor in liver of rats with non-alcoholic fatty liver disease. Zhongguo Zu Zhi Hua Xue Yu Xi Bao Hua Xue Za Zhi. 2005; 14 (6): 613-617.
26. Guo F, Bakal K, Minokoshi Y, et al. Leptin signaling targets the thyrotropin-releasing hormone gene promoter in vivo. Endocrinology. 2004; 145(5): 2221-2227.