Glucose uptake enhancing activity of puerarin and the role of C-glucoside suggested from activity of related compounds

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 15, 2010, Pages 4333-4336

  Kato, Eisuke ^a   Kawabata, Jun ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Diabetes mellitus; Glucose uptake; Isoflavone; PPAR ; Puerarin

Indexed keywords

C GLUCOSIDE; CARBOHYDRATE DERIVATIVE; DAIDZEIN; GLUCOSE; INSULIN; ISOFLAVONE; KAEMPFEROL; PUERARIN; QUERCETIN; UNCLASSIFIED DRUG;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CELL LINE; CONTROLLED STUDY; DRUG SYNTHESIS; GLUCOSE TRANSPORT; IN VITRO STUDY; INSULIN SENSITIVITY; NONHUMAN; STRUCTURE ACTIVITY RELATION;

3T3-L1 CELLS; ANIMALS; DIABETES MELLITUS; GLUCOSE; GLUCOSIDES; ISOFLAVONES; MICE;

EID: 77955422033     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.06.077     Document Type: Article

References (17)

1. World Health Organization (WHO). Fact sheet No. 312 'Diabetes', http://www.who.int/mediacentre/factsheets/fs312/en/ (accessed Apr 2010).
2. A.P. Jorge, H. Horst, E. De Sousa, M.G. Pizzolatti, and F.R.M.B. Silva Chem. Biol. Interact. 149 2004 89
3. F.L. Hsu, I.M. Liu, D.H. Kuo, W.C. Chen, H.C. Su, and J.T. Cheng J. Nat. Prod. 66 2003 788
4. L. Zanatta, Â. Rosso, P. Folador, M.S.R.B. Figueiredo, M.G. Pizzolatti, L.D. Leite, and F.R.M.B. Silva J. Nat. Prod. 71 2008 532
5. T. Murakami, Y. Nishikawa, and T. Ando Chem. Pharm. Bull. 8 1960 688
6. D.Y.W. Lee, W.-Y. Zhang, and V.V.R. Karnati Tetrahedron Lett. 44 2003 6857
7. R.A. Eade, F.J. McDonald, and H.P. Pham Aust. J. Chem. 31 1978 2699
8. + Found m/z 432.1040, C 21 H ) 20 O 10 + requires m/z 432.1057.
9. + Found m/z 328.0913, C 18 H 16 O 6 + requires m/z 328.0947.
10. N. Yamamoto, T. Sato, K. Kawasaki, S. Murosaki, and Y. Yamamoto Anal. Biochem. 351 2006 139
11. m 590) was measured by microplate reader (Bio-tech Instruments Inc., Synergy™ MX) for quantification of the amount of 2-DG uptake of the cells. Protein concentration of the lysate was quantified by Quickstart protein assay (Bio-Rad Laboratories Inc.) with BSA as the standard and the 2-DG uptake values were calculated as nmol/mg· protein. The blank amount was subtracted as a basal glucose uptake, and the relative amount against the control value was calculated. Each sample was tested at least three times of individual experiment and average value with standard error is shown as a result.
12. J.M. Lehmann, L.B. Moore, T.A. Smith-Oliver, W.O. Wilkison, T.M. Willson, and S.A. Kliewer J. Biol. Chem. 270 1995 12953
13. H. Zhang, F. Yang, J. Qi, X.-C. Song, Z.-F. Hu, D.-N. Zhu, and B.-Y. Yu J. Nat. Prod. 73 2010 548
14. X.-K. Fang, J. Gao, and D.-N. Zhu Life Sciences 82 2008 615
15. M. Xu, S. Xiao, Y. Sun, X. Zheng, Y. Ou-yang, and C. Guan Life Sciences 77 2005 3183
16. B.K. Chacko, R.T. Chandler, T.L. D'Alessandro, A. Mundhekar, N.K.H. Khoo, N. Botting, S. Barnes, and R.P. Patel J. Nutr. 137 2007 351
17. L.L. Fan, D.D. O'Keefe, and W.J. Powell Jr. Acta Pharm. Sin. 19 1984 801