Restoration of autophagy by puerarin in ethanol-treated hepatocytes via the activation of AMP-activated protein kinase

Biochemical and Biophysical Research Communications

Volumn 414, Issue 2, 2011, Pages 361-366

  Noh, Byung Kyu ^a   Lee, Jung Kyu ^a   Jun, Hee jin ^a   Lee, Ji Hae ^a   Jia, Yaoyao ^a   Hoang, Minh Hien ^a   Kim, Jung Wan ^b   Park, Kwan Hwa ^c   Lee, Sung Joon ^a  

^a Korea University   (South Korea)

^b SolarLight Ltd   (South Korea)

^c Sangmyuung University   (South Korea)

Author keywords

Alcoholic liver damage; AMPK; Autophagy; MTOR; Puerarin

Indexed keywords

ALCOHOL; CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; ISOFLAVONE; MAMMALIAN TARGET OF RAPAMYCIN; MICROTUBULE ASSOCIATED PROTEIN 1; PUERARIN; TRIACYLGLYCEROL;

ALCOHOL CONSUMPTION; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AUTOPHAGY; CELL LEVEL; CELL VIABILITY; CONTROLLED STUDY; DOSE RESPONSE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LIPID STORAGE; LIVER CELL; LIVER INJURY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PUERARIA; RAT;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; AUTOPHAGY; CELL LINE, TUMOR; ENZYME ACTIVATION; ETHANOL; HEPATOCYTES; ISOFLAVONES; MICROTUBULE-ASSOCIATED PROTEINS; RATS;

MAMMALIA; PUERARIA MONTANA VAR. LOBATA;

EID: 80054836991     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.09.077     Document Type: Article

References (29)

1. McCullough A.J., O'Shea R.S., Dasarathy S., Dis A.A.S.L., Gastroenterology A.C. Alcoholic liver disease. Hepatology 2010, 51:307-328.
2. Isselbac Kj. Interrelationship of alcohol and lipid metabolism in liver. Psychosom. Med. 1966, 28:424.
3. Donohue T.M., Zetterman R.K., Tuma D.J. Effect of chronic ethanol administration on protein catabolism in rat-liver. Alcohol. Clin. Exp. Res. 1989, 13:49-57.
4. Rabinowitz J.D., White E. Autophagy and metabolism. Science 2010, 330:1344-1348.
5. Stromhaug P.E., Klionsky D.J. Approaching the molecular mechanism of autophagy. Traffic 2001, 2:524-531.
6. Klionsky D.J., Emr S.D. Cell biology - Autophagy as a regulated pathway of cellular degradation. Science 2000, 290:1717-1721.
7. Yin X.M., Ding W.X., Gao W.T. Autophagy in the liver. Hepatology 2008, 47:1773-1785.
8. Schmelzle T., Hall M.N. TOR, a central controller of cell growth. Cell 2000, 103:253-262.
9. Meijer A.J., Meley D., Bauvy C., Houben-Weerts J.H.P.M., Dubbelhuis P.F., Helmond M.T.J., Codogno P. AMP-activated protein kinase and the regulation of autophagic proteolysis. J. Biol. Chem. 2006, 281:34870-34879.
10. You M., Matsumoto M., Pacold C.M., Cho W.K., Crabb D.W. The role of AMP-activated protein kinase in the action of ethanol in the liver. Gastroenterology 2004, 127:1798-1808.
11. Feng Z., Zhang H., Levine A.J., Jin S. The coordinate regulation of the p53 and mTOR pathways in cells. Proc. Natl. Acad. Sci. USA 2005, 102:8204-8209.
12. You M. AMP-activated protein kinase as a new target of ethanol action in the liver. Alcohol. Clin. Exp. Res. 2004, 28:190a.
13. Hibi T., Tomita K., Tamiya G., Ando S., Kitamura N., Koizumi H., Kato S., Horie Y., Kaneko T., Azuma T., Nagata H., Ishii H. AICAR, an AMPK activator, has protective effects on alcohol-induced fatty liver in rats. Alcohol. Clin. Exp. Res. 2005, 29:240s-245s.
14. Bergheim I., Guo L.P., Davis M.A., Lambert J.C., Beier J.I., Duveau I., Luyendyk J.P., Roth R.A., Arteel G.E. Metformin prevents alcohol-induced liver injury in the mouse: critical role of plasminogen activator inhibitor-1. Gastroenterology 2006, 130:2099-2112.
15. Lee S.J., Chung M.J., Sung N.J., Park C.S., Kweon D.K., Mantovani A., Moon T.W., Park K.H. Antioxidative and hypocholesterolemic activities of water-soluble puerarin glycosides in HepG2 cells and in C57BL/6J mice. Eur. J. Pharmacol. 2008, 578:159-170.
16. Han P., Li J., Li W.J., Yu Z.L., Wang Q., Wu D.S. [Potential antiviral drug Pueraria crude extract and puerarin protect against ethanol-induced cytotoxicity in embryonic mouse hippocampal cultures], Zhonghua shi yan he lin chuang bing du xue za zhi=Zhonghua shiyan he linchuang bingduxue zazhi. Chin. J. Exp. Clin. Virol. 2005, 19:244-247.
17. Zhao M., Du Y.Q., Yuan L., Wang N.N. Protective effect of puerarin on acute alcoholic liver injury. Am. J. Chin. Med. 2010, 38:241-249.
18. Hien T.T., Kim H.G., Han E.H., Kang K.W., Jeong H.G. Molecular mechanism of suppression of MDR1 by puerarin from Pueraria lobata via NF-kappaB pathway and cAMP-responsive element transcriptional activity-dependent up-regulation of AMP-activated protein kinase in breast cancer MCF-7/adr cells. Mol. Nutr. Food. Res. 2010, 54:918-928.
19. Hozumi Y., Kawano M., Jordan V.C. In vitro study of the effect of raloxifene on lipid metabolism compared with tamoxifen. Eur. J. Endocrinol. 2000, 143:427-430.
20. Rubin E., Lieber C.S. Fatty liver, alcoholic hepatitis and cirrhosis produced by alcohol in primates. N. Engl. J. Med. 1974, 290:128-135.
21. Randall G., Heaton N.S. Dengue virus-induced autophagy regulates lipid metabolism. Cell. Host Microbe. 2010, 8:422-432.
22. Ding W.-X., Li M., Chen X., Ni H.-M., Lin C.-W., Gao W., Lu B., Stolz D.B., Clemens D.L., Yin X.-M. Autophagy reduces acute ethanol-induced hepatotoxicity and steatosis in mice. Gastroenterology 2010, 139:1740-1752.
23. Kim D.H., Jung C.H., Ro S.H., Cao J., Otto N.M. mTOR regulation of autophagy. Febs Lett. 2010, 584:1287-1295.
24. Lee S.J., Chung H.J., Chung M.J., Houng S.J., Jeun J., Kweon D.K., Choi C.H., Park J.T., Park K.H. Toxicological evaluation of the isoflavone puerarin and its glycosides. Eur. Food. Res. Technol. 2009, 230:145-153.
25. Oh S.Y., Choi S.J., Kim K.H., Cho E.Y., Kim J.H., Roh C.R. Autophagy-related proteins, LC3 and beclin-1, in placentas from pregnancies complicated by preeclampsia. Reprod. Sci. 2008, 15:912-920.
26. Sudarsanam S., Johnson D.E. Functional consequences of mTOR inhibition. Curr. Opin. Drug. Disc. 2010, 13:31-40.
27. Hoyer-Hansen M., Jaattela M. AMP-activated protein kinase - A universal regulator of autophagy?. Autophagy 2007, 3:381-383.
28. Inoki K., Zhu T.Q., Guan K.L. TSC2 mediates cellular energy response to control cell growth and survival. Cell 2003, 115:577-590.
29. Castro J., Garcia-Villafranca J., Guillen A. Ethanol consumption impairs regulation of fatty acid metabolism by decreasing the activity of AMP-activated protein kinase in rat liver. Biochimie 2008, 90:460-466.