Puerarin protects dopaminergic neurons against 6-hydroxydopamine neurotoxicity via inhibiting apoptosis and upregulating glial cell line-derived neurotrophic factor in a rat model of Parkinson's disease

Planta Medica

Volumn 76, Issue 16, 2010, Pages 1820-1826

  Zhu, Guoqi ^a,b   Wang, Xuncui ^b   Chen, Yuefa ^b   Yang, Shu ^b   Cheng, Hui ^b   Wang, Ning ^b   Li, Qinglin ^b  

^a FUDAN UNIVERSITY   (China)

^b ANHUI UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

apoptosis; Fabaceae; GDNF; Parkinson's disease; Pueraria lobata; puerarin

Indexed keywords

BIOLOGICAL MARKER; DIHYDROXYPHENYLACETIC ACID; DOPAMINE; NEUROTROPHIC FACTOR; OXIDOPAMINE; PROTEIN BAX; PROTEIN BCL 2; PUERARIN; TYROSINE 3 MONOOXYGENASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL COUNT; CELL DEATH; CELL PROTECTION; CONTROLLED STUDY; CORPUS STRIATUM; DNA FRAGMENTATION; DOPAMINERGIC NERVE CELL; DRUG MECHANISM; GENE EXPRESSION REGULATION; GLIA CELL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; NERVE CELL NECROSIS; NEUROPROTECTION; NEUROTOXICITY; NICK END LABELING; NONHUMAN; PARKINSON DISEASE; PROTEIN EXPRESSION; RAT; SUBSTANTIA NIGRA;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL COUNT; DISEASE MODELS, ANIMAL; DNA FRAGMENTATION; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; HYDROXYDOPAMINES; ISOFLAVONES; MALE; NEUROPROTECTIVE AGENTS; PARKINSON DISEASE; PHYTOTHERAPY; PLANT EXTRACTS; PLANT ROOTS; PUERARIA; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; STAINING AND LABELING; SUBSTANTIA NIGRA; TYROSINE 3-MONOOXYGENASE; UP-REGULATION;

ANIMALIA; FABACEAE; PUERARIA MONTANA VAR. LOBATA; RATTUS;

EID: 78349270212     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0030-1249976     Document Type: Article

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