Measurement and control of host cell proteins (HCPs) in CHO cell bioprocesses

Current Opinion in Biotechnology

Volumn 30, Issue , 2014, Pages 153-160

  Hogwood, Catherine ^a   Bracewell, Daniel G ^b   Smales, C Mark ^a  

^a UNIVERSITY OF KENT   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; MOLECULES; MONOCLONAL ANTIBODIES; PROTEINS; PURIFICATION;

CHINESE HAMSTER OVARY CELLS; CULTURE TEMPERATURE; HOST CELL PROTEIN; MEASUREMENT AND CONTROL; PRODUCTION PROCESS; RECENT RESEARCHES; REGULATORY REQUIREMENTS; SHEAR SENSITIVITY; BIOPROCESSES; CHO CELL;

CELLS;

CELL PROTEIN; HOST CELL PROTEIN; UNCLASSIFIED DRUG; RECOMBINANT PROTEIN;

CELL CULTURE; CELL VIABILITY; CELLULAR DISTRIBUTION; CHO CELL LINE; ENZYME LINKED IMMUNOSORBENT ASSAY; INCUBATION TIME; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROCESS DESIGN; PROCESS MONITORING; PROCESS TECHNOLOGY; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; PROTEIN PURIFICATION; PROTEIN SYNTHESIS; REVIEW; SHEAR STRESS; BIOPROCESS; CELLULAR PARAMETERS; CHROMATOGRAPHY; DOWNSTREAM PROCESSING; HOST CELL; INFRARED SPECTROSCOPY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; POLYACRYLAMIDE GEL ELECTROPHORESIS; SURFACE ENHANCED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; TWO DIMENSIONAL GEL ELECTROPHORESIS; WESTERN BLOTTING; ANIMAL; CRICETULUS; GENETICS; ISOLATION AND PURIFICATION; METABOLISM;

ANIMALS; CHO CELLS; CRICETULUS; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; MASS SPECTROMETRY; RECOMBINANT PROTEINS;

EID: 84904257689     PISSN: 09581669     EISSN: 18790429     Source Type: Journal    
DOI: 10.1016/j.copbio.2014.06.017     Document Type: Review

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