Analysis of host-cell proteins in biotherapeutic proteins by comprehensive online two-dimensional liquid chromatography/mass spectrometry

mAbs

Volumn 4, Issue 1, 2012, Pages 24-44

  Doneanu, Catalin E ^a   Xenopoulos, Alex ^b   Fadgen, Keith ^a   Murphy, Jim ^a   Skilton, St John ^a   Prentice, Holly ^b,c   Stapels, Martha ^a   Chen, Weibin ^a  

^a WATERS CORPORATION   (United States)

^b MILLIPORE CORPORATION   (United States)

^c Momenta Pharmaceuticals Inc   (United States)

Author keywords

Biotherapeutic proteins; HCP; Host cell proteins; mAbs; Protein quantification

Indexed keywords

CELL PROTEIN; MONOCLONAL ANTIBODY; TRYPSIN;

ALKYLATION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOLOGICAL THERAPY; CELL ENERGY; CELL LINE; HIGH THROUGHPUT SCREENING; ISOTOPE LABELING; LIQUID CHROMATOGRAPHY; LOW ENERGY RADIATION; MASS SPECTROMETRY; NONHUMAN; PH; PHASE TRANSITION; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN PURIFICATION; PROTEIN TARGETING; REVERSED PHASE LIQUID CHROMATOGRAPHY; TIME OF FLIGHT MASS SPECTROMETRY; TWO DIMENSIONAL LIQUID CHROMATOGRAPHY;

ANTIBODIES, MONOCLONAL; BIOTECHNOLOGY; CHROMATOGRAPHY, LIQUID; HUMANS; MASS SPECTROMETRY; PEPTIDES; PROTEINS; PROTEOMICS; RECOMBINANT PROTEINS;

EID: 84863075257     PISSN: 19420862     EISSN: 19420870     Source Type: Journal    
DOI: 10.4161/mabs.4.1.18748     Document Type: Article

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