Studying host cell protein interactions with monoclonal antibodies using high throughput protein A chromatography

Biotechnology Journal

Volumn 7, Issue 10, 2012, Pages 1233-1241

  Sisodiya, Vikram N ^a   Lequieu, Joshua ^a,b   Rodriguez, Maricel ^a   McDonald, Paul ^a   Lazzareschi, Kathlyn P ^a  

^a GENENTECH INC   (United States)

^b University of Wisconsin Madison   (United States)

Author keywords

Downstream processing; Host cell proteins; Monoclonal antibodies; Protein A chromatography; Protein interactions

Indexed keywords

AFFINITY INTERACTIONS; ANTIBODY CONCENTRATION; BATCH BINDING; CELL LINES; CELL PROTEINS; CHINESE HAMSTER OVARY CELLS; DOWNSTREAM-PROCESSING; HIGH THROUGHPUT; HOST CELL PROTEIN; HYDROPHOBIC COMPONENTS; PROTEIN A; PROTEIN A CHROMATOGRAPHY; PROTEIN INTERACTION;

CELL CULTURE; CELLS; CHROMATOGRAPHY; MONOCLONAL ANTIBODIES; PURIFICATION; RESINS; SODIUM CHLORIDE; SURFACE PLASMON RESONANCE;

PROTEINS;

HYDROCHLORIC ACID; MONOCLONAL ANTIBODY; PROTEIN A; RESIN;

ANIMAL CELL; ARTICLE; CELL CULTURE; CHROMATOGRAPHY; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; HOST CELL; HYDROPHOBICITY; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; STATIC ELECTRICITY;

ANIMALS; ANTIBODIES, MONOCLONAL; CHO CELLS; CHROMATOGRAPHY, AFFINITY; CRICETINAE; CRICETULUS; GUANIDINE; HIGH-THROUGHPUT SCREENING ASSAYS; HYDROGEN-ION CONCENTRATION; PROTEIN BINDING; PROTEINS; SODIUM CHLORIDE; STAPHYLOCOCCAL PROTEIN A;

CRICETULUS GRISEUS;

EID: 84867222068     PISSN: 18606768     EISSN: 18607314     Source Type: Journal    
DOI: 10.1002/biot.201100479     Document Type: Article

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