Fishing human monoclonal antibodies from a CHO cell supernatant with boronic acid magnetic particles

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 903, Issue , 2012, Pages 163-170

  Borlido, L ^a   Azevedo, A M ^a   Sousa, A G ^a   Oliveira, P H ^a   Roque, A C A ^b   Aires Barros, M R ^a  

^a INSTITUTO SUPERIOR TÉCNICO   (Portugal)

^b UNIVERSIDADE NOVA DE LISBOA   (Portugal)

Author keywords

Affinity purification; Boronic acid; Downstream processing; Magnetic particles; Monoclonal antibody

Indexed keywords

AFFINITY INTERACTIONS; AFFINITY PURIFICATION; BORONIC ACID; CHINESE HAMSTER OVARY CELLS; CHO CELL; COMPETING EFFECTS; CULTURE SUPERNATANT; DOWNSTREAM-PROCESSING; FUNCTIONALIZED; GENOMIC DNA; HOST CELL PROTEIN; MAGNETIC PARTICLE; MAMMALIAN CELL CULTURE; MONOCLONAL ANTIBODIES (MAB); MULTI-CYCLE; PH VALUE; PROCESS YIELD; PRODUCT PURITY; PROTEIN A; PURIFICATION PROCESS;

ADSORPTION; CELL CULTURE; GLUCOSE; MONOCLONAL ANTIBODIES; PH EFFECTS; PROTEINS; PURIFICATION;

MAGNETIC BUBBLES;

BORONIC ACID DERIVATIVE; BORONIC ACID MAGNETIC PARTICLE; CELL PROTEIN; GENOMIC DNA; GLUCOSE; HUMAN MONOCLONAL ANTIBODY; LACTIC ACID; PROTEIN A; UNCLASSIFIED DRUG;

ADSORPTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL CULTURE; CHO CELL; COST EFFECTIVENESS ANALYSIS; DRUG PURIFICATION; FEMALE; NONHUMAN; PH; PRIORITY JOURNAL; SUPERNATANT;

ADSORPTION; ANIMALS; ANTIBODIES, MONOCLONAL; BORONIC ACIDS; CHO CELLS; CHROMATOGRAPHY, AFFINITY; CRICETINAE; CRICETULUS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; HYDROGEN-ION CONCENTRATION; MAGNETS;

CRICETULUS GRISEUS; MAMMALIA;

EID: 84864951835     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2012.07.014     Document Type: Article

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