Host cell protein clearance during protein a chromatography: Development of an improved column wash Step

Biotechnology Progress

Volumn 24, Issue 5, 2008, Pages 1115-1121

  Shukla, Abhinav A ^a,b   Hinckley, Peter ^a  

^a AMGEN INC   (United States)

^b BRISTOL MYERS SQUIBB COMPANY   (United States)

Author keywords

Host cell protein; Monoclonal antibodies; Platform process; Protein A chromatography; Wash

Indexed keywords

BIOPHARMACEUTICALS; CHROMATOGRAPHIC RESINS; CLINICAL TRIALS; COLUMN LOADINGS; DIRECT INTERACTIONS; DOWNSTREAM PROCESSES; FUSION PROTEINS; HOST CELL PROTEIN; HOST CELL PROTEINS; ISO PROPANOLS; PLATFORM PROCESS; POLISHING STEPS; PROTEIN A; PROTEIN A CHROMATOGRAPHIES; PROTEIN A CHROMATOGRAPHY; RAPID DEVELOPMENTS; WASH;

ABS RESINS; CELL CULTURE; CELLS; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; COLUMN CHROMATOGRAPHY; COLUMNS (STRUCTURAL); CONTAMINATION; CYTOLOGY; DIGITAL SIGNAL PROCESSING; FLOW INTERACTIONS; FUSION REACTIONS; IMPURITIES; MONOCLONAL ANTIBODIES; PROTEINS; RESINS; SURFACE PLASMON RESONANCE; THEOREM PROVING; UREA;

ANTIBODIES;

HYBRID PROTEIN; IMMUNOGLOBULIN FC FRAGMENT; MONOCLONAL ANTIBODY; STAPHYLOCOCCUS PROTEIN A;

ARTICLE; CHEMISTRY; CHROMATOGRAPHY; INSTRUMENTATION; ISOLATION AND PURIFICATION; METHODOLOGY;

ANTIBODIES, MONOCLONAL; CHROMATOGRAPHY; IMMUNOGLOBULIN FC FRAGMENTS; RECOMBINANT FUSION PROTEINS; STAPHYLOCOCCAL PROTEIN A;

EID: 56249116669     PISSN: 87567938     EISSN: None     Source Type: Journal    
DOI: 10.1002/btpr.50     Document Type: Article

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