Chinese hamster genome database: An online resource for the CHO community at

Biotechnology and Bioengineering

Volumn 109, Issue 6, 2012, Pages 1353-1356

  Hammond, Stephanie ^a,b   Kaplarevic, Mihailo ^b   Borth, Nicole ^c,d   Betenbaugh, Michael J ^e   Lee, Kelvin H ^a,b  

^a University of Delaware   (United States)

^b UNIVERSITY OF DELAWARE   (United States)

^c UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES   (Austria)

^d AUSTRIAN CENTRE OF INDUSTRIAL BIOTECHNOLOGY   (Austria)

^e Johns Hopkins University   (United States)

Author keywords

Chinese hamster ovary cell; CHO genome; Database

Indexed keywords

CHINESE HAMSTER; CHO CELL; DATA BASE; FEMALE; GENOME; GENOMICS; IN VITRO STUDY; MEDICAL RESEARCH; NONHUMAN; NOTE;

ANIMALS; CHO CELLS; COMPUTATIONAL BIOLOGY; CRICETINAE; CRICETULUS; DATABASES, NUCLEIC ACID; GENOME;

CRICETULUS GRISEUS;

EID: 84859908354     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.24374     Document Type: Note

References (23)

1. Becker J, Hackl M, Rupp O, Jakobi T, Schneider J, Szczepanowski R, Bekel T, Borth N, Goesmann A, Grillari J, Kaltschmidt C, Noll T, Pühler A, Tauch A, Brinkrolf K. 2011. Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing. J Biotechnol 156(3): 227-235.
2. Benson DA, Karsch-Mizrachi I, Lipman DJ, Ostell J, Sayers EW. 2011. GenBank. Nucleic Acids Res 39: D32-D37.
3. Birzele F, Schaub J, Rust W, Clemens C, Baum P, Kaufmann H, Weith A, Schulz TW, Hildebrandt T. 2010. Into the unknown: Expression profiling without genome sequence information in CHO by next generation sequencing. Nucleic Acids Res 38(12): 3999-4010.
4. Blake JA, Bult CJ, Kadin JA, Richardson JE, Eppig JT. 2011. The Mouse Genome Database (MGD): Premier model organism resource for mammalian genomics and genetics. Nucleic Acids Res 39: D842-D848.
5. Carbon S, Ireland A, Mungall CJ, Shu S, Marshall B, Lewis S. 2009. AmiGO: Online access to ontology and annotation data. Bioinformatics 25(2): 288-289.
6. Clarke C, Doolan P, Barron N, Meleady P, O'Sullivan F, Gammell P, Melville M, Leonard M, Clynes M. 2011. Large scale microarray profiling and coexpression network analysis of CHO cells identifies transcriptional modules associated with growth and productivity. J Biotechnol 155(3): 350-359.
7. Hackl M, Jakobi T, Blom J, Doppmeier D, Brinkrolf K, Szczepanowski R, Bernhart SH, Siederdissen CH, Bort JA, Wieser M. and others. 2011. Next-generation sequencing of the Chinese hamster ovary microRNA transcriptome: Identification, annotation and profiling of microRNAs as targets for cellular engineering. J Biotechnol 153(1-2): 62-75.
8. Hammond S, Swanberg JC, Kaplarevic M, Lee KH. 2011. Genomic sequencing and analysis of a Chinese hamster ovary cell line using Illumina sequencing technology. BMC Genomics 12: 67.
9. Jayapal KP, Wlashcin KF, Hu WS. 2007. Recombinant protein therapeutics from CHO cells-20 years and counting. Chem Eng Prog 103(7): 40-47.
10. Johnson KC, Jacob NM, Nissom PM, Hackl M, Lee LH, Yap M, Hu WS. 2011. Conserved microRNAs in Chinese hamster ovary cell lines. Biotechnol Bioeng 108(2): 475-480.
11. Kantardjieff A, Nissom PM, Chuah SH, Yusufi F, Jacob NM, Mulukutla BC, Yap M, Hu WS. 2009. Developing genomic platforms for Chinese hamster ovary cells. Biotechnol Adv 27(6): 1028-1035.
12. Kantardjieff A, Jacob NM, Yee JC, Epstein E, Kok YJ, Philp R, Betenbaugh M, Hu WS. 2010. Transcriptome and proteome analysis of Chinese hamster ovary cells under low temperature and butyrate treatment. J Biotechnol 145(2): 143-159.
13. Kao FT, Puck TT. 1968. Genetics of somatic mammalian cells, VII. Induction and isolation of nutritional mutants in Chinese hamster cells. PNAS 60(4): 1275-1281.
14. Kim YJ, Doyle ML. 2010. Structural mass spectrometry in protein therapeutics discovery. Anal Chem 82(17): 7083-7089.
15. Leinonen R, Akhtar R, Birney E, Bower L, Cerdeno-Tarraga A, Cheng Y, Cleland I, Faruque N, Goodgame N, Gibson R. and others. 2011. The European nucleotide archive. Nucleic Acids Res 39: D28-D31.
16. Partridge MA, Davidson MM, Hei TK. 2007. The complete nucleotide sequence of Chinese hamster (Cricetulus griseus) mitochondrial DNA. DNA Seq 18(5): 341-346.
17. Pascoe DE, Arnott D, Papoutsakis ET, Miller WM, Andersen DC. 2007. Proteome analysis of antibody-producing CHO cell lines with different metabolic profiles. Biotechnol Bioeng 98(2): 391-410.
18. Petri V, Shimoyama M, Hayman GT, Smith JR, Tutaj M, de Pons J, Dwinell MR, Munzenmaier DH, Twigger SN, Jacob HJ. 2011. The Rat Genome Database pathway portal. Database (Oxford) 2011: bar010.
19. Puck TT, Cieciura SJ, Robinson A. 1958. Genetics of somatic mammalian cells. III. Long-term cultivation of euploid cells from human and animal subjects. J Exp Med 108(6): 945-956.
20. Tweedie S, Ashburner M, Falls K, Leyland P, McQuilton P, Marygold S, Millburn G, Osumi-Sutherland D, Schroeder A, Seal R. and others. 2009. FlyBase: enhancing Drosophila Gene Ontology annotations. Nucleic Acids Res 37: D555-D559.
21. Urlaub G, Chasin LA. 1980. Isolation of Chinese hamster cell mutants deficient in dihydrofolate reductase activity. PNAS 77(7): 4216-4220.
22. Urlaub G, Kas E, Carothers AM, Chasin LA. 1983. Deletion of the diploid dihydrofolate reductase locus from cultured mammalian cells. Cell 33(2): 405-412.
23. Xu X, Nagarajan H, Lewis NE, Pan S, Cai Z, Liu X, Chen W, Xie M, Wang W, Hammond S. and others. 2011. The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line. Nat Biotechnol 29(8): 735-741.