Host cell protein adsorption characteristics during protein a chromatography

Biotechnology Progress

Volumn 28, Issue 4, 2012, Pages 1037-1044

  Tarrant, Richard D R ^a   Velez Suberbie, M Lourdes ^a   Tait, Andrew S ^a   Smales, C Mark ^b   Bracewell, Daniel G ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF KENT   (United Kingdom)

Author keywords

Host cell proteins; Monoclonal antibodies; Protein A chromatography; Proteomics

Indexed keywords

2D-PAGE; CELL LINES; CONTROLLED PORE GLASS; CRITICAL ANALYSIS; ELEVATED LEVEL; HOST CELL PROTEIN; IMPURITIES IN; IMPURITY PROFILE; INDIVIDUAL COMPONENTS; MONOCLONAL ANTIBODIES (MAB); PLATFORM PROCESS; PROCESS ENGINEER; PROCESS STEPS; PROCESS UNDERSTANDING; PROCESS-RELATED IMPURITIES; PROTEIN A CHROMATOGRAPHY; PROTEOMICS; RESIDUAL IMPURITIES; SAMPLE ENRICHMENT; SCREENING TOOL; SINGLE-STEP; STANDARD CONDITIONS;

ADSORPTION; BONE; CELL CULTURE; CHROMATOGRAPHY; IMPURITIES; MATRIX ALGEBRA; MOLECULAR BIOLOGY; MONOCLONAL ANTIBODIES; PURIFICATION; REMOVAL; RESINS;

PROTEINS;

IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY; PROTEIN; STAPHYLOCOCCUS PROTEIN A;

ADSORPTION; AFFINITY CHROMATOGRAPHY; ANIMAL; ARTICLE; CHEMISTRY; CHO CELL; CULTURE TECHNIQUE; EVALUATION; GENETICS; HAMSTER; INSTRUMENTATION; ISOLATION AND PURIFICATION; METABOLISM; METHODOLOGY; PROTEIN BINDING;

ADSORPTION; ANIMALS; ANTIBODIES, MONOCLONAL; CELL CULTURE TECHNIQUES; CHO CELLS; CHROMATOGRAPHY, AFFINITY; CRICETINAE; IMMUNOGLOBULIN G; PROTEIN BINDING; PROTEINS; STAPHYLOCOCCAL PROTEIN A;

EID: 84864846839     PISSN: 87567938     EISSN: 15206033     Source Type: Journal    
DOI: 10.1002/btpr.1581     Document Type: Article

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