-
1
-
-
33748201603
-
Running interference: Prospects and obstacles to using small interfering RNAs as small molecule drugs
-
Dykxhoorn DM, Lieberman J. Running interference: prospects and obstacles to using small interfering RNAs as small molecule drugs. Annu. Rev. Biomed. Eng. 8, 377-402 (2006).
-
(2006)
Annu. Rev. Biomed. Eng.
, vol.8
, pp. 377-402
-
-
Dykxhoorn, D.M.1
Lieberman, J.2
-
2
-
-
33645148088
-
The silent treatment: SiRNAs as small molecule drugs
-
Dykxhoorn DM, Palliser D, Lieberman J. The silent treatment: siRNAs as small molecule drugs. Gene Ther. 13(6), 541-552 (2006).
-
(2006)
Gene Ther.
, vol.13
, Issue.6
, pp. 541-552
-
-
Dykxhoorn, D.M.1
Palliser, D.2
Lieberman, J.3
-
3
-
-
34447559636
-
Interfering with disease: A progress report on siRNA-based therapeutics
-
De Fougerolles A, Vornlocher HP, Maraganore J, Lieberman J. Interfering with disease: a progress report on siRNA-based therapeutics. Nat. Rev. Drug Discov. 6(6), 443-453 (2007).
-
(2007)
Nat. Rev. Drug Discov.
, vol.6
, Issue.6
, pp. 443-453
-
-
De Fougerolles, A.1
Vornlocher, H.P.2
Maraganore, J.3
Lieberman, J.4
-
4
-
-
70349316690
-
Therapeutic applications of RNAi for silencing virus replication
-
Tripp RA, Tompkins SM. Therapeutic applications of RNAi for silencing virus replication. Methods Mol. Biol. 555, 43-61 (2009).
-
(2009)
Methods Mol. Biol.
, vol.555
, pp. 43-61
-
-
Tripp, R.A.1
Tompkins, S.M.2
-
5
-
-
82255175105
-
Biology and applications of small nucleolar RNAs
-
Bratkovic T, Rogelj B. Biology and applications of small nucleolar RNAs. Cell. Mol. Life Sci. 68(23), 3843-3851 (2011).
-
(2011)
Cell. Mol. Life Sci.
, vol.68
, Issue.23
, pp. 3843-3851
-
-
Bratkovic, T.1
Rogelj, B.2
-
6
-
-
84866295474
-
Characterizing ncRNAs in human pathogenic protists using high-throughput sequencing technology
-
Collins LJ. Characterizing ncRNAs in human pathogenic protists using high-throughput sequencing technology. Front. Genet. 2, 96 (2011).
-
(2011)
Front. Genet.
, vol.2
, pp. 96
-
-
Collins, L.J.1
-
7
-
-
79958274671
-
An introduction to small non-coding RNAs: MiRNA and snoRNA
-
Holley CL, Topkara VK. An introduction to small non-coding RNAs: miRNA and snoRNA. Cardiovasc. Drugs Ther. 25(2), 151-159 (2011).
-
(2011)
Cardiovasc. Drugs Ther.
, vol.25
, Issue.2
, pp. 151-159
-
-
Holley, C.L.1
Topkara, V.K.2
-
8
-
-
80155208165
-
SNOntology: Myriads of novel SnoRNAs or just a mirage?
-
Makarova JA, Kramerov DA. SNOntology: myriads of novel SnoRNAs or just a mirage? BMC Genomics 12(1), 543 (2011).
-
(2011)
BMC Genomics
, vol.12
, Issue.1
, pp. 543
-
-
Makarova, J.A.1
Kramerov, D.A.2
-
9
-
-
80053574876
-
From snoRNA to miRNA: Dual function regulatory non-coding RNAs
-
Scott MS, Ono M. From snoRNA to miRNA: dual function regulatory non-coding RNAs. Biochimie 93(11), 1987-1992 (2011).
-
(2011)
Biochimie
, vol.93
, Issue.11
, pp. 1987-1992
-
-
Scott, M.S.1
Ono, M.2
-
10
-
-
81355142141
-
Non-coding RNAs in human disease
-
Esteller M. Non-coding RNAs in human disease. Nat. Rev. Genet. 12(12), 861-874 (2011).
-
(2011)
Nat. Rev. Genet.
, vol.12
, Issue.12
, pp. 861-874
-
-
Esteller, M.1
-
11
-
-
84904082355
-
RNA interference therapeutics for tumour therapy: Promising work in progress
-
Lattime EC, Gerson SL (Eds). Academic Press
-
Tsujiuchi T, Wakabayashi T, Miller AD, Natsume A. RNA interference therapeutics for tumour therapy: promising work in progress. In:Gene Therapy of Cancer (3rd Edition) . Lattime EC, Gerson SL (Eds). Academic Press, 393-408 (2014).
-
(2014)
Gene Therapy of Cancer (3rd Edition)
, pp. 393-408
-
-
Tsujiuchi, T.1
Wakabayashi, T.2
Miller, A.D.3
Natsume, A.4
-
12
-
-
84876440888
-
CRISPR-Cas systems and RNA-guided interference Wiley Interdiscip
-
Barrangou R. CRISPR-Cas systems and RNA-guided interference. Wiley Interdiscip. Rev. RNA 4(3), 267-278 (2013).
-
(2013)
Rev. RNA
, vol.4
, Issue.3
, pp. 267-278
-
-
Barrangou, R.1
-
13
-
-
84879264708
-
ZFN TALEN and CRISPR/Cas-based methods for genome engineering
-
Gaj T, Gersbach CA, Barbas CF 3rd. ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering. Trends Biotechnol. 31(7), 397-405 (2013).
-
(2013)
Trends Biotechnol.
, vol.31
, Issue.7
, pp. 397-405
-
-
Gaj, T.1
Gersbach, C.A.2
Barbas III, C.F.3
-
14
-
-
84879584456
-
CRISPR interference: A structural perspective
-
Reeks J, Naismith JH, White MF. CRISPR interference: a structural perspective. Biochem. J. 453(2), 155-166 (2013).
-
(2013)
Biochem. J.
, vol.453
, Issue.2
, pp. 155-166
-
-
Reeks, J.1
Naismith, J.H.2
White, M.F.3
-
15
-
-
84880121815
-
Exploiting CRISPR/Cas: Interference mechanisms and applications
-
Richter H, Randau L, Plagens A. Exploiting CRISPR/Cas: interference mechanisms and applications. Int. J. Mol. Sci. 14(7), 14518-14531 (2013).
-
(2013)
Int. J. Mol. Sci.
, vol.14
, Issue.7
, pp. 14518-14531
-
-
Richter, H.1
Randau, L.2
Plagens, A.3
-
16
-
-
36849044732
-
Nonviral delivery of synthetic siRNAs in vivo
-
Akhtar S, Benter IF. Nonviral delivery of synthetic siRNAs in vivo. J. Clin. Invest. 117(12), 3623-3632 (2007).
-
(2007)
J. Clin. Invest.
, vol.117
, Issue.12
, pp. 3623-3632
-
-
Akhtar, S.1
Benter, I.F.2
-
17
-
-
34047190259
-
Hydrophobization and bioconjugation for enhanced siRNA delivery and targeting
-
De Paula D, Bentley MV, Mahato RI. Hydrophobization and bioconjugation for enhanced siRNA delivery and targeting. RNA 13(4), 431-456 (2007).
-
(2007)
RNA
, vol.13
, Issue.4
, pp. 431-456
-
-
De Paula, D.1
Bentley, M.V.2
Mahato, R.I.3
-
18
-
-
67249096677
-
Nonviral methods for siRNA delivery
-
Gao K, Huang L. Nonviral methods for siRNA delivery. Mol. Pharm. 6(3), 651-658 (2009).
-
(2009)
Mol. Pharm.
, vol.6
, Issue.3
, pp. 651-658
-
-
Gao, K.1
Huang, L.2
-
20
-
-
57349114898
-
Stability study of unmodified siRNA and relevance to clinical use
-
Hickerson RP, Vlassov AV, Wang Q et al. Stability study of unmodified siRNA and relevance to clinical use. Oligonucleotides 18(4), 345-354 (2008).
-
(2008)
Oligonucleotides
, vol.18
, Issue.4
, pp. 345-354
-
-
Hickerson, R.P.1
Vlassov, A.V.2
Wang, Q.3
-
21
-
-
74049153383
-
Systemic delivery and quantification of unformulated interfering RNAs in vivo
-
Morin A, Gallou-Kabani C, Mathieu JR, Cabon F. Systemic delivery and quantification of unformulated interfering RNAs in vivo. Curr. Top. Med. Chem. 9(12), 1117-1129 (2009).
-
(2009)
Curr. Top. Med. Chem.
, vol.9
, Issue.12
, pp. 1117-1129
-
-
Morin, A.1
Gallou-Kabani, C.2
Mathieu, J.R.3
Cabon, F.4
-
23
-
-
67249142681
-
SiRNA delivery and targeting
-
Cheng K, Mahato RI. siRNA delivery and targeting. Mol. Pharm. 6(3), 649-650 (2009).
-
(2009)
Mol. Pharm.
, vol.6
, Issue.3
, pp. 649-650
-
-
Cheng, K.1
Mahato, R.I.2
-
24
-
-
55649089421
-
State of the art and perspectives for the delivery of antisense oligonucleotides and siRNA by polymeric nanocarriers
-
Fattal E, Bochot A. State of the art and perspectives for the delivery of antisense oligonucleotides and siRNA by polymeric nanocarriers. Int. J. Pharm. 364(2), 237-248 (2008).
-
(2008)
Int. J. Pharm.
, vol.364
, Issue.2
, pp. 237-248
-
-
Fattal, E.1
Bochot, A.2
-
25
-
-
41949117146
-
Liposomal nanomedicines: An emerging field
-
Fenske DB, Chonn A, Cullis PR. Liposomal nanomedicines: an emerging field. Toxicol. Pathol. 36(1), 21-29 (2008).
-
(2008)
Toxicol. Pathol.
, vol.36
, Issue.1
, pp. 21-29
-
-
Fenske, D.B.1
Chonn, A.2
Cullis, P.R.3
-
27
-
-
57349152290
-
Targeted delivery of siRNA by nonviral vectors: Lessons learned from recent advances
-
Li SD, Huang L. Targeted delivery of siRNA by nonviral vectors: lessons learned from recent advances. Curr. Opin. Investig. Drugs 9(12), 1317-1323 (2008).
-
(2008)
Curr. Opin. Investig. Drugs
, vol.9
, Issue.12
, pp. 1317-1323
-
-
Li, S.D.1
Huang, L.2
-
28
-
-
33847099637
-
Lipid-based nanoparticles for nucleic acid delivery
-
Li W, Szoka FC Jr. Lipid-based nanoparticles for nucleic acid delivery. Pharm. Res. 24(3), 438-449 (2007).
-
(2007)
Pharm. Res.
, vol.24
, Issue.3
, pp. 438-449
-
-
Li, W.1
Szoka Jr., F.C.2
-
29
-
-
59249099019
-
Extracellular targeting of synthetic therapeutic nucleic acid formulations
-
Philipp A, Meyer M, Wagner E. Extracellular targeting of synthetic therapeutic nucleic acid formulations. Curr. Gene Ther. 8(5), 324-334 (2008).
-
(2008)
Curr. Gene Ther.
, vol.8
, Issue.5
, pp. 324-334
-
-
Philipp, A.1
Meyer, M.2
Wagner, E.3
-
30
-
-
72949119713
-
Lipidic systems for in vivo siRNA delivery
-
Wu SY, McMillan NA. Lipidic systems for in vivo siRNA delivery. AAPS J. 11(4), 639-652 (2009).
-
(2009)
AAPS J.
, vol.11
, Issue.4
, pp. 639-652
-
-
Wu, S.Y.1
McMillan, N.A.2
-
31
-
-
61849162695
-
SiRNA conjugate delivery systems
-
Jeong JH, Mok H, Oh YK, Park TG. siRNA conjugate delivery systems. Bioconjug. Chem. 20(1), 5-14 (2009).
-
(2009)
Bioconjug. Chem.
, vol.20
, Issue.1
, pp. 5-14
-
-
Jeong, J.H.1
Mok, H.2
Oh, Y.K.3
Park, T.G.4
-
32
-
-
68249155376
-
Bioreducible polymers for efficient gene and siRNA delivery
-
Jere D, Arote R, Jiang HL, Kim YK, Cho MH, Cho CS. Bioreducible polymers for efficient gene and siRNA delivery. Biomed. Mater. 4(2), 25020 (2009).
-
(2009)
Biomed. Mater.
, vol.4
, Issue.2
, pp. 25020
-
-
Jere, D.1
Arote, R.2
Jiang, H.L.3
Kim, Y.K.4
Cho, M.H.5
Cho, C.S.6
-
33
-
-
70449089802
-
Strategies for targeted nonviral delivery of siRNAs in vivo
-
Kim SS, Garg H, Joshi A, Manjunath N. Strategies for targeted nonviral delivery of siRNAs in vivo. Trends Mol. Med. 15(11), 491-500 (2009).
-
(2009)
Trends Mol. Med.
, vol.15
, Issue.11
, pp. 491-500
-
-
Kim, S.S.1
Garg, H.2
Joshi, A.3
Manjunath, N.4
-
34
-
-
27744466964
-
Synthetic, self-assembly ABCD nanoparticles; A structural paradigm for viable synthetic non-viral vectors
-
Kostarelos K, Miller AD. Synthetic, self-assembly ABCD nanoparticles; a structural paradigm for viable synthetic non-viral vectors. Chem. Soc. Rev. 34(11), 970-994 (2005).
-
(2005)
Chem. Soc. Rev.
, vol.34
, Issue.11
, pp. 970-994
-
-
Kostarelos, K.1
Miller, A.D.2
-
35
-
-
60149094505
-
RNA interference: From basic research to therapeutic applications
-
Kurreck J. RNA interference: from basic research to therapeutic applications. Angew. Chem. Int. Ed. Engl. 48(8), 1378-1398 (2009).
-
(2009)
Angew. Chem. Int. Ed. Engl.
, vol.48
, Issue.8
, pp. 1378-1398
-
-
Kurreck, J.1
-
36
-
-
45249103527
-
Towards safe nanoparticle technologies for nucleic acid therapeutics
-
Miller AD. Towards safe nanoparticle technologies for nucleic acid therapeutics. Tumori 94(2), 234-245 (2008).
-
(2008)
Tumori
, vol.94
, Issue.2
, pp. 234-245
-
-
Miller, A.D.1
-
37
-
-
80053513757
-
Synthetic nucleic acid delivery systems in gene therapy
-
doi:10.1002/9780470015902.a0005745.pub2, Wiley & Sons, Chichester, UK
-
Miller AD. Synthetic nucleic acid delivery systems in gene therapy. In: Encyclopedia of Life Sciences. doi:10.1002/9780470015902.a0005745.pub2 Wiley & Sons, Chichester, UK (2008).
-
(2008)
Encyclopedia of Life Sciences
-
-
Miller, A.D.1
-
38
-
-
45249092189
-
Gene therapy
-
Taylor JB, Triggle DJ (Eds). Elsevier, Oxford, UK
-
Thanou M, Waddington S, Miller AD. Gene therapy. In:Comprehensive Medicinal Chemistry II . Taylor JB, Triggle DJ (Eds). Elsevier, Oxford, UK, 297-320 (2007).
-
(2007)
Comprehensive Medicinal Chemistry II
, pp. 297-320
-
-
Thanou, M.1
Waddington, S.2
Miller, A.D.3
-
39
-
-
84887762938
-
Delivery of RNAi therapeutics: Work in progress
-
Miller AD. Delivery of RNAi therapeutics: work in progress. Expert Rev. Med. Devices 10(6), 781-811 (2013).
-
(2013)
Expert Rev. Med. Devices
, vol.10
, Issue.6
, pp. 781-811
-
-
Miller, A.D.1
-
40
-
-
84903960313
-
Auto-associative lipid-based systems for nonviral nucleic acid delivery
-
Scherman D (Ed.). Imperial College Press, London, UK
-
Escriou V, Mignet N, Miller AD. Auto-associative lipid-based systems for nonviral nucleic acid delivery. In:Advanced Textbook on Gene Transfer, Gene Therapy and Genetic Pharmacology . Scherman D (Ed.). Imperial College Press, London, UK, 221-254 (2014).
-
(2014)
Advanced Textbook on Gene Transfer, Gene Therapy and Genetic Pharmacology
, pp. 221-254
-
-
Escriou, V.1
Mignet, N.2
Miller, A.D.3
-
41
-
-
0038482054
-
The problem with cationic liposome/micelle-based non-viral vector systems for gene therapy
-
Miller AD. The problem with cationic liposome/micelle-based non-viral vector systems for gene therapy. Curr. Med. Chem. 10(14), 1195-1211 (2003).
-
(2003)
Curr. Med. Chem.
, vol.10
, Issue.14
, pp. 1195-1211
-
-
Miller, A.D.1
-
42
-
-
0032858150
-
Stabilized plasmid-lipid particles for regional gene therapy: Formulation and transfection properties
-
Zhang YP, Sekirov L, Saravolac EG et al. Stabilized plasmid-lipid particles for regional gene therapy: formulation and transfection properties. Gene Ther. 6(8), 1438-1447 (1999).
-
(1999)
Gene Ther.
, vol.6
, Issue.8
, pp. 1438-1447
-
-
Zhang, Y.P.1
Sekirov, L.2
Saravolac, E.G.3
-
43
-
-
0032991616
-
Stabilized plasmid-lipid particles: Construction and characterization
-
Wheeler JJ, Palmer L, Ossanlou M et al. Stabilized plasmid-lipid particles: construction and characterization. Gene Ther. 6(2), 271-281 (1999).
-
(1999)
Gene Ther.
, vol.6
, Issue.2
, pp. 271-281
-
-
Wheeler, J.J.1
Palmer, L.2
Ossanlou, M.3
-
44
-
-
0033036668
-
Stabilized plasmid-lipid particles: Factors influencing plasmid entrapment and transfection properties
-
Mok KW, Lam AM, Cullis PR. Stabilized plasmid-lipid particles: factors influencing plasmid entrapment and transfection properties. Biochim. Biophys. Acta 1419(2), 137-150 (1999).
-
(1999)
Biochim. Biophys. Acta
, vol.1419
, Issue.2
, pp. 137-150
-
-
Mok, K.W.1
Lam, A.M.2
Cullis, P.R.3
-
45
-
-
23444445660
-
Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs
-
Morrissey DV, Lockridge JA, Shaw L et al. Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs. Nat. Biotechnol. 23(8), 1002-1007 (2005).
-
(2005)
Nat. Biotechnol.
, vol.23
, Issue.8
, pp. 1002-1007
-
-
Morrissey, D.V.1
Lockridge, J.A.2
Shaw, L.3
-
46
-
-
33646185371
-
RNAi-mediated gene silencing in non-human primates
-
Zimmermann TS, Lee AC, Akinc A et al. RNAi-mediated gene silencing in non-human primates. Nature 441(7089), 111-114 (2006).
-
(2006)
Nature
, vol.441
, Issue.7089
, pp. 111-114
-
-
Zimmermann, T.S.1
Lee, A.C.2
Akinc, A.3
-
47
-
-
76349111051
-
Rational design of cationic lipids for siRNA delivery
-
Semple SC, Akinc A, Chen J et al. Rational design of cationic lipids for siRNA delivery. Nat. Biotechnol. 28(2), 172-176 (2010).
-
(2010)
Nat. Biotechnol.
, vol.28
, Issue.2
, pp. 172-176
-
-
Semple, S.C.1
Akinc, A.2
Chen, J.3
-
48
-
-
82955233888
-
Influence of cationic lipid composition on gene silencing properties of lipid nanoparticle formulations of siRNA in antigen-presenting cells
-
Basha G, Novobrantseva TI, Rosin N et al. Influence of cationic lipid composition on gene silencing properties of lipid nanoparticle formulations of siRNA in antigen-presenting cells. Mol. Ther. 19(12), 2186-2200 (2011).
-
(2011)
Mol. Ther.
, vol.19
, Issue.12
, pp. 2186-2200
-
-
Basha, G.1
Novobrantseva, T.I.2
Rosin, N.3
-
49
-
-
84863201108
-
Lipid nanoparticle siRNA systems for silencing the androgen receptor in human prostate cancer in vivo
-
Lee JB, Zhang K, Tam YY et al. Lipid nanoparticle siRNA systems for silencing the androgen receptor in human prostate cancer in vivo. Int. J. Cancer 131(5), E781-E790 (2012).
-
(2012)
Int. J. Cancer
, vol.131
, Issue.5
-
-
Lee, J.B.1
Zhang, K.2
Tam, Y.Y.3
-
50
-
-
84865079107
-
Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo
-
Jayaraman M, Ansell SM, Mui BL et al. Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo. Angew. Chem. Int. Ed. Engl. 51(34), 8529-8533 (2012).
-
(2012)
Angew. Chem. Int. Ed. Engl.
, vol.51
, Issue.34
, pp. 8529-8533
-
-
Jayaraman, M.1
Ansell, S.M.2
Mui, B.L.3
-
51
-
-
0024557781
-
Effects of apolipoproteins A-IV and A-I on the uptake of phospholipid liposomes by hepatocytes
-
Bisgaier CL, Siebenkas MV, Williams KJ. Effects of apolipoproteins A-IV and A-I on the uptake of phospholipid liposomes by hepatocytes. J. Biol. Chem. 264(2), 862-866 (1989).
-
(1989)
J. Biol. Chem.
, vol.264
, Issue.2
, pp. 862-866
-
-
Bisgaier, C.L.1
Siebenkas, M.V.2
Williams, K.J.3
-
52
-
-
74149092120
-
Evaluation of efficacy, biodistribution, and inflammation for a potent siRNA nanoparticle: Effect of dexamethasone co-treatment
-
Abrams MT, Koser ML, Seitzer J et al. Evaluation of efficacy, biodistribution, and inflammation for a potent siRNA nanoparticle: effect of dexamethasone co-treatment. Mol. Ther. 18(1), 171-180 (2010).
-
(2010)
Mol. Ther.
, vol.18
, Issue.1
, pp. 171-180
-
-
Abrams, M.T.1
Koser, M.L.2
Seitzer, J.3
-
53
-
-
78650180150
-
Analysis of lipid nanoparticles by Cryo-EM for characterizing siRNA delivery vehicles
-
Crawford R, Dogdas B, Keough E et al. Analysis of lipid nanoparticles by Cryo-EM for characterizing siRNA delivery vehicles. Int. J. Pharm. 403(1-2), 237-244 (2011).
-
(2011)
Int. J. Pharm.
, vol.403
, Issue.1-2
, pp. 237-244
-
-
Crawford, R.1
Dogdas, B.2
Keough, E.3
-
54
-
-
78649683035
-
Quantitative evaluation of siRNA delivery in vivo
-
Pei Y, Hancock PJ, Zhang H et al. Quantitative evaluation of siRNA delivery in vivo. RNA 16(12), 2553-2563 (2010).
-
(2010)
RNA
, vol.16
, Issue.12
, pp. 2553-2563
-
-
Pei, Y.1
Hancock, P.J.2
Zhang, H.3
-
55
-
-
79952187464
-
Mechanistically probing lipid-siRNA nanoparticle-associated toxicities identifies Jak inhibitors effective in mitigating multifaceted toxic responses
-
Tao W, Mao X, Davide JP et al. Mechanistically probing lipid-siRNA nanoparticle-associated toxicities identifies Jak inhibitors effective in mitigating multifaceted toxic responses. Mol. Ther. 19(3), 567-575 (2011).
-
(2011)
Mol. Ther.
, vol.19
, Issue.3
, pp. 567-575
-
-
Tao, W.1
Mao, X.2
Davide, J.P.3
-
56
-
-
33748331337
-
RNA interference in the mouse vascular endothelium by systemic administration of siRNA-lipoplexes for cancer therapy
-
Santel A, Aleku M, Keil O et al. RNA interference in the mouse vascular endothelium by systemic administration of siRNA-lipoplexes for cancer therapy. Gene Ther. 13(18), 1360-1370 (2006).
-
(2006)
Gene Ther.
, vol.13
, Issue.18
, pp. 1360-1370
-
-
Santel, A.1
Aleku, M.2
Keil, O.3
-
57
-
-
33746883220
-
A novel siRNA-lipoplex technology for RNA interference in the mouse vascular endothelium
-
Santel A, Aleku M, Keil O et al. A novel siRNA-lipoplex technology for RNA interference in the mouse vascular endothelium. Gene Ther. 13(16), 1222-1234 (2006).
-
(2006)
Gene Ther.
, vol.13
, Issue.16
, pp. 1222-1234
-
-
Santel, A.1
Aleku, M.2
Keil, O.3
-
58
-
-
57149086661
-
Atu027, a liposomal small interfering RNA formulation targeting protein kinase N3, inhibits cancer progression
-
Aleku M, Schulz P, Keil O et al. Atu027, a liposomal small interfering RNA formulation targeting protein kinase N3, inhibits cancer progression. Cancer Res. 68(23), 9788-9798 (2008).
-
(2008)
Cancer Res.
, vol.68
, Issue.23
, pp. 9788-9798
-
-
Aleku, M.1
Schulz, P.2
Keil, O.3
-
59
-
-
85027927478
-
An amino acid-based amphoteric liposomal delivery system for systemic administration of siRNA
-
Adami RC, Seth S, Harvie P et al. An amino acid-based amphoteric liposomal delivery system for systemic administration of siRNA. Mol. Ther. 19(6), 1141-1151 (2011).
-
(2011)
Mol. Ther.
, vol.19
, Issue.6
, pp. 1141-1151
-
-
Adami, R.C.1
Seth, S.2
Harvie, P.3
-
60
-
-
55349125661
-
Tumor regression in mice by delivery of Bcl-2 small interfering RNA with pegylated cationic liposomes
-
Sonoke S, Ueda T, Fujiwara K et al. Tumor regression in mice by delivery of Bcl-2 small interfering RNA with pegylated cationic liposomes. Cancer Res. 68(21), 8843-8851 (2008).
-
(2008)
Cancer Res.
, vol.68
, Issue.21
, pp. 8843-8851
-
-
Sonoke, S.1
Ueda, T.2
Fujiwara, K.3
-
61
-
-
84891831905
-
Knockdown of beta-catenin with dicer-substrate siRNAs reduces liver tumor burden in vivo
-
Dudek H, Wong DH, Arvan R et al. Knockdown of beta-catenin with dicer-substrate siRNAs reduces liver tumor burden in vivo. Mol. Ther. 22(1), 92-101 (2014).
-
(2014)
Mol. Ther.
, vol.22
, Issue.1
, pp. 92-101
-
-
Dudek, H.1
Wong, D.H.2
Arvan, R.3
-
62
-
-
54949125913
-
Folate-linked lipid-based nanoparticles for synthetic siRNA delivery in KB tumor xenografts
-
Yoshizawa T, Hattori Y, Hakoshima M, Koga K, Maitani Y. Folate-linked lipid-based nanoparticles for synthetic siRNA delivery in KB tumor xenografts. Eur. J. Pharm. Biopharm. 70(3), 718-725 (2008).
-
(2008)
Eur. J. Pharm. Biopharm.
, vol.70
, Issue.3
, pp. 718-725
-
-
Yoshizawa, T.1
Hattori, Y.2
Hakoshima, M.3
Koga, K.4
Maitani, Y.5
-
63
-
-
33845679807
-
Surface-modified LPD nanoparticles for tumor targeting
-
Li SD, Huang L. Surface-modified LPD nanoparticles for tumor targeting. Ann. N. Y. Acad. Sci. 1082, 1-8 (2006).
-
(2006)
Ann. N. Y. Acad. Sci.
, vol.1082
, pp. 1-8
-
-
Li, S.D.1
Huang, L.2
-
64
-
-
33750417183
-
Targeted delivery of antisense oligodeoxynucleotide and small interference RNA into lung cancer cells
-
Li SD, Huang L. Targeted delivery of antisense oligodeoxynucleotide and small interference RNA into lung cancer cells. Mol. Pharm. 3(5), 579-588 (2006).
-
(2006)
Mol. Pharm.
, vol.3
, Issue.5
, pp. 579-588
-
-
Li, S.D.1
Huang, L.2
-
65
-
-
52049121804
-
An efficient and low immunostimulatory nanoparticle formulation for systemic siRNA delivery to the tumor
-
Chono S, Li SD, Conwell CC, Huang L. An efficient and low immunostimulatory nanoparticle formulation for systemic siRNA delivery to the tumor. J. Control. Release 131(1), 64-69 (2008).
-
(2008)
J. Control. Release
, vol.131
, Issue.1
, pp. 64-69
-
-
Chono, S.1
Li, S.D.2
Conwell, C.C.3
Huang, L.4
-
66
-
-
67249131198
-
Novel cationic lipid that delivers siRNA and enhances therapeutic effect in lung cancer cells
-
Chen Y, Sen J, Bathula SR, Yang Q, Fittipaldi R, Huang L. Novel cationic lipid that delivers siRNA and enhances therapeutic effect in lung cancer cells. Mol. Pharm. 6(3), 696-705 (2009).
-
(2009)
Mol. Pharm.
, vol.6
, Issue.3
, pp. 696-705
-
-
Chen, Y.1
Sen, J.2
Bathula, S.R.3
Yang, Q.4
Fittipaldi, R.5
Huang, L.6
-
67
-
-
70349542520
-
Nanoparticles evading the reticuloendothelial system: Role of the supported bilayer
-
Li SD, Huang L. Nanoparticles evading the reticuloendothelial system: role of the supported bilayer. Biochim. Biophys Acta 1788(10), 2259-2266 (2009).
-
(2009)
Biochim. Biophys Acta
, vol.1788
, Issue.10
, pp. 2259-2266
-
-
Li, S.D.1
Huang, L.2
-
68
-
-
38849166053
-
Systemic leukocyte-directed siRNA delivery revealing cyclin D1 as an anti-inflammatory target
-
Peer D, Park EJ, Morishita Y, Carman CV, Shimaoka M. Systemic leukocyte-directed siRNA delivery revealing cyclin D1 as an anti-inflammatory target. Science 319(5863), 627-630 (2008).
-
(2008)
Science
, vol.319
, Issue.5863
, pp. 627-630
-
-
Peer, D.1
Park, E.J.2
Morishita, Y.3
Carman, C.V.4
Shimaoka, M.5
-
69
-
-
65349118108
-
Systemic siRNA delivery to leukocyte-implicated diseases
-
Peer D, Shimaoka M. Systemic siRNA delivery to leukocyte-implicated diseases. Cell Cycle 8(6), 853-859 (2009).
-
(2009)
Cell Cycle
, vol.8
, Issue.6
, pp. 853-859
-
-
Peer, D.1
Shimaoka, M.2
-
70
-
-
84555195893
-
Integrin-targeted stabilized nanoparticles for an efficient delivery of siRNAs in vitro and in vivo
-
Srinivasan C, Peer D, Shimaoka M. Integrin-targeted stabilized nanoparticles for an efficient delivery of siRNAs in vitro and in vivo. Methods Mol. Biol. 820, 105-116 (2012).
-
(2012)
Methods Mol. Biol.
, vol.820
, pp. 105-116
-
-
Srinivasan, C.1
Peer, D.2
Shimaoka, M.3
-
71
-
-
67249148563
-
Controlling HBV replication in vivo by intravenous administration of triggered PEGylated siRNA-nanoparticles
-
Carmona S, Jorgensen MR, Kolli S et al. Controlling HBV replication in vivo by intravenous administration of triggered PEGylated siRNA-nanoparticles. Mol. Pharm. 6(3), 706-717 (2009).
-
(2009)
Mol. Pharm.
, vol.6
, Issue.3
, pp. 706-717
-
-
Carmona, S.1
Jorgensen, M.R.2
Kolli, S.3
-
72
-
-
84875467836
-
pH-Triggered nanoparticle mediated delivery of siRNA to liver cells in vitro and in vivo
-
Kolli S, Wong SP, Harbottle R, Johnston B, Thanou M, Miller AD. pH-Triggered nanoparticle mediated delivery of siRNA to liver cells in vitro and in vivo. Bioconjug. Chem. 24(3), 314-332 (2013).
-
(2013)
Bioconjug. Chem.
, vol.24
, Issue.3
, pp. 314-332
-
-
Kolli, S.1
Wong, S.P.2
Harbottle, R.3
Johnston, B.4
Thanou, M.5
Miller, A.D.6
-
73
-
-
78651352062
-
Novel multifunctional nanoparticle mediates siRNA tumour delivery, visualisation and therapeutic tumour reduction in vivo
-
Kenny GD, Kamaly N, Kalber TL et al. Novel multifunctional nanoparticle mediates siRNA tumour delivery, visualisation and therapeutic tumour reduction in vivo. J. Control. Release 149(2), 111-116 (2011).
-
(2011)
J. Control. Release
, vol.149
, Issue.2
, pp. 111-116
-
-
Kenny, G.D.1
Kamaly, N.2
Kalber, T.L.3
-
74
-
-
80052552280
-
Efficient topical delivery of plasmid DNA to lung in vivo mediated by putative triggered, PEGylated pDNA nanoparticles
-
Aissaoui A, Chami M, Hussein M, Miller AD. Efficient topical delivery of plasmid DNA to lung in vivo mediated by putative triggered, PEGylated pDNA nanoparticles. J. Control. Release 154(3), 275-284 (2011).
-
(2011)
J. Control. Release
, vol.154
, Issue.3
, pp. 275-284
-
-
Aissaoui, A.1
Chami, M.2
Hussein, M.3
Miller, A.D.4
-
75
-
-
38949123316
-
Bimodal paramagnetic and fluorescent liposomes for cellular and tumor magnetic resonance imaging
-
Kamaly N, Kalber T, Ahmad A et al. Bimodal paramagnetic and fluorescent liposomes for cellular and tumor magnetic resonance imaging. Bioconjug. Chem. 19(1), 118-129 (2008).
-
(2008)
Bioconjug. Chem.
, vol.19
, Issue.1
, pp. 118-129
-
-
Kamaly, N.1
Kalber, T.2
Ahmad, A.3
-
76
-
-
65249161653
-
Folate receptor targeted bimodal liposomes for tumor magnetic resonance imaging
-
Kamaly N, Kalber T, Thanou M, Bell JD, Miller AD. Folate receptor targeted bimodal liposomes for tumor magnetic resonance imaging. Bioconjug. Chem. 20(4), 648-655 (2009).
-
(2009)
Bioconjug. Chem.
, vol.20
, Issue.4
, pp. 648-655
-
-
Kamaly, N.1
Kalber, T.2
Thanou, M.3
Bell, J.D.4
Miller, A.D.5
-
77
-
-
76849089676
-
A novel bimodal lipidic contrast agent for cellular labelling and tumour MRI
-
Kamaly N, Kalber T, Kenny G, Bell J, Jorgensen M, Miller A. A novel bimodal lipidic contrast agent for cellular labelling and tumour MRI. Org. Biomol. Chem. 8(1), 201-211 (2010).
-
(2010)
Org. Biomol. Chem.
, vol.8
, Issue.1
, pp. 201-211
-
-
Kamaly, N.1
Kalber, T.2
Kenny, G.3
Bell, J.4
Jorgensen, M.5
Miller, A.6
-
78
-
-
84885178465
-
Examination of the effect of increasing the number of intra-disulfide amino functional groups on the performance of small molecule cyclic polyamine disulfide vectors
-
Drake CR, Aissaoui A, Argyros O, Thanou M, Steinke JH, Miller AD. Examination of the effect of increasing the number of intra-disulfide amino functional groups on the performance of small molecule cyclic polyamine disulfide vectors. J. Control. Release 171(1), 81-90 (2013).
-
(2013)
J. Control. Release
, vol.171
, Issue.1
, pp. 81-90
-
-
Drake, C.R.1
Aissaoui, A.2
Argyros, O.3
Thanou, M.4
Steinke, J.H.5
Miller, A.D.6
-
79
-
-
0034743833
-
Physico-chemical analysis of cationic liposome-DNA complexes (lipoplexes) with respect to in vitro and in vivo gene delivery efficiency
-
Stewart L, Manvell M, Hillery E et al. Physico-chemical analysis of cationic liposome-DNA complexes (lipoplexes) with respect to in vitro and in vivo gene delivery efficiency. J. Chem. Soc., Perkin Trans. 2, 624-632 (2001).
-
(2001)
J. Chem. Soc., Perkin Trans.
, vol.2
, pp. 624-632
-
-
Stewart, L.1
Manvell, M.2
Hillery, E.3
-
80
-
-
80053538507
-
Post-coupling strategy enables true receptor-targeted nanoparticles
-
Chen J, Jorgensen MR, Thanou M, Miller AD. Post-coupling strategy enables true receptor-targeted nanoparticles. J. RNAi Gene Silencing 7, 449-455 (2011).
-
(2011)
J. RNAi Gene Silencing
, vol.7
, pp. 449-455
-
-
Chen, J.1
Jorgensen, M.R.2
Thanou, M.3
Miller, A.D.4
-
81
-
-
61849132133
-
Targeting the urokinase plasminogen activator receptor with synthetic self-assembly nanoparticles
-
Wang M, Lowik DW, Miller AD, Thanou M. Targeting the urokinase plasminogen activator receptor with synthetic self-assembly nanoparticles. Bioconjug. Chem. 20(1), 32-40 (2009).
-
(2009)
Bioconjug. Chem.
, vol.20
, Issue.1
, pp. 32-40
-
-
Wang, M.1
Lowik, D.W.2
Miller, A.D.3
Thanou, M.4
-
82
-
-
84880534127
-
Effect of surface charge and ligand organization on the specific cell-uptake of uPAR-targeted nanoparticles
-
Wang M, Miller AD, Thanou M. Effect of surface charge and ligand organization on the specific cell-uptake of uPAR-targeted nanoparticles. J. Drug Target. 21(7), 684-692 (2013).
-
(2013)
J. Drug Target.
, vol.21
, Issue.7
, pp. 684-692
-
-
Wang, M.1
Miller, A.D.2
Thanou, M.3
-
83
-
-
12444339877
-
Nuclear localisation sequence templated nonviral gene delivery vectors. Investigation of intracellular trafficking events of LMD and LD vector systems
-
Keller M, Harbottle RP, Perouzel E et al. Nuclear localisation sequence templated nonviral gene delivery vectors. investigation of intracellular trafficking events of LMD and LD vector systems. Chembiochem 4(4), 286-298 (2003).
-
(2003)
Chembiochem
, vol.4
, Issue.4
, pp. 286-298
-
-
Keller, M.1
Harbottle, R.P.2
Perouzel, E.3
-
84
-
-
0035078410
-
Steric stabilization of fusogenic liposomes by a low-pH sensitive PEG - Diortho ester - Lipid conjugate
-
Guo X, Szoka FC Jr. Steric stabilization of fusogenic liposomes by a low-pH sensitive PEG - diortho ester - lipid conjugate. Bioconjug. Chem. 12(2), 291-300 (2001).
-
(2001)
Bioconjug. Chem.
, vol.12
, Issue.2
, pp. 291-300
-
-
Guo, X.1
Szoka Jr., F.C.2
-
85
-
-
14044252938
-
Toward synthetic viruses: Endosomal pH-triggered deshielding of targeted polyplexes greatly enhances gene transfer in vitro and in vivo
-
Walker GF, Fella C, Pelisek J et al. Toward synthetic viruses: endosomal pH-triggered deshielding of targeted polyplexes greatly enhances gene transfer in vitro and in vivo. Mol. Ther. 11(3), 418-425 (2005).
-
(2005)
Mol. Ther.
, vol.11
, Issue.3
, pp. 418-425
-
-
Walker, G.F.1
Fella, C.2
Pelisek, J.3
-
86
-
-
37349044610
-
A novel IRQ ligand-modified nano-carrier targeted to a unique pathway of caveolar endocytic pathway
-
Mudhakir D, Akita H, Tan E, Harashima H. A novel IRQ ligand-modified nano-carrier targeted to a unique pathway of caveolar endocytic pathway. J. Control. Release 125(2), 164-173 (2008).
-
(2008)
J. Control. Release
, vol.125
, Issue.2
, pp. 164-173
-
-
Mudhakir, D.1
Akita, H.2
Tan, E.3
Harashima, H.4
-
87
-
-
69949155656
-
A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo
-
Hatakeyama H, Ito E, Akita H et al. A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo. J. Control. Release 139(2), 127-132 (2009).
-
(2009)
J. Control. Release
, vol.139
, Issue.2
, pp. 127-132
-
-
Hatakeyama, H.1
Ito, E.2
Akita, H.3
-
88
-
-
33845625261
-
Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid
-
Hatakeyama H, Akita H, Kogure K et al. Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid. Gene Ther. 14(1), 68-77 (2007).
-
(2007)
Gene Ther.
, vol.14
, Issue.1
, pp. 68-77
-
-
Hatakeyama, H.1
Akita, H.2
Kogure, K.3
-
89
-
-
0344873301
-
Pharmaco attributes of dioleoylphosphatidylethanolamine/ cholesterylhemisuccinate liposomes containing different types of cleavable lipopolymers
-
Zhang JX, Zalipsky S, Mullah N, Pechar M, Allen TM. Pharmaco attributes of dioleoylphosphatidylethanolamine/ cholesterylhemisuccinate liposomes containing different types of cleavable lipopolymers. Pharmacol. Res. 49(2), 185-198 (2004).
-
(2004)
Pharmacol. Res.
, vol.49
, Issue.2
, pp. 185-198
-
-
Zhang, J.X.1
Zalipsky, S.2
Mullah, N.3
Pechar, M.4
Allen, T.M.5
-
90
-
-
84875464303
-
Enzyme-triggered PEGylated pDNA-nanoparticles for controlled release of pDNA in tumors
-
Yingyuad P, Mevel M, Prata C et al. Enzyme-triggered PEGylated pDNA-nanoparticles for controlled release of pDNA in tumors. Bioconjug. Chem. 24(3), 343-362 (2013).
-
(2013)
Bioconjug. Chem.
, vol.24
, Issue.3
, pp. 343-362
-
-
Yingyuad, P.1
Mevel, M.2
Prata, C.3
-
91
-
-
84901396278
-
Enzyme-triggered PEGylated siRNA-nanoparticles for controlled release of siRNA
-
Yingyuad P, Mével M, Prata C, Kontogiorgis C, Thanou M, Miller AD. Enzyme-triggered PEGylated siRNA-nanoparticles for controlled release of siRNA. J. RNAi Gene Silencing 10, 490-499 (2014).
-
(2014)
J. RNAi Gene Silencing
, vol.10
, pp. 490-499
-
-
Yingyuad, P.1
Mével, M.2
Prata, C.3
Kontogiorgis, C.4
Thanou, M.5
Miller, A.D.6
-
92
-
-
78649944492
-
Bioresponsive small molecule polyamines as non-cytotoxic alternative to polyethylenimine
-
Drake CR, Aissaoui A, Argyros O et al. Bioresponsive small molecule polyamines as non-cytotoxic alternative to polyethylenimine. Mol. Pharm. 7(6), 2040-2055 (2010).
-
(2010)
Mol. Pharm.
, vol.7
, Issue.6
, pp. 2040-2055
-
-
Drake, C.R.1
Aissaoui, A.2
Argyros, O.3
-
93
-
-
0033199557
-
New detachable poly(ethylene glycol) conjugates: Cysteine-cleavable lipopolymers regenerating natural phospholipid, diacyl phosphatidylethanolamine
-
Zalipsky S, Qazen M, Walker JA 2nd, Mullah N, Quinn YP, Huang SK. New detachable poly(ethylene glycol) conjugates: cysteine-cleavable lipopolymers regenerating natural phospholipid, diacyl phosphatidylethanolamine. Bioconjug. Chem. 10(5), 703-707 (1999).
-
(1999)
Bioconjug. Chem.
, vol.10
, Issue.5
, pp. 703-707
-
-
Zalipsky, S.1
Qazen, M.2
Walker II, J.A.3
Mullah, N.4
Quinn, Y.P.5
Huang, S.K.6
-
94
-
-
69949164681
-
Novel peptide ligand directs liposomes toward EGF-R high-expressing cancer cells in vitro and in vivo
-
Song S, Liu D, Peng J et al. Novel peptide ligand directs liposomes toward EGF-R high-expressing cancer cells in vitro and in vivo. FASEB J. 23(5), 1396-1404 (2009).
-
(2009)
FASEB J.
, vol.23
, Issue.5
, pp. 1396-1404
-
-
Song, S.1
Liu, D.2
Peng, J.3
-
95
-
-
77954243341
-
Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms
-
Akinc A, Querbes W, De S et al. Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms. Mol. Ther. 18(7), 1357-1364 (2010).
-
(2010)
Mol. Ther.
, vol.18
, Issue.7
, pp. 1357-1364
-
-
Akinc, A.1
Querbes, W.2
De, S.3
-
96
-
-
38849095313
-
Clostridium neurotoxin fragments as potential targeting moieties for liposomal gene delivery to the CNS
-
Andreu A, Fairweather N, Miller AD. Clostridium neurotoxin fragments as potential targeting moieties for liposomal gene delivery to the CNS. Chembiochem 9(2), 219-231 (2008).
-
(2008)
Chembiochem
, vol.9
, Issue.2
, pp. 219-231
-
-
Andreu, A.1
Fairweather, N.2
Miller, A.D.3
-
97
-
-
22144437300
-
Synthesis and Application of integrin targeting lipopeptides in targeted gene delivery
-
Waterhouse JE, Harbottle RP, Keller M et al. Synthesis and Application of integrin targeting lipopeptides in targeted gene delivery. Chembiochem 6(7), 1212-1223 (2005).
-
(2005)
Chembiochem
, vol.6
, Issue.7
, pp. 1212-1223
-
-
Waterhouse, J.E.1
Harbottle, R.P.2
Keller, M.3
-
98
-
-
56349102126
-
Tf-lipoplexes for neuronal siRNA delivery: A promising system to mediate gene silencing in the CNS
-
Cardoso AL, Simoes S, De Almeida LP et al. Tf-lipoplexes for neuronal siRNA delivery: a promising system to mediate gene silencing in the CNS. J. Control. Release 132(2), 113-123 (2008).
-
(2008)
J. Control. Release
, vol.132
, Issue.2
, pp. 113-123
-
-
Cardoso, A.L.1
Simoes, S.2
De Almeida, L.P.3
-
99
-
-
47649089265
-
Induction of apoptosis in murine neuroblastoma by systemic delivery of transferrin-shielded siRNA polyplexes for downregulation of RNA
-
Tietze N, Pelisek J, Philipp A et al. Induction of apoptosis in murine neuroblastoma by systemic delivery of transferrin-shielded siRNA polyplexes for downregulation of RNA. Oligonucleotides 18(2), 161-174 (2008).
-
(2008)
Oligonucleotides
, vol.18
, Issue.2
, pp. 161-174
-
-
Tietze, N.1
Pelisek, J.2
Philipp, A.3
-
100
-
-
30744457637
-
Tumor-targeting nanoimmunoliposome complex for short interfering RNA delivery
-
Pirollo KF, Zon G, Rait A et al. Tumor-targeting nanoimmunoliposome complex for short interfering RNA delivery. Hum. Gene Ther. 17(1), 117-124 (2006).
-
(2006)
Hum. Gene Ther.
, vol.17
, Issue.1
, pp. 117-124
-
-
Pirollo, K.F.1
Zon, G.2
Rait, A.3
-
101
-
-
0032077216
-
An RGD-oligolysine peptide: A prototype construct for integrin-mediated gene delivery
-
Harbottle RP, Cooper RG, Hart SL et al. An RGD-oligolysine peptide: a prototype construct for integrin-mediated gene delivery. Hum. Gene Ther. 9(7), 1037-1047 (1998).
-
(1998)
Hum. Gene Ther.
, vol.9
, Issue.7
, pp. 1037-1047
-
-
Harbottle, R.P.1
Cooper, R.G.2
Hart, S.L.3
-
102
-
-
33644827912
-
RGD-based strategies for selective delivery of therapeutics and imaging agents to the tumour vasculature
-
Temming K, Schiffelers RM, Molema G, Kok RJ. RGD-based strategies for selective delivery of therapeutics and imaging agents to the tumour vasculature. Drug Resist. Updat. 8(6), 381-402 (2005).
-
(2005)
Drug Resist. Updat.
, vol.8
, Issue.6
, pp. 381-402
-
-
Temming, K.1
Schiffelers, R.M.2
Molema, G.3
Kok, R.J.4
-
103
-
-
33845654382
-
Small interfering RNA delivery to the liver by intravenous administration of galactosylated cationic liposomes in mice
-
Sato A, Takagi M, Shimamoto A, Kawakami S, Hashida M. Small interfering RNA delivery to the liver by intravenous administration of galactosylated cationic liposomes in mice. Biomaterials 28(7), 1434-1442 (2007).
-
(2007)
Biomaterials
, vol.28
, Issue.7
, pp. 1434-1442
-
-
Sato, A.1
Takagi, M.2
Shimamoto, A.3
Kawakami, S.4
Hashida, M.5
-
105
-
-
33745128099
-
Aptamer mediated siRNA delivery
-
Chu TC, Twu KY, Ellington AD, Levy M. Aptamer mediated siRNA delivery. Nucleic Acids Res. 34(10), e73 (2006).
-
(2006)
Nucleic Acids Res.
, vol.34
, Issue.10
-
-
Chu, T.C.1
Twu, K.Y.2
Ellington, A.D.3
Levy, M.4
-
106
-
-
28544444484
-
Phosphorothioate-stimulated uptake of short interfering RNA by human cells
-
Overhoff M, Sczakiel G. Phosphorothioate-stimulated uptake of short interfering RNA by human cells. EMBO Rep. 6(12), 1176-1181 (2005).
-
(2005)
EMBO Rep.
, vol.6
, Issue.12
, pp. 1176-1181
-
-
Overhoff, M.1
Sczakiel, G.2
-
107
-
-
64549083734
-
The therapeutic potential of LNA-modified siRNAs: Reduction of off-target effects by chemical modification of the siRNA sequence
-
Fluiter K, Mook OR, Baas F. The therapeutic potential of LNA-modified siRNAs: reduction of off-target effects by chemical modification of the siRNA sequence. Methods Mol. Biol. 487, 189-203 (2009).
-
(2009)
Methods Mol. Biol.
, vol.487
, pp. 189-203
-
-
Fluiter, K.1
Mook, O.R.2
Baas, F.3
-
108
-
-
67649865399
-
The effect of chemical modification and nanoparticle formulation on stability and biodistribution of siRNA in mice
-
Gao S, Dagnaes-Hansen F, Nielsen EJ et al. The effect of chemical modification and nanoparticle formulation on stability and biodistribution of siRNA in mice. Mol. Ther. 17(7), 1225-1233 (2009).
-
(2009)
Mol. Ther.
, vol.17
, Issue.7
, pp. 1225-1233
-
-
Gao, S.1
Dagnaes-Hansen, F.2
Nielsen, E.J.3
-
109
-
-
66249133061
-
Naked siLNA-mediated gene silencing of lung bronchoepithelium EGFP expression after intravenous administration
-
Glud SZ, Bramsen JB, Dagnaes-Hansen F et al. Naked siLNA-mediated gene silencing of lung bronchoepithelium EGFP expression after intravenous administration. Oligonucleotides 19(2), 163-168 (2009).
-
(2009)
Oligonucleotides
, vol.19
, Issue.2
, pp. 163-168
-
-
Glud, S.Z.1
Bramsen, J.B.2
Dagnaes-Hansen, F.3
-
110
-
-
42249093319
-
LNA-mediated microRNA silencing in non-human primates
-
Elmen J, Lindow M, Schutz S et al. LNA-mediated microRNA silencing in non-human primates. Nature 452(7189), 896-899 (2008).
-
(2008)
Nature
, vol.452
, Issue.7189
, pp. 896-899
-
-
Elmen, J.1
Lindow, M.2
Schutz, S.3
-
111
-
-
79953202455
-
Silencing of microRNA families by seed-targeting tiny LNAs
-
Obad S, Dos Santos CO, Petri A et al. Silencing of microRNA families by seed-targeting tiny LNAs. Nature Genet. 43(4), 371-378 (2011).
-
(2011)
Nature Genet.
, vol.43
, Issue.4
, pp. 371-378
-
-
Obad, S.1
Dos Santos, C.O.2
Petri, A.3
-
112
-
-
78649877710
-
Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates
-
Straarup EM, Fisker N, Hedtjarn M et al. Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates. Nucleic Acids Res. 38(20), 7100-7111 (2010).
-
(2010)
Nucleic Acids Res.
, vol.38
, Issue.20
, pp. 7100-7111
-
-
Straarup, E.M.1
Fisker, N.2
Hedtjarn, M.3
-
113
-
-
84883118140
-
Safety and efficacy of RNAi therapy for transthyretin amyloidosis
-
Coelho T, Adams D, Silva A et al. Safety and efficacy of RNAi therapy for transthyretin amyloidosis. N. Engl. J. Med. 369(9), 819-829 (2013).
-
(2013)
N. Engl. J. Med.
, vol.369
, Issue.9
, pp. 819-829
-
-
Coelho, T.1
Adams, D.2
Silva, A.3
-
114
-
-
84892741671
-
Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: A randomised, single-blind, placebo-controlled, Phase 1 trial
-
Fitzgerald K, Frank-Kamenetsky M, Shulga-Morskaya S et al. Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, Phase 1 trial. Lancet 383(9911), 60-68 (2014).
-
(2014)
Lancet
, vol.383
, Issue.9911
, pp. 60-68
-
-
Fitzgerald, K.1
Frank-Kamenetsky, M.2
Shulga-Morskaya, S.3
-
115
-
-
33748254700
-
MAGfect: A novel liposome formulation for MRI labelling and visualization of cells
-
Oliver M, Ahmad A, Kamaly N et al. MAGfect: a novel liposome formulation for MRI labelling and visualization of cells. Org. Biomol. Chem. 4(18), 3489-3497 (2006).
-
(2006)
Org. Biomol. Chem.
, vol.4
, Issue.18
, pp. 3489-3497
-
-
Oliver, M.1
Ahmad, A.2
Kamaly, N.3
-
116
-
-
84887632056
-
Lipid-based nanoparticles in cancer diagnosis and therapy
-
Miller AD. Lipid-based nanoparticles in cancer diagnosis and therapy. J. Drug Deliv. 2013, 165981 (2013).
-
(2013)
J. Drug Deliv.
, vol.2013
, pp. 165981
-
-
Miller, A.D.1
-
117
-
-
36649027868
-
Pulmonary delivery of nucleic acids
-
Birchall J. Pulmonary delivery of nucleic acids. Expert Opin. Drug Deliv. 4(6), 575-578 (2007).
-
(2007)
Expert Opin. Drug Deliv.
, vol.4
, Issue.6
, pp. 575-578
-
-
Birchall, J.1
-
118
-
-
34248650151
-
Non-viral siRNA delivery to the lung
-
Thomas M, Lu JJ, Chen J, Klibanov AM. Non-viral siRNA delivery to the lung. Adv. Drug Deliv. Rev. 59(2-3), 124-133 (2007).
-
(2007)
Adv. Drug Deliv. Rev.
, vol.59
, Issue.2-3
, pp. 124-133
-
-
Thomas, M.1
Lu, J.J.2
Chen, J.3
Klibanov, A.M.4
-
119
-
-
34547645206
-
Blood-brain barrier transport of non-viral gene and RNAi therapeutics
-
Boado RJ. Blood-brain barrier transport of non-viral gene and RNAi therapeutics. Pharm. Res. 24(9), 1772-1787 (2007).
-
(2007)
Pharm. Res.
, vol.24
, Issue.9
, pp. 1772-1787
-
-
Boado, R.J.1
-
120
-
-
56749131859
-
Assessing siRNA pharmacodynamics in a luciferase-expressing mouse
-
Svensson RU, Shey MR, Ballas ZK et al. Assessing siRNA pharmacodynamics in a luciferase-expressing mouse. Mol. Ther. 16(12), 1995-2001 (2008).
-
(2008)
Mol. Ther.
, vol.16
, Issue.12
, pp. 1995-2001
-
-
Svensson, R.U.1
Shey, M.R.2
Ballas, Z.K.3
-
121
-
-
31144448577
-
Quantum dots to monitor RNAi delivery and improve gene silencing
-
Chen AA, Derfus AM, Khetani SR, Bhatia SN. Quantum dots to monitor RNAi delivery and improve gene silencing. Nucleic Acids Res. 33(22), e190 (2005).
-
(2005)
Nucleic Acids Res.
, vol.33
, Issue.22
-
-
Chen, A.A.1
Derfus, A.M.2
Khetani, S.R.3
Bhatia, S.N.4
-
122
-
-
67649948599
-
MMP-9 gene silencing by a quantum dot-siRNA nanoplex delivery to maintain the integrity of the blood brain barrier
-
Bonoiu A, Mahajan SD, Ye L et al. MMP-9 gene silencing by a quantum dot-siRNA nanoplex delivery to maintain the integrity of the blood brain barrier. Brain Res. 1282, 142-155 (2009).
-
(2009)
Brain Res.
, vol.1282
, pp. 142-155
-
-
Bonoiu, A.1
Mahajan, S.D.2
Ye, L.3
-
123
-
-
58149088420
-
Quantum dot-carrier peptide conjugates suitable for imaging and delivery applications
-
Walther C, Meyer K, Rennert R, Neundorf I. Quantum dot-carrier peptide conjugates suitable for imaging and delivery applications. Bioconjug. Chem. 19(12), 2346-2356 (2008).
-
(2008)
Bioconjug. Chem.
, vol.19
, Issue.12
, pp. 2346-2356
-
-
Walther, C.1
Meyer, K.2
Rennert, R.3
Neundorf, I.4
-
124
-
-
37549064689
-
Cell-penetrating peptide for enhanced delivery of nucleic acids and drugs to ocular tissues including retina and cornea
-
Johnson LN, Cashman SM, Kumar-Singh R. Cell-penetrating peptide for enhanced delivery of nucleic acids and drugs to ocular tissues including retina and cornea. Mol. Ther. 16(1), 107-114 (2008).
-
(2008)
Mol. Ther.
, vol.16
, Issue.1
, pp. 107-114
-
-
Johnson, L.N.1
Cashman, S.M.2
Kumar-Singh, R.3
-
125
-
-
34848918210
-
Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging
-
Bartlett DW, Su H, Hildebrandt IJ, Weber WA, Davis ME. Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging. Proc. Natl Acad. Sci. USA 104(39), 15549-15554 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, Issue.39
, pp. 15549-15554
-
-
Bartlett, D.W.1
Su, H.2
Hildebrandt, I.J.3
Weber, W.A.4
Davis, M.E.5
-
126
-
-
33847720312
-
In vivo imaging of siRNA delivery and silencing in tumors
-
Medarova Z, Pham W, Farrar C, Petkova V, Moore A. In vivo imaging of siRNA delivery and silencing in tumors. Nat. Med. 13(3), 372-377 (2007).
-
(2007)
Nat. Med.
, vol.13
, Issue.3
, pp. 372-377
-
-
Medarova, Z.1
Pham, W.2
Farrar, C.3
Petkova, V.4
Moore, A.5
-
127
-
-
60149090385
-
Imaging of cationic multifunctional liposome-mediated delivery of COX-2 siRNA
-
Mikhaylova M, Stasinopoulos I, Kato Y, Artemov D, Bhujwalla ZM. Imaging of cationic multifunctional liposome-mediated delivery of COX-2 siRNA. Cancer Gene Ther. 16(3), 217-226 (2009).
-
(2009)
Cancer Gene Ther.
, vol.16
, Issue.3
, pp. 217-226
-
-
Mikhaylova, M.1
Stasinopoulos, I.2
Kato, Y.3
Artemov, D.4
Bhujwalla, Z.M.5
-
128
-
-
47349091366
-
Proton-sponge coated quantum dots for siRNA delivery and intracellular imaging
-
Yezhelyev MV, Qi L, O'Regan RM, Nie S, Gao X. Proton-sponge coated quantum dots for siRNA delivery and intracellular imaging. J. Am. Chem. Soc. 130(28), 9006-9012 (2008).
-
(2008)
J. Am. Chem. Soc.
, vol.130
, Issue.28
, pp. 9006-9012
-
-
Yezhelyev, M.V.1
Qi, L.2
O'regan, R.M.3
Nie, S.4
Gao, X.5
-
129
-
-
59849091278
-
Peptide-mediated cellular delivery of oligonucleotide-based therapeutics in vitro: Quantitative evaluation of overall efficacy employing easy to handle reporter systems
-
Laufer SD, Restle T. Peptide-mediated cellular delivery of oligonucleotide-based therapeutics in vitro: quantitative evaluation of overall efficacy employing easy to handle reporter systems. Curr. Pharm. Des. 14(34), 3637-3655 (2008).
-
(2008)
Curr. Pharm. Des.
, vol.14
, Issue.34
, pp. 3637-3655
-
-
Laufer, S.D.1
Restle, T.2
-
130
-
-
35348861314
-
Cellular uptake and intracellular release are major obstacles to the therapeutic application of siRNA: Novel options by phosphorothioate-stimulated delivery
-
Mescalchin A, Detzer A, Wecke M, Overhoff M, Wunsche W, Sczakiel G. Cellular uptake and intracellular release are major obstacles to the therapeutic application of siRNA: novel options by phosphorothioate-stimulated delivery. Expert Opin. Biol. Ther. 7(10), 1531-1538 (2007).
-
(2007)
Expert Opin. Biol. Ther.
, vol.7
, Issue.10
, pp. 1531-1538
-
-
Mescalchin, A.1
Detzer, A.2
Wecke, M.3
Overhoff, M.4
Wunsche, W.5
Sczakiel, G.6
-
131
-
-
59849125915
-
Phosphorothioate-stimulated cellular uptake of siRNA: A cell culture model for mechanistic studies
-
Detzer A, Overhoff M, Mescalchin A, Rompf M, Sczakiel G. Phosphorothioate-stimulated cellular uptake of siRNA: a cell culture model for mechanistic studies. Curr. Pharm. Des. 14(34), 3666-3673 (2008).
-
(2008)
Curr. Pharm. Des.
, vol.14
, Issue.34
, pp. 3666-3673
-
-
Detzer, A.1
Overhoff, M.2
Mescalchin, A.3
Rompf, M.4
Sczakiel, G.5
-
132
-
-
62549161328
-
Increased RNAi is related to intracellular release of siRNA via a covalently attached signal peptide
-
Detzer A, Overhoff M, Wunsche W et al. Increased RNAi is related to intracellular release of siRNA via a covalently attached signal peptide. RNA 15(4), 627-636 (2009).
-
(2009)
RNA
, vol.15
, Issue.4
, pp. 627-636
-
-
Detzer, A.1
Overhoff, M.2
Wunsche, W.3
-
133
-
-
74049105646
-
Phosphorothioate-stimulated uptake of siRNA by mammalian cells: A novel route for delivery
-
Detzer A, Sczakiel G. Phosphorothioate-stimulated uptake of siRNA by mammalian cells: a novel route for delivery. Curr. Top. Med. Chem. 9(12), 1109-1116 (2009).
-
(2009)
Curr. Top. Med. Chem.
, vol.9
, Issue.12
, pp. 1109-1116
-
-
Detzer, A.1
Sczakiel, G.2
-
134
-
-
54249143980
-
Barriers to successful delivery of short interfering RNA after systemic administration
-
White PJ. Barriers to successful delivery of short interfering RNA after systemic administration. Clin. Exp. Pharmacol. Physiol. 35(11), 1371-1376 (2008).
-
(2008)
Clin. Exp. Pharmacol. Physiol.
, vol.35
, Issue.11
, pp. 1371-1376
-
-
White, P.J.1
-
135
-
-
37549032712
-
Breaking the bonds: Non-viral vectors become chemically dynamic
-
Wolff JA, Rozema DB. Breaking the bonds: non-viral vectors become chemically dynamic. Mol. Ther. 16(1), 8-15 (2008).
-
(2008)
Mol. Ther.
, vol.16
, Issue.1
, pp. 8-15
-
-
Wolff, J.A.1
Rozema, D.B.2
-
136
-
-
34548484580
-
Delivery of short interfering RNA using endosomolytic cell-penetrating peptides
-
Lundberg P, El-Andaloussi S, Sutlu T, Johansson H, Langel U. Delivery of short interfering RNA using endosomolytic cell-penetrating peptides. FASEB J. 21(11), 2664-2671 (2007).
-
(2007)
FASEB J.
, vol.21
, Issue.11
, pp. 2664-2671
-
-
Lundberg, P.1
El-Andaloussi, S.2
Sutlu, T.3
Johansson, H.4
Langel, U.5
-
137
-
-
24944577514
-
Cationic lipid saturation influences intracellular delivery of encapsulated nucleic acids
-
Heyes J, Palmer L, Bremner K, Maclachlan I. Cationic lipid saturation influences intracellular delivery of encapsulated nucleic acids. J. Control. Release 107(2), 276-287 (2005).
-
(2005)
J. Control. Release
, vol.107
, Issue.2
, pp. 276-287
-
-
Heyes, J.1
Palmer, L.2
Bremner, K.3
Maclachlan, I.4
-
138
-
-
34848901058
-
Specific subcellular localization of siRNAs delivered by lipoplex in MCF-7 breast cancer cells
-
Lavigne C, Thierry AR. Specific subcellular localization of siRNAs delivered by lipoplex in MCF-7 breast cancer cells. Biochimie 89(10), 1245-1251 (2007).
-
(2007)
Biochimie
, vol.89
, Issue.10
, pp. 1245-1251
-
-
Lavigne, C.1
Thierry, A.R.2
-
139
-
-
70849097385
-
Monitoring the disassembly of siRNA polyplexes in serum is crucial for predicting their biological efficacy
-
Buyens K, Meyer M, Wagner E, Demeester J, De Smedt SC, Sanders NN. Monitoring the disassembly of siRNA polyplexes in serum is crucial for predicting their biological efficacy. J. Control. Release 141(1), 38-41 (2010).
-
(2010)
J. Control. Release
, vol.141
, Issue.1
, pp. 38-41
-
-
Buyens, K.1
Meyer, M.2
Wagner, E.3
Demeester, J.4
De Smedt, S.C.5
Sanders, N.N.6
-
140
-
-
30944456368
-
Navigare necessere est. Improved navigation would help to solve two crucial problems in modern drug therapy: Toxicity and precise delivery
-
Kraljevic S, Pavelic K. Navigare necessere est. Improved navigation would help to solve two crucial problems in modern drug therapy: toxicity and precise delivery. EMBO Rep. 6(8), 695-700 (2005).
-
(2005)
EMBO Rep.
, vol.6
, Issue.8
, pp. 695-700
-
-
Kraljevic, S.1
Pavelic, K.2
-
141
-
-
24644504130
-
Toxicogenomics of cationic lipid-based vectors for gene therapy: Impact of microarray technology
-
Omidi Y, Barar J, Akhtar S. Toxicogenomics of cationic lipid-based vectors for gene therapy: impact of microarray technology. Curr. Drug Deliv. 2(4), 429-441 (2005).
-
(2005)
Curr. Drug Deliv.
, vol.2
, Issue.4
, pp. 429-441
-
-
Omidi, Y.1
Barar, J.2
Akhtar, S.3
-
142
-
-
57149137351
-
Systemic delivery of DNA or siRNA mediated by linear polyethylenimine (L-PEI) does not induce an inflammatory response
-
Bonnet ME, Erbacher P, Bolcato-Bellemin AL. Systemic delivery of DNA or siRNA mediated by linear polyethylenimine (L-PEI) does not induce an inflammatory response. Pharm. Res. 25(12), 2972-2982 (2008).
-
(2008)
Pharm. Res.
, vol.25
, Issue.12
, pp. 2972-2982
-
-
Bonnet, M.E.1
Erbacher, P.2
Bolcato-Bellemin, A.L.3
-
144
-
-
85157183564
-
-
PCT/US2009/036223
-
Bumcrot D: PCT/US2009/036223 (2009).
-
(2009)
-
-
Bumcrot, D.1
|