Analysis of lipid nanoparticles by Cryo-EM for characterizing siRNA delivery vehicles

International Journal of Pharmaceutics

Volumn 403, Issue 1-2, 2011, Pages 237-244

  Crawford, Randy ^a   Dogdas, Belma ^a   Keough, Edward ^a   Haas, R Matthew ^a   Wepukhulu, Wickliffe ^a   Krotzer, Steven ^a   Burke, Paul A ^a   Sepp Lorenzino, Laura ^a   Bagchi, Ansuman ^a   Howell, Bonnie J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Drug delivery; Dynamic light scattering; Imaging; Liposome characterization; Nanodrugs; Oligonucleotides

Indexed keywords

CHOLESTEROL; LIPID; MACROGOL; NANOPARTICLE; SMALL INTERFERING RNA;

ARTICLE; AUTOANALYSIS; CRYOELECTRON MICROSCOPY; DRUG DELIVERY SYSTEM; IMAGE ANALYSIS; LIGHT SCATTERING; METHODOLOGY; MORPHOLOGY; PARTICLE SIZE; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS;

CRYOELECTRON MICROSCOPY; DRUG CARRIERS; IMAGE ENHANCEMENT; LIGHT; LIPIDS; NANOPARTICLES; PARTICLE SIZE; RNA, SMALL INTERFERING; SCATTERING, RADIATION; SURFACE PROPERTIES;

EID: 78650180150     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2010.10.025     Document Type: Article

References (26)

1. M.T. Abrams, M. Koser, J. Seitzer, S.C. Williams, M.A. DiPietro, W. Wang, A. Shaw, X. Mao, V. Jadhav, J.P. Davide, P.A. Burke, A.B. Sachs, S.M. Stirdivant, and L. Sepp-Lorenzino Evaluation of efficacy, biodistribution, and inflammation for a potent siRNA nanoparticle: effect of dexamethasone co-treatment Mol. Ther. 18 2009 171 180
2. M. Almgren, K. Edwards, and G. Karlsson Cryo transmission electron microscopy of liposomes and related structures Colloid Surf. A 174 2000 3 21
3. A. Beekman, D. Shan, A. Ali, W. Dai, S. Ward-Smith, and M. Goldenberg Micrometer-scale particle sizing by laser diffraction: critical impact of the imaginary component of refractive index Pharm. Res. 22 2005 518 522
4. N. Berclaz, E. Blochliger, M. Muller, and P. Luisi Matrix effect of vesicle formation as investigated by cryotransmission electron microscopy J. Phys. Chem. 105 2001 1065 1071
5. M. Borkovec Measuring particle size by light scattering K. Holmberg, Handbook of Applied Surface and Colloid Chemistry 2002 John Wiley New Jersey 357 370
6. K.A. Edwards, and A.J. Baeumner Analysis of liposomes Talanta 68 2006 1432 1441
7. D.F. Emrich, and C.G. Thanos The pinpoint promise of nanoparticle-based drug delivery and molecular diagnosis Biomol. Eng. 23 2006 171 184
8. C.B. Frantzen, L. Ingebrigtsen, M. Skar, and L. Brandl Assessing the accuracy of routine photon correlation spectroscopy analysis of heterogenous size distributions AAPS PharmSciTec. 4 2003 E36
9. P.M. Frederik, and D.H.W. Hubert Cryoelectron microscopy of liposomes Methods Enzymol. 391 2005 431 448
10. M. Gaumet, A. Vargas, R. Gurny, and F. Delie Nanoparticles for drug delivery: the need for precision in reporting particle size parameters Eur. J. Pharm. Biopharm. 69 2008 1 9
11. R.C. Gonzalez, and R.E. Woods Digital Image Processing 3rd ed. 2008 Prentice-Hall Upper Saddle River, NJ
12. R.M. Haralick, S.R. Sternberg, and X. Zhuang Image analysis using mathematical morphology IEEE Trans. Pattern Anal. Mach. Intell. 9 1987 532 550
13. L. Ingebrigtsen, and M. Brandl Determination of the size distribution of liposomes by SEC fractionation, and PCS analysis and enzymatic assay of lipid content AAPS PharmSciTech. 3 2002 E7
14. D.V. Morrissey, J.A. Lockridge, L. Shaw, K. Blanchard, K. Jensen, W. Breen, K. Hartsough, L. Machemer, S. Radka, V. Jadhav, N. Vaish, S. Zinnen, C. Vargeese, K. Bowman, C.S. Shaffer, L.B. Jeffs, A. Judge, I. MacLachlan, and B. Polisky Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs Nat. Biotechnol. 23 2005 1002 1007
15. R.H. Müller, K. Mäder, and S. Gohla Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art Eur. J. Pharm. Biopharm. 50 2000 161 177
16. N. Otsu A threshold selection method from gray-level histograms IEEE Trans. Syst. Man. Cybern. 9 1979 62 66
17. A.J. Paine Error estimates in the sampling from particle size distributions Part. Part. Syst. Charact. 10 1993 26 32
18. Prow, T.W., 2004. Nanomedicine: Targeted Nanoparticles for the Delivery of Biosensors and Therapeutic Genes. Ph.D. Thesis. University of Texas, Medical Branch, TX.
19. L. Sepp-Lorenzino, and M.K. Ruddy Challenges and opportunities for local and systemic delivery of siRNA and antisense oligonucleotides Clin. Pharmacol. Ther. 84 2008 628 632
20. R. Singh, and J.W. Lillard Nanoparticle-based targeted drug delivery Exp. Mol. Pathol. 86 2009 215 223
21. T. Tasdizen, E. Jurruss, and R.T. Whitaker Non-uniform illumination correction in transmission electron microscopy MICCAI Workshop on Microscopic Image Analysis with Applications in Biology 2008
22. E. Vigneau, C. Loisel, M.F. Devaux, and P. Cantoni Number of particles for the determination of size distribution from microscopic images Powder Technol. 107 2000 243 250
23. K.A. Whitehead, R. Langer, and D.G. Anderson Knocking down barriers: advances in siRNA delivery Nat. Rev. Drug Discov. 8 2009 129 138
24. F. Wincott, A. DiRenzo, C. Shaffer, S. Grimm, D. Tracz, C. Workman, D. Sweedler, C. Gonzalez, S. Scaringe, and N. Usman Synthesis, deprotection, analysis and purification of RNA and ribozymes Nucleic Acids Res. 23 1995 2677 2684
25. R.I. Zhdanov, O.V. Podobed, and V.V. Vlassov Cationic lipid-DNA complexes-lipoplexes-for gene transfer and therapy Bioelectrochemistry 58 2002 53 64
26. K. Zuiderveld Contrast limited adaptive histogram equalization P. Heckbert, Graphics Gems IV 1994 Academic Press Boston, MA 474 485