Examination of the effect of increasing the number of intra-disulfide amino functional groups on the performance of small molecule cyclic polyamine disulfide vectors

Journal of Controlled Release

Volumn 171, Issue 1, 2013, Pages 81-90

  Drake, Christopher R ^a,c   Aissaoui, Abderrahim ^a   Argyros, Orestis ^a   Thanou, Maya ^a,b   Steinke, Joachim H G ^a   Miller, Andrew D ^a,b  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cyclic polyamine disulfide; Gene therapy; Non viral vector; Reducible

Indexed keywords

BIOLOGICAL ORGANS; CELL CULTURE; CELLS; GENE THERAPY; MOLECULAR BIOLOGY; MOLECULES;

AMINO FUNCTIONAL GROUP; LUNG EPITHELIAL CELLS; NASAL ADMINISTRATION; NONVIRAL VECTORS; POLYAMINES; REDUCIBLE; STRUCTURE ACTIVITY RELATIONSHIPS; TEMPLATED POLYMERIZATION;

SULFUR COMPOUNDS;

1,2 DITHIA 5,10,14,19,23,28 HEXAAZATRIACONTANE; 1,2 DITHIA 5,9,14,18,23,27,32,36,38 OCTAAZACYCLOOCTATRIACONTANE; ACETYLCYSTEINE; CYCLIC POLYAMINE DISULFIDE; DISULFIDE; FUNCTIONAL GROUP; HEXANE; NANOPARTICLE; OCTANE; PLASMID DNA; POLYPLEX NANOPARTICLE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; GENE THERAPY; HUMAN; HUMAN CELL; IN VITRO GENE TRANSFER; IN VITRO STUDY; IN VIVO STUDY; LUNG ALVEOLUS CELL; LUNG ALVEOLUS EPITHELIUM; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; SYNTHESIS;

CYCLIC POLYAMINE DISULFIDE; GENE THERAPY; NON-VIRAL VECTOR; REDUCIBLE;

ACETYLCYSTEINE; ANIMALS; BETA-GALACTOSIDASE; CELL LINE, TUMOR; CELL SURVIVAL; CHO CELLS; CRICETULUS; DISULFIDES; DNA; FEMALE; GENETIC VECTORS; HUMANS; LUCIFERASES; LUNG; MICE; MICE, INBRED BALB C; NANOPARTICLES; PLASMIDS; POLYAMINES; TRANSFECTION;

EID: 84885178465     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.02.014     Document Type: Article

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