메뉴 건너뛰기




Volumn 24, Issue 9, 2007, Pages 1772-1787

Blood-brain barrier transport of non-viral gene and RNAi therapeutics

Author keywords

Blood brain barrier; Brain; Drug delivery; Gene therapy; Liposomes; RNAi

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; IMMUNOLIPOSOME; INSULIN RECEPTOR; LUCIFERASE; MACROGOL; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 8314; MONOCLONAL ANTIBODY 8D3; MONOCLONAL ANTIBODY OX26; OXIDOPAMINE; SHORT HAIRPIN RNA; TRANSFERRIN RECEPTOR; UNCLASSIFIED DRUG;

EID: 34547645206     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-007-9321-5     Document Type: Review
Times cited : (84)

References (79)
  • 1
    • 0033036668 scopus 로고    scopus 로고
    • Stabilized plasmid-lipid particles: Factors influencing plasmid entrapment and transfection properties
    • K. W. Mok, A. M. Lam, and P. R. Cullis. Stabilized plasmid-lipid particles: factors influencing plasmid entrapment and transfection properties. Biochim. Biophys. Acta 1419:137-150 (1999).
    • (1999) Biochim. Biophys. Acta , vol.1419 , pp. 137-150
    • Mok, K.W.1    Lam, A.M.2    Cullis, P.R.3
  • 3
    • 0037079071 scopus 로고    scopus 로고
    • Drug and gene delivery to the brain: The vascular route
    • W. M. Pardridge. Drug and gene delivery to the brain: the vascular route. Neuron. 36:555-558 (2002).
    • (2002) Neuron , vol.36 , pp. 555-558
    • Pardridge, W.M.1
  • 4
    • 0029062270 scopus 로고
    • Adenovirus gene transfer causes inflammation in the brain
    • A. P. Byrnes, J. E. Rusby, M. J. Wood, and H. M. Charlton. Adenovirus gene transfer causes inflammation in the brain. Neuroscience 66:1015-1024 (1995).
    • (1995) Neuroscience , vol.66 , pp. 1015-1024
    • Byrnes, A.P.1    Rusby, J.E.2    Wood, M.J.3    Charlton, H.M.4
  • 6
    • 0031010215 scopus 로고    scopus 로고
    • Intracranial administration of adenovirus expressing HSV-TK in combination with ganciclovir produces a dose-dependent, self-limiting inflammatory response
    • J. G. Smith, S. E. Raper, E. B. Wheeldon, D. Hackney, K. Judy, J. M. Wilson, and S. L. Eck. Intracranial administration of adenovirus expressing HSV-TK in combination with ganciclovir produces a dose-dependent, self-limiting inflammatory response. Hum. Gene Ther. 8:943-954 (1997).
    • (1997) Hum. Gene Ther. , vol.8 , pp. 943-954
    • Smith, J.G.1    Raper, S.E.2    Wheeldon, E.B.3    Hackney, D.4    Judy, K.5    Wilson, J.M.6    Eck, S.L.7
  • 7
    • 0031687273 scopus 로고    scopus 로고
    • Intracerebral injection of adenovirus harboring the HSVtk gene combined with ganciclovir administration: Toxicity study in nonhuman primates
    • M. J. Driesse, A. J. Vincent, P. A. Sillevis Smitt, J. M. Kros, P. M. Hoogerbrugge, C. J. Avezaat, D. Valerio, and A. Bout. Intracerebral injection of adenovirus harboring the HSVtk gene combined with ganciclovir administration: toxicity study in nonhuman primates. Gene Ther. 5:1122-1129 (1998).
    • (1998) Gene Ther. , vol.5 , pp. 1122-1129
    • Driesse, M.J.1    Vincent, A.J.2    Sillevis Smitt, P.A.3    Kros, J.M.4    Hoogerbrugge, P.M.5    Avezaat, C.J.6    Valerio, D.7    Bout, A.8
  • 10
    • 0032741719 scopus 로고    scopus 로고
    • Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirusmediated gene therapy: Implications for clinical trials
    • R. A. Dewey, G. Morrissey, C. M. Cowsill, D. Stone, F. Bolognani, N. J. Dodd, T. D. Southgate, D. Klatzmann, H. Lassmann, M. G. Castro, and P. R. Lowenstein. Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirusmediated gene therapy: implications for clinical trials. Nat. Med. 5:1256-1263 (1999).
    • (1999) Nat. Med , vol.5 , pp. 1256-1263
    • Dewey, R.A.1    Morrissey, G.2    Cowsill, C.M.3    Stone, D.4    Bolognani, F.5    Dodd, N.J.6    Southgate, T.D.7    Klatzmann, D.8    Lassmann, H.9    Castro, M.G.10    Lowenstein, P.R.11
  • 12
    • 0034059394 scopus 로고    scopus 로고
    • Neutralisation of adenovirus infectivity by ascitic fluid from ovarian cancer patients
    • Y. Stallwood, K. D. Fisher, P. H. Gallimore, and V. Mautner. Neutralisation of adenovirus infectivity by ascitic fluid from ovarian cancer patients. Gene Ther. 7:637-643 (2000).
    • (2000) Gene Ther. , vol.7 , pp. 637-643
    • Stallwood, Y.1    Fisher, K.D.2    Gallimore, P.H.3    Mautner, V.4
  • 15
    • 0031013538 scopus 로고    scopus 로고
    • Loss of binding and entry of liposome-DNA complexes decreases transfection efficiency in differentiated airway epithelial cells
    • H. Matsui, L. G. Johnson, S. H. Randell, and R. C. Boucher. Loss of binding and entry of liposome-DNA complexes decreases transfection efficiency in differentiated airway epithelial cells. J. Biol. Chem. 272:1117-1126 (1997).
    • (1997) J. Biol. Chem , vol.272 , pp. 1117-1126
    • Matsui, H.1    Johnson, L.G.2    Randell, S.H.3    Boucher, R.C.4
  • 16
    • 0033022958 scopus 로고    scopus 로고
    • Cationic lipids are essential for gene delivery mediated by intravenous administration of lipoplexes
    • L. G. Barron, L. S. Uyechi, and F. C. Szoka, Jr. Cationic lipids are essential for gene delivery mediated by intravenous administration of lipoplexes. Gene Ther. 6:1179-1183 (1999).
    • (1999) Gene Ther. , vol.6 , pp. 1179-1183
    • Barron, L.G.1    Uyechi, L.S.2    Szoka Jr., F.C.3
  • 17
    • 0030008620 scopus 로고    scopus 로고
    • Pharmacokinetics, tissue distribution, and expression efficiency of plasmid [33P]DNA following intravenous administration of DNA/cationic lipid complexes in mice: Use of a novel radionuclide approach
    • G. Osaka, K. Carey, A. Cuthbertson, P. Godowski, T. Patapoff, A. Ryan, T. Gadek, and J. Mordenti. Pharmacokinetics, tissue distribution, and expression efficiency of plasmid [33P]DNA following intravenous administration of DNA/cationic lipid complexes in mice: use of a novel radionuclide approach. J. Pharm. Sci. 85:612-618 (1996).
    • (1996) J. Pharm. Sci , vol.85 , pp. 612-618
    • Osaka, G.1    Carey, K.2    Cuthbertson, A.3    Godowski, P.4    Patapoff, T.5    Ryan, A.6    Gadek, T.7    Mordenti, J.8
  • 18
    • 0034815482 scopus 로고    scopus 로고
    • Receptor-mediated gene targeting to tissues in vivo following intravenous administration of pegylated immunoliposomes
    • N. Shi, R. J. Boado, and W. M. Pardridge. Receptor-mediated gene targeting to tissues in vivo following intravenous administration of pegylated immunoliposomes. Pharm. Res. 18:1091-1095 (2001).
    • (2001) Pharm. Res , vol.18 , pp. 1091-1095
    • Shi, N.1    Boado, R.J.2    Pardridge, W.M.3
  • 19
    • 0035940380 scopus 로고    scopus 로고
    • Brain-specific expression of an exogenous gene after i.v. administration
    • N. Shi, Y. Zhang, C. Zhu, R. J. Boado, and W. M. Pardridge. Brain-specific expression of an exogenous gene after i.v. administration. Proc. Natl. Acad. Sci. U.S.A. 98:12754-12759 (2001).
    • (2001) Proc. Natl. Acad. Sci. U.S.A , vol.98 , pp. 12754-12759
    • Shi, N.1    Zhang, Y.2    Zhu, C.3    Boado, R.J.4    Pardridge, W.M.5
  • 20
    • 0037249449 scopus 로고    scopus 로고
    • Intravenous nonviral gene therapy causes normalization of striatal tyrosine hydroxylase and reversal of motor impairment in experimental parkinsonism
    • Y. Zhang, F. Calon, C. Zhu, R. J. Boado, and W. M. Pardridge. Intravenous nonviral gene therapy causes normalization of striatal tyrosine hydroxylase and reversal of motor impairment in experimental parkinsonism. Hum. Gene Ther. 14:1-12 (2003).
    • (2003) Hum. Gene Ther. , vol.14 , pp. 1-12
    • Zhang, Y.1    Calon, F.2    Zhu, C.3    Boado, R.J.4    Pardridge, W.M.5
  • 21
    • 2542561420 scopus 로고    scopus 로고
    • Intravenous RNA interference gene therapy targeting the human epidermal growth factor receptor prolongs survival in intracranial brain cancer
    • Y. Zhang, Y. F. Zhang, J. Bryant, A. Charles, R. J. Boado, and W. M. Pardridge. Intravenous RNA interference gene therapy targeting the human epidermal growth factor receptor prolongs survival in intracranial brain cancer. Clin. Cancer Res. 10:3667-3677 (2004).
    • (2004) Clin. Cancer Res. , vol.10 , pp. 3667-3677
    • Zhang, Y.1    Zhang, Y.F.2    Bryant, J.3    Charles, A.4    Boado, R.J.5    Pardridge, W.M.6
  • 23
    • 0842279809 scopus 로고
    • Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors
    • A. Gabizon, D. Papahadjopoulos. Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors. Proc. Natl. Acad. Sci. U.S.A. 85:6949-6953 (1988).
    • (1988) Proc. Natl. Acad. Sci. U.S.A , vol.85 , pp. 6949-6953
    • Gabizon, A.1    Papahadjopoulos, D.2
  • 24
    • 0037222013 scopus 로고    scopus 로고
    • Global non-viral gene transfer to the primate brain following intravenous administration
    • Y. Zhang, F. Schlachetzki, and W. M. Pardridge. Global non-viral gene transfer to the primate brain following intravenous administration. Molec. Ther. 7:11-17 (2003).
    • (2003) Molec. Ther. , vol.7 , pp. 11-17
    • Zhang, Y.1    Schlachetzki, F.2    Pardridge, W.M.3
  • 25
    • 1942506065 scopus 로고    scopus 로고
    • Gene therapy of the brain: The trans-vascular approach
    • F. Schlachetzki, Y. Zhang, R. J. Boado, and W. M. Pardridge. Gene therapy of the brain: the trans-vascular approach. Neurology. 62:1275-1281 (2004)
    • (2004) Neurology , vol.62 , pp. 1275-1281
    • Schlachetzki, F.1    Zhang, Y.2    Boado, R.J.3    Pardridge, W.M.4
  • 26
    • 0033996507 scopus 로고    scopus 로고
    • Transport across the primate blood-brain barrier of a genetically engineered chimeric monoclonal antibody to the human insulin receptor
    • M. J. Coloma, H. J. Lee, A. Kurihara, E. M. Landaw, R. J. Boado, S. L. Morrison, and W. M. Pardridge. Transport across the primate blood-brain barrier of a genetically engineered chimeric monoclonal antibody to the human insulin receptor. Pharm. Res. 17:266-274 (2000).
    • (2000) Pharm. Res. , vol.17 , pp. 266-274
    • Coloma, M.J.1    Lee, H.J.2    Kurihara, A.3    Landaw, E.M.4    Boado, R.J.5    Morrison, S.L.6    Pardridge, W.M.7
  • 27
    • 33846897981 scopus 로고    scopus 로고
    • Humanization of antihuman insulin receptor antibody for drug targeting across the human blood-brain barrier
    • R. J. Boado, Y-F. Zhang, Y. Zhang, and W. M. Pardridge. Humanization of antihuman insulin receptor antibody for drug targeting across the human blood-brain barrier. Biotechnol. Bioeng. 96:381-391 (2007).
    • (2007) Biotechnol. Bioeng. , vol.96 , pp. 381-391
    • Boado, R.J.1    Zhang, Y.-F.2    Zhang, Y.3    Pardridge, W.M.4
  • 28
    • 1342332987 scopus 로고    scopus 로고
    • Gene targeting in vivo with pegylated immunoliposomes
    • W. M. Pardridge. Gene targeting in vivo with pegylated immunoliposomes. Methods Enzymol. 373:507-528 (2003).
    • (2003) Methods Enzymol. , vol.373 , pp. 507-528
    • Pardridge, W.M.1
  • 29
    • 0035120280 scopus 로고    scopus 로고
    • Stealth liposomes and tumor targeting: One step further in the quest for the magic bullet
    • A. Gabizon. Stealth liposomes and tumor targeting: one step further in the quest for the magic bullet. Clin. Cancer Res. 7:223-225 (2001).
    • (2001) Clin. Cancer Res , vol.7 , pp. 223-225
    • Gabizon, A.1
  • 30
    • 0036518450 scopus 로고    scopus 로고
    • Receptor-mediated delivery of an antisense gene to human brain cancer cells
    • Y. Zhang, H. Jeong Lee, R. J. Boado, and W. M. Pardridge. Receptor-mediated delivery of an antisense gene to human brain cancer cells. J. Gene Med. 4:183-194 (2002).
    • (2002) J. Gene Med. , vol.4 , pp. 183-194
    • Zhang, Y.1    Jeong Lee, H.2    Boado, R.J.3    Pardridge, W.M.4
  • 31
    • 0003312375 scopus 로고    scopus 로고
    • Marked enhancement in gene expression by targeting the human insulin receptor
    • Y. Zhang, R. J. Boado, and W. M. Pardridge. Marked enhancement in gene expression by targeting the human insulin receptor. J. Gene Med. 5:157-163 (2003).
    • (2003) J. Gene Med. , vol.5 , pp. 157-163
    • Zhang, Y.1    Boado, R.J.2    Pardridge, W.M.3
  • 32
    • 1942523210 scopus 로고    scopus 로고
    • In vivo knockdown of gene expression in brain cancer with intravenous RNAi in adult rats
    • Y. Zhang, R. J. Boado, and W. M. Pardridge. In vivo knockdown of gene expression in brain cancer with intravenous RNAi in adult rats. J. Gene Med. 5:1039-1045 (2003).
    • (2003) J. Gene Med. , vol.5 , pp. 1039-1045
    • Zhang, Y.1    Boado, R.J.2    Pardridge, W.M.3
  • 33
    • 1842636306 scopus 로고    scopus 로고
    • Normalization of striatal tyrosine hydroxylase and reversal of motor impairment in experimental Parkinsonism with intravenous nonviral gene therapy and brainspecific promoter
    • Y. Zhang, F. Schlachetzki, Y. F. Zhang, R. J. Boado, and W. M. Pardridge. Normalization of striatal tyrosine hydroxylase and reversal of motor impairment in experimental Parkinsonism with intravenous nonviral gene therapy and brainspecific promoter. Hum. Gene Ther. 15:339-350 (2004).
    • (2004) Hum. Gene Ther. , vol.15 , pp. 339-350
    • Zhang, Y.1    Schlachetzki, F.2    Zhang, Y.F.3    Boado, R.J.4    Pardridge, W.M.5
  • 34
    • 0028071526 scopus 로고
    • Nuclear signaling pathways for polypeptides ligands and their membrane receptors
    • D. A. Jans. Nuclear signaling pathways for polypeptides ligands and their membrane receptors. FASEB J. 8:841-847 (1994).
    • (1994) FASEB J , vol.8 , pp. 841-847
    • Jans, D.A.1
  • 35
    • 0035870121 scopus 로고    scopus 로고
    • Nuclear accumulation of exogenous DNA fragments in viable cells mediated by FGF-2 and DNA release upon cellular injury
    • D. He, W. Casscells, D. A. Engler. Nuclear accumulation of exogenous DNA fragments in viable cells mediated by FGF-2 and DNA release upon cellular injury. Exp. Cell Res. 265:31-45 (2001).
    • (2001) Exp. Cell Res , vol.265 , pp. 31-45
    • He, D.1    Casscells, W.2    Engler, D.A.3
  • 36
    • 0035127432 scopus 로고    scopus 로고
    • Establishment of latent Epstein-Barr virus infection and stable episomal maintenance in urine B-cell lines
    • K. M. Haan, A. Aiyar, R. Longnecker. Establishment of latent Epstein-Barr virus infection and stable episomal maintenance in urine B-cell lines. J. Virol. 75:3016-3020 (2001).
    • (2001) J. Virol. , vol.75 , pp. 3016-3020
    • Haan, K.M.1    Aiyar, A.2    Longnecker, R.3
  • 37
    • 0033231184 scopus 로고    scopus 로고
    • Components of vectors for gene transfer and expression in mammalian cells
    • S. Makrides. Components of vectors for gene transfer and expression in mammalian cells. Protein Exp. Purif. 17:181-202 (1999).
    • (1999) Protein Exp. Purif , vol.17 , pp. 181-202
    • Makrides, S.1
  • 38
    • 0032529006 scopus 로고    scopus 로고
    • Ten nucleotide cis element in the 3′-untranslated region of the GLUT1 glucose transporter mRNA increases gene expression via mRNA stabilization
    • R. J. Boado, and W. M. Pardridge. Ten nucleotide cis element in the 3′-untranslated region of the GLUT1 glucose transporter mRNA increases gene expression via mRNA stabilization. Mol. Brain Res. 59:109-113 (1998).
    • (1998) Mol. Brain Res. , vol.59 , pp. 109-113
    • Boado, R.J.1    Pardridge, W.M.2
  • 39
    • 0033534409 scopus 로고    scopus 로고
    • Amplification of gene expression using both 5'- and 3'-untranslated regions of GLUT1 glucose transporter mRNA
    • R. J. Boado, W. M. Pardridge. Amplification of gene expression using both 5'- and 3'-untranslated regions of GLUT1 glucose transporter mRNA. Mol. Brain Res. 63:371-374 (1999).
    • (1999) Mol. Brain Res. , vol.63 , pp. 371-374
    • Boado, R.J.1    Pardridge, W.M.2
  • 40
    • 33745591896 scopus 로고    scopus 로고
    • Decline in exogenous gene expression in primate brain following intravenous administration is due to plasmid degradation
    • C. Chu, Y. Zhang, R. J. Boado, and W. M. Pardridge. Decline in exogenous gene expression in primate brain following intravenous administration is due to plasmid degradation. Pharm. Res. 23:1586-1590 (2006).
    • (2006) Pharm. Res. , vol.23 , pp. 1586-1590
    • Chu, C.1    Zhang, Y.2    Boado, R.J.3    Pardridge, W.M.4
  • 41
    • 0347555450 scopus 로고    scopus 로고
    • Organ-specific gene expression in the rhesus monkey eye following intravenous non-viral gene transfer
    • Y. Zhang, F. Schlachetzki, J. Y. Li, R. J. Boado, W. M. Pardridge. Organ-specific gene expression in the rhesus monkey eye following intravenous non-viral gene transfer. Mol. Vis. 9:465-472 (2003).
    • (2003) Mol. Vis. , vol.9 , pp. 465-472
    • Zhang, Y.1    Schlachetzki, F.2    Li, J.Y.3    Boado, R.J.4    Pardridge, W.M.5
  • 42
    • 0031105295 scopus 로고    scopus 로고
    • Gene therapy for Parkinson's disease: An approach to the prevention or palliation of levodopa-associated motor complications
    • M. M. Mouradian, and T. N. Chase. Gene therapy for Parkinson's disease: an approach to the prevention or palliation of levodopa-associated motor complications. Exp. Neurol. 144:51-57 (1997).
    • (1997) Exp. Neurol. , vol.144 , pp. 51-57
    • Mouradian, M.M.1    Chase, T.N.2
  • 44
    • 0029586876 scopus 로고
    • Immunocytochemical localization of GTP cyclohydrolase I in the brain, adrenal gland, and liver of mice
    • I. Nagatsu, H. Ichinose, M. Sakai, K. Titani, M. Suzuki, and T. Nagatsu. Immunocytochemical localization of GTP cyclohydrolase I in the brain, adrenal gland, and liver of mice. J. Neural. Transm. Gen. Sect. 102:175-188 (1995).
    • (1995) J. Neural. Transm. Gen. Sect , vol.102 , pp. 175-188
    • Nagatsu, I.1    Ichinose, H.2    Sakai, M.3    Titani, K.4    Suzuki, M.5    Nagatsu, T.6
  • 45
    • 0031974577 scopus 로고    scopus 로고
    • Localization of GTP cyclohydrolase in monoaminergic but not nitric oxide-producing cells
    • O. Hwang, H. Baker, S. Gross, and T. H. Joh. Localization of GTP cyclohydrolase in monoaminergic but not nitric oxide-producing cells. Synapse. 28:140-153 (1998).
    • (1998) Synapse , vol.28 , pp. 140-153
    • Hwang, O.1    Baker, H.2    Gross, S.3    Joh, T.H.4
  • 46
    • 0032926746 scopus 로고    scopus 로고
    • GTP cyclohydrolase I gene expression in the brains of male and female hph-1 mice
    • M. Shimoji, K. Hirayama, K. Hyland, and G. Kapatos. GTP cyclohydrolase I gene expression in the brains of male and female hph-1 mice. J. Neurochem. 72:757-764 (1999).
    • (1999) J. Neurochem , vol.72 , pp. 757-764
    • Shimoji, M.1    Hirayama, K.2    Hyland, K.3    Kapatos, G.4
  • 47
    • 0030996320 scopus 로고    scopus 로고
    • Immunohistochemical colocalization of GTP cyclohydrolase I in the nigrostriatal system with tyrosine hydroxylase
    • I. Nagatsu, R. Arai, M. Sakai, Y. Yamawaki, T. Takeuchi, N. Karasawa, and T. Nagatsu. Immunohistochemical colocalization of GTP cyclohydrolase I in the nigrostriatal system with tyrosine hydroxylase. Neurosci Lett. 224:185-188 (1997).
    • (1997) Neurosci Lett , vol.224 , pp. 185-188
    • Nagatsu, I.1    Arai, R.2    Sakai, M.3    Yamawaki, Y.4    Takeuchi, T.5    Karasawa, N.6    Nagatsu, T.7
  • 49
    • 0028172887 scopus 로고
    • 5' upstream DNA sequence of the rat tyrosine hydroxylase gene directs high-level and tissue-specific expression to catecholaminergic neurons in the central nervous system of transgenic mice
    • N. Min, T. H. Joh, K. S. Kim, C. Peng, and J. H. Son. 5' upstream DNA sequence of the rat tyrosine hydroxylase gene directs high-level and tissue-specific expression to catecholaminergic neurons in the central nervous system of transgenic mice. Mol. Brain Res. 27:281-289 (1994).
    • (1994) Mol. Brain Res , vol.27 , pp. 281-289
    • Min, N.1    Joh, T.H.2    Kim, K.S.3    Peng, C.4    Son, J.H.5
  • 50
    • 0036788304 scopus 로고    scopus 로고
    • Gene silencing in mammals by small interfering RNAs
    • M. McManus, and P. Sharp. Gene silencing in mammals by small interfering RNAs. Genetics. 3:737-747 (2002).
    • (2002) Genetics , vol.3 , pp. 737-747
    • McManus, M.1    Sharp, P.2
  • 51
    • 0037146606 scopus 로고    scopus 로고
    • Breakthrough of the year. Small RNAs make a big splash
    • J. Couzin. Breakthrough of the year. Small RNAs make a big splash. Science. 298:2296-2297 (2002).
    • (2002) Science , vol.298 , pp. 2296-2297
    • Couzin, J.1
  • 52
    • 0037089589 scopus 로고    scopus 로고
    • Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells
    • P. Paddison, A. Caudy, E. Bernstein, G. Hannon, and D. Conklin. Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells. Genes Dev. 16:948-958 (2002).
    • (2002) Genes Dev , vol.16 , pp. 948-958
    • Paddison, P.1    Caudy, A.2    Bernstein, E.3    Hannon, G.4    Conklin, D.5
  • 54
    • 0036351317 scopus 로고    scopus 로고
    • Analysis of gene function in somatic mammalian cells using small interfering RNAs
    • S. M. Elbashir, J. Harborth, K. Weber, and T. Tuschl. Analysis of gene function in somatic mammalian cells using small interfering RNAs. Methods. 26:199-213 (2002).
    • (2002) Methods , vol.26 , pp. 199-213
    • Elbashir, S.M.1    Harborth, J.2    Weber, K.3    Tuschl, T.4
  • 55
    • 0037134020 scopus 로고    scopus 로고
    • A system for stable expression of short interfering RNAs in mammalian cells
    • T. R. Brummelkamp, R. Bernards, and R. Agami. A system for stable expression of short interfering RNAs in mammalian cells. Science 296:550-553 (2002).
    • (2002) Science , vol.296 , pp. 550-553
    • Brummelkamp, T.R.1    Bernards, R.2    Agami, R.3
  • 57
    • 12344269275 scopus 로고    scopus 로고
    • RNA interference and nonviral targeted gene therapy of experimental brain cancer
    • R. J. Boado. RNA interference and nonviral targeted gene therapy of experimental brain cancer. NeuroRx. 2:139-150 (2005).
    • (2005) NeuroRx , vol.2 , pp. 139-150
    • Boado, R.J.1
  • 58
    • 0034651861 scopus 로고    scopus 로고
    • Abnormal expression of hepatoma and alteration of gamma-glutamyl transferase gene methylation status in patients with hepatocellular carcinoma
    • D. Yao, D. Jiang, Z. Huang, J. Lu, Q. Tao, Z. Yu, and X. Meng. Abnormal expression of hepatoma and alteration of gamma-glutamyl transferase gene methylation status in patients with hepatocellular carcinoma. Cancer. 88:761-769 (2000).
    • (2000) Cancer , vol.88 , pp. 761-769
    • Yao, D.1    Jiang, D.2    Huang, Z.3    Lu, J.4    Tao, Q.5    Yu, Z.6    Meng, X.7
  • 59
    • 0026508882 scopus 로고
    • Densitydependent regulation of cell surface gamma-glutamyl transpeptidase in cultured glial cells
    • K. Morgenstern, O. Hanson-Painton, B. Wang, and L. De Bault. Densitydependent regulation of cell surface gamma-glutamyl transpeptidase in cultured glial cells. J. Cell Physiol. 150:104-115 (1992).
    • (1992) J. Cell Physiol. , vol.150 , pp. 104-115
    • Morgenstern, K.1    Hanson-Painton, O.2    Wang, B.3    De Bault, L.4
  • 60
    • 0036788304 scopus 로고    scopus 로고
    • Gene silencing in mammals by small interfering RNAs
    • M. T. McManus, and P. A. Sharp. Gene silencing in mammals by small interfering RNAs. Nat. Rev. Genet. 3:737-747 (2002).
    • (2002) Nat. Rev. Genet , vol.3 , pp. 737-747
    • McManus, M.T.1    Sharp, P.A.2
  • 61
    • 0037303455 scopus 로고    scopus 로고
    • Simultaneous inhibition of GSK3. and GSK3. using hairpin siRNA expression vectors
    • J. Y. Yu, J. Taylor, S. L. DeRuiter, A. B. Vojtek, and D. L. Turner. Simultaneous inhibition of GSK3. and GSK3. using hairpin siRNA expression vectors. Molec. Ther. 7:228-236 (2003).
    • (2003) Molec. Ther. , vol.7 , pp. 228-236
    • Yu, J.Y.1    Taylor, J.2    Deruiter, S.L.3    Vojtek, A.B.4    Turner, D.L.5
  • 62
    • 0036665418 scopus 로고    scopus 로고
    • Antisense gene therapy of brain cancer with an artificial virus gene delivery system
    • Y. Zhang, C. Zhu, and W. M. Pardridge. Antisense gene therapy of brain cancer with an artificial virus gene delivery system. Molec. Ther. 6:67-72 (2002).
    • (2002) Molec. Ther. , vol.6 , pp. 67-72
    • Zhang, Y.1    Zhu, C.2    Pardridge, W.M.3
  • 63
    • 0035881276 scopus 로고    scopus 로고
    • Guyer. Stimulation of mitogenic pathways through kinase-impaired mutants of the epidermal growth factor receptor
    • J. A. Ewald, K. J. Coker, J. O. Price, J. V. Staros, C. A. Guyer. Stimulation of mitogenic pathways through kinase-impaired mutants of the epidermal growth factor receptor. Exp. Cell Res. 268:262-273 (2001).
    • (2001) Exp. Cell Res. , vol.268 , pp. 262-273
    • Ewald, J.A.1    Coker, K.J.2    Price, J.O.3    Staros, J.V.4    Guyer, C.A.5
  • 65
    • 0037699025 scopus 로고    scopus 로고
    • PTEN decreases in vivo vascularization of experimental gliomas in spite of proangiogenic stimuli
    • Abe T, Terada K, Wakimoto H, Inoue R, Tyminski E, et al. PTEN decreases in vivo vascularization of experimental gliomas in spite of proangiogenic stimuli. Cancer Res. 63:2300-2305 (2003).
    • (2003) Cancer Res. , vol.63 , pp. 2300-2305
    • Abe, T.1    Terada, K.2    Wakimoto, H.3    Inoue, R.4    Tyminski., E.5
  • 69
    • 0035878671 scopus 로고    scopus 로고
    • Monoclonal antibody 806 inhibits the growth of tumor xenografts expressing either the de2-7 or amplified epidermal growth factor receptor (EGFR) but not wild-type EGFR
    • R. B. Luwor, T. G. Johns, C. Murone, H. J. Huang, W. K. Cavenee, G. Ritter, L. G. Old, A. W. Burgess, and A. M. Scott. Monoclonal antibody 806 inhibits the growth of tumor xenografts expressing either the de2-7 or amplified epidermal growth factor receptor (EGFR) but not wild-type EGFR. Cancer Res. 61:5355-5361 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 5355-5361
    • Luwor, R.B.1    Johns, T.G.2    Murone, C.3    Huang, H.J.4    Cavenee, W.K.5    Ritter, G.6    Old, L.G.7    Burgess, A.W.8    Scott, A.M.9
  • 71
    • 0037431502 scopus 로고    scopus 로고
    • Suppression of EGFRvIII-mediated proliferation and tumorigenesis of breast cancer cells by ribozyme
    • X. Luo, X. Gong, and C. K. Tang. Suppression of EGFRvIII-mediated proliferation and tumorigenesis of breast cancer cells by ribozyme. Int. J. Cancer. 104:716-721 (2003).
    • (2003) Int. J. Cancer , vol.104 , pp. 716-721
    • Luo, X.1    Gong, X.2    Tang, C.K.3
  • 72
    • 1342306385 scopus 로고    scopus 로고
    • Targeting Alzheimer's disease genes with RNA interference: An efficient strategy for silencing mutant alleles
    • V. M. Miller, C. M. Gouvion, B. L. Davidson, and H. L. Paulson. Targeting Alzheimer's disease genes with RNA interference: an efficient strategy for silencing mutant alleles. Nucleic Acids Res. 32:661-668 (2004).
    • (2004) Nucleic Acids Res. , vol.32 , pp. 661-668
    • Miller, V.M.1    Gouvion, C.M.2    Davidson, B.L.3    Paulson, H.L.4
  • 73
    • 34447571799 scopus 로고    scopus 로고
    • Comparison of cDNA and genomic forms of tyrosine hydroxylase gene therapy of the brain with Trojan horse liposomes
    • (in press).
    • C-F. Xia, C. Chu, J. Li, Y. Wang, Y. Zhang, R. J. Boado, and W. M. Pardridge. Comparison of cDNA and genomic forms of tyrosine hydroxylase gene therapy of the brain with Trojan horse liposomes. J. Gene Med. (2007) (in press).
    • (2007) J. Gene Med.
    • Xia, C.-F.1    Chu, C.2    Li, J.3    Wang, Y.4    Zhang, Y.5    Boado, R.J.6    Pardridge, W.M.7
  • 74
    • 0344084043 scopus 로고    scopus 로고
    • Absence of toxicity of chronic weekly intravenous gene therapy with pegylated immunoliposomes
    • Y-F. Zhang, R. J. Boado, and W. M. Pardridge. Absence of toxicity of chronic weekly intravenous gene therapy with pegylated immunoliposomes. Pharm. Res. 20:1779-1785 (2003).
    • (2003) Pharm. Res. , vol.20 , pp. 1779-1785
    • Zhang, Y.-F.1    Boado, R.J.2    Pardridge, W.M.3
  • 75
    • 0034623009 scopus 로고    scopus 로고
    • Sleeping Beauty, a wide host-range transposon vector for genetic transformation in vertebrates
    • Z. Izsvak, Z. Ivics, and R. H. Plasterk. Sleeping Beauty, a wide host-range transposon vector for genetic transformation in vertebrates. J. Mol. Biol. 302:93-102 (2000).
    • (2000) J. Mol. Biol , vol.302 , pp. 93-102
    • Izsvak, Z.1    Ivics, Z.2    Plasterk, R.H.3
  • 77
    • 0025836586 scopus 로고
    • Selective transport of an anti-transferrin receptor antibody through the blood-brain barrier in vivo
    • W. M. Pardridge, J. L. Buciak, and P. M. Friden. Selective transport of an anti-transferrin receptor antibody through the blood-brain barrier in vivo. J. Pharmacol. Exp. Ther. 259:66-70 (1991).
    • (1991) J. Pharmacol. Exp. Ther. , vol.259 , pp. 66-70
    • Pardridge, W.M.1    Buciak, J.L.2    Friden, P.M.3
  • 78
    • 0002595302 scopus 로고    scopus 로고
    • Targeting rat anti-mouse transferrin receptor monoclonal antibodies through blood-brain barrier in mouse
    • J. H. Lee, B. Engelhardt, J. Lesley, U. Bickel, and W. M. Pardridge. Targeting rat anti-mouse transferrin receptor monoclonal antibodies through blood-brain barrier in mouse. J. Pharmacol. Exp. Ther. 292:1048-1052 (2000).
    • (2000) J. Pharmacol. Exp. Ther. , vol.292 , pp. 1048-1052
    • Lee, J.H.1    Engelhardt, B.2    Lesley, J.3    Bickel, U.4    Pardridge, W.M.5
  • 79
    • 0029009048 scopus 로고
    • Human insulin receptor monoclonal antibody undergoes high affinity binding to human brain capillaries in vitro and rapid transcytosis through the blood-brain barrier in vivo in the primate
    • W. M. Padridge, Y. S. Kang, J. L. Buciak, and J. Yang. Human insulin receptor monoclonal antibody undergoes high affinity binding to human brain capillaries in vitro and rapid transcytosis through the blood-brain barrier in vivo in the primate. Pharm. Res. 12:807-816 (1995).
    • (1995) Pharm. Res. , vol.12 , pp. 807-816
    • Padridge, W.M.1    Kang, Y.S.2    Buciak, J.L.3    Yang, J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.