Enzyme-triggered PEGylated pDNA-nanoparticles for controlled release of pDNA in tumors

Bioconjugate Chemistry

Volumn 24, Issue 3, 2013, Pages 343-362

  Yingyuad, Peerada ^a   Mével, Mathieu ^a   Prata, Carla ^a   Furegati, Stefan ^a   Kontogiorgis, Christos ^a   Thanou, Maya ^b   Miller, Andrew D ^a,b  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME ACTIVITY; NUCLEIC ACIDS; POLYETHYLENE GLYCOLS; TUMORS;

BIOLOGICAL FLUIDS; COLLOIDAL STABILITY; CONTROLLED RELEASE; ENZYME-ASSISTED; IN-VIVO; NANOPARTICLE INTERACTION; PEGYLATED; PLASMID DNA; SURFACE LAYERS; TARGET SITES;

NANOPARTICLES;

ELASTASE; GELATINASE A; LIPID; MACROGOL 2000; NANOPARTICLE; PLASMID DNA; PROPIDIUM IODIDE;

AGAR GEL ELECTROPHORESIS; ARTICLE; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME STRUCTURE; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; IN VITRO GENE TRANSFER; IN VITRO STUDY; IN VIVO STUDY; LEUKOCYTE; NEOPLASM; PHOTON CORRELATION SPECTROSCOPY; PHYSICAL CHEMISTRY; STATIC ELECTRICITY; TARGET CELL; ZETA POTENTIAL;

EID: 84875464303     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc300419g     Document Type: Article

References (47)

1. Miller, A. D. (2003) The problem with cationic liposome/micelle-based non-viral vector systems for gene therapy Curr. Med. Chem. 10, 1195-1211
2. Fletcher, S., Ahmad, A., Perouzel, E., Heron, A., Miller, A. D., and Jorgensen, M. R. (2006) In vivo studies of dialkynoyl analogues of DOTAP demonstrate improved gene transfer efficiency of cationic liposomes in mouse lung J. Med. Chem. 49, 349-357
3. Fletcher, S., Ahmad, A., Perouzel, E., Jorgensen, M. R., and Miller, A. D. (2006) A dialkanoyl analogue of DOPE improves gene transfer of lower-charged, cationic lipoplexes Org. Biomol. Chem. 4, 196-199
4. Fletcher, S., Ahmad, A., Price, W. S., Jorgensen, M. R., and Miller, A. D. (2008) Biophysical properties of CDAN/DOPE-analogue lipoplexes account for enhanced gene delivery ChemBioChem 9, 455-463
5. Tagawa, T., Manvell, M., Brown, N., Keller, M., Perouzel, E., Murray, K. D., Harbottle, R. P., Tecle, M., Booy, F., Brahimi-Horn, M. C., Coutelle, C., Lemoine, N. R., Alton, E. W. F. W., and Miller, A. D. (2002) Characterisation of LMD virus-like nanoparticles self-assembled from cationic liposomes, adenovirus core peptide μ (mu) and plasmid DNA Gene Ther. 9, 564-576
6. Kostarelos, K. and Miller, A. D. (2005) Synthetic, self-assembly ABCD nanoparticles; a structural paradigm for viable synthetic non-viral vectors Chem. Soc. Rev. 34, 970-994
7. Miller, A. D. (2008) Towards safe nanoparticle technologies for nucleic acid therapeutics Tumori 94, 234-245
8. Miller, A. D. (2008) Synthetic nucleic acid delivery systems in gene therapy, in Encyclopedia of Life Sciences, J. Wiley & Sons, DOI: 10.1002/9780470015902.a0005745.pub2.
9. Aissaoui, A., Chami, M., Hussein, M., and Miller, A. D. (2011) Efficient topical delivery of plasmid DNA to lung in vivo mediated by putative triggered, PEGylated pDNA nanoparticles J. Controlled Release 154, 275-284
10. Drake, C. R., Aissaoui, A., Argyros, O., Serginson, J. M., Monnery, B. D., Thanou, M., Steinke, J. H. G., and Miller, A. D. (2010) Bioresponsive small molecule polyamines as non-cytotoxic alternative to polyethylenimine Mol. Pharmaceutics 7, 2040-2055
11. Hatakeyama, H., Akita, H., Kogure, K., Oishi, M., Nagasaki, Y., Kihira, Y., Ueno, M., Kobayashi, H., Kikuchi, H., and Harashima, H. (2007) Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid Gene Ther. 14, 68-77
12. Pak, C. C., Ali, S., Janoff, A. S., and Meers, P. (1998) Triggerable liposomal fusion by enzyme cleavage of a novel peptide-lipid conjugate Biochim. Biophys. Acta 1372, 13-27
13. Pak, C. C., Erukulla, R. K., Ahl, P. L., Janoff, A. S., and Meers, P. (1999) Elastase activated liposomal delivery to nucleated cells Biochim. Biophys. Acta 1419, 111-126
14. Han, F. and Zhu, H. G. (2010) Caveolin-1 regulating the invasion and expression of matrix metalloproteinase (MMPs) in pancreatic carcinoma cells J. Surg. Res. 159, 443-450
15. Hyuga, S., Nishikawa, Y., Sakata, K., Tanaka, H., Yamagata, S., Sugita, K., Saga, S., Matsuyama, M., and Shimizu, S. (1994) Autocrine factor enhancing the secretion of M(r) 95,000 gelatinase (matrix metalloproteinase 9) in serum-free medium conditioned with murine metastatic colon carcinoma cells Cancer Res. 54, 3611-3616
16. Kean, M. J., Williams, K. C., Skalski, M., Myers, D., Burtnik, A., Foster, D., and Coppolino, M. G. (2009) VAMP3, syntaxin-13 and SNAP23 are involved in secretion of matrix metalloproteinases, degradation of the extracellular matrix and cell invasion J. Cell. Sci. 122, 4089-4098
17. Lin, S. W., Lee, M. T., Ke, F. C., Lee, P. P., Huang, C. J., Ip, M. M., Chen, L., and Hwang, J. J. (2000) TGFbeta1 stimulates the secretion of matrix metalloproteinase 2 (MMP2) and the invasive behavior in human ovarian cancer cells, which is suppressed by MMP inhibitor BB3103 Clin. Exp. Metastasis 18, 493-499
18. Lu, N., Ling, Y., Gao, Y., Chen, Y., Mu, R., Qi, Q., Liu, W., Zhang, H., Gu, H., Wang, S., Yang, Y., and Guo, Q. (2008) Endostar suppresses invasion through downregulating the expression of matrix metalloproteinase-2/9 in MDA-MB-435 human breast cancer cells Exp. Biol. Med. 233, 1013-1020
19. Morgunova, E., Tuuttila, A., Bergmann, U., and Tryggvason, K. (2002) Structural insight into the complex formation of latent matrix metalloproteinase 2 with tissue inhibitor of metalloproteinase 2 Proc. Natl. Acad. Sci. U.S.A. 99, 7414-7419
20. Stellas, D., El Hamidieh, A., and Patsavoudi, E. (2010) Monoclonal antibody 4C5 prevents activation of MMP2 and MMP9 by disrupting their interaction with extracellular HSP90 and inhibits formation of metastatic breast cancer cell deposits BMC Cell Biol. 11, 51
21. Wang, F. Q., So, J., Reierstad, S., and Fishman, D. A. (2005) Matrilysin (MMP-7) promotes invasion of ovarian cancer cells by activation of progelatinase Int. J. Cancer 114, 19-31
22. Mével, M., Kamaly, N., Carmona, S., Oliver, M. H., Jorgensen, M. R., Crowther, C., Salazar, F. H., Marion, P. L., Fujino, M., Natori, Y., Thanou, M., Arbuthnot, P., Yaouanc, J.-J., Jaffres, P. A., and Miller, A. D. (2010) DODAG; a versatile new cationic lipid that mediates efficient delivery of pDNA and siRNA J. Controlled Release 143, 222-232
23. Lee, G. Y., Park, K., Kim, S. Y., and Byun, Y. (2007) MMPs-specific PEGylated peptide-DOX conjugate micelles that can contain free doxorubicin Eur. J. Pharm. Biopharm. 67, 646-654
24. Lv, H., Zhang, S., Wang, B., Cui, S., and Yan, J. (2006) Toxicity of cationic lipids and cationic polymers in gene delivery J. Controlled Release 114, 100-109
25. Miller, C. R., Bondurant, B., McLean, S. D., McGovern, K. A., and O'Brien, D. F. (1998) Liposome-cell interactions in vitro: effect of liposome surface charge on the binding and endocytosis of conventional and sterically stabilized liposomes Biochemistry 37, 12875-12883
26. Koltover, I., Salditt, T., Radler, J. O., and Safinya, C. R. (1998) An inverted hexagonal phase of cationic liposome-DNA complexes related to DNA release and delivery Science 281, 78-81
27. Wasungu, L. and Hoekstra, D. (2006) Cationic lipids, lipoplexes and intracellular delivery of genes J. Controlled Release 116, 255-264
28. Hong, K., Zheng, W., Baker, A., and Papahadjopoulos, D. (1997) Stabilization of cationic liposome-plasmid DNA complexes by polyamines and poly(ethylene glycol)-phospholipid conjugates for efficient in vivo gene delivery FEBS Lett. 400, 233-237
29. Li, S., Rizzo, M. A., Bhattacharya, S., and Huang, L. (1998) Characterization of cationic lipid-protamine-DNA (LPD) complexes for intravenous gene delivery Gene Ther. 5, 930-937
30. Stewart, L., Manvell, M., Hillery, E., Etheridge, C. J., Cooper, R. G., Stark, H., van-Heel, M., Preuss, M., Alton, E. W. F. W., and D., M. A. (2001) Physico-chemical analysis of cationic liposome-DNA complexes (lipoplexes) with respect to in vitro and in vivo gene delivery efficiency J. Chem. Soc., Perkin Trans. 2 624-632
31. Strijkers, G. J., Mulder, W. J., van Heeswijk, R. B., Frederik, P. M., Bomans, P., Magusin, P. C., and Nicolay, K. (2005) Relaxivity of liposomal paramagnetic MRI contrast agents MAGMA 18, 186-192
32. Kirby, C., Clarke, J., and Gregoriadis, G. (1980) Effect of the cholesterol content of small unilamellar liposomes on their stability in vivo and in vitro Biochem. J. 186, 591-598
33. Semple, S. C., Chonn, A., and Cullis, P. R. (1996) Influence of cholesterol on the association of plasma proteins with liposomes Biochemistry 35, 2521-2525
34. Cooper, R. G., Etheridge, C. J., Stewart, L., Marshall, J., Rudginsky, S., Cheng, S. H., and Miller, A. D. (1998) Polyamine analogues of 3β-[N-(N′,N′-dimethylaminoethane)carbamoyl] cholesterol (DC-Chol) as agents for gene delivery Chem. Eur. J. 4, 137-152
35. Templeton, N. S., Lasic, D. D., Frederik, P. M., Strey, H. H., Roberts, D. D., and Pavlakis, G. N. (1997) Improved DNA: liposome complexes for increased systemic delivery and gene expression Nat. Biotechnol. 15, 647-652
36. Kamaly, N., Kalber, T., Ahmad, A., Oliver, M. H., So, P. W., Herlihy, A. H., Bell, J. D., Jorgensen, M. R., and Miller, A. D. (2008) Bimodal paramagnetic and fluorescent liposomes for cellular and tumor magnetic resonance imaging Bioconjugate Chem. 19, 118-129
37. Zelphati, O., Uyechi, L. S., Barron, L. G., and Szoka, F. C., Jr. (1998) Effect of serum components on the physico-chemical properties of cationic lipid/oligonucleotide complexes and on their interactions with cells Biochim. Biophys. Acta 1390, 119-133
38. Crook, K., Stevenson, B. J., Dubouchet, M., and Porteous, D. J. (1998) Inclusion of cholesterol in DOTAP transfection complexes increases the delivery of DNA to cells in vitro in the presence of serum Gene Ther. 5, 137-143
39. Waterhouse, J. E., Harbottle, R. P., Keller, M., Kostarelos, K., Coutelle, C., Jorgensen, M. R., and Miller, A. D. (2005) Synthesis and Application of Integrin Targeting Lipopeptides in Targeted Gene Delivery ChemBioChem 6, 1212-1223
40. Farokhzad, O. C., Jon, S., Khademhosseini, A., Tran, T. N., Lavan, D. A., and Langer, R. (2004) Nanoparticle-aptamer bioconjugates: a new approach for targeting prostate cancer cells Cancer Res. 64, 7668-7672
41. Zeisig, R., Arndt, D., Stahn, R., and Fichtner, I. (1998) Physical properties and pharmacological activity in vitro and in vivo of optimized liposomes prepared from a new cancerostatic alkylphospholipid Biochim. Biophys. Acta 1414, 238-248
42. Kubista, M., Akerman, B., and Norden, B. (1987) Characterization of interaction between DNA and 4′,6-diamidino-2-phenylindole by optical spectroscopy Biochemistry 26, 4545-4553
43. Huang, L. and Liu, Y. (2011) In Vivo Delivery of RNAi with Lipid-Based Nanoparticles Annu. Rev. Biomed. Eng. 13, 507-530
44. Terada, T., Iwai, M., Kawakami, S., Yamashita, F., and Hashida, M. (2006) Novel PEG-matrix metalloproteinase-2 cleavable peptide-lipid containing galactosylated liposomes for hepatocellular carcinoma-selective targeting J. Controlled Release 111, 333-342
45. Harris, T. J., von Maltzahn, G., Derfus, A. M., Ruoslahti, E., and Bhatia, S. N. (2006) Proteolytic actuation of nanoparticle self-assembly Angew. Chem., Int. Ed. Engl. 45, 3161-3165
46. Kamaly, N., Kalber, T., Thanou, M., Bell, J. D., and Miller, A. D. (2009) Folate receptor targeted bimodal liposomes for tumor magnetic resonance imaging Bioconjugate Chem. 20, 648-655
47. Song, S., Liu, D., Peng, J., Deng, H., Guo, Y., Xu, L. X., Miller, A. D., and Xu, Y. (2009) Novel peptide ligand directs liposomes toward EGF-R high-expressing cancer cells in vitro and in vivo FASEB J. 23, 1396-1404