Novel multifunctional nanoparticle mediates siRNA tumour delivery, visualisation and therapeutic tumour reduction in vivo

Journal of Controlled Release

Volumn 149, Issue 2, 2011, Pages 111-116

  Kenny, Gavin D ^a,c   Kamaly, Nazila ^a,b   Kalber, Tammy L ^a   Brody, Leigh P ^a   Sahuri, Meliz ^a   Shamsaei, Elham ^a   Miller, Andrew D ^b   Bell, Jimmy D ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Liposome; Magnetic resonance imaging; Paramagnetic; siRNA; Survivin; Tumour therapy

Indexed keywords

IN-VIVO; INTRAVENOUS INJECTIONS; LOCALISATION; MULTI-FUNCTIONAL NANOPARTICLES; PARAMAGNETIC; RNA INTERFERENCE; SIRNA; SIRNA DELIVERY; SMALL INTERFERING RNA (SIRNA); SURVIVIN; TUMOUR GROWTH; TUMOUR THERAPY; TUMOURS; VISUALISATION;

FLUORESCENCE; FLUORESCENCE MICROSCOPY; MAGNETIC RESONANCE IMAGING; NANOPARTICLES; PARAMAGNETIC MATERIALS; PARAMAGNETISM; RESONANCE; RNA; TUMORS; VISUALIZATION;

GENE THERAPY;

LIPOSOME; MACROGOL; NANOPARTICLE; SMALL INTERFERING RNA; SURVIVIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DRUG FORMULATION; FEMALE; FLUORESCENCE MICROSCOPY; GENE EXPRESSION; HUMAN; HUMAN CELL; IMAGE ENHANCEMENT; IN VIVO STUDY; LIPOSOMAL GENE DELIVERY SYSTEM; MOUSE; NANOPARTICLE GENE DELIVERY SYSTEM; NANOPHARMACEUTICS; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; RNA INTERFERENCE; TUMOR XENOGRAFT;

ANIMALS; BLOTTING, WESTERN; CHEMISTRY, PHARMACEUTICAL; CONTRAST MEDIA; DRUG STABILITY; FEMALE; FLUORESCENT DYES; INHIBITOR OF APOPTOSIS PROTEINS; LIPOSOMES; MAGNETIC RESONANCE IMAGING; MICE; MICE, INBRED BALB C; MICE, NUDE; MICROSCOPY, FLUORESCENCE; NANOPARTICLES; NEOPLASMS; REPRESSOR PROTEINS; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EID: 78651352062     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2010.09.020     Document Type: Article

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